Rohan Shah, Inae Jang Kim, Lewis Oh, Javaneh Abbasian, Asim V Farooq
{"title":"Bilateral Secondary Glaucoma Associated with Congenital Herpes Simplex Virus Keratitis: A Case Report and Review of the Literature.","authors":"Rohan Shah, Inae Jang Kim, Lewis Oh, Javaneh Abbasian, Asim V Farooq","doi":"10.1080/09273948.2025.2555382","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To highlight a relatively underappreciated yet significant complication of neonatal ocular herpes simplex virus (HSV) infection.</p><p><strong>Methods: </strong>Observational case report of a 4-week-old patient with congenital ocular HSV infection over the course of 6-year follow-up.</p><p><strong>Results: </strong>We describe a case of a neonate who developed bilateral HSV keratitis who subsequently developed bilateral glaucoma 9 months following primary infection. This patient ultimately required multiple goniotomies and glaucoma drainage device placement to achieve IOP control.</p><p><strong>Conclusions: </strong>We hypothesize that the combination of initial HSV infection and associated inflammation damaged the trabecular meshwork and led to peripheral anterior synechiae, ultimately reducing outflow in this patient's developing eyes. This case is an example of a potentially underappreciated manifestation of congenital ocular HSV and its complications.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-3"},"PeriodicalIF":2.0000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ocular Immunology and Inflammation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09273948.2025.2555382","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: To highlight a relatively underappreciated yet significant complication of neonatal ocular herpes simplex virus (HSV) infection.
Methods: Observational case report of a 4-week-old patient with congenital ocular HSV infection over the course of 6-year follow-up.
Results: We describe a case of a neonate who developed bilateral HSV keratitis who subsequently developed bilateral glaucoma 9 months following primary infection. This patient ultimately required multiple goniotomies and glaucoma drainage device placement to achieve IOP control.
Conclusions: We hypothesize that the combination of initial HSV infection and associated inflammation damaged the trabecular meshwork and led to peripheral anterior synechiae, ultimately reducing outflow in this patient's developing eyes. This case is an example of a potentially underappreciated manifestation of congenital ocular HSV and its complications.
期刊介绍:
Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.