Nutrition Research最新文献

{"title":"David Kritchevsky Graduate Student Award for Nutrition Research","authors":"","doi":"10.1016/S0271-5317(25)00056-9","DOIUrl":"10.1016/S0271-5317(25)00056-9","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Page iii"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic supplementation contributes to glycemic control in adults with type 2 diabetes: A systematic review and network meta-analysis","authors":"Dengrong Ma ,&nbsp;Pingping Zhao ,&nbsp;Jie Gao ,&nbsp;Hui Suo ,&nbsp;Xinyuan Guo ,&nbsp;Mei Han ,&nbsp;Xiaohui Zan ,&nbsp;Chongyang Chen ,&nbsp;Xiaoyu Lyu ,&nbsp;Hui Wang ,&nbsp;Jingfang Liu","doi":"10.1016/j.nutres.2025.03.002","DOIUrl":"10.1016/j.nutres.2025.03.002","url":null,"abstract":"<div><div>Type 2 diabetes mellitus (T2DM) is a chronic medical condition prevalent worldwide. Currently, probiotic therapy has demonstrated favorable outcomes in T2DM management, albeit with a lingering controversy. In this network meta-analysis (NMA), we aimed to assess and rank the glycemic control efficacy of various probiotic strains or combinations in T2DM patients. A systematic literature review was conducted across 4 major databases (PubMed, Embase, Web of Science, and Cochrane Library) including data published up to November 8, 2023, to identify randomized controlled trials (RCTs) on probiotic therapy in T2DM patients. The quality of the included RCTs was evaluated using the risk-of-bias tool version 2, while Bayesian NMA was used for analysis. The efficacy of different probiotics and their combinations was ranked based on the surface under the cumulative ranking curve (SUCRA) for various outcome indicators. This study included 1861 T2DM patients from 30 RCTs. The combination of LAC (<em>Lactobacillus</em>) + BIF (<em>Bifidobacterium</em>) + PRO (<em>Propionibacterium</em>) + STR (<em>Streptococcus</em>) exhibited the most favorable effect in reducing the fasting plasma glucose concentration and improving the homeostatic model assessment of insulin resistance (SUCRA: 88.8% and 77.3%). For reducing the concentration of glycated hemoglobin A1c, BIF (SUCRA: 93.1%) was the most effective; for improving insulin secretion, LAC + BIF (SUCRA: 84.7%) exhibited the most favorable outcome for improving insulin secretion. Cluster analysis of the 4 outcome indicators showed that the LAC + BIF + STR combination may have superior therapeutic effects. Multistrain probiotic combinations demonstrated greater glycemic control effects than single-strain probiotics. Thus, LAC + BIF + STR may be a promising probiotic combination for the treatment of T2DM. Nevertheless, owing to the inherent limitations of existing studies, further research is warranted to ascertain the long-term efficacy of probiotics.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 133-152"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervention design and adherence to Mediterranean diet in the Cardiovascular Risk Prevention with a Mediterranean Dietary Pattern Reduced in Saturated Fat (CADIMED) randomized trial","authors":"Lourdes Chávez-Alfaro ,&nbsp;Carmen Tenorio Jiménez ,&nbsp;Víctor Silveira-Sanguino ,&nbsp;María José Noguera Gómez ,&nbsp;Concepción Fernández-Moreno ,&nbsp;Ana María Rodríguez Cuesta ,&nbsp;Antonio F. Lebrón Arana ,&nbsp;Óscar Segura Calvo ,&nbsp;Ignacio Merino De Haro ,&nbsp;Concepción M. Aguilera ,&nbsp;Carolina Gómez-Llorente ,&nbsp;Óscar Daniel Rangel-Huerta ,&nbsp;Nerys Astbury ,&nbsp;Aurora Pérez-Cornago ,&nbsp;Marta Guasch-Ferre ,&nbsp;Carmen Piernas","doi":"10.1016/j.nutres.2025.03.001","DOIUrl":"10.1016/j.nutres.2025.03.001","url":null,"abstract":"<div><div>Effective interventions targeting modifiable cardiovascular disease (CVD) risk factors, such as diet, are urgently needed. The Cardiovascular Risk Prevention with a Mediterranean Dietary Pattern Reduced in Saturated Fat study hypothesizes that eliminating red and processed meat in the context of a Mediterranean diet (MD) will significantly modify circulating low-density lipoprotein cholesterol concentration and the fatty acid profile compared to general CVD prevention advice. Here we describe the intervention design and summarize baseline dietary intakes (mean ± standard deviation) related to MD adherence and red/processed