Nutrition Research最新文献

David Kritchevsky Graduate Student Award for Nutrition Research 大卫-克里切夫斯基营养研究研究生奖

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-10-01 DOI: 10.1016/S0271-5317(24)00137-4

引用次数: 0

Editorial office and Board Members 编辑部和董事会成员

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-10-01 DOI: 10.1016/S0271-5317(24)00136-2

引用次数: 0

Increasing particle size of oat flours decreases postprandial glycemia and increases appetite in healthy adults 增大燕麦粉的粒度可降低健康成年人的餐后血糖值并增加食欲

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-10-01 DOI: 10.1016/j.nutres.2024.07.006

{"title":"Increasing particle size of oat flours decreases postprandial glycemia and increases appetite in healthy adults","authors":"","doi":"10.1016/j.nutres.2024.07.006","DOIUrl":"10.1016/j.nutres.2024.07.006","url":null,"abstract":"<div><div>Consumption of oats is associated with lowered risks of type 2 diabetes and obesity. However, many oat-based products (e.g., breakfast cereals) use finely milled flours but are associated with health claims based on oats of larger particle sizes. The objective of this study was to test the hypothesis that increasing oat flour particle size will result in lower postprandial glycemia and appetite. Using a randomized-controlled, crossover design, 20 participants (10 males, 10 females; age: 25.3 ± 1.0 years; body mass index: 23.2 ± 0.6 kg/m<sup>2</sup>) consumed a serving of porridge made using 40 g of coarse (675.7 ± 19.6 µm), whole (443.3 ± 36.2 µm), fine (96.0 ± 2.1 µm), or a commercial (375.9 ± 14.8 µm) oat flour unmatched in available carbohydrate, protein, and dietary fiber content. After a 12-hour overnight fast, blood glucose, insulin, and appetite were measured at 15 to 30-minute intervals over 120 minutes posttreatment consumption. Coarse and whole flours led to lower blood glucose between 30 and 60 minutes (<em>P</em> < .02). Blood glucose area under the curve (AUC) was lower after coarse than fine and commercial oat flours (<em>P</em> < 0.03), and after whole than fine oat flour (<em>P</em> < .002). Both coarse and whole oat flours resulted in lower insulin AUC than finer flours (<em>P</em> < .05). Appetite AUC was lower after the commercial than coarse flour (<em>P</em> < .007). Controlling milling to produce coarser oat flour to add to common foods may have health benefits. This study was registered at ClinicalTrials.gov (NCT05291351).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher sweet beverage consumption was associated with increased gestational weight gain and birth weight: A Chinese cohort study 甜饮料消费量增加与妊娠体重增加和出生体重增加有关：一项中国队列研究

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-09-20 DOI: 10.1016/j.nutres.2024.09.013

{"title":"Higher sweet beverage consumption was associated with increased gestational weight gain and birth weight: A Chinese cohort study","authors":"","doi":"10.1016/j.nutres.2024.09.013","DOIUrl":"10.1016/j.nutres.2024.09.013","url":null,"abstract":"<div><div>Diet during pregnancy is crucial to maternal metabolism and fetal development, so exploring the most potent food risk factor could improve maternal and child health. In this study, we investigated the diet and lifestyle of 833 healthy pregnant women in the second trimester from November 2020 to August 2021. Based on the Tianjin Antenatal Care System in China, we followed up with these women and recorded their gestational weight gain (GWG) and newborn birth weight. We conducted a dietary survey through FFQ based on the food groups recommended by the Chinese Dietary Guidelines and included common ultra-processed foods. We collected 219 semi-quantitative FFQs and 614 self-reported FFQs for analysis. According to the consumption frequency of 12 food groups, 4 dietary patterns were extracted by principal component analysis. We analyzed the associations of food energy, consumption frequency, and dietary patterns with GWG and birth weight, especially GWG in the first and second trimesters (f-GWG). The results showed that f-GWG was positively correlated with food energy. Beverage consumption was associated with f-GWG (<em>r</em> = 0.288, <em>P</em> = .026) in obese pregnant women. A dietary pattern that favors high consumption of ultra-processed foods (fried foods, baked desserts, and sweet beverages) was associated with increased GWGs. Non-obesity women with high consumption of baked desserts and sweet beverages had higher GWGs (<em>P</em> < .05). After adjusting for confounding factors (including total energy, physical activity, and sleep quality), only sweet beverage consumption was associated with f-GWG (<em>β</em> 0.498, 95%CI 0.153-0.843) and birth weight (<em>β</em> 0.124, 95%CI 0.009-0.240). Sweet beverage consumption is a key adjustable risk factor for prenatal care.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supplementation of spermidine at 40 mg/day has minimal effects on circulating polyamines: An exploratory double-blind randomized controlled trial in older men 每天补充 40 毫克的亚精胺对循环多胺的影响微乎其微：一项针对老年男性的探索性双盲随机对照试验

