Analysis of Clinical Characteristics and Posterior Segment Parameters in Multiple Sclerosis-Associated Uveitis with Optical Coherence Tomography Angiography.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-10-07 DOI:10.1080/09273948.2025.2568646

Nurtaç Yeşilyaprak, Ali Mert Koçer, Hayat Güven, Bülent Güven, Fatma Avşar Ertürk, Pınar Çakar Özdal

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引用次数: 0

Abstract

Purpose: To describe the clinical characteristics of multiple sclerosis-associated uveitis (MSAU), to examine its relationship with multiple sclerosis (MS), using optical coherence tomography angiography (OCT-A) and spectral-domain optical coherence tomography (SD-OCT) parameters of patients.

Methods: The study included 58 eyes of 29 patients with MSAU, 102 eyes of 55 patients with MS, and 41 eyes of 41 healthy controls (HC). The eyes were divided into four subgroups depending on history of optic neuritis (MSON+, MSAUON+, MSON-, MSAUON-). All underwent OCT-A and SD-OCT. The data collected from MS, MSAU and control groups was compared.

Results: In MS patients, intermediate uveitis was the most common type of uveitis (41.4%). In unilateral MSON+ patients; a significant decrease was observed in the radial peripapillary capillary plexus (RPC), superficial capillary plexus (SCP), pRNFL and macular thickness in the ON+ eye compared to the healthy eye (p < 0.05). In ON- eyes, SCP density was found as control group, MS, and MSAU, respectively, from highest to lowest (p < 0.005). In the MSAUON- group; SCP, deep capillary plexus density (DCP) were significantly decreased compared to MS and control groups (p < 0.005). Macular thickness was decreased in the MSON- group compared to the control group (p < 0.005).

Conclusion: Intermediate uveitis is the most common form of uveitis in MS patients. Optic neuritis causes a decrease in SCP, RPC, RNFL, and macular thickness, it does not create a significant change in DCP. The diffuse reduction in all retinal capillary plexus layers in MSAU may accelerate the neurodegenerative process in ganglion cells.

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光学相干断层血管造影分析多发性硬化相关性葡萄膜炎的临床特征和后段参数。

目的：利用光学相干断层血管造影（OCT-A）和光谱域光学相干断层扫描（SD-OCT）参数，描述多发性硬化相关性葡萄膜炎（MSAU）的临床特征，探讨其与多发性硬化症（MS）的关系。方法：29例MSAU患者58眼，55例MS患者102眼，41例健康对照（HC） 41眼。根据视神经炎病史将眼睛分为4个亚组（MSON+、MSAUON+、MSON-、MSAUON-）。所有患者均行OCT-A和SD-OCT检查。比较MS组、MSAU组和对照组的数据。结果：在MS患者中，中度葡萄膜炎是最常见的葡萄膜炎类型（41.4%）。单侧MSON+患者；结论：中度葡萄膜炎是多发性硬化症患者最常见的葡萄膜炎形式。结论：中度葡萄膜炎是多发性硬化症患者最常见的葡萄膜炎形式。视神经炎可引起SCP、RPC、RNFL和黄斑厚度的降低，但不会引起DCP的显著变化。MSAU视网膜毛细血管丛各层弥漫性减少可能加速神经节细胞的神经退行性过程。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.