meat intakes in a sample of 81 participants. The Cardiovascular Risk Prevention with a Mediterranean Dietary Pattern Reduced in Saturated Fat study is a two-arm, 8-week parallel randomized controlled intervention trial involving a final sample of 156 adults (≥18 years) with dyslipidemia (not undergoing pharmacological treatment) recruited from healthcare and community settings in Granada (Spain). The primary outcome will assess changes in circulating low-density lipoprotein cholesterol and the fatty acid profile, whilst secondary outcomes will measure changes in CVD-related metabolites/biomarkers, gut microbiome, diet/lifestyle, and intervention feasibility/acceptability. Preliminary findings indicate low MD adherence (Mediterranean Diet Adherence Screener score 7.6 ± 1.9), and high consumption of red and processed meat (1.04 ± 0.90) servings/d). These results underscore the need for targeted dietary interventions to address the growing burden of dyslipidemia and CVD. If successful, this intervention holds potential for scalability and significant impact on public health, dietary guidelines, and advancements in nutrition science by improving MD adherence and reducing CVD risk factors in adults with dyslipidemia.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 120-132"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish consumption is inversely associated with stroke in Korean adults: the Korea National Health and Nutrition Examination Survey, 2013 to 2021","authors":"Eunje Kim,&nbsp;Youjin Je","doi":"10.1016/j.nutres.2025.03.010","DOIUrl":"10.1016/j.nutres.2025.03.010","url":null,"abstract":"<div><div>There is growing evidence supporting a potential role of fish consumption in relation to stroke risk. Several studies have examined the association between fish consumption and stroke risk in various populations, but none have been conducted in Koreans. We hypothesized that there may also be an inverse association between fish consumption and stroke risk in Korean adults. Therefore, we conducted a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey, 2013 to 2021. A total of 30,143 adults aged 19 to 64 years were included in the analysis. Fish consumption was assessed using a 24-hour dietary recall, and the subjects were categorized into four groups based on their total fish consumption (0, 0≤ to &lt;1/2, 1/2≤ to &lt;1, ≥1 serving/d). Stroke status was assessed using questionnaires. Multivariable logistic regression model was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for physician-diagnosed stroke. After adjusting for covariates, high fish consumption was associated with 46% lower odds of stroke in Korean adults compared with no fish consumption (OR 0.54; 95% CI, 0.31-0.94, <em>P</em> for trend = .041). A similar inverse association was found in male adults (OR 0.47; 95% CI, 0.23-0.97, <em>P</em> for trend = .042), and an inverse association between moderate fish consumption and stroke risk was found in female adults (OR 0.22; 95% CI, 0.06-0.78). Our findings suggest that high fish consumption is associated with lower odds of stroke in Korean adults, particularly in men, and moderate fish consumption was associated with lower odds of stroke in women.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"137 ","pages":"Pages 47-55"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory control is related to fecal short-chain fatty acid concentrations in adults with overweight and obesity","authors":"Nathaniel B. Willis ,&nbsp;Corinne N. Cannavale ,&nbsp;Anne M. Walk ,&nbsp;Nicholas A. Burd ,&nbsp;Hannah D. Holscher ,&nbsp;Naiman A. Khan","doi":"10.1016/j.nutres.2025.03.006","DOIUrl":"10.1016/j.nutres.2025.03.006","url":null,"abstract":"<div><div>Obesity is a pro-inflammatory condition with negative effects on executive functioning. Increased inflammation dysregulates gastrointestinal homeostasis and alters microbiota community composition. The gut microbiota produce immunomodulatory short-chain fatty acids (SCFA) that have been related to cognition in obesity, but the neural effects are not explored. Here, we hypothesized that greater fecal SCFA would be positively related to neuroelectric markers of inhibitory control and conflict monitoring in obesity. A cross-sectional