Malnutrition outweighs sarcopenia and adiposity as a predictor of survival in colorectal cancer patients

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research Pub Date : 2025-04-03 DOI:10.1016/j.nutres.2025.04.001

Mylena Pinto dos Santos , Mariana Vieira Barbosa , Nilian Carla Souza , Renata Brum Martucci

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引用次数: 0

Abstract

Colorectal cancer (CRC) patients often face nutritional disturbances, including malnutrition, changes in skeletal muscle index (SMI), and adipose tissue. We hypothesized that malnutrition, sarcopenia and nutritional disorders, as low muscle strength, low SMI, and reduced adipose tissue can negatively impact survival. This study aimed to assess the impact of malnutrition, SMI, muscle strength, sarcopenia, and adipose tissue on CRC patient survival. We analyzed 2 cohorts of CRC patients in this longitudinal study. Nutritional status was assessed by Patient-Generated Subjective Global Assessment (PG-SGA) and those classified as B and C were considered with malnutrition. Computed tomography (CT) scans of the third lumbar vertebra (L3) measured SMI and various adipose tissue fractions (visceral, subcutaneous, intramuscular, and total). Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2). The primary outcome was 5-year overall survival. Of 266 patients (mean age 60.7 years, 53.0% male), 11.3% had sarcopenia, 27.0% were malnourished, and 40.0% died. After adjusting for clinical variables, Cox regression analysis showed that only Malnutrition (HR: 1.96; CI: 1.35-2.84; P ≤ .001) significantly impacted survival. In CRC patients, Malnutrition outweighs sarcopenia and adiposity as a predictor of survival in colorectal cancer patients.

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作为结直肠癌患者生存的预测指标，营养不良超过肌肉减少症和肥胖

结直肠癌（CRC）患者经常面临营养紊乱，包括营养不良、骨骼肌指数（SMI）变化和脂肪组织。我们假设营养不良、肌肉减少症和营养失调，如低肌肉力量、低SMI和脂肪组织减少会对生存产生负面影响。本研究旨在评估营养不良、重度精神分裂症、肌肉力量、肌肉减少症和脂肪组织对结直肠癌患者生存的影响。我们在这项纵向研究中分析了2组结直肠癌患者。采用患者主观整体评估（PG-SGA）对营养状况进行评估，B级和C级为营养不良。第三腰椎（L3）的计算机断层扫描（CT）测量了SMI和各种脂肪组织（内脏、皮下、肌肉内和总）。肌少症是根据欧洲老年人肌少症工作组2 （EWGSOP2）定义的。主要终点是5年总生存率。266例患者（平均年龄60.7岁，男性53.0%）中，11.3%患有肌肉减少症，27.0%营养不良，40.0%死亡。在调整临床变量后，Cox回归分析显示只有营养不良(HR: 1.96；置信区间:1.35—-2.84;P≤0.001)显著影响生存率。在结直肠癌患者中，营养不良比肌肉减少症和肥胖更能预测结直肠癌患者的生存。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Research 医学-营养学

CiteScore

7.60

自引率

2.20%

发文量

107

审稿时长

58 days

期刊介绍： Nutrition Research publishes original research articles, communications, and reviews on basic and applied nutrition. The mission of Nutrition Research is to serve as the journal for global communication of nutrition and life sciences research on diet and health. The field of nutrition sciences includes, but is not limited to, the study of nutrients during growth, reproduction, aging, health, and disease. Articles covering basic and applied research on all aspects of nutrition sciences are encouraged, including: nutritional biochemistry and metabolism; metabolomics, nutrient gene interactions; nutrient requirements for health; nutrition and disease; digestion and absorption; nutritional anthropology; epidemiology; the influence of socioeconomic and cultural factors on nutrition of the individual and the community; the impact of nutrient intake on disease response and behavior; the consequences of nutritional deficiency on growth and development, endocrine and nervous systems, and immunity; nutrition and gut microbiota; food intolerance and allergy; nutrient drug interactions; nutrition and aging; nutrition and cancer; obesity; diabetes; and intervention programs.