{"title":"Therapeutic roles of coenzyme Q10 in peripheral nerve injury-induced neurosensory disturbances: Mechanistic insights from injury to recovery","authors":"Thanyaphorn Vachirarojpisan , Bhumrapee Srivichit , Savitri Vaseenon , Warit Powcharoen , Napatsorn Imerb","doi":"10.1016/j.nutres.2024.07.011","DOIUrl":"10.1016/j.nutres.2024.07.011","url":null,"abstract":"<div><p>Peripheral nerve injuries (PNIs) are prevalent conditions mainly resulting from systemic causes, including autoimmune diseases and diabetes mellitus, or local causes, for example, chemical injury and perioperative nerve injury, which can cause a varying level of neurosensory disturbances (NSDs). Coenzyme Q10 (CoQ10) is an essential regulator of mitochondrial respiration and oxidative metabolism. Here, we review the pathophysiology of NSDs caused by PNIs, the current understanding of CoQ10’s bioactivities, and its potential therapeutic roles in nerve regeneration, based on evidence from experimental and clinical studies involving CoQ10 supplementation. In summary, CoQ10 supplementation shows promise as a neuroprotective agent, potentially enhancing treatment efficacy for NSDs by reducing oxidative stress and inflammation. Future studies should focus on well-designed clinical trials with large sample sizes, using CoQ10 formulations with proven bioavailability and varying treatment duration, to further elucidate its neuroprotective effects and to optimize nerve regeneration in PNIs-induced NSDs.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"129 ","pages":"Pages 55-67"},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-08-30DOI: 10.1016/j.nutres.2024.08.002
Susan J. Ward , Alison M. Coates , Katherine L. Baldock , Ty E. Stanford , Alison M. Hill
{"title":"Better diet quality is associated with reduced body pain in adults regardless of adiposity: Findings from the Whyalla Intergenerational Study of Health","authors":"Susan J. Ward , Alison M. Coates , Katherine L. Baldock , Ty E. Stanford , Alison M. Hill","doi":"10.1016/j.nutres.2024.08.002","DOIUrl":"10.1016/j.nutres.2024.08.002","url":null,"abstract":"<div><div>Dietary intake has been associated with pain and physical function, but it is unclear if these relationships are mediated by adiposity. Data were derived from the Whyalla Intergenerational Study of Health (n = 654, 57% women). Structural equation modelling tested the hypotheses that adiposity (body mass index (BMI), waist circumference (WC), or body fat (BF, dual energy x-ray absorptiometry)) would mediate the relationship between diet quality (Dietary Guideline Index (DGI) total, core, or non-core scores) and pain (Short Form-36 bodily pain scale (SF36-BPS)), or physical function (grip-strength), overall, and by gender. Adiposity did not mediate a relationship between DGI scores and pain. Direct effects were observed between DGI total scores and SF36-BPS accounting for BMI (β = 0.170, 95% CI 0.002, 0.339), and between DGI core food scores and SF36-BPS (BMI, β = 0.278, 95% CI 0.070, 0.486; WC, β = 0.266, 95% CI 0.058, 0.474; BF, β = 0.266, 95% CI 0.060, 0.473). In women, direct effects existed between DGI scores and SF36-BPS (DGI total scores, BMI, β = 0.388, 95% CI 0.162, 0.613; WC, β = 0.372, 95% CI 0.146, 0.598; BF, β = 0.382, 95% CI 0.158, 0.605, and DGI core scores, BMI, β = 0.482, 95% CI 0.208, 0.757; WC, β = 0.472, 95% CI 0.197, 0.747; BF, β = 0.467, 95% CI 0.195, 0.739), and DGI total scores and grip-strength (BMI, β = 0.075, 95% CI 0.008, 0.142; WC, β = 0.076, 95% CI 0.009, 0.143; BF, β = 0.079, 95% CI 0.011, 0.146). Better diet quality is associated with lower bodily pain, irrespective of adiposity. Findings highlight the potential role of diet quality in pain management and function, particularly in women.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"130 ","pages":"Pages 22-33"},"PeriodicalIF":3.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142319723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-08-30DOI: 10.1016/j.nutres.2024.08.001
Anitra C. Carr , Emma Vlasiuk , Masuma Zawari , Helen Lunt
{"title":"Understanding the additional impact of prediabetes and type 2 diabetes mellitus on vitamin C requirements in people living with obesity","authors":"Anitra C. Carr , Emma Vlasiuk , Masuma Zawari , Helen Lunt","doi":"10.1016/j.nutres.2024.08.001","DOIUrl":"10.1016/j.nutres.2024.08.001","url":null,"abstract":"<div><p>Obesity and diabetes are known to negatively affect vitamin C status. However, whether the presence of diabetes, in addition to obesity, contributes an additional impact on vitamin C status is currently uncertain. In a cohort of 152 adults living with obesity, we assessed metabolic and nutrient parameters in participants without diabetes (<em>n</em> = 92), and with prediabetes (<em>n =</em> 22) and type 2 diabetes mellitus (T2DM; <em>n =</em> 35). Vitamin C concentrations