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Antioxidant and inflammatory potential of diet is associated with risk of asthma-chronic obstructive pulmonary disease overlap: Findings from NHANES (2003-2018) 饮食的抗氧化和炎症潜力与哮喘-慢性阻塞性肺疾病重叠的风险相关:NHANES的研究结果(2003-2018)
IF 3.4 3区 医学
Nutrition Research Pub Date : 2025-03-01 DOI: 10.1016/j.nutres.2025.01.010
Yuhuan Wei , Li Qin , Xiaoling Wang , Yuan Cui , Yunhua Zhao , Shaoye Huo , Lihong Wang , Teng Li , Chunhai Shao
{"title":"Antioxidant and inflammatory potential of diet is associated with risk of asthma-chronic obstructive pulmonary disease overlap: Findings from NHANES (2003-2018)","authors":"Yuhuan Wei ,&nbsp;Li Qin ,&nbsp;Xiaoling Wang ,&nbsp;Yuan Cui ,&nbsp;Yunhua Zhao ,&nbsp;Shaoye Huo ,&nbsp;Lihong Wang ,&nbsp;Teng Li ,&nbsp;Chunhai Shao","doi":"10.1016/j.nutres.2025.01.010","DOIUrl":"10.1016/j.nutres.2025.01.010","url":null,"abstract":"<div><div>Previous studies have explored the connection between the dietary inflammation index (DII) and asthma-COPD Overlap (ACO); however, the relationship between diet and the risk of ACO from an antioxidant perspective remains unexamined. We hypothesized that a proinflammatory diet may increase the risk of ACO by promoting inflammation, whereas an antioxidant diet may reduce the risk by mitigating inflammation. To test this hypothesis, we conducted a cross-sectional study utilizing data from the National Health and Nutrition Examination Survey (NHANES) in 2003-2018, including 23,050 participants. The study employed propensity score matching (PSM), logistic regression, restricted cubic splines (RCS), and mediation analysis. Pre-PSM and post-PSM RCS analyses indicated a positive correlation between DII and ACO, while the composite dietary antioxidant index (CDAI) demonstrated a negative association (<em>P-overall</em> &lt;0 .05). Pre-PSM and post-PSM logistic regression results showed that higher DII scores were associated with an increased risk of ACO, while higher CDAI scores correlated with a reduced risk of ACO (<em>P</em> &lt;0 .05). Mediation analysis further indicated that pro-inflammatory diets increased ACO risk through elevated levels of white blood cells (WBC), eosinophil counts (EC), systemic immune-inflammation index (SII), and system inflammation response index (SIRI) (<em>P</em> &lt; 0.05). In contrast, antioxidant diets reduced the risk of ACO events by decreasing the levels of these inflammatory markers (<em>P</em> &lt; 0.05). In conclusion, higher DII scores may increase the risk of ACO, while higher CDAI scores may decrease it. Both DII and CDAI mediate their effects through inflammatory markers, including WBC, EC, SII, and SIRI.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 128-140"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Full-fat versus non-fat yogurt consumption improves glucose homeostasis and metabolic hormone regulation in individuals with prediabetes: A randomized-controlled trial 一项随机对照试验:全脂酸奶与脱脂酸奶可改善糖尿病前期个体的葡萄糖稳态和代谢激素调节
IF 3.4 3区 医学
Nutrition Research Pub Date : 2025-02-28 DOI: 10.1016/j.nutres.2025.02.005
Victoria M. Taormina , Simonne Eisenhardt , Matthew P. Gilbert , Matthew E. Poynter , C. Lawrence Kien , Jana Kraft
{"title":"Full-fat versus non-fat yogurt consumption improves glucose homeostasis and metabolic hormone regulation in individuals with prediabetes: A randomized-controlled trial","authors":"Victoria M. Taormina ,&nbsp;Simonne Eisenhardt ,&nbsp;Matthew P. Gilbert ,&nbsp;Matthew E. Poynter ,&nbsp;C. Lawrence Kien ,&nbsp;Jana Kraft","doi":"10.1016/j.nutres.2025.02.005","DOIUrl":"10.1016/j.nutres.2025.02.005","url":null,"abstract":"<div><div>Dietary guidance recommends consuming low- or non-fat dairy foods for metabolic health, yet observational research indicates full-fat yogurt intake may not detrimentally affect type 2 diabetes risk. Randomized-controlled