Nutrition Research最新文献

{"title":"Dietary intake and plasma isoflavones are inversely associated with inflammatory markers in breast cancer survivors: A cross-sectional study","authors":"Sihan Song ,&nbsp;Zisun Kim ,&nbsp;Hyun Jo Youn ,&nbsp;Jihyoung Cho ,&nbsp;Yoo Seok Kim ,&nbsp;Jun Won Min ,&nbsp;Sang-Woon Choi ,&nbsp;Adrian A. Franke ,&nbsp;Shinyoung Jun ,&nbsp;Hyojee Joung ,&nbsp;Jung Eun Lee","doi":"10.1016/j.nutres.2025.03.007","DOIUrl":"10.1016/j.nutres.2025.03.007","url":null,"abstract":"<div><div>The role of isoflavones in breast cancer, particularly their relationship with inflammatory markers, remains underexplored. We hypothesized that higher intakes of soy and isoflavones are inversely associated with inflammatory markers in breast cancer survivors. This cross-sectional study included 432 breast cancer survivors (mean age: 52 years). We assessed dietary soy and isoflavone intake and measured plasma concentrations of isoflavones, high-sensitivity C-reactive protein (hsCRP), adiponectin, interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α. Generalized linear and logistic regression models were used to obtain adjusted least squares means (LSmeans) and odds ratios (ORs) for individual or combined (if associated with soy intake) inflammatory markers. Participants with higher soy and isoflavone intakes had lower hsCRP and IL-6 concentrations and higher adiponectin concentrations. The LSmeans (95% confidence intervals, CIs) of the lowest and highest quintiles of soy food intake were 0.71 (0.49, 0.96) and 0.52 (0.33, 0.73) for hsCRP (mg/L), and 0.42 (-0.08, 0.91) and -0.02 (-0.50, 0.46) for the combined scores of hsCRP and adiponectin. The OR (95% CI) comparing extreme quintiles of isoflavone intake was 0.43 (0.20, 0.94) for elevated hsCRP. When plasma isoflavone concentrations were examined in relation to the combined scores of hsCRP and IL-6, the OR (95% CI) comparing the extreme quintiles was 0.32 (0.12, 0.91). Our results suggest that dietary soy and isoflavone intake, as well as plasma isoflavone concentrations, are inversely associated with inflammatory markers in breast cancer survivors. These findings highlight the need for further research to better understand their clinical implications.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 22-32"},"PeriodicalIF":3.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to the Dietary Approaches to Stop Hypertension diet was associated with the risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis of observational studies","authors":"Sadra Momeni ,&nbsp;Fatemeh Hajizadeh-Sharafabad ,&nbsp;Mohammad Reza Pashaei","doi":"10.1016/j.nutres.2025.03.005","DOIUrl":"10.1016/j.nutres.2025.03.005","url":null,"abstract":"<div><div>The Dietary Approaches to Stop Hypertension (DASH) diet has long been recommended for the management of hypertension, while it may provide other metabolic benefits. This study aimed to analyze the association between the DASH diet and nonalcoholic fatty liver disease (NAFLD) risk through a systematic review and meta-analysis. We hypothesized that the adherence to DASH diet is inversely associated with NAFLD risk. PubMed, Web of Science, Scopus, and Google Scholar were searched to find relevant publications up to September 2024. We included observational studies evaluating the association between the DASH diet score and the risk of NAFLD. Pooling effect sizes was conducted using a random effects model to determine the odd ratio (OR) of incident NAFLD associated with the DASH diet. Eight studies with a total of 120937 participants were included in the meta-analysis. The pooled OR for NAFLD in the highest score of the DASH diet vs. lowest score was 0.78 (95% CI: 0.70-0.86, <em>P</em> &lt; .001), indicating a significant inverse association between the DASH diet and NAFLD risk. The result was stable to sensitivity analysis. A significant heterogeneity was observed between studies (I²=62.7%, <em>P</em> = .009). Overall, this meta-analysis showed that individuals with the highest score of the DASH diet were 22% less likely to have NAFLD in comparison to those with the lowest score of the DASH diet, independent of body mass index. Further high-quality prospective studies are needed to confirm the protective effect of the DASH diet on NAFLD.