Nutrition ResearchPub Date : 2026-02-01Epub Date: 2025-12-17DOI: 10.1016/j.nutres.2025.12.006
Adem Erik , Sakhi Mohammad Hamidy , Hilal Karamancıoğlu , Büşra Nur Küçük Kırtıklı
{"title":"AI in nutrition: multi-criteria analysis of diet plans across diverse client profiles","authors":"Adem Erik , Sakhi Mohammad Hamidy , Hilal Karamancıoğlu , Büşra Nur Küçük Kırtıklı","doi":"10.1016/j.nutres.2025.12.006","DOIUrl":"10.1016/j.nutres.2025.12.006","url":null,"abstract":"<div><div>The advancement of artificial intelligence (AI) technologies has resulted in the proliferation of novel applications in various fields, including nutrition. One of the most notable applications involves AI-generated and guided diet plans. The present study evaluates diet plans generated by various AI tools (e.g., ChatGPT, Gemini, DeepSeek, etc.) for individuals with different health profiles using a multi-criteria decision-making (MCDM) framework. A series of authentic client scenarios were formulated on the basis of anonymized clinical cases that had been provided by a registered dietitian. These scenarios incorporated medical history, lifestyle habits, dietary patterns, and other relevant factors. For each client's profile, a set of standardized prompts were submitted to different AI tools to generate comparable diet plans. The resulting diet plans were evaluated based on several main and sub-criteria, including appropriateness, feasibility, nutritional adequacy, degree of personalization, ethical compliance, reproducibility, and linguistic clarity. The evaluation employed MCDM methods, namely LBWA for weighting, COPRAS, and PROMETHEE-I/II for ranking. The findings indicate that GPTPLUS demonstrated the highest overall ranking; DeepSeek exhibited consistent second-tier performance; and mid-tier models (GPT-4.0, GPT-4.5, Grook3) exchanged positions depending on the scenario and method. The results at the criterion level were found to be aligned with clinical priorities. Moreover, Claude's refusal to formulate a dietary plan for a client under the age of 18 indicates a paucity of standardized ethical guidelines governing the utilization of AI tools. The findings emphasize the potential of AI as a supportive tool in healthcare services, while concurrently addressing ethical considerations and practical limitations.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"146 ","pages":"Pages 53-67"},"PeriodicalIF":3.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low-digestible glucans promote rapid recovery from 5-fluorouracil-induced small intestinal villous atrophy while enhancing glucagon-like peptide-2 secretion in rats","authors":"Rikako Nishina , Shingo Hino , Chikara Kato , Naomichi Nishimura","doi":"10.1016/j.nutres.2025.12.009","DOIUrl":"10.1016/j.nutres.2025.12.009","url":null,"abstract":"<div><div>Small intestinal villous atrophy, a frequent complication of cancer chemotherapy, impairs nutrient absorption and worsens participant quality of life. Although the glucagon-like peptide-2 (GLP-2) analog teduglutide can promote villus regeneration, its clinical application is limited. We hypothesized that dietary low-digestible glucans (LDGs) would enhance GLP-2 secretion and accelerate mucosal recovery. This study evaluated whether LDGs stimulate GLP-2 secretion and facilitate recovery from 5-fluorouracil (5-FU)-induced villous atrophy in rats. Male Sprague-Dawley rats were treated with 5-FU to induce villous atrophy, followed by diets containing resistant maltodextrin (RMD) or isomaltodextrin as LDGs. Portal GLP-2 concentrations, small intestinal villus height, maltase activity, and cecal short-chain fatty acid concentrations were assessed at 3 and 6 days after LDG supplementation. LDG supplementation significantly increased portal GLP-2 concentrations and accelerated recovery of villus height in the small intestine, especially in the ileum, compared with controls. Notably, villus height in the RMD group recovered within 3 days, whereas 6 days were required in controls. Both RMD and isomaltodextrin increased cecal tissue weight, and LDGs induced only a transient reduction in cecal acetate concentration. However, when 5-FU was administered concurrently, LDGs did not promote villus recovery, suggesting that their effect requires preserved epithelial proliferative capacity. In summary, LDGs promote rapid recovery of small intestinal villi after chemotherapy-induced injury, possibly through enhanced GLP-2 secretion. Dietary LDGs may offer a novel nutritional intervention to support mucosal recovery in participants undergoing cancer chemotherapy.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"146 ","pages":"Pages 82-93"},"PeriodicalIF":3.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2026-02-01Epub Date: 2025-12-17DOI: 10.1016/j.nutres.2025.12.007