trials are needed to further explore this relationship. Our aim was to evaluate the effect of substituting full-fat (3.25%) yogurt for non-fat yogurt on type 2 diabetes risk in individuals with prediabetes. We hypothesized beneficial effects on measures of glucose homeostasis, insulin sensitivity, and metabolic hormone response following short-term consumption of 3 full-fat yogurt servings daily. Thirteen individuals completed the 8-week randomized, double-masked crossover controlled-feeding trial comprised 2, 3-week experimental diet periods in which participants consumed 3 daily servings of full-fat or non-fat yogurt; a 1-week control preceded each diet period. Following each diet period, changes in whole-body glucose handling and metabolic hormone concentrations were measured using mixed meal and oral glucose tolerance tests. Our primary outcome measure was the blood glucose concentration at the 120-minute time point during the oral glucose tolerance test. Though differences in the primary outcome measure were not observed, the full-fat yogurt diet resulted in lower concentrations of blood fructosamine, a marker of average blood glucose concentrations over 2 to 3 weeks. Further, fasting glucagon-like peptide-1 and post-prandial glucose-dependent insulinotropic polypeptide concentrations were greater following the full-fat yogurt diet. Our preliminary results indicate that short-term consumption of full-fat relative to non-fat yogurt beneficially affected aspects of glucose homeostasis and metabolic hormone regulation in individuals with prediabetes, warranting further randomized-controlled research. This trial is registered at clinicaltrials.gov (NCT03577119).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 39-52"},"PeriodicalIF":3.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dairy consumption is associated with breast cancer risk: a comprehensive meta-analysis stratified by hormone receptor and menopausal status, and age 乳制品消费与乳腺癌风险相关:一项由激素受体、绝经状态和年龄分层的综合荟萃分析
IF 3.4 3区 医学
Nutrition Research Pub Date : 2025-02-27 DOI: 10.1016/j.nutres.2025.02.003
Seokyung An , Madhawa Gunathilake , Jeongseon Kim
{"title":"Dairy consumption is associated with breast cancer risk: a comprehensive meta-analysis stratified by hormone receptor and menopausal status, and age","authors":"Seokyung An ,&nbsp;Madhawa Gunathilake ,&nbsp;Jeongseon Kim","doi":"10.1016/j.nutres.2025.02.003","DOIUrl":"10.1016/j.nutres.2025.02.003","url":null,"abstract":"<div><div>Breast cancer (BC) is a prevalent global health concern, with various risk factors contributing to its heterogeneity. This comprehensive meta-analysis aims to explore the association between dairy consumption and BC risk, stratified by hormone receptor, menopausal status, and age. To assess the association between dairy consumption and BC risk, a systematic literature review based on studies published until December 2024 retrieved from PubMed, SCOPUS, Web of Science, and Cochrane Library. Summary relative risks (RRs) with corresponding 95% confidence intervals (CIs) were calculated and then aggregated using random-effects models. Summary RR from 51 studies with 62,602 BC cases showed that overall dairy consumption is inversely associated with BC risk (RR = 0.91, 95% CI: 0.84-0.98, <em>I</em><sup>2</sup> = 75%), particularly among individuals aged over 45 (RR = 0.81, 95% CI: 0.68-0.98, <em>I</em><sup>2</sup> = 0%). Notably, higher intake of low-fat dairy products showed potential protective effects (RR = 0.91, 95% CI: 0.84-0.98, <em>I</em><sup>2</sup> = 56%), especially in premenopausal women (skimmed milk, RR = 0.86, 95% CI: 0.76-0.97, <em>I</em><sup>2</sup> = 0%). Fermented dairy products, including yogurt, exhibited a decreased BC risk, particularly in postmenopausal women (RR = 0.91, 95% CI: 0.87-0.96, <em>I</em><sup>2</sup> = 0%). However, a positive association was observed between total milk intake and the risk of estrogen receptor-negative BC (RR = 1.31, 95% CI: 1.08-1.59, <em>I</em><sup>2</sup> = 0%). This meta-analysis provides comprehensive insights into the association between specific dairy product consumption and BC risk. The findings highlight the protective impact of specific dairy products on different subtypes, offering valuable insights for BC prevention.