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"137 ","pages":"Pages 14-21"},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of prebiotics on growth metrics in infants: A GRADE approach systematic review and meta-analysis of randomized clinical trials","authors":"Seyedeh-Tarlan Mirzohreh ,&nbsp;Asma Sohrabnavi ,&nbsp;Padideh Panahi ,&nbsp;Zeinab Nikniaz ,&nbsp;Mahdieh Abbasalizad Farhangi ,&nbsp;Sevana Daneghian ,&nbsp;Leila Nikniaz","doi":"10.1016/j.nutres.2025.03.003","DOIUrl":"10.1016/j.nutres.2025.03.003","url":null,"abstract":"<div><div>Breastfeeding is often not feasible for all mothers, making infant formula a critical alternative for ensuring infant safety and nutrition. We hypothesized that the inclusion of prebiotics in infant formula significantly affects growth metrics in infants compared to standard formula. This study aims to fill a knowledge gap regarding the effects of prebiotics in infant formula on infant growth and development, particularly given the varying compositions and durations of prebiotic supplementation. A systematic review was conducted following PRISMA guidelines, analyzing 24 studies sourced from databases such as PubMed and Cochrane, with risk of bias assessed using RoB-2 for randomized controlled trials (RCTs). The findings revealed no significant differences in weight gain (WG), height gain (HG), or head circumference gain (HCG) between prebiotic-fed infants and control groups overall. However, infants receiving prebiotics for 3 or more months exhibited a significant decrease in WG compared to controls (SMD -0.479, <em>P</em> &lt; .05). Notably, those fed formulas containing fructo-oligosaccharides/galacto-oligosaccharides and a combination of polydextrose/galacto-oligosaccharides/lactulose demonstrated improved WG (SMDs of 0.214 and 0.184, <em>P</em> &lt; .05 respectively). Conversely, infants on formulas with inulin-enriched oligo-fructose (IOF) experienced reduced WG and HG. In conclusion, while prebiotics did not consistently enhance growth metrics, specific combinations showed potential benefits, emphasizing the need for tailored approaches in infant formula design to optimize growth without compromising health.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"137 ","pages":"Pages 22-46"},"PeriodicalIF":3.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apparently healthy young black adults report lower total fluid intake and exhibit higher plasma copeptin than young White adults","authors":"Nina L. Stute ,&nbsp;Braxton A. Linder ,&nbsp;Sofia O. Sanchez ,&nbsp;Joseph D. Vondrasek ,&nbsp;Brett Cross ,&nbsp;McKenna A. Tharpe ,&nbsp;Zach J. Hutchison ,&nbsp;Melissa Pangelinan ,&nbsp;Colleen X. Muñoz ,&nbsp;Gregory J. Grosicki ,&nbsp;Thomas Fuller-Rowell ,&nbsp;Austin T. Robinson","doi":"10.1016/j.nutres.2025.02.007","DOIUrl":"10.1016/j.nutres.2025.02.007","url":null,"abstract":"<div><div>Underhydration is associated with higher plasma copeptin concentration ([copeptin]), an arginine vasopressin surrogate associated with multiple chronic diseases. Middle-aged and older Black individuals are more likely to be underhydrated and exhibit higher [copeptin] than White individuals. However, limited data exists on racial differences in [copeptin] in young adults. Therefore, we tested the hypothesis that apparently healthy young Black adults would report lower fluid intake and exhibit higher plasma [copeptin] than young White adults. Participants (n = 86; sex: 40F/46M; race: White n = 48, Black n = 38; age: 21<span><math><mrow><mspace></mspace><mo>±</mo><mspace></mspace></mrow></math></span>2 years, BMI: 25<span><math><mo>±</mo></math></span>4 kg/m²) completed 3-day food and fluid diaries. We operationalized beverages into 8 categories (water, sugar-sweetened beverages, milk/non-dairy alternatives, juice, nonaloric beverages (eg, diet drinks), coffee or tea (noncaloric), coffee or tea (caloric), and alcohol) and measured plasma [copeptin]. We assessed racial differences in fluid intake and [copeptin] and also examined relations between race, fluid intake, and [copeptin] via regression and correlation analyses. Compared with White adults, Black adults consumed less total fluid (64.0[31.3] vs. 89.7[53.6] oz), water, alcohol, and coffee/tea (noncaloric and caloric) but more juice (<em>p</em>s &lt; .05). Black participants exhibited higher plasma [copeptin] (6.38[4.83] vs. 4.45[2.92] pmol/L, <em>P</em> = .021). In the whole cohort, plasma [copeptin] was negatively correlated with water intake (<span><math><mrow><mi>ρ</mi><mspace></mspace></mrow></math></span>= -0.249, <em>P</em> = .021). However, racial differences in [copeptin] were attenuated by 27% when accounting for total fluid intake. Black young adults reported lower fluid intake and exhibited higher plasma [copeptin] than White young adults. Interventions are needed to address racial disparities in hydration practices, potentially attenuating racial differences in [copeptin] and related health disparities.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 81-93"},"PeriodicalIF":3.