cohort of 87 adults (35 ± 6 years, 53 females) with overweight and obesity (BMI = 32 ± 6 kg/m²) provided fresh fecal samples and participated in cognitive testing to assess response inhibition and conflict monitoring with electroencephalographic recording. Linear regressions, controlling for age, sex, BMI, and energy-adjusted dietary fiber intake, revealed positive relationships between NoGo N2 mean amplitude and fecal SCFA concentrations. Linear discriminant analysis effect size (LEfSe) revealed 16 amplicon sequence variants differentially abundant between high and low butyrate groups with <em>Roseburia</em> and <em>Adlercreutzia</em> individually related to NoGo N2 mean amplitude in MaAsLin2 modeling. Thus, greater fecal SCFA concentrations and SCFA producing microbiota (i.e., <em>Roseburia</em>) were related to markers of superior conflict monitoring in the NoGo task when adjusting for key covariates. These data highlight key associations between bacterial derived gut signaling molecules and neural regulation in cognitive domains particularly relevant to weight status that warrant further investigation.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 12-21"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher serum vitamin B6 is associated with lower all-cause mortality among cancer survivors in the National Health and Nutrition Examination Survey","authors":"Yutong Zhao,&nbsp;Ruhua Zhou,&nbsp;Fangting Lin,&nbsp;Caixia Zhang","doi":"10.1016/j.nutres.2025.03.011","DOIUrl":"10.1016/j.nutres.2025.03.011","url":null,"abstract":"<div><div>Variations in serum concentrations of vitamin B₆, vitamin B₁₂, and folate may influence cancer development and progression. However, the association between these 3 serum B vitamins and all-cause mortality among cancer survivors remains unclear. We evaluated the potential associations between serum vitamins B₆, B₁₂, and folate and all-cause mortality among cancer survivors. Our hypothesis proposed that higher serum concentrations of vitamin B₆, vitamin B₁₂, and folate might be inversely associated with a lower risk of all-cause mortality in this population. Data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were used. All-cause mortality was determined by linking participant data to National Death Index records till 31 December 2019. Serum vitamins B₆, B₁₂, and folate status were measured. Multivariable Cox regression analyses were applied to investigate the relationship between serum vitamins B₆, B₁₂, and folate concentrations and all-cause mortality among cancer survivors. Serum vitamin B₆ was inversely associated with all-cause mortality, with a fully-adjusted HR of 0.54 (95%CI: 0.38, 0.78, <em>P</em> _trend&lt; .001). However, no statistically significant association was observed between serum vitamin B₁₂ as well as serum folate concentration and all-cause mortality among cancer survivors (B₁₂: fully-adjust HR = 0.90, 95%CI: 0.63, 1.27, <em>P</em> _trend = .771; folate: fully-adjust HR = 0.82, 95%CI: 0.63, 1.08, <em>P</em> _trend = .269). No statistically significant interaction for age, sex, and BMI was found in stratified analyses. No non-linear relationship was found except for serum folate. These results suggest that higher serum vitamin B₆ may be associated with improved survival in cancer survivors.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 1-11"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketone therapy improves cardiac function and structure in rodents with heart failure: A systematic review and meta-analysis","authors":"Tingting Lv ,&nbsp;Chunyan Liu ,&nbsp;Mengfei Ye ,&nbsp;Gang Li ,&nbsp;Zheng Liu","doi":"10.1016/j.nutres.2025.03.008","DOIUrl":"10.1016/j.nutres.2025.03.008","url":null,"abstract":"<div><div>This meta-analysis aimed to quantitatively assess the effects of ketone intervention on cardiac function and structure in rodents with heart failure (HF). We hypothesized that ketone intervention could enhance the cardiac function and structure in HF. We systematically searched PubMed, Cochrane Library, and Embase databases for relevant studies up to April 13, 2024. Ketone therapy encompassed a ketogenic diet, ketone esters, medium-chain triglycerides, and β-hydroxybutyrate. The effect measures are mainly expressed