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-09-19 DOI: 10.1016/j.nutres.2024.09.012

{"title":"Supplementation of spermidine at 40 mg/day has minimal effects on circulating polyamines: An exploratory double-blind randomized controlled trial in older men","authors":"","doi":"10.1016/j.nutres.2024.09.012","DOIUrl":"10.1016/j.nutres.2024.09.012","url":null,"abstract":"<div><div>This study represents the first investigation into the safety of a novel, high-purity spermidine trihydrochloride supplement (hpSPD) in humans. Spermidine, a natural compound found in various foods, has demonstrated potential health benefits in animal and epidemiological studies. However, evidence from clinical trials and safety evaluations of spermidine supplements is limited because pure spermidine for human administration has not been available. In this randomized, double-blind, within-subject and placebo-controlled trial, 37 healthy men (age 50–70 years; body mass index, 18.5–28 kg/m<sup>2</sup>) were administered either hpSPD or a placebo. We hypothesized that 7-day and 28-day dosing of 40 mg/day of hpSPD would have minimal effects on safety, although metabolic and polyamine homeostasis has not previously been examined at this dosage level. Consistent with our hypothesis, 40 mg/day hpSPD did not result in any significant changes in clinical, lipids, chemistry, or hematological parameters compared to placebo. Compliance was high, and no study product-related adverse events were reported. Substantial changes in serum and urine polyamine concentrations were not observed following hpSPD supplementation, suggesting effective homeostatic control of full-dose highly purified spermidine supplements with no evidence of adaptation of spermidine metabolism at 40 mg/day. These findings suggest that hpSPD at 40 mg/day for up to 28 days is safe and well-tolerated in healthy older men. The study is consistent with preclinical results and provides important evidence supporting the safety of high-purity spermidine supplementation, enabling further research with single-molecule spermidine to investigate its potential biology for improving human health. This trial was registered at clinicaltrials.gov (NCT05459961).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological and transcriptome data identify association between iron overload and metabolic dysfunction-associated steatotic liver disease and hepatic fibrosis 流行病学和转录组数据确定了铁超载与代谢功能障碍相关的脂肪肝和肝纤维化之间的联系。

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-09-18 DOI: 10.1016/j.nutres.2024.09.011

{"title":"Epidemiological and transcriptome data identify association between iron overload and metabolic dysfunction-associated steatotic liver disease and hepatic fibrosis","authors":"","doi":"10.1016/j.nutres.2024.09.011","DOIUrl":"10.1016/j.nutres.2024.09.011","url":null,"abstract":"<div><div>The primary objective of this study was to examine the association between iron overload (IO), metabolic dysfunction-associated steatotic liver disease (MASLD), and hepatic fibrosis. We hypothesized that there is a significant association. Data from the NHANES (2017-2020) were analyzed to explore IO's impact on MASLD and hepatic fibrosis in U.S. adults. We assessed serum ferritin, controlled attenuation parameter (CAP), liver stiffness measurement (LSM), and various covariates. Gene expression data were sourced from the FerrDb V2 and GEO databases. Differential gene expression analysis, Protein-Protein Interaction (PPI) Network construction, and Gene Ontology (GO) and KEGG pathway enrichment analyses were performed. The study verified the link between MASLD, hepatic fibrosis, and iron overload hub genes. This study of 5927 participants, averaging 46.78 years of age, revealed significant correlations between serum ferritin and CAP, LSM, after adjusting for covariates. Threshold effect analysis indicated nonlinear associations between serum ferritin and CAP, LSM, with distinct patterns observed by age and gender. Moreover, the area under the ROC curve for serum ferritin with MASLD and hepatic fibrosis was 0.8272 and 0.8376, respectively, demonstrating its performance in assessing these conditions. Additionally, molecular analyses identified potential hub genes associated with iron overload and MASLD, and hepatic fibrosis, revealing the underlying mechanisms. Our study findings reveal an association between iron overload, MASLD, and hepatic fibrosis. Additionally, the hub genes may be implicated in iron overload and subsequently contribute to the progression of MASLD and hepatic fibrosis. These findings support precision nutrition strategies.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal-level anti-inflammatory bioactivities of whole wheat: Rationale, design, and methods of a randomized, controlled, crossover dietary trial in adults with prediabetes 全麦的肠道级抗炎生物活性：糖尿病前期成人随机对照交叉膳食试验的原理、设计和方法。