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The combined indicator of vitamin B12 status calculated using 3-parameters (3cB12) is negatively associated with mortality among US adults: NHANES 1999 to 2004","authors":"Yanmei Li,&nbsp;Huifen Wang,&nbsp;Shuo Chen,&nbsp;Qilu Wei,&nbsp;Yini Liu,&nbsp;Zhenmei Song,&nbsp;Shiyu Du","doi":"10.1016/j.nutres.2025.02.008","DOIUrl":"10.1016/j.nutres.2025.02.008","url":null,"abstract":"<div><div>The association between vitamin B₁₂ status and the risk of mortality is controversial. The combined indicator calculated using 3 traditional parameters (3cB₁₂) can be used to indicate vitamin B₁₂ status. We hypothesize that vitamin B₁₂ deficiency indicated by 3cB₁₂ may be related to high mortality risks. To evaluate the association between 3cB₁₂ and all-cause, cardiovascular disease (CVD) and cancer-related mortality, we used Cox proportional hazard models, cumulative Kaplan–Meier curves, and smooth curve fitting to assess data from NHANES 1999 to 2004. A total of 12,103 adults (20 years and older) were included in the analyses and 3595 participants were determined as deceased. The median follow-up duration was 202 months. In the fully adjusted model, all three mortality rates decreased along with the increase in 3cB₁₂ scores, with hazard ratio (HR) [95% confidence interval (CI)]: 0.81 (0.75, 0.87) for all-cause mortality, HR (95% CI): 0.83 (0.72, 0.95) for CVD mortality, and HR (95% CI): 0.79 (0.66, 0.96) for cancer-related mortality. When 3cB₁₂ was divided into two groups, individuals in the lower 3cB₁₂ group (3cB₁₂ &lt; −0.5) showed increased risks of all-cause mortality [HR (95% CI): 1.73 (1.48, 2.02)] and CVD mortality [HR (95% CI): 1.84 (1.31, 2.59)], as compared to the higher 3cB₁₂ group (3cB₁₂ ≥ −0.5). The smooth fitting curves represented a negative linear relationship between 3cB₁₂ and all three types of mortality (<em>P</em> for nonlinearity &gt;.05). In conclusion, the extrapolation of 3cB₁₂ from conventional metrics affords a novel perspective for evaluating B₁₂ nutritional status and mortality risk.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 53-63"},"PeriodicalIF":3.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial office and Board Members","authors":"","doi":"10.1016/S0271-5317(25)00037-5","DOIUrl":"10.1016/S0271-5317(25)00037-5","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages i-ii"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher dietary vegetable and fruit intake along with their biomarkers is inversely associated with all-cause mortality among cancer survivors","authors":"Mianmian Jiang,&nbsp;Caixia Zhang","doi":"10.1016/j.nutres.2025.02.001","DOIUrl":"10.1016/j.nutres.2025.02.001","url":null,"abstract":"<div><div>The association between dietary vegetable and fruit (VF) intake and survival outcomes among cancer survivors remains unclear, with limited research available on the association between VF-related biomarkers and mortality in this population. We hypothesized that there were inverse relationships between dietary VF intake, serum carotenoids, serum vitamin C, composite biomarker score and both all-cause and cancer-specific mortality among cancer survivors. This study analyzed cancer survivors from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2018 cycles for VF intake (n = 4326), and from NHANES III, 2003 to 2006, and 2017 to 2018 cycles for serum carotenoids (n = 2187), serum vitamin C (n = 2267), and composite biomarker score (n = 2131). Weighted multivariable Cox proportional hazards regression models were used to assess the associations between exposures and mortality, computing hazard ratio (HR) and 95% CI. Dietary VF intake was significantly associated with a lower risk of all-cause mortality (HR = 0.80, 95% CI: 0.67−0.96) over a median follow-up of 6.9 years. For serum biomarkers, higher concentration of total carotenoids (median follow-up: 10.0 years), vitamin C (median follow-up: 9.4 years) and higher composite biomarker score (median follow-up: 10.1 years) were associated with lower risks of all-cause mortality, with HRs (95% CIs) of 0.73 (0.58−0.92), 0.73 (0.56−0.95), and 0.73 (0.57−0.95), respectively. Additionally, only vitamin C was linked to cancer-specific mortality, with HRs (95% CIs) of 0.55 (0.37−0.81). Higher VF intake and their associated biomarkers are associated with a lower risk of all-cause mortality among U.S. cancer survivors.