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 68-75"},"PeriodicalIF":3.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yeast mannans promote laxation and specifically modulate microbiota composition in older adults: An open-label pilot study 酵母甘露聚糖可促进老年人通便并特别调节微生物群的组成:一项开放标签试验研究。
IF 3.4 3区 医学
Nutrition Research Pub Date : 2025-02-26 DOI: 10.1016/j.nutres.2025.02.004
Melissa L. Moreno , Pieter Van den Abbeele , Aurélien Baudot , Thomas A. Tompkins , Diana H. Taft , Runzhe Yao , Jeremie Auger , James Colee , Wendy J. Dahl
{"title":"Yeast mannans promote laxation and specifically modulate microbiota composition in older adults: An open-label pilot study","authors":"Melissa L. Moreno ,&nbsp;Pieter Van den Abbeele ,&nbsp;Aurélien Baudot ,&nbsp;Thomas A. Tompkins ,&nbsp;Diana H. Taft ,&nbsp;Runzhe Yao ,&nbsp;Jeremie Auger ,&nbsp;James Colee ,&nbsp;Wendy J. Dahl","doi":"10.1016/j.nutres.2025.02.004","DOIUrl":"10.1016/j.nutres.2025.02.004","url":null,"abstract":"<div><div>Yeast mannans (YM) are potential prebiotics that may improve laxation. The aim was to evaluate the effects of YM on gastrointestinal symptoms, with a hypothesis of high tolerance. A secondary aim assessed stool frequency. Fecal microbiota composition (16S rRNA gene amplicon sequencing) and targeted urine metabolites (LC-MS/MS) were explored. An <em>ex vivo</em> simulation of digestion and fermentation (6 donors) compared YM to the reference prebiotic inulin followed by an open-label pilot study, with a 1-week baseline and 2-week intervention of 15 g/d of YM. <em>Ex vivo</em> findings showed increased <em>Bacteroides faecis, B. ovatus, Parabacteroides merdae, P. distasonis, Blautia faecis</em>, and <em>Bifidobacterium</em> spp. in response to YM. Participants (<em>n</em> = 20, 71.4 ± 11.0 y) reported no change with YM for burping, constipation, diarrhea, flatulence/gas, nausea, reflux/heartburn, or rumblings/noise, rated from 0 for none to 3 for severe symptoms. Cramping/pain marginally increased from baseline (0.02 ± 0.01) to intervention (0.05 ± 0.02; <em>P</em> = .046), as did distention/bloating (baseline, 0.07 ± 0.03; intervention week 2, 0.15 ± 0.05; <em>P</em> = .037). This high tolerability was explained by the <em>ex vivo</em> finding that YM induced less gas production than inulin (–45%). Stool frequency trended higher with YM (1.53 ± 0.15 stools/d) compared to baseline (1.35 ± 0.11) (<em>P</em> = .079); participants with ≤1 stools/d (<em>n</em> = 8) showed an increase (0.84 ± 0.14 to 1.19 ± 0.32; <em>P</em> = .016). <em>In vivo</em> compositional changes in fecal microbiota suggest increased <em>B. faecis, B. ovatus, P. merdae,</em> and <em>P. distasonis</em> levels in response to YM. Overall, YM elicited specific microbiota modulation with minimal gastrointestinal symptoms and the potential to increase stool frequency, supporting its prebiotic potential. This trial was registered at clinicaltrials.gov (NCT05939336).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 15-27"},"PeriodicalIF":3.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultra-processed food intake is associated with a displacement of the traditional diet of Costa Rican adolescents 超加工食品的摄入与哥斯达黎加青少年传统饮食的改变有关
IF 3.4 3区 医学
Nutrition Research Pub Date : 2025-02-19 DOI: 10.1016/j.nutres.2025.02.002
Kenny Mendoza , Rafael Monge-Rojas , Rulamán Vargas-Quesada , Josiemer Mattei