were measured in plasma and leukocytes using HPLC and vitamin C intakes were assessed using 24-hour dietary recall. Metabolic severity scores were derived using gender, ethnicity, height, weight, waist circumference, systolic blood pressure, fasting glucose, HDL, and triglyceride values. In people living with obesity, those with prediabetes and T2DM had increased metabolic dysregulation and decreased vitamin C status relative to those without diabetes (<em>P</em> < .05). Vitamin C deficiency was observed in a high proportion (23%-32%) of participants with prediabetes and T2DM and ≥50% had hypovitaminosis C. However, there was no difference in vitamin C intake between those without diabetes and those with prediabetes or T2DM (<em>P</em> > .05). There was a significant inverse correlation between plasma vitamin C status and metabolic severity score (<em>r</em> = -0.290, <em>P</em> < .001). Linear regression indicated that for every 1-unit increase in metabolic severity score, there was a 6.5 µmol/L decrease in vitamin C status. Thus, the enhanced metabolic dysregulation observed with prediabetes and T2DM is associated with an increased demand for vitamin C in people living with obesity.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"130 ","pages":"Pages 1-10"},"PeriodicalIF":3.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0271531724001088/pdfft?md5=4dcd7f770898f1a0396c25ae41df57b3&pid=1-s2.0-S0271531724001088-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-08-01DOI: 10.1016/j.nutres.2024.07.002
Bettina Hieronimus , Simon Hammann , Maren C. Podszun
{"title":"Can the AI tools ChatGPT and Bard generate energy, macro- and micro-nutrient sufficient meal plans for different dietary patterns?","authors":"Bettina Hieronimus , Simon Hammann , Maren C. Podszun","doi":"10.1016/j.nutres.2024.07.002","DOIUrl":"10.1016/j.nutres.2024.07.002","url":null,"abstract":"<div><p>Artificial intelligence chatbots based on large language models have recently emerged as an alternative to traditional online searches and are also entering the nutrition space. In this study, we wanted to investigate whether the artificial intelligence chatbots ChatGPT and Bard (now Gemini) can create meal plans that meet the dietary reference intake (DRI) for different dietary patterns. We further hypothesized that nutritional adequacy could be improved by modifying the prompts used. Meal plans were generated by 3 accounts for different dietary patterns (omnivorous, vegetarian, and vegan) using 2 distinct prompts resulting in 108 meal plans total. The nutrient content of the plans was subsequently analyzed and compared to the DRIs. On average, the meal plans contained less energy and carbohydrates but mostly exceeded the DRI for protein. Vitamin D and fluoride fell below the DRI for all plans, whereas only the vegan plans contained insufficient vitamin B<sub>12</sub>. ChatGPT suggested using vitamin B<sub>12</sub> supplements in 5 of 18 instances, whereas Bard never recommended supplements. There were no significant differences between the prompts or the tools. Although the meal plans generated by ChatGPT and Bard met most DRIs, there were some exceptions, particularly for vegan diets. These tools maybe useful for individuals looking for general dietary inspiration, but they should not be relied on to create nutritionally adequate meal plans, especially for individuals with restrictive dietary needs.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"128 ","pages":"Pages 105-114"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0271531724000915/pdfft?md5=bf93e7d5f008fb898fce35dcd948d075&pid=1-s2.0-S0271531724000915-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141696456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-08-01DOI: 10.1016/j.nutres.2024.06.010
Yung-Fang Hsiao , Shao-Bin Cheng , Chia-Yu Lai , Hsiao-Tien Liu , Hui-Chen Lin , Yi-Chia Huang
{"title":"Vascular endothelial growth factor is associated with hepatocellular carcinoma recurrence, independent of folate and glutathione-related antioxidant enzymes: A follow-up study","authors":"Yung-Fang Hsiao , Shao-Bin Cheng , Chia-Yu Lai , Hsiao-Tien Liu , Hui-Chen Lin , Yi-Chia Huang","doi":"10.1016/j.nutres.2024.06.010","DOIUrl":"10.1016/j.nutres.2024.06.010","url":null,"abstract":"<div><p>The associations of tumor angiogenesis with folate and antioxidant capacities in patients with hepatocellular carcinoma (HCC) and their effects on HCC recurrence have not yet been investigated. We investigated the changes and relationships of VEGF, folate, GSH, and GSH-related antioxidant enzymes in patients with HCC before tumor resection, as well as 1 month, 1 year, and 3 years after tumor resection, and their effects on HCC recurrence. 