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-09-18 DOI: 10.1016/j.nutres.2024.09.010

{"title":"Intestinal-level anti-inflammatory bioactivities of whole wheat: Rationale, design, and methods of a randomized, controlled, crossover dietary trial in adults with prediabetes","authors":"","doi":"10.1016/j.nutres.2024.09.010","DOIUrl":"10.1016/j.nutres.2024.09.010","url":null,"abstract":"<div><div>Randomized controlled trials (RCT) demonstrate that whole wheat consumption improves glycemia. However, substantial inter-individual variation is often observed, highlighting that dietary whole grain recommendations may not support the health of all persons. The objective of this report is to describe the rationale and design of a planned RCT aimed at establishing the gut microbiota and metabolome signatures that predict whole wheat-mediated improvements in glucose tolerance in adults with prediabetes. It is hypothesized that a controlled diet containing wheat bread (WHEAT; 160 g/day) compared with refined bread (WHITE) will improve glucose tolerance in a gut microbiota-mediated manner. Biospecimens will be collected before and after each 2-week study arm. Testing for oral glucose tolerance and gastrointestinal permeability will be performed post-intervention. Assessments will include oral glucose tolerance (primary outcome) and secondary outcomes including gut microbiota, targeted and untargeted metabolomics of fecal and plasma samples, intestinal and host inflammatory responses, and intestinal permeability. WHEAT is predicted to alleviate glucose intolerance by shifting microbiota composition to increase short-chain fatty acid-producing bacteria while reducing populations implicated in intestinal inflammation, barrier dysfunction, and systemic endotoxemia. Further, benefits from WHEAT are anticipated to correlate with gut-level and systemic metabolomic responses that can help to explain the expected inter-individual variability in glucose tolerance. Thus, knowledge gained from integrating multi-omic responses associating with glucose tolerance could help to establish a precision nutrition-based framework that can alleviate cardiometabolic risk. This framework could inform novel dietary whole grain recommendations by enhancing our understanding of inter-individual responsiveness to whole grain consumption.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher docosahexaenoic acid proportions in blood are inversely associated with the prevalence of prediabetes: Evidence from the UK Biobank 血液中较高的二十二碳六烯酸比例与糖尿病前期的发病率成反比：来自英国生物库的证据。

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-09-17 DOI: 10.1016/j.nutres.2024.09.009

{"title":"Higher docosahexaenoic acid proportions in blood are inversely associated with the prevalence of prediabetes: Evidence from the UK Biobank","authors":"","doi":"10.1016/j.nutres.2024.09.009","DOIUrl":"10.1016/j.nutres.2024.09.009","url":null,"abstract":"<div><div>Prediabetes and type 2 diabetes mellitus are growing global health concerns, predisposing individuals to various vascular complications. Lifestyle modifications, including dietary interventions, offer promising avenues for prevention and management. Using a multivariable-adjusted model, we analyzed the cross-sectional associations between plasma proportions (% of total fatty acids) of omega-3 polyunsaturated fatty acids (<em>n</em>3 PUFA, including total <em>n</em>3 PUFA, docosahexaenoic acid [DHA], non-DHA <em>n</em>3 PUFA), and glycated hemoglobin A1c (HbA1c) as well as the prevalence of prediabetes in a sample from the UK Biobank cohort. Our hypothesis was that proportions of <em>n</em>3 PUFA, especially DHA, would by inversely associated with the prediabetes prevalence. The sample (<em>n</em> = 92,762; 54.5% females) had an average age of 56 years and was overweight (mean body mass index = 27). The mean plasma DHA proportion in the sample was 2.03% (standard deviation [SD] = 0.67%), non-DHA <em>n</em>3 PUFA was 2.41% (SD = 1.02%) and total <em>n</em>3 PUFA was 4.43% (SD = 1.56%). Prediabetic individuals were identified by blood HbA1c proportions between 5.7% and 6.4% (39-46 mmol/mol) according to American Diabetes Association criteria. Each of the three <em>n</em>3 PUFA biomarkers was inversely associated with HbA1c proportions. In particular, DHA showed the strongest inverse association, with an OR of 0.62 (95% confidence intervals: 0.58, 0.67; <em>P</em> < .001) when comparing quintiles 5 to 1 in a fully adjusted model. These findings suggest a potential protective role of <em>n</em>3 PUFA, particularly DHA, in mitigating the risk of having prediabetes. Further prospective investigations are needed to clarify whether long-chain <em>n</em>3 PUFA could function as modifiable factors for prediabetes.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A matter of the metric? Sugar content overestimation is less pronounced in sugar cubes versus grams 计量单位的问题？方糖与克糖相比，糖含量被高估的情况不那么明显。