Maedeh Moradi , Zinat Mohammadpour , Gilly A. Hendrie , Paige G. Brooker , Leonie K. Heilbronn , Jessica A. Grieger
{"title":"Moderate intake of bitter foods is associated with lower risk of type 2 diabetes: A secondary analysis of the 2011-12 National Nutrition and Physical Activity Survey","authors":"Maedeh Moradi , Zinat Mohammadpour , Gilly A. Hendrie , Paige G. Brooker , Leonie K. Heilbronn , Jessica A. Grieger","doi":"10.1016/j.nutres.2025.12.007","DOIUrl":"10.1016/j.nutres.2025.12.007","url":null,"abstract":"<div><div>The sensory properties of food are increasingly recognized for their potential role in regulating blood glucose and cardiometabolic risk factors. This cross-sectional secondary analysis of the 2011–2012 National Nutrition and Physical Activity Survey (NNPAS) aimed to examine the association between dietary bitterness and cardiometabolic risk in Australian adults aged ≥19 years. We hypothesize that higher food and beverage bitterness scores might be associated with lower risk of cardiometabolic risk factors. The study used data from 8975 participants; 225 (∼2%) of the population had type 2 diabetes. Dietary bitterness was calculated as a “bitterness score” by multiplying sensory panel–assigned bitter taste values (from the Commonwealth Scientific and Industrial Research Organisation Sensory Diet Database) by the grams of each item consumed, and then summing these values separately for solid foods and for beverages within the NNPAS. Differences across dietary bitterness tertiles were assessed using analysis of variance for continuous variables and chi-squared tests for categorical variables. Multinomial logistic regression was used to assess the association between tertiles of bitterness score and cardiometabolic outcomes, including type 2 diabetes, dyslipidemia, and blood pressure. Participants in the second tertile, but not the highest tertile of bitterness score from foods had lower risk of type 2 diabetes, as defined by fasting plasma glucose (relative risk ratio [RRR] = 0.30; 95% confidence intervals [CI], 0.15–0.60), and glycated hemoglobin (HbA1c) (RRR = 0.43; 95% CI, 0.25–0.75) compared to the lowest tertile. No significant associations were observed between bitterness scores derived from beverages and cardiometabolic risk factors. Consumption of foods with a medium bitterness score was inversely associated with type 2 diabetes risk in Australian adults and may have potential to be included in diabetes prevention efforts.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"146 ","pages":"Pages 40-52"},"PeriodicalIF":3.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2026-02-01Epub Date: 2025-12-06DOI: 10.1016/j.nutres.2025.12.001
Tatei Haramara Colmenares Villa , Guadalupe Ruiz-Vivanco , Leonardo M. Porchia , Enrique Torres-Rasgado , Esther López-Bayghen , M. Elba Gonzalez-Mejia
{"title":"Dietary vitamins A and K are inversely associated with visceral adiposity in US adults: NHANES 2011–2018","authors":"Tatei Haramara Colmenares Villa , Guadalupe Ruiz-Vivanco , Leonardo M. Porchia , Enrique Torres-Rasgado , Esther López-Bayghen , M. Elba Gonzalez-Mejia","doi":"10.1016/j.nutres.2025.12.001","DOIUrl":"10.1016/j.nutres.2025.12.001","url":null,"abstract":"<div><div>Excess visceral adipose tissue (VAT) poses a growing global health concern, impacting adults across all obesity classes. While some nutrients have been linked to lower abdominal fat, the broader relationship between overall nutrient intake and VAT remains unclear. This cross-sectional study examined the correlations between dietary nutrient intake and VAT area among US adults. Data were obtained from the National Health and Nutrition