as standardized mean difference (SMD) and 95% confidence interval (CI). Our meta-analysis included 24 animal studies. Ketone therapy significantly improved left ventricular ejection fraction (SMD: 1.31, 95% CI: 0.79-1.82, <em>I</em>² = 77%), cardiac output (SMD: 0.70, 95% CI: 0.28-1.11, <em>I</em>² = 0%), and ameliorated myocardial hypertrophy (SMD: −1.95, 95% CI: −2.76 to −1.13, <em>I</em>² = 76%), myocardial fibrosis (SMD: −0.87, 95% CI: −1.60 to −0.15, <em>I</em>² = 68%), and ventricular remodeling in HF rodents. Subgroup analysis indicated that ketone intervention worsened myocardial fibrosis in non-HF rodents (SMD: 0.86, 95% CI: 0.09-1.63, <em>I</em>² = 78%) and had no significant effect on cardiac function. Additionally, further subgroup analysis indicated that ketogenic diet significantly alleviated cardiac hypertrophy and fibrosis, whereas ketone esters did not yield significant effects. The effect of ketone on left ventricular ejection fraction strengthened with the duration of intervention. Our results suggested that ketone therapy significantly improved the cardiac systolic function and structure in rodents with HF, and had no effect in rodents non-HF. Thus, ketone intervention may be a promising treatment for HF patients.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"137 ","pages":"Pages 56-70"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of prebiotics on growth metrics in infants: A GRADE approach systematic review and meta-analysis of randomized clinical trials","authors":"Seyedeh-Tarlan Mirzohreh ,&nbsp;Asma Sohrabnavi ,&nbsp;Padideh Panahi ,&nbsp;Zeinab Nikniaz ,&nbsp;Mahdieh Abbasalizad Farhangi ,&nbsp;Sevana Daneghian ,&nbsp;Leila Nikniaz","doi":"10.1016/j.nutres.2025.03.003","DOIUrl":"10.1016/j.nutres.2025.03.003","url":null,"abstract":"<div><div>Breastfeeding is often not feasible for all mothers, making infant formula a critical alternative for ensuring infant safety and nutrition. We hypothesized that the inclusion of prebiotics in infant formula significantly affects growth metrics in infants compared to standard formula. This study aims to fill a knowledge gap regarding the effects of prebiotics in infant formula on infant growth and development, particularly given the varying compositions and durations of prebiotic supplementation. A systematic review was conducted following PRISMA guidelines, analyzing 24 studies sourced from databases such as PubMed and Cochrane, with risk of bias assessed using RoB-2 for randomized controlled trials (RCTs). The findings revealed no significant differences in weight gain (WG), height gain (HG), or head circumference gain (HCG) between prebiotic-fed infants and control groups overall. However, infants receiving prebiotics for 3 or more months exhibited a significant decrease in WG compared to controls (SMD -0.479, <em>P</em> &lt; .05). Notably, those fed formulas containing fructo-oligosaccharides/galacto-oligosaccharides and a combination of polydextrose/galacto-oligosaccharides/lactulose demonstrated improved WG (SMDs of 0.214 and 0.184, <em>P</em> &lt; .05 respectively). Conversely, infants on formulas with inulin-enriched oligo-fructose (IOF) experienced reduced WG and HG. In conclusion, while prebiotics did not consistently enhance growth metrics, specific combinations showed potential benefits, emphasizing the need for tailored approaches in infant formula design to optimize growth without compromising health.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"137 ","pages":"Pages 22-46"},"PeriodicalIF":3.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apparently healthy young black adults report lower total fluid intake and exhibit higher plasma copeptin than young White adults","authors":"Nina L. Stute ,&nbsp;Braxton A. Linder ,&nbsp;Sofia O. Sanchez ,&nbsp;Joseph D. Vondrasek ,&nbsp;Brett Cross ,&nbsp;McKenna A. Tharpe ,&nbsp;Zach J. Hutchison ,&nbsp;Melissa Pangelinan ,&nbsp;Colleen X. Muñoz ,&nbsp;Gregory J. Grosicki ,&nbsp;Thomas Fuller-Rowell ,&nbsp;Austin T. Robinson","doi":"10.1016/j.nutres.2025.02.007","DOIUrl":"10.1016/j.nutres.2025.02.007","url":null,"abstract":"<div><div>Underhydration is associated with higher plasma copeptin concentration ([copeptin]), an arginine vasopressin surrogate associated