Nutrition Research最新文献_第4页

Editorial office and Board Members

IF 3.4 3区医学

Nutrition Research Pub Date : 2025-01-01 DOI: 10.1016/S0271-5317(25)00010-7

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Editorial office and Board Members

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-12-01 DOI: 10.1016/S0271-5317(24)00159-3

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David Kritchevsky Graduate Student Award for Nutrition Research

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-12-01 DOI: 10.1016/S0271-5317(24)00160-X

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Polyphenols from Prunus salicina L. alleviate weight gain, obesity-related hyperlipidemia, hepatic steatosis, hyperglycemia, and modulate gut microbiota in mice fed a high-fat diet 从水杨梅中提取的多酚类物质可减轻以高脂肪饮食喂养的小鼠的体重增加、与肥胖相关的高脂血症、肝脏脂肪变性和高血糖，并调节肠道微生物区系

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-11-05 DOI: 10.1016/j.nutres.2024.11.001

Haizhao Song , Jing Lu , Qiang Chu

{"title":"Polyphenols from Prunus salicina L. alleviate weight gain, obesity-related hyperlipidemia, hepatic steatosis, hyperglycemia, and modulate gut microbiota in mice fed a high-fat diet","authors":"Haizhao Song , Jing Lu , Qiang Chu","doi":"10.1016/j.nutres.2024.11.001","DOIUrl":"10.1016/j.nutres.2024.11.001","url":null,"abstract":"<div><div>Hyperlipidemia, hepatic steatosis, and hyperglycemia are prevalent metabolic disorders closely linked to obesity. The objective of this research was to examine the potential advantageous impacts of polyphenols extracted from <em>Prunus salicina</em> L. fruit (PSFP) on hyperlipidemia, hepatic steatosis, and hyperglycemia induced by a high-fat diet (HFD), as well as to elucidate the underlying mechanisms involved. Male C57BL/6J mice, free from specific pathogens, were assigned randomly into three groups. These groups were then subjected to a 14-week dietary intervention, including a low-fat diet, an HFD, or an HFD plus with PSFP via intragastric administration. The obesity-related biochemical indexes were evaluated. To assess alterations in gut microbiota resulting from PSFP treatment, 16S rRNA sequencing was performed. UPLC-ESI-MS/MS assay identified 162 distinct polyphenolic compounds in PSFP. The administration of PSFP significantly reduced both body weight gain and hyperlipidemia induced by HFD. In addition, PSFP ameliorated hepatic steatosis induced by HFD and enhanced liver function in mice. PSFP treatment also ameliorated HFD-induced insulin resistance and hyperglycemia, evidenced by the observed decrease in fasting serum concentrations of glucose and insulin, improved insulin sensitivity, and restored glucose tolerance. Moreover, PSFP modulated the composition and abundance of specific microbial genus, including <em>Lachnospiraceae NK4A136 group, Akkermansia, Parabacteroides, Enterococcus, Adlercreutzia</em>, and <em>Roseburia</em>. Correlation analysis indicated significant associations between gut microbiota and physiological indices associated with obesity. These findings suggested that PSFP supplementation ameliorated HFD-induced hyperlipidemia, hepatic steatosis, and hyperglycemia, potentially through modulating the gut microbiota composition and abundance of specific taxa.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"132 ","pages":"Pages 152-163"},"PeriodicalIF":3.4,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Whole milk intake is associated with lower body weight and body mass index in American adults 全脂牛奶的摄入量与美国成年人较低的体重和体重指数有关

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-11-04 DOI: 10.1016/j.nutres.2024.11.002

Moises Torres-Gonzalez , Matthew A. Pikosky , Kristin Ricklefs-Johnson , Kristin Fulgoni , Victor L. Fulgoni III , Sanjiv Agarwal , Christopher J. Cifelli