Examination Survey (2011–2018). Participants aged 18–65 years without major pathologies were included. VAT area (cm<sup>2</sup>) was determined using dual-energy X-ray absorptiometry, with ≥100 cm<sup>2</sup> defined as VAT obese (VatOB). Nutrient data were derived from 24-hour dietary recall interviews. Associations between nutrient intake and VAT were evaluated using complex-sample linear regression and Least Absolute Shrinkage and Selection Operator (LASSO) regression. Among the 6526 participants (n<sub>weighted</sub>=68,060,478), 36.5% were VatOB. Linear regression confirmed positive correlations between VAT and carbohydrate, total fat, and sodium intake. Interestingly, the less stringent LASSO model not only confirmed these correlations but also identified inverse correlations with potassium, magnesium, vitamins A, C, B<sub>1</sub>, E, and K. However, the more stringent LASSO model found that only vitamins A and K maintained significant correlations with VAT after accounting for energy intake and macronutrient variables. In summary, VAT was positively correlated with higher intakes of carbohydrates, fat, and sodium, and inversely correlated with several micronutrients—most consistently with vitamins A and K. These results reflect nutrient–VAT associations, for which further longitudinal studies are needed to determine whether nutrient intake causally influences VAT accumulation.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"146 ","pages":"Pages 26-39"},"PeriodicalIF":3.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2026-02-01Epub Date: 2025-10-01DOI: 10.1016/j.nutres.2025.09.013
Xujie Zhang , Yan Gao , Jing Song , Hongjuan Wang
{"title":"Higher dietary fish consumption is associated with a lower risk of osteoporosis: A meta-analysis of observational studies","authors":"Xujie Zhang , Yan Gao , Jing Song , Hongjuan Wang","doi":"10.1016/j.nutres.2025.09.013","DOIUrl":"10.1016/j.nutres.2025.09.013","url":null,"abstract":"<div><div>While numerous epidemiological studies have investigated the relationship between fish consumption and osteoporosis risk, findings remain inconclusive. This meta-analysis hypothesizes that higher fish intake is associated with a lower risk of osteoporosis. A systematic search of PubMed, Web of Science, and Wan Fang was conducted for relevant studies published up to October 2024. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed or random effects models based on heterogeneity. Fourteen studies comprising 26,145 participants were included. The pooled OR for osteoporosis comparing the highest to lowest fish consumption levels was 0.62 (95% CI, 0.49-0.79; <em>I</em>² = 79.4). Among perimenopausal women, higher fish intake was associated with a lower risk of osteoporosis (OR, 0.54; 95% CI, 0.32-0.90; <em>I</em>² = 83.5). Significant associations were observed in both case-control studies (OR, 0.28; 95% CI, 0.16-0.50; <em>I</em>² = 0.0) and cross-sectional studies (OR, 0.70; 95% CI, 0.55-0.87; <em>I</em>² = 79.6%). Subgroup analysis indicated an inverse association in the lumbar and/or femoral regions (OR, 0.59; 95% CI, 0.42-0.85; <em>I</em>² = 85.4%) and the calcaneus region (OR, 0.73; 95% CI, 0.54-0.97; <em>I</em>² = 0.0%). These findings suggest that may reduce osteoporosis risk, supporting the potential role of a fish-rich diet in bone health maintenance. Further prospective and interventional studies are needed to verify the causal relationship.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"146 ","pages":"Pages 121-128"},"PeriodicalIF":3.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2026-02-01Epub Date: 2025-12-29DOI: 10.1016/j.nutres.2025.12.010
Han Li , Miao Li , Sijia Fei , Ting Xie , Lixin Guo , Qi Pan
