Nutrition Research最新文献

{"title":"Emotional and uncontrolled eating behaviors are associated with poorer glycemic control in patients with type 2 diabetes","authors":"Ana Carolina Freitag ,&nbsp;Olívia Garbin Koller ,&nbsp;Vanessa Machado Menezes ,&nbsp;Vivian Cristine Luft ,&nbsp;Jussara Carnevale de Almeida","doi":"10.1016/j.nutres.2025.06.006","DOIUrl":"10.1016/j.nutres.2025.06.006","url":null,"abstract":"<div><div>Type 2 diabetes mellitus (T2DM) is a prevalent and multifactorial disease closely linked to overweight. Positive associations between body mass index (BMI) and dysfunctional eating behavior have been observed. However, research specifically examining eating behaviors among individuals with T2DM remains limited. We hypothesized that disordered eating behavior in this population is associated with poorer metabolic control. Thus, this study aimed to investigate the relationship between eating behavior patterns and metabolic control in outpatients with T2DM. In this cross-sectional study, the Three Factor Eating Questionnaire (TFEQ-R21) was administered to 238 outpatients with T2DM. BMI, glycemic control, blood lipids concentration, and blood pressure were examined as outcomes. Eating behavior patterns were identified through cluster analysis based on TFEQ-R21 dimensions. Linear regression models were used to investigate the associations between eating behavior patterns and outcomes, adjusting for age, sex, sedentary lifestyle, and psychiatric medication use. The study was approved by the Hospital's Ethics Committee (ID 2020-0654). Two eating behavior patterns were identified: <em>cognitive restraint</em> (<em>n</em> = 174) and <em>emotional and uncontrolled eating behavior</em> (<em>n</em> = 64). The <em>emotional and uncontrolled eating behavior</em> pattern was associated with higher BMI (b = 2.35; 95% CI = 0.68-4.01), HbA1c (b = 0.54; 95% CI = 0.06-1.01), and triglyceride values (b = 64.42; 95% CI = 16.99-111.86) after adjusting for confounders. In this sample of outpatients with T2DM, the <em>emotional and uncontrolled eating behavior</em> pattern was associated with higher BMI, HbA1c, and triglyceride values as compared to the <em>cognitive restraint eating behavior</em> pattern<em>.</em></div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"140 ","pages":"Pages 93-101"},"PeriodicalIF":3.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional hypothalamic amenorrhea and dietary intervention: A systematic review to guide further research in amenorrheic women without overt eating disorder","authors":"Anna Paola Amoroso ,&nbsp;Simona Fiorini ,&nbsp;Lenycia de Cassya Lopes Neri ,&nbsp;Monica Guglielmetti ,&nbsp;Anna Tagliabue ,&nbsp;Rossella Elena Nappi ,&nbsp;Cinzia Ferraris","doi":"10.1016/j.nutres.2025.06.008","DOIUrl":"10.1016/j.nutres.2025.06.008","url":null,"abstract":"<div><div>Functional hypothalamic amenorrhea (FHA) is a multifactorial condition caused by psychological stress, energy deficit, weight loss, and excessive physical activity in the absence of adequate energy intake. Nutrition plays a key role in FHA treatment, with the primary intervention focused on correcting energy imbalance. Evidence regarding the exact amount of energy required to restore menses, the timeframe for recovery, and the optimal nutritional practices to support long-term recovery and optimize reproductive outcomes, remain limited. In this review, we aimed to assess if dietary intervention affects the nutritional status, food intake, nutrition knowledge, and hormonal milieu in women with FHA. We performed this review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method, using the Population, Intervention, Control, Outcome, Study design criteria. A quality appraisal checklist for case series was used. The search included 4 databases and was restricted to English and Italian languages. Eleven articles were included. Five of these referred to the same population analyzed in 2 randomized controlled trials (RCTs); 3 nonrandomized controlled trials (NRCTs); and 1 nonrandomized uncontrolled trial, and 2 case series. Overall, the risk of bias was low for RCTs and moderate-to-high for NRCTs. Menstrual cycle can be restored in 1 to 12 months. One article indicated an additional 350 kcal/d energy intake to achieve this. However, the long-term impact of nutritional intervention alone remains unclear. Further research with a comprehensive, patient-centered approach is needed to confirm these findings and to clarify the possible role of nutritional counseling in FHA treatment.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"140 ","pages":"Pages 102-115"},"PeriodicalIF":3.