Type 2 Uveal Effusion Syndrome with Psoriasis Vulgaris: A Case Report.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-07-01 DOI:10.1080/09273948.2025.2525493

Chen Zhou, Yunfeng Lu, Lingying Ge, Chenglang Xin, Xue Yin

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引用次数: 0

Abstract

Purpose: To report the case of uveal effusion syndrome (UES) in a 35-year-old woman with psoriasis vulgaris, emphasizing scleral pathology and systemic inflammatory contributions mediated by proteomic alterations.

Methods: Medical history, clinical findings and treatment were reviewed, along with histopathological and proteomic analysis.

Results: A 35-year-old woman presented with retinal and choroidal detachments in the left eye and scleral thickening (3 mm vs. normal 1 mm). Concurrently, her psoriasis symptoms worsened. Histology revealed collagen disorganization and extracellular matrix remodeling in the sclera, accompanied by elevated inflammatory factors (e.g. MCP-4, RANTES, Fractalkine). Treatment included partial sclerotomy, leading to resolution of detachments and improved visual acuity.

Conclusion: Systemic inflammation associated with psoriasis may contribute to UES pathogenesis. Dermatologists should refer psoriasis patients for ophthalmologic examinations, while ophthalmologists should be aware of underlying health conditions when treating UES.

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2型葡萄膜积液综合征伴寻常型银屑病1例。

目的：报告一例35岁女性寻常型银屑病患者的葡萄膜积液综合征（UES），强调由蛋白质组学改变介导的巩膜病理和全身炎症贡献。方法：回顾患者的病史、临床表现和治疗，并进行组织病理学和蛋白质组学分析。结果：一名35岁女性，左眼视网膜和脉络膜脱离，巩膜增厚（3mm vs正常1mm）。同时，她的牛皮癣症状加重。组织学显示巩膜胶原组织紊乱和细胞外基质重塑，并伴有炎症因子升高（如MCP-4、RANTES、Fractalkine）。治疗包括部分巩膜切开术，导致分离的解决和视力的改善。结论：银屑病的全身性炎症可能参与UES的发病机制。皮肤科医生应推荐牛皮癣患者进行眼科检查，而眼科医生在治疗UES时应了解潜在的健康状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.