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 141-157"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"David Kritchevsky Graduate Student Award for Nutrition Research","authors":"","doi":"10.1016/S0271-5317(25)00038-7","DOIUrl":"10.1016/S0271-5317(25)00038-7","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Page iii"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bugs got milk? Exploring the potential of lactose as a prebiotic ingredient for the human gut microbiota of lactose-tolerant individuals","authors":"Rita de Cassia Pessotti ,&nbsp;Mathilde Guerville ,&nbsp;Laira Lorraine Agostinho ,&nbsp;Cristina Stewart Bittencourt Bogsan ,&nbsp;Mateus Kawata Salgaço ,&nbsp;Amandine Ligneul ,&nbsp;Miller Nunes de Freitas ,&nbsp;Cristiano Ruch Werneck Guimarães ,&nbsp;Katia Sivieri","doi":"10.1016/j.nutres.2025.02.006","DOIUrl":"10.1016/j.nutres.2025.02.006","url":null,"abstract":"<div><div>Milk consumption is important to help meet daily nutrient requirements. However, lactose—present in dairy products—has been associated with digestive discomfort in individuals who are lactose intolerant or have inadequate lactase activity. Yet, a new perspective on this dietary component has emerged: its potential as a prebiotic for the lactose-tolerant population. We hypothesized that ingestion of lactose may improve the microbial community structure and metabolism of the gut microbiota from healthy adults. First, we assessed the acute impact of lactose ingestion on the gut microbiota of adults using a short-duration <em>in vitro</em> batch colonic model. Subsequently, we employed a long-duration <em>in vitro</em> dynamic multivessel colonic model to evaluate the effects of lactose chronic ingestion. In both cases, a mixture of lactose/galactose/glucose was administered in a defined proportion to mimic lactose metabolism and galactose/glucose absorption in lactose-tolerant adults. The hypothesis was confirmed, as a modulatory prebiotic effect was revealed on the microbial community structure and metabolism of the microbiota upon treatments simulating the ingestion of three doses of lactose, equivalent to half a glass, one glass, and two glasses of cow's milk. The long-duration model confirmed this potential, increasing the relative abundance of the beneficial genera <em>Lactobacillus, Akkermansia</em>, and <em>Faecalibacterium</em>, while the usually detrimental genus <em>Clostridium</em> decreased. Additionally, the health-promoting microbial metabolites acetate, propionate, and lactate were increased. Therefore, lactose ingestion could positively modulate the gut microbiota in healthy lactose-tolerant adults, thereby promoting gut health and shedding light on the dietary benefits of consuming milk.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 64-80"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and inflammatory potential of diet is associated with risk of asthma-chronic obstructive pulmonary disease overlap: Findings from NHANES (2003-2018)","authors":"Yuhuan Wei ,&nbsp;Li Qin ,&nbsp;Xiaoling Wang ,&nbsp;Yuan Cui ,&nbsp;Yunhua Zhao ,&nbsp;Shaoye Huo ,&nbsp;Lihong Wang ,&nbsp;Teng Li ,&nbsp;Chunhai Shao","doi":"10.1016/j.nutres.2025.01.010","DOIUrl":"10.1016/j.nutres.2025.01.010","url":null,"abstract":"<div><div>Previous studies have explored the connection between the dietary inflammation index (DII) and asthma-COPD Overlap (ACO); however, the relationship between diet and the risk of ACO from an antioxidant perspective remains unexamined. We hypothesized that a proinflammatory diet may increase the risk of ACO by promoting inflammation, whereas an antioxidant diet may reduce the risk by mitigating inflammation. To test this hypothesis, we conducted a cross-sectional study utilizing data from the National Health and Nutrition Examination Survey (NHANES) in 2003-2018, including 23,050 participants. The study employed propensity score matching (PSM), logistic regression, restricted cubic splines (RCS), and mediation analysis. Pre-PSM and post-PSM RCS analyses indicated a positive correlation between DII and ACO, while the composite dietary antioxidant index (CDAI) demonstrated a negative association (<em>P-overall</em> &lt;0 .05). Pre-PSM and post-PSM logistic regression results showed that higher DII scores were associated with an increased risk of ACO, while higher CDAI scores correlated with a reduced risk of ACO (<em>P</em> &lt;0 .05). Mediation analysis further indicated that pro-inflammatory diets increased ACO risk through elevated levels of white blood cells (WBC), eosinophil counts (EC), systemic immune-inflammation index (SII), and system inflammation response index (SIRI) (<em>P</em> &lt; 0.05). In contrast, antioxidant diets reduced the risk of ACO events by decreasing the levels of these inflammatory markers (<em>P</em> &lt; 0.05). In conclusion, higher DII scores may increase the risk of ACO, while higher CDAI scores may decrease it. Both DII and CDAI mediate their effects through inflammatory markers, including WBC, EC, SII, and SIRI.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 128-140"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}