{"title":"Whole milk intake is associated with lower body weight and body mass index in American adults","authors":"Moises Torres-Gonzalez , Matthew A. Pikosky , Kristin Ricklefs-Johnson , Kristin Fulgoni , Victor L. Fulgoni III , Sanjiv Agarwal , Christopher J. Cifelli","doi":"10.1016/j.nutres.2024.11.002","DOIUrl":"10.1016/j.nutres.2024.11.002","url":null,"abstract":"<div><div>The objective was to determine if whole milk intake or total milk intake behaviors are associated with body weight (weight) and related parameters in adults. We hypothesize that whole milk intake would be inversely associated with body weight measures. Whole milk (including flavored whole milk) intake was assessed using 24-hour dietary recall data of the National Health and Nutrition Examination Survey 2001-2018 for adults age 20+ years (<em>N</em> = 43,038). Weight and related parameters were measured, and history of self-reported weights and total milk intake were obtained from questionnaire data. The association of whole milk intake with weight was assessed via regression after adjusting for demographic and lifestyle-related covariates. The average body mass index (BMI) was about 29 kg/m<sup>2</sup> and weight was 76 to 89 kg. About 66% of the population were overweight or obese. Average whole milk intake among consumers was 1.0 to 1.4 cups eq/d. Whole milk intake was inversely associated (<em>P</em> < .05) with weight, BMI, waist circumference, and the prevalence of obesity. Whole milk intake was also inversely associated (<em>P</em> < .01) with trying to lose weight in the past year. In most cases, milk intake behavior at ages 5 to 12, 13 to 17, or 18 to 35 years was not associated with BMI. The results indicate that whole milk intake was inversely associated with weight, BMI, and prevalence of obesity, and these findings may provide additional evidence to support dietary recommendations for whole milk.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"132 ","pages":"Pages 180-189"},"PeriodicalIF":3.4,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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David Kritchevsky Graduate Student Award for Nutrition Research 大卫-克里切夫斯基营养研究研究生奖

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-11-01 DOI: 10.1016/S0271-5317(24)00147-7

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Editorial office and Board Members 编辑部和董事会成员

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-11-01 DOI: 10.1016/S0271-5317(24)00146-5

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Polyphenols have unique cellular effects that are distinct from antioxidant function in Toll-like receptor 4–mediated inflammation in RAW264.7 macrophage-like cells 在 RAW264.7 巨噬细胞样细胞中，多酚在 Toll 样受体 4 介导的炎症中具有不同于抗氧化功能的独特细胞效应

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-10-28 DOI: 10.1016/j.nutres.2024.10.007

Rami S. Najjar , Wesley W. Grace , Ana P.S. Siqueira , Alivia M. Setka , Wen Lu , Siming Wang , Rafaela G. Feresin

{"title":"Polyphenols have unique cellular effects that are distinct from antioxidant function in Toll-like receptor 4–mediated inflammation in RAW264.7 macrophage-like cells","authors":"Rami S. Najjar , Wesley W. Grace , Ana P.S. Siqueira , Alivia M. Setka , Wen Lu , Siming Wang , Rafaela G. Feresin","doi":"10.1016/j.nutres.2024.10.007","DOIUrl":"10.1016/j.nutres.2024.10.007","url":null,"abstract":"<div><div>Plant polyphenols are bioactive compounds touted for their antioxidant effects, and this is often the primary attribute used to explain their health benefits. However, we hypothesize that polyphenols have molecular properties independent of antioxidant function. The objective of this study was to investigate whether polyphenols had distinct molecular effects compared to pure antioxidants. RAW 264.7 macrophages were pretreated with either TEMPOL, a superoxide scavenger, N-acetyl cysteine, a hydroxyl radical and hydrogen peroxide scavenger, or polyphenol extracts from blackberry, blueberry, raspberry, strawberry, kale, and baru nut. After 1 hour of pretreatment, cells were treated with lipopolysaccharides (100 ng/mL) for an additional 6 hour. Antioxidants and polyphenol extracts elicited antioxidant effects in vitro; however, polyphenols regulated redox proteins in a distinct, protective manner, whereas antioxidants, TEMPOL, and N-acetyl cysteine, did not. Additionally, distinct effects were observed in downstream Toll-like receptor 4 signaling and transcriptional activity of inflammatory proteins. We conclude that polyphenols have unique molecular effects that are independent of just their free radical scavenging capacity. This work advances our molecular understanding of how polyphenols act to target inflammation.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"132 ","pages":"Pages 136-151"},"PeriodicalIF":3.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Genetic variants in the PKD1L2/BCO1 region are associated with β-carotene, lutein, and zeaxanthin: A genome-wide association study of plasma carotenoids PKD1L2/BCO1区域的基因变异与β-胡萝卜素、叶黄素和玉米黄质有关：血浆类胡萝卜素的全基因组关联研究

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-10-28 DOI: 10.1016/j.nutres.2024.10.008