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-09-14 DOI: 10.1016/j.nutres.2024.09.007

{"title":"A matter of the metric? Sugar content overestimation is less pronounced in sugar cubes versus grams","authors":"","doi":"10.1016/j.nutres.2024.09.007","DOIUrl":"10.1016/j.nutres.2024.09.007","url":null,"abstract":"<div><div>To make healthy food choices, consumers need to be aware of the sugar content of foods. Units act as an environmental cue that might influence sugar content estimation accuracy. The present study (1) tested whether estimations of sugar content are more accurate in sugar cubes vs grams, (2) compared accuracy of sugar content to estimations of the foods’ weight and energy content, and (3) investigated gender, education, and body mass index as potential correlates. A sample of 886 adults was randomly assigned to estimating the sugar content of 10 common foods in grams or cubes. Estimations of sugar content diverged considerably from actual values in both groups (0.22 ≤ Cohen's <em>d</em>s<sub>gram</sub><sub>s</sub> ≤ 1.20; 0.20 ≤ Cohen's <em>d</em>s<sub>cubes</sub> ≤ 1.10), but were more pronounced for sugar content estimations in grams in 7 out of 10 foods (<em>t</em>s ≥ 4.04, <em>P</em>s < .001, Cohen's <em>d</em>s ≥ 0.14). Sugar content misestimation was somewhat more pronounced than misestimation of weight (0.05 ≤ Cohen's <em>d</em>s ≤ 1.43) and energy content (0.04 ≤ Cohen's <em>d</em>s ≤ 1.19). Relationships between sugar content misestimation and gender (0.00 ≤ Cohen's <em>d</em>s ≤ 0.33), education (–0.07 ≤ <em>r</em> ≤ 0.11), and body mass index (–0.08 ≤ <em>r</em> ≤ 0.06) were mostly negligible. Although sugar content estimations were somewhat more accurate in sugar cubes vs grams, estimation accuracy is generally low. In addition to promoting consumers’ knowledge through labeling and education, additional avenues for interventions might need to be explored for sizeable effects on food choices.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The high-fat diet and low-dose streptozotocin type-2 diabetes model induces hyperinsulinemia and insulin resistance in male but not female C57BL/6J mice 高脂饮食和低剂量链脲佐菌素 2 型糖尿病模型可诱导雄性 C57BL/6J 小鼠产生高胰岛素血症和胰岛素抵抗，但不会诱导雌性 C57BL/6J 小鼠产生高胰岛素血症和胰岛素抵抗。

IF 3.4 3区医学

Nutrition Research Pub Date : 2024-09-14 DOI: 10.1016/j.nutres.2024.09.008

{"title":"The high-fat diet and low-dose streptozotocin type-2 diabetes model induces hyperinsulinemia and insulin resistance in male but not female C57BL/6J mice","authors":"","doi":"10.1016/j.nutres.2024.09.008","DOIUrl":"10.1016/j.nutres.2024.09.008","url":null,"abstract":"<div><div>Translation of preclinical findings on the efficacy of dietary interventions for metabolic disease to human clinical studies is challenging due to the predominant use of male rodents in animal research. Our objective was to evaluate a combined high-fat (HF) diet and low-dose streptozotocin (STZ) model for induction of type-2 diabetes (T2D) in male and female C57BL/6J mice. We hypothesized that T2D biomarkers would differ significantly between sexes. Mice were administered either a low-fat (LF) diet (10% kcal from fat), or HF diet (60% kcal from fat) + STZ injections (30 mg/kg/d for 3 days). Both sexes gained weight and developed impaired postprandial oral glucose tolerance on the HF+STZ treatment compared to LF. Only male mice on HF + STZ developed fasting hyperglycemia, fasting hyperinsulinemia and insulin resistance, suggesting that the underlying causes of postprandial hyperglycemia differed between sexes. Principal component analysis of measures such as body weights, glucose and insulin concentrations indicated metabolic derangement for males only on HF+STZ treatment, while LF group males and both groups of females significantly overlapped. Based on our data, we accept our hypothesis that the combined high-fat diet and low-dose STZ model for T2D phenotypes differs significantly in its effect on mice based on sex. The HF diet + low-dose STZ model is not useful for studying insulin resistance in females. Other models are needed to model T2D, and study the effects of dietary interventions in this disease, in females. Sexual dimorphism remains a significant challenge for both preclinical and clinical research.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0