{"title":"Ultra-processed food intake is associated with a displacement of the traditional diet of Costa Rican adolescents","authors":"Kenny Mendoza ,&nbsp;Rafael Monge-Rojas ,&nbsp;Rulamán Vargas-Quesada ,&nbsp;Josiemer Mattei","doi":"10.1016/j.nutres.2025.02.002","DOIUrl":"10.1016/j.nutres.2025.02.002","url":null,"abstract":"<div><div>Ultra-processed food (UPF) intake is high among adolescent populations worldwide. This study aimed to characterize the UPF intake and assess its contribution to the traditional diet of Costa Rican adolescents. Using cross-sectional data from 3-day food records obtained from 818 adolescents (13-18 years) from San José, Costa Rica, we calculated the daily % of total energy intake (TEI) from Nova-defined UPF, the Traditional Costa Rica Adolescents Diet Score (TCRAD; higher score reflecting higher traditional adherence), other nutrients, and fiber. The multivariable-adjusted mean UPF intakes were compared across participants’ characteristics, mealtime, and days of the week, and assessed for association with TCRAD (continuous score and by adherence categories) and dietary components. UPF intake represented 35.9% of the TEI and was higher on weekdays (<em>vs.</em> weekends), among female adolescents (vs males), urban areas (<em>vs.</em> rural), and higher socioeconomic status. UPF were consumed mostly as snacks (43.5%), in the morning: (58.5%) and afternoon (41.5%). Each 10-percentage-point increase in the total UPF energy contribution was associated with -0.44 (SE = 0.04; <em>P</em> &lt; .0001) lower TCRAD score. UPF was inversely associated with fiber and beneficial micronutrients, and directly associated with added sugars and <em>trans</em> fats. The multivariable-adjusted UPF intake was lower at moderate (38.5%, <em>P</em> &lt; .0001) and high (29.9%, <em>P</em> &lt; .0001) adherence to the TCRAD, compared with low adherence (43.9%). Our results support widespread trends of UPF displacing healthy diets. Strategies to reduce UPF consumption, especially during school hours, and encourage healthy traditional diets, are needed for Costa Rican adolescents.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 1-14"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic variants in insulin, leptin, and their receptors are associated with overweight in a Brazilian asthma cohort 在巴西哮喘队列中,胰岛素、瘦素及其受体的遗传变异与超重有关
IF 3.4 3区 医学
Nutrition Research Pub Date : 2025-02-04 DOI: 10.1016/j.nutres.2025.01.012
Raísa Coelho , Álvaro A. Cruz , Louise Lima , Ana Paula Melo , Emília Belitardo , Candace Machado , Jamille Souza Fernandes , Gustavo Nunes de Oliveira Costa , Adelmir Souza-Machado , Gabriela Pimentel Pinheiro , Cinthia Vila Nova Santana , Camila Alexandrina Figueiredo , Ryan dos S. Costa
{"title":"Genetic variants in insulin, leptin, and their receptors are associated with overweight in a Brazilian asthma cohort","authors":"Raísa Coelho ,&nbsp;Álvaro A. Cruz ,&nbsp;Louise Lima ,&nbsp;Ana Paula Melo ,&nbsp;Emília Belitardo ,&nbsp;Candace Machado ,&nbsp;Jamille Souza Fernandes ,&nbsp;Gustavo Nunes de Oliveira Costa ,&nbsp;Adelmir Souza-Machado ,&nbsp;Gabriela Pimentel Pinheiro ,&nbsp;Cinthia Vila Nova Santana ,&nbsp;Camila Alexandrina Figueiredo ,&nbsp;Ryan dos S. Costa","doi":"10.1016/j.nutres.2025.01.012","DOIUrl":"10.1016/j.nutres.2025.01.012","url":null,"abstract":"<div><div>Obesity is often characterized by meta-inflammation and is influenced by the interaction between genetic predisposition and environmental factors. Common features include impaired insulin action and elevated leptin concentrations, which are accompanied by a simultaneous reduction in sensitivity to these hormones. We hypothesized that single nucleotide variants in protein-coding genes and their receptors may influence the dysfunctions observed in obesity. For that, we investigate the association between single nucleotide variants in the