{"title":"Elevated C18:1-acylcarnitine is associated with a higher fibrosis-4 index through inflammation mediation: A cross-sectional study","authors":"Han Li , Miao Li , Sijia Fei , Ting Xie , Lixin Guo , Qi Pan","doi":"10.1016/j.nutres.2025.12.010","DOIUrl":"10.1016/j.nutres.2025.12.010","url":null,"abstract":"<div><div>As a major response to chronic hepatic injury, liver fibrosis presents a growing global health challenge. However, its association with metabolomic signatures remains unclear. In this study of 492 patients, we evaluated associations between 30 metabolites and liver fibrosis, which was assessed non-invasively using the fibrosis-4 (FIB-4) index. We hypothesized that metabolic changes promote fibrosis partly through inflammatory pathways. Propensity score matching, Spearman’s correlation, binary logistic regression, and restricted cubic spline analyses were employed to identify key metabolites associated with fibrosis risk. Mediation analysis further investigated inflammatory biomarkers as potential mediators. Elevated plasma glutamine [odds ratio (OR) = 1.02, 95% confidence interval (CI) = 1.00-1.04], log-transformed C18:1-acylcarnitine (OR = 2.59, 95% CI = 1.12-5.95), and betaine (OR = 1.20, 95% CI = 1.06-1.36) were strongly related to increased liver fibrosis risks, whereas lower alanine concentration (OR = 0.97, 95% CI = 0.95-1.00) correlated with decreased risks. Several metabolites [specifically alanine, log-transformed C18:1-acylcarnitine, and betaine (all <em>P</em> overall < .05, <em>P</em> non-linear > .05)] showed linear dose-response relationships with fibrosis risk. Inflammatory factors, notably the neutrophil-percentage-to-albumin ratio (mediation proportion = 49.7%, <em>P</em> = .01), and metabolites including glutamic acid (mediation proportion = –23.4%, <em>P</em> = .47) and betaine (mediation proportion = 48.3%, <em>P</em> = .03), significantly mediated the relationship between C18:1-acylcarnitine and liver fibrosis. Our findings suggest that dysregulation of key metabolomic biomarkers may interact with inflammatory responses, thereby accelerating liver fibrosis, and underscore the modulating roles of inflammation in the progression of liver fibrosis.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"146 ","pages":"Pages 97-110"},"PeriodicalIF":3.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2026-01-01Epub Date: 2025-11-24DOI: 10.1016/j.nutres.2025.11.009
Arwa M. Amin , Hamza Mostafa
{"title":"Vitamin E and cognitive function: A systematic review of clinical evidence","authors":"Arwa M. Amin , Hamza Mostafa","doi":"10.1016/j.nutres.2025.11.009","DOIUrl":"10.1016/j.nutres.2025.11.009","url":null,"abstract":"<div><div>Cognitive impairment is a hallmark of Alzheimer’s disease (AD) and represents a challenge for patients and the health care system worldwide. Current pharmacological treatments of AD focus on addressing symptom management, with limited options to prevent or slow cognitive decline. Vitamin E is one of the suggested antioxidants that has a protective role against cognitive impairment (CI). We aimed to systematically review the literature and evaluate the evidence on the role of vitamin E in cognitive function. Four databases, PubMed, Scopus, Web of Science, and Cochrane Library, were searched for clinical studies published between 2012 and 2022. Study selection and data extraction followed PRISMA guidelines, and eligible studies were classified into 3 classes: vitamin E supplements, dietary vitamin E, and multivitamins containing vitamin E. A total of 43 clinical studies involving 80,488 participants were identified. Of them, one on vitamin E supplement, 18 on dietary vitamin E, and 24 on multivitamins containing vitamin E. Overall, this systematic review suggest that vitamin E, particularly when consumed as a dietary component or multivitamin supplement with other vitamins, herbs, and minerals, is associated with a protective effect against cognitive impairment, probably mediated by the synergistic effect of other components of the dietary pattern or the multivitamin supplement. However, clinical studies specifically investigating the role of tocotrienols and non-α-tocopherols isoforms, or their combinations in CI, remain limited and warrant further investigations.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"145 ","pages":"Pages 66-86"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2026-01-01Epub Date: 2025-11-19DOI: 10.1016/j.nutres.2025.11.005
Heather J. Leidy , Steve M. Douglas , Naiman A. Khan , Kathy A. Greaves