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"David Kritchevsky Graduate Student Award for Nutrition Research","authors":"","doi":"10.1016/S0271-5317(25)00083-1","DOIUrl":"10.1016/S0271-5317(25)00083-1","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"139 ","pages":"Page iii"},"PeriodicalIF":3.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma advanced glycation products are associated with increased risk of depression in middle-aged and elderly Chinese adults","authors":"Yebing Zhang ,&nbsp;Yu Zhang ,&nbsp;Fengfei Xie ,&nbsp;Nimei Zeng ,&nbsp;Renfang Han ,&nbsp;Yun Wang ,&nbsp;Zhongxiao Wan","doi":"10.1016/j.nutres.2025.06.004","DOIUrl":"10.1016/j.nutres.2025.06.004","url":null,"abstract":"<div><div>Depression is becoming a critical health challenge for the middle-aged and elderly populations. Existing evidence on the associations between body accumulations of advanced glycation end products (AGEs) and depression remain inconsistent. We hypothesized that plasma AGEs concentration might be positively correlated with the incidence of depression in middle-aged and elderly adults. In this cross-sectional study with 586 participants (201 males and 385 females, mean age: 62.18 years old) from Suzhou city, depression was assessed via the Center for Epidemiologic Studies Depression scale 10-item version (CES-D-10). Plasma AGEs of free Nε-carboxymethyl-L-lysine (CML), Nε-(1-carboxyethyl) lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1), as well as protein bound CEL and CML were measured with ultraperformance liquid chromatography and tandem mass spectrometry. Multivariate linear regression analysis and logistic regression analysis were utilized to determine the associations between specific plasma AGEs and CES-D-10 score and the incidence of depression, respectively. The incidence of depression was 8.02%. Plasma protein bound CEL and CML concentration were positively correlated with CES-D-10 score (CEL: β=0.12, <em>P</em>=0.018; CML: β=0.14; <em>P</em>=0.034) in the linear regression analysis. Compared to those below the median concentration of bound CEL and CML, participants with bound CEL and CML concentration above the median had increased risk of depression [ORs (95% CI): 2.33 (1.13-4.84), <em>P</em>=0.023, and ORs (95% CI): 2.27 (1.16-4.43), <em>P</em>=0.016, respectively] in the logistic regression analysis. Elevated plasma bound CEL and CML might be associated with increased risk of depression. Further studies are required to confirm the associations between specific AGEs and the risk of depression.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"140 ","pages":"Pages 59-68"},"PeriodicalIF":3.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial office and Board Members","authors":"","doi":"10.1016/S0271-5317(25)00082-X","DOIUrl":"10.1016/S0271-5317(25)00082-X","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"139 ","pages":"Pages i-ii"},"PeriodicalIF":3.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sweetened beverage intake across moderate intake range is not associated with pregnancy-related weight change or biomarkers of glycemic control","authors":"Mia G. Kwan ,&nbsp;Leah M. Lipsky ,&nbsp;Kyle S. Burger ,&nbsp;Grace E. Shearrer ,&nbsp;Tonja R. Nansel","doi":"10.1016/j.nutres.2025.06.007","DOIUrl":"10.1016/j.nutres.2025.06.007","url":null,"abstract":"<div><div>While sweetened beverage intake is associated with weight and glycemic outcomes in the general population, relations during pregnancy are unclear. This prospective observational study tested the hypothesis that greater sweetened beverage intake would be associated with higher pregnancy-related weight change and glucose regulation biomarkers. The Pregnancy Eating Attributes Study recruited participants with uncomplicated singleton pregnancies ≤12 weeks gestation and no major chronic illness from 2 obstetrics clinics in the University of North Carolina at Chapel Hill Healthcare System from November 2014 to October 2016. Data from participants with completed pregnancy dietary recalls (n = 365) were analyzed. Intake (oz) of sugar-sweetened beverages (SSB) and non-nutritive sweetened beverages (NNSB) was calculated from 24-h dietary recalls across pregnancy and across postpartum. Weight was measured throughout pregnancy to 1-year postpartum to determine gestational weight gain adequacy and 1-year postpartum weight retention; fasting blood glucose and insulin were obtained in the 2nd trimester. Multinomial logistic regressions estimated associations of sweetened beverage intake with gestational weight gain adequacy; linear regressions estimated associations of sweetened beverage intake with postpartum weight retention, fasting blood glucose, and insulin. In analyses adjusted for age, household income-poverty ratio, education, marital status, and physical activity, neither SSB nor NNSB intake during pregnancy was associated with excessive gestational weight gain, postpartum weight retention, fasting glucose or fasting insulin. Additionally, SSB and NNSB intake in postpartum were unassociated with postpartum weight retention. Sweetened beverages may not contribute to excess pregnancy-related weight gain or glucose dysregulation within the moderate range of intake observed in this sample.