LEP, LEPR, INS, and INSR genes with excess weight in a Brazilian population drawn from an asthma cohort. The study included 703 individuals with excess weight and 333 controls (individuals without overweight) from ProAR foundation. Genotyping was conducted using a commercial Illumina Multi-Ethnic Global Array panel (MEGA, Illumina), which contains 1.5 million markers. Logistic regression was employed to identify associations with the overweight using PLINK 2.0. The analysis was adjusted for age, sex, corticosteroids, and the principal component 1 representing ethnicity to control for confounding factors due to population structure. Variants in the LEP and LEPR genes exhibited the strongest associations with the risk of overweight in our population, whereas the associations with INSR were predominantly negative. The lone variant in the INS gene did not demonstrate a significant association with the outcome. Finally, anthropometric indices showed associations with various genotypes, particularly in the receptor variants. Associations in the genes studied with overweight and the distribution of body fat potentially impacts metabolic dysfunctions, which should be further investigated in other studies.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 28-38"},"PeriodicalIF":3.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
David Kritchevsky Graduate Student Award for Nutrition Research 大卫·克里切夫斯基营养研究研究生奖
IF 3.4 3区 医学
Nutrition Research Pub Date : 2025-02-01 DOI: 10.1016/S0271-5317(25)00021-1
{"title":"David Kritchevsky Graduate Student Award for Nutrition Research","authors":"","doi":"10.1016/S0271-5317(25)00021-1","DOIUrl":"10.1016/S0271-5317(25)00021-1","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Page iii"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A better diet quality based on the Healthy Eating Index-2020 is associated with lower energy intake and age but not with a pre-diabetes/T2DM diagnosis among Hispanic women with overweight/obesity 在超重/肥胖的西班牙裔女性中,基于健康饮食指数-2020的更好的饮食质量与较低的能量摄入和年龄相关,但与糖尿病前期/ 2型糖尿病诊断无关。
IF 3.4 3区 医学
Nutrition Research Pub Date : 2025-02-01 DOI: 10.1016/j.nutres.2025.01.002
Mayra Arias-Gastélum , Nangel M. Lindberg , Michael C. Leo , Sara Gille , Katie Vaughn , Elizabeth Shuster , Erin S. LeBlanc , Victor J. Stevens , Sonia Vega-López
{"title":"A better diet quality based on the Healthy Eating Index-2020 is associated with lower energy intake and age but not with a pre-diabetes/T2DM diagnosis among Hispanic women with overweight/obesity","authors":"Mayra Arias-Gastélum ,&nbsp;Nangel M. Lindberg ,&nbsp;Michael C. Leo ,&nbsp;Sara Gille ,&nbsp;Katie Vaughn ,&nbsp;Elizabeth Shuster ,&nbsp;Erin S. LeBlanc ,&nbsp;Victor J. Stevens ,&nbsp;Sonia Vega-López","doi":"10.1016/j.nutres.2025.01.002","DOIUrl":"10.1016/j.nutres.2025.01.002","url":null,"abstract":"<div><div>Low diet quality is related to obesity and type 2 diabetes mellitus (T2DM) risk among Hispanic women. This cross-sectional study compared diet quality among Hispanic women with overweight/obesity based on their T2DM diagnosis (pre-diabetes/T2DM group, n = 104 vs no diagnosis, at-risk group, n = 84). It was hypothesized that having a pre-diabetes or T2DM diagnosis would be associated with better diet quality based on the Healthy Eating Index (HEI)-2020 score. Means were compared using a 2-sample t-test for parametric and Kruskal-Wallis for non-parametric variables. Women with pre-diabetes/T2DM reported a lower intake of total energy (1378 ± 557 vs 1644 ± 703 kcal; <em>P</em> = .004) and cholesterol (228 ± 140 vs 299 ± 216 mg; <em>P</em> = .007). Total HEI score was higher for pre-diabetes/T2DM than the at-risk group (64 ± 8 vs 62 ± 9; <em>P</em> = .027). Among all participants, adequacy subscores were excellent for whole fruits, greens &amp; beans, total proteins, and seafood and plant proteins, good for