{"title":"Middle-school students who consumed school breakfast perform better on tasks assessing cognitive flexibility and executive function","authors":"Heather J. Leidy , Steve M. Douglas , Naiman A. Khan , Kathy A. Greaves","doi":"10.1016/j.nutres.2025.11.005","DOIUrl":"10.1016/j.nutres.2025.11.005","url":null,"abstract":"<div><div>Breakfast improves nutrient adequacy, weight management, and cognitive performance in children; however, less is known regarding the quality, type, and location of breakfast, particularly in adolescents. The purpose of this cross-sectional study was to examine whether consuming breakfast at home or school elicits greater cognitive performance compared to skipping breakfast in 236 urban middle-school students from low-income households. During a single school day, 3 hours after the start of school, students completed questionnaires assessing breakfast consumption followed by a 20-minute computerized cognitive performance assessment, CNS Vital Signs. Students were retrospectively grouped according to the following breakfast habits on the morning of testing: school breakfast (SCHOOL [<em>N</em> = 36]); home breakfast (HOME [<em>N</em> = 50]); school and home breakfast (BOTH [<em>N</em> = 21]); or no breakfast (SKIP [<em>N</em> = 85]). SCHOOL had higher cognitive flexibility (61.5 ± 4.2 percentile-for-age) vs SKIP (46.7 ± 2.6 percentile-for-age, <em>P</em> = .006) and HOME (49.8 ± 3.8 percentile-for-age, <em>P</em> = .05), but was not different versus BOTH (50.6 ± 9.6 percentile-for-age, NS, <em>P</em> = .220). SCHOOL had higher executive function (58.3 ± 4.2 percentile-for-age) vs SKIP (48.0 ± 2.5 percentile-for-age, <em>P</em> = .04) and BOTH (36.8 ± 7.2 percentile-for-age, <em>P</em> = .003) and trended towards higher scores vs HOME (48.7 ± 3.5 percentile-for-age, <em>P</em> = .08). No other differences occurred. Students who eat breakfast at school perform better on select cognitive function tasks compared to those who skip breakfast or eat breakfast at home, highlighting the importance of school breakfast in middle-school adolescents from low-income households.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"145 ","pages":"Pages 1-7"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2026-01-01Epub Date: 2025-11-17DOI: 10.1016/j.nutres.2025.11.004
Ashi Mittal, Shvetank Sharma
{"title":"Gut microbiota and nutritional interventions in alcohol-associated liver disease: Mechanisms and therapeutic advances","authors":"Ashi Mittal, Shvetank Sharma","doi":"10.1016/j.nutres.2025.11.004","DOIUrl":"10.1016/j.nutres.2025.11.004","url":null,"abstract":"<div><div>Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide. Despite growing awareness of its burden, treatment options remain limited, with abstinence as the only widely accepted intervention. Recent research underscores the critical role of the gut-liver axis and nutritional status, particularly dietary protein, in modulating ALD pathogenesis and progression. This review aims to integrate current knowledge on the interplay between gut microbiota, dietary protein, and alcohol-induced liver injury, and to evaluate microbiota-targeted therapeutic strategies, including fecal microbiota transplantation (FMT), within this context. We examine how chronic alcohol intake reshapes the gut microbiome, impairs barrier function, and alters microbial metabolism. We discuss how dietary protein, based on source, quantity, and amino acid composition, influences microbial ecology and metabolite profiles, with plant and dairy proteins emerging as beneficial. The review also highlights advances in FMT, which shows promise in improving outcomes in severe alcoholic hepatitis. However, its efficacy is modulated by donor microbial composition and recipient compatibility, both of which may be influenced by diet. Furthermore, we address emerging evidence on the role of fungal and viral communities, which remain understudied contributors to ALD. Despite substantial progress, significant knowledge gaps persist. These include the need for clinical validation of preclinical findings, deeper exploration of nonbacterial microbiota, and a lack of personalized, nutrition-based interventions. Addressing these gaps through integrative, multiomic approaches will be essential to advancing precision therapeutics in ALD.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"145 ","pages":"Pages 8-24"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}