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"140 ","pages":"Pages 69-76"},"PeriodicalIF":3.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of maternal high-fat diet to intestinal barrier integrity and disease in offspring","authors":"Chen Zhang ,&nbsp;Weiqi Zhong ,&nbsp;Long Miao ,&nbsp;Zhibing Lin ,&nbsp;Shiqi Sun ,&nbsp;Minmin Jiang ,&nbsp;Cuiyuan Jin ,&nbsp;Liyun Shi","doi":"10.1016/j.nutres.2025.06.003","DOIUrl":"10.1016/j.nutres.2025.06.003","url":null,"abstract":"<div><div>High-fat diet (HFD) has been demonstrated to negatively affect the exacerbation of chronic diseases, such as obesity, diabetes, gastrointestinal disease, cardiovascular disease, and central nervous system disease. Research has revealed that maternal HFD affects the intestinal barrier integrity of offspring in multiple ways. Offspring not only “inherit” the abnormal gut microbiota induced by maternal HFD, thus having long-term effects on offspring health, but also are profoundly affected by various factors, such as the placental environment, mode of birth, and breast milk nutrition. In this review, we summarize recent epidemiological studies, clinical studies and animal experiments, and we evaluate the threat of maternal HFD to offspring health. We discuss the associations between maternal HFD and the intestinal barrier of offspring in the context of maternal-infant influence pathways, the gut microbiota and associated metabolism, intestinal physical barriers, and intestinal immune barriers. Further, we interpret the available evidence and its limitations. We believe that medical professionals and society must respond to the harmful effects of HFD to improve outcomes in the future.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"140 ","pages":"Pages 77-92"},"PeriodicalIF":3.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimicronutrient and omega-3 fatty acid supplementation reduces low-grade inflammation in older participants: An exploratory study","authors":"Felix Kerlikowsky ,&nbsp;Karsten Krüger ,&nbsp;Andreas Hahn ,&nbsp;Jan Philipp Schuchardt","doi":"10.1016/j.nutres.2025.06.005","DOIUrl":"10.1016/j.nutres.2025.06.005","url":null,"abstract":"<div><div>Aging is associated with chronic low-grade inflammation, while the status of anti-inflammatory (INFLA) micronutrients such as long-chain omega-3 fatty acids (<em>n</em>-3 PUFA), vitamin D, folate, and cobalamin is often low in older people. We hypothesized that <em>n</em>-3 PUFA and certain micronutrients reduce low-grade inflammation in older participants. To test this hypothesis the aim of this randomised, double-blinded, 12-week intervention study involving 112 healthy and physically active older participants (75.6 ± 3.9 years) was to investigate the effect of a multimicronutrient and <em>n</em>-3 PUFA supplementation in physiological doses (i.e., 400 µg folic acid, 100 µg cobalamin, 50 µg cholecalciferol, and 1000 mg eicosapentaenoic acid + docosahexaenoic acid per day) on INFLA biomarkers, which were aggregated in the INFLA score. Dietary intake data were converted into the energy-adjusted dietary inflammatory index (E-DII). A significant increase in the nutrient status biomarkers Omega-3 Index, serum 25-hydroxycholecalciferol, red blood cell folate, and holotranscobalamin was observed in the intervention group compared to the placebo group (all <em>P</em> &lt; .001). In a multiadjusted model (age, sex, body mass index, E-DII, Omega-3 Index), the intervention significantly decreased the INFLA score compared to placebo (<em>P</em> = .036). Participants with a more pro-INFLA E-DII at baseline and higher age showed a greater decrease in the INFLA score than those with a more anti-INFLA E-DII (<em>P</em> = .028) and lower age (<em>P</em> = .043). An effect of multimicronutrient + <em>n</em>-3 PUFA supplementation seems to be more pronounced in older participants with higher age and those with a pro-INFLA background diet.</div><div><strong>Trial registration:</strong> This study is officially recorded in the German Clinical Trials Register (DRKS00021302, registration date: 23.04.2020).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"140 ","pages":"Pages 46-58"},"PeriodicalIF":3.