Joseph Jamnik , Sara Mahdavi , Ahmed El-Sohemy

{"title":"Genetic variants in the PKD1L2/BCO1 region are associated with β-carotene, lutein, and zeaxanthin: A genome-wide association study of plasma carotenoids","authors":"Joseph Jamnik , Sara Mahdavi , Ahmed El-Sohemy","doi":"10.1016/j.nutres.2024.10.008","DOIUrl":"10.1016/j.nutres.2024.10.008","url":null,"abstract":"<div><div>Carotenoid consumption has been associated with a reduced risk of several chronic diseases. Inter-individual genetic variation may explain some of the observed differences in plasma carotenoid concentrations between individuals. Identifying genetic variants associated with circulating carotenoids in young adults may help identify individuals at increased risk for developing conditions associated with low carotenoids later in life. We hypothesize that common genetic variants are associated with circulating carotenoid concentrations in a population of young adults. A genome-wide association study (GWAS) on plasma carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lutein, and zeaxanthin) was conducted in Caucasians (n = 393) from the Toronto Nutrigenomics and Health Study. Replication cohorts included individuals of Caucasian (n = 193), East Asian (n = 436) and South Asian (n = 135) ethnicity. Linear regression adjusted for age, sex, BMI, total serum cholesterol, dietary carotenoid intake and population structure were used to identify associations between genetic variants and plasma carotenoids. Associations that met the threshold for genome-wide significance (<em>p</em> < 5 × 10<sup>-8</sup>) in unadjusted and partially adjusted models were not observed in the replication cohorts. No variants achieved genome-wide significance in fully adjusted models. Previously identified associations between variation in the <em>PKD1L2/BCO1</em> region and β-carotene, lutein and zeaxanthin were replicated in the GWAS cohort (<em>p</em> < .05). Established variation in the <em>PKD1L2/BCO1</em> region is associated with plasma carotenoids. These variants may help to identify individuals who require greater amounts of these antioxidants and to provide precision nutrition recommendations for optimal intake of various carotenoids.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"132 ","pages":"Pages 164-179"},"PeriodicalIF":3.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Absorption, anti-inflammatory, antioxidant, and cardioprotective impacts of a novel fasting mimetic containing spermidine, nicotinamide, palmitoylethanolamide, and oleoylethanolamide: A pilot dose-escalation study in healthy young adult men 一种含有亚精胺、烟酰胺、棕榈酰乙醇酰胺和油酰乙醇酰胺的新型空腹模拟物的吸收、抗炎、抗氧化和心脏保护作用：一项针对健康年轻成年男性的试验性剂量递增研究。

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-10-23 DOI: 10.1016/j.nutres.2024.10.006

Christopher H. Rhodes , Brian V. Hong , Xinyu Tang , Cheng-Yu Weng , Jea Woo Kang , Joanne K. Agus , Carlito B. Lebrilla , Angela M. Zivkovic

{"title":"Absorption, anti-inflammatory, antioxidant, and cardioprotective impacts of a novel fasting mimetic containing spermidine, nicotinamide, palmitoylethanolamide, and oleoylethanolamide: A pilot dose-escalation study in healthy young adult men","authors":"Christopher H. Rhodes , Brian V. Hong , Xinyu Tang , Cheng-Yu Weng , Jea Woo Kang , Joanne K. Agus , Carlito B. Lebrilla , Angela M. Zivkovic","doi":"10.1016/j.nutres.2024.10.006","DOIUrl":"10.1016/j.nutres.2024.10.006","url":null,"abstract":"<div><div>This pilot dose-escalation study evaluated the absorption and metabolism of a novel fasting mimetic formulation containing spermidine, nicotinamide, palmitoylethanolamide (PEA), and oleoylethanolamide (OEA) taken as oral supplements in young adults. Five healthy men consumed a standardized breakfast, followed by control (wheat flour) or low, medium, or high doses of supplements containing spermidine, nicotinamide, PEA, and OEA 2 hours later. Blood was drawn at 0, 1, 2, and 4 hours after the supplement (2, 3, 4, and 6 hours postprandial). Plasma concentrations of spermidine, 1-methylnicotinamide, PEA and OEA were quantified by liquid chromatography-mass spectrometry. The secretion of tumor necrosis factor alpha and production of reactive oxygen species by stimulated macrophages incubated with plasma, and cholesterol efflux capacity of plasma were analyzed. Plasma 1-methylnicotinamide, PEA, and OEA concentrations increased after supplement intake (<em>P</em> < .05). Spermidine concentrations decreased in the control arm (<em>P</em> < .05) but not the supplement arms. Net incremental area under the curve for tumor necrosis factor alpha and reactive oxygen species in stimulated macrophages decreased when incubated with plasma following supplement intake (<em>P</em> < .05). Intake of the combined supplements showed they were bioavailable and increased in plasma in a dose-dependent manner and provide preliminary data showing enhanced plasma anti-inflammatory and antioxidant functions.</div><div>This trial was registered at clinicaltrials.gov (NCT05017428).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"132 ","pages":"Pages 125-135"},"PeriodicalIF":3.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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