with multiple chronic diseases. Middle-aged and older Black individuals are more likely to be underhydrated and exhibit higher [copeptin] than White individuals. However, limited data exists on racial differences in [copeptin] in young adults. Therefore, we tested the hypothesis that apparently healthy young Black adults would report lower fluid intake and exhibit higher plasma [copeptin] than young White adults. Participants (n = 86; sex: 40F/46M; race: White n = 48, Black n = 38; age: 21<span><math><mrow><mspace></mspace><mo>±</mo><mspace></mspace></mrow></math></span>2 years, BMI: 25<span><math><mo>±</mo></math></span>4 kg/m²) completed 3-day food and fluid diaries. We operationalized beverages into 8 categories (water, sugar-sweetened beverages, milk/non-dairy alternatives, juice, nonaloric beverages (eg, diet drinks), coffee or tea (noncaloric), coffee or tea (caloric), and alcohol) and measured plasma [copeptin]. We assessed racial differences in fluid intake and [copeptin] and also examined relations between race, fluid intake, and [copeptin] via regression and correlation analyses. Compared with White adults, Black adults consumed less total fluid (64.0[31.3] vs. 89.7[53.6] oz), water, alcohol, and coffee/tea (noncaloric and caloric) but more juice (<em>p</em>s &lt; .05). Black participants exhibited higher plasma [copeptin] (6.38[4.83] vs. 4.45[2.92] pmol/L, <em>P</em> = .021). In the whole cohort, plasma [copeptin] was negatively correlated with water intake (<span><math><mrow><mi>ρ</mi><mspace></mspace></mrow></math></span>= -0.249, <em>P</em> = .021). However, racial differences in [copeptin] were attenuated by 27% when accounting for total fluid intake. Black young adults reported lower fluid intake and exhibited higher plasma [copeptin] than White young adults. Interventions are needed to address racial disparities in hydration practices, potentially attenuating racial differences in [copeptin] and related health disparities.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 81-93"},"PeriodicalIF":3.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The combined indicator of vitamin B12 status calculated using 3-parameters (3cB12) is negatively associated with mortality among US adults: NHANES 1999 to 2004","authors":"Yanmei Li,&nbsp;Huifen Wang,&nbsp;Shuo Chen,&nbsp;Qilu Wei,&nbsp;Yini Liu,&nbsp;Zhenmei Song,&nbsp;Shiyu Du","doi":"10.1016/j.nutres.2025.02.008","DOIUrl":"10.1016/j.nutres.2025.02.008","url":null,"abstract":"<div><div>The association between vitamin B₁₂ status and the risk of mortality is controversial. The combined indicator calculated using 3 traditional parameters (3cB₁₂) can be used to indicate vitamin B₁₂ status. We hypothesize that vitamin B₁₂ deficiency indicated by 3cB₁₂ may be related to high mortality risks. To evaluate the association between 3cB₁₂ and all-cause, cardiovascular disease (CVD) and cancer-related mortality, we used Cox proportional hazard models, cumulative Kaplan–Meier curves, and smooth curve fitting to assess data from NHANES 1999 to 2004. A total of 12,103 adults (20 years and older) were included in the analyses and 3595 participants were determined as deceased. The median follow-up duration was 202 months. In the fully adjusted model, all three mortality rates decreased along with the increase in 3cB₁₂ scores, with hazard ratio (HR) [95% confidence interval (CI)]: 0.81 (0.75, 0.87) for all-cause mortality, HR (95% CI): 0.83 (0.72, 0.95) for CVD mortality, and HR (95% CI): 0.79 (0.66, 0.96) for cancer-related mortality. When 3cB₁₂ was divided into two groups, individuals in the lower 3cB₁₂ group (3cB₁₂ &lt; −0.5) showed increased risks of all-cause mortality [HR (95% CI): 1.73 (1.48, 2.02)] and CVD mortality [HR (95% CI): 1.84 (1.31, 2.59)], as compared to the higher 3cB₁₂ group (3cB₁₂ ≥ −0.5). The smooth fitting curves represented a negative linear relationship between 3cB₁₂ and all three types of mortality (<em>P</em> for nonlinearity &gt;.05). In conclusion, the extrapolation of 3cB₁₂ from conventional metrics affords a novel perspective for evaluating B₁₂ nutritional status and mortality risk.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 53-63"},"PeriodicalIF":3.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}