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher serum carotenoid concentrations are associated with lower mortality in adults with advanced cardiovascular-kidney-metabolic syndrome","authors":"Xiaoyun Li ,&nbsp;Zhijuan Liao ,&nbsp;Siyan Huo ,&nbsp;Fangna Gu ,&nbsp;Yong Yin ,&nbsp;Xuanchu Ge","doi":"10.1016/j.nutres.2025.06.002","DOIUrl":"10.1016/j.nutres.2025.06.002","url":null,"abstract":"<div><div>This study aimed to investigate the associations between serum carotenoid concentrations and all-cause mortality among adults with advanced cardiovascular-kidney-metabolic (CKM) syndrome. Data were analyzed from 1285 adults aged ≥20 years with advanced CKM syndrome (stages 3 or 4), identified from the National Health and Nutrition Examination Survey 2001 to 2006 cohort. Five serum carotenoids were assessed as exposures, including α-carotene, β-carotene, lycopene, lutein/zeaxanthin, and total carotenoids. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs, while quantile g-computation (Qgcomp) regression was employed to examine the joint effects of all carotenoids. During a median follow-up of 11.8 years, 936 (72.8%) deaths were recorded. Age- and sex-standardized all-cause mortality rates decreased across increasing quartiles of several serum carotenoids, most notably lycopene, for which the mortality rate declined from 106.6 (95% CI: 90.1-123.1) per 1000 person-years in the lowest quartile to 62.4 (95% CI: 54.6-70.1) in the highest quartile. Adjusted for potential confounders, higher concentrations of α-carotene (HR = 0.64, 95% CI: 0.49-0.84), β-carotene (HR = 0.76, 95% CI: 0.61-0.95), lutein/zeaxanthin (HR = 0.75, 95% CI: 0.59-0.96), lycopene (HR = 0.63, 95% CI: 0.49-0.81), and total carotenoids (HR = 0.81, 95% CI: 0.66-1.00) were significantly associated with lower all-cause mortality, while no significant association was observed for β-cryptoxanthin. Qgcomp regression demonstrated a significant joint protective effect of serum carotenoids on all-cause mortality (HR = 0.87, 95% CI: 0.79-0.95, <em>P</em> &lt; .01), with lycopene contributing the most to the overall protective effect. In conclusion, the joint effect of serum carotenoids was independently associated with lower all-cause mortality in adults with advanced CKM syndrome, with lycopene showing the strongest contribution among the 5 carotenoids studied.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"140 ","pages":"Pages 34-45"},"PeriodicalIF":3.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary inflammatory index as a modifiable risk factor for sarcopenia in adults with type 2 diabetes: A cross-sectional study","authors":"Serap Balaban Barta ,&nbsp;Rıfat Bozkus ,&nbsp;Hilal Simsek ,&nbsp;Bengisu Kosal ,&nbsp;Aslı Ucar","doi":"10.1016/j.nutres.2025.05.007","DOIUrl":"10.1016/j.nutres.2025.05.007","url":null,"abstract":"<div><div>There is growing evidence that a proinflammatory diet contributes to the increased risk of sarcopenia by exacerbating low-grade inflammation and insulin resistance, ultimately inducing muscle loss in adults with type 2 diabetes. This study aimed to analyze the association of dietary inflammatory index (DII), physical activity level, and body composition with sarcopenia in adults with type 2 diabetes. The hypothesis of this study was that higher DII increases the risk of sarcopenia. This cross-sectional study was conducted with 249 adults aged 50 years and older with type 2 diabetes who were admitted to the Internal Medicine Department of a tertiary hospital in Türkiye. Nutritional status was determined by 24-hour recall, dietary inflammatory status by energy-adjusted-DII, and physical activity by the International Physical Activity Questionnaire-Short Form. Muscle strength was measured by handgrip dynamometer, body composition analysis was measured by bioelectrical impedance method, and sarcopenia was defined according to EWGSOP-2 criteria. The mean age of the participants was 62.1 ± 6.9 years and the prevalence of sarcopenia was 15.7%. Handgrip strength and appendicular skeletal muscle mass significantly decreased with increasing DII score from tertile 1 to 3 (<em>P</em> &lt; .05). A higher DII score was an independent risk factor for sarcopenia (odds ratio = 2.36, 95% confidence interval: 1.25-4.47, <em>P</em> = .008). This study shows that increased DII was independently associated with sarcopenia in adults with type 2 diabetes after adjustment for potential confounders. Dietary strategies aimed at reducing the potential for inflammation through dietary patterns rich in antioxidants, fiber, and omega-3 fatty acids may be useful in managing the risk of sarcopenia in adults with type 2 diabetes aged 50 years and older.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"140 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}