total fruits (77%); fair for total vegetables and fatty acids (64% for both); and poor for whole grains, and dairy (20% and 53%, respectively). Moderation subscores were very good for added sugars (89%), good for saturated fats (78%), and poor for refined grains, and sodium (44% and 33%, respectively). Compared to the at-risk group, women with pre-diabetes/T2DM had higher fatty acid ratio scores (7 ± 2 vs 6 ± 3, <em>P</em> = .039). Multiple linear regression revealed that pre-diabetes/T2DM did not significantly impact diet quality, but energy intake and age did. Overall, HEI subscores underscore the need to improve diet quality through key food groups in Hispanic women with overweight/obesity, regardless of T2DM status.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Pages 88-98"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supplementation with heat-sterilized Lactobacillus crispatus strain KT-11 stimulates the T cell–related immune function of healthy Japanese adults: A pilot randomized, placebo-controlled, double-blind, parallel-group study 补充热灭菌的马铃薯乳杆菌菌株KT-11刺激健康日本成年人的T细胞相关免疫功能:一项随机、安慰剂对照、双盲、平行组研究。
IF 3.4 3区 医学
Nutrition Research Pub Date : 2025-02-01 DOI: 10.1016/j.nutres.2024.12.004
Itsuki Watanabe , Naoko Suzuki , Tsuyoshi Takara
{"title":"Supplementation with heat-sterilized Lactobacillus crispatus strain KT-11 stimulates the T cell–related immune function of healthy Japanese adults: A pilot randomized, placebo-controlled, double-blind, parallel-group study","authors":"Itsuki Watanabe ,&nbsp;Naoko Suzuki ,&nbsp;Tsuyoshi Takara","doi":"10.1016/j.nutres.2024.12.004","DOIUrl":"10.1016/j.nutres.2024.12.004","url":null,"abstract":"<div><div>Viral infections are a global public health threat, reaffirming the importance of immune function. We previously identified <em>Lactobacillus crispatus</em> strain KT-11 (KT-11) and found that heat-sterilized KT-11 affect counts of T cell and dendritic cell <em>in vitro</em>, as well as promoted immunoglobulin A production and prevented weight loss caused by influenza virus infection <em>in vivo</em>. It was hypothesized that heat-sterilized KT-11 affects immune cell count/activity even in healthy individuals. We conducted a pilot study to examine the design to verify the effects of heat-sterilized KT-11 supplementation on immune cell count/activity and physical condition. This was a pilot randomized, double-blind, placebo-controlled, parallel-group study including 22 healthy adults who consumed either KT-11 or placebo for 4 weeks. Immunological status (immune cell count/activity and its score) and various immune-related indicators including SARS-CoV-2 immunoglobulin G antibody were assessed, and a physical condition questionnaire was administered. The primary outcome was immune cell count/activity (T cell subsets, B cell, natural killer cell) and overall immunological status score after 4 weeks. Two patients were excluded because of noncompliance; the final analysis included 20 participants (10 participants/group). The KT-11 group had a significantly higher CD3<sup>+</sup> T cell count versus placebo group. The female subgroup also had a significantly higher CD8<sup>+</sup>CD28<sup>+</sup> T cell count. Although the KT-11 group showed no changes in SARS-CoV-2 immunoglobulin G titer, it had fewer self-reported common cold-like symptoms, particularly fatigue. This pilot study showed that KT-11 affected immune cell profiles, suggesting that the feasibility of a verification study. This trial was registered at UMIN Clinical Trials Registry (UMIN000046991).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Pages 99-112"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial office and Board Members 编辑部和董事会成员
IF 3.4 3区 医学
Nutrition Research Pub Date : 2025-02-01 DOI: 10.1016/S0271-5317(25)00020-X
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