95 HCC patients who underwent tumor resection were recruited. Patients were followed up before tumor resection (pre-resection), 1 month after tumor resection (post-resection), 1 year, and 3 years of follow-up. The recurrence and survival status of patients were evaluated. Plasma VEGF concentrations decreased slightly during follow-up. Serum folate and GSH concentrations and plasma GPx and GR activities increased significantly from pre-resection to post-resection and remained stable at follow-up. Pre-resection plasma VEGF was positively correlated with GSH, GPx, and GR, but negatively correlated with folate and GST. The high pre-resection plasma VEGF was a significant predictor of a high HCC rate (hazard ratio = 1.05, <em>p</em> = 0.035), remaining significant after adjustments for folate, GSH, GPx, GR, and GST to diminish their interference with VEGF. Pre-tumor-resection plasma VEGF constitutes a potential independent marker for predicting HCC recurrence. However, the associations of plasma VEGF with folate and GSH-related antioxidant capacities in HCC patients cannot be ignored.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"128 ","pages":"Pages 70-81"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141712580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-08-01DOI: 10.1016/j.nutres.2024.06.006
Anwen Huang , Weiyan Huang , Yufei Ye , Lulu Liu , Haiyan Wang , Xiaolu Bian , Yingyi Qin , Zhiyong Guo , Wei Chen
{"title":"High composite dietary antioxidant index is associated with reduced risk of kidney stones: a cross-sectional analysis of NHANES 2007-2020","authors":"Anwen Huang , Weiyan Huang , Yufei Ye , Lulu Liu , Haiyan Wang , Xiaolu Bian , Yingyi Qin , Zhiyong Guo , Wei Chen","doi":"10.1016/j.nutres.2024.06.006","DOIUrl":"10.1016/j.nutres.2024.06.006","url":null,"abstract":"<div><p>The composite dietary antioxidant index (CDAI) is commonly utilized to assess antioxidant intake across diseases, but its association with kidney stones is unclear. We hypothesized that higher CDAI is associated with reduced kidney stone risk. Using National Health and Nutrition Examination Survey 2007-2020 data, we calculated CDAI based on vitamins A, C, E, selenium, zinc, and carotenoids intake in 29,280 adults. Stone formers had lower CDAI, with significant gender differences. Restricted cubic spline showed an L-shaped curve, with the steepest decline before CDAI of 1.449. In multivariate logistic regression, moderate and high CDAI tertiles were associated with reduced kidney stone odds compared to the lowest tertile (odds ratio [95% CI]): 0.85 [0.73, 0.99], <em>P</em> = .035 and 0.80 [0.66, 0.95], <em>P</em> = .014, respectively). Vitamin C had the highest negative correlation weight with kidney stones. Significant interactions were found for age and diabetes subgroups. In conclusion, higher CDAI may reduce kidney stone risk, especially with adequate vitamin C intake. Further cohort studies are warranted to confirm the causal association.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"128 ","pages":"Pages 60-69"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141766882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Docosahexaenoic Acid and Pregnancy: A Systematic Review and Meta-Analysis of the Association with Improved Maternal and Fetal Health","authors":"Kiran Bilgundi , Gollapalle Lakshminarayanashastry Viswanatha , Kowshik Muttur Purushottam , Jeena John , Akshatha P. Kamath , Anoop Kishore , Pawan Ganesh Nayak , Krishnadas Nandakumar","doi":"10.1016/j.nutres.2024.06.008","DOIUrl":"10.1016/j.nutres.2024.06.008","url":null,"abstract":"<div><p>This study aimed to investigate the effects of prenatal docosahexaenoic acid (DHA) supplementation on pregnancy outcomes through a systematic review and meta-analysis. We hypothesized that prenatal DHA intake through supplements will improve pregnancy outcomes. Detailed literature search was performed using online databases such as PubMed, EMBASE, and Google Scholar till November 2022, to identify the randomized controlled trials (RCT) with maternal intake of DHA supplementation during the latter half of pregnancy compared to the placebo/control. Based on the inclusion and exclusion criteria, nine RCTs involving 5710 subjects were included. This meta-analysis showed that DHA supplementation (450-800 mg/day) was associated with a significantly higher birth weight of infants (Inverse variance [IV]: 101.71 [57.36-146.06] at 95% CI, <em>P =</em> .00001, <em>I<sup>2</sup></em> = 0%), and fewer low birth weights (LBWs) (Mantel–Haenszel [M–H]: 0.53 [0.33-0.86] at 95% CI, <em>P</em> = .01, <em>I<sup>2</sup></em> = 72%), with lesser but statistically insignificant pre-term births (PTB) (M–H: -0.02 [-0.04 to 0.00] at 95% CI, <em>P</em> = .07, <em>I<sup>2</sup></em> = 0%) compared to the placebo. However, the DHA supplementation has no effect on gestational length (IV: -2.26 [-9.64 to 5.12] at 95% CI, <em>P</em> = .55, <em>I<sup>2</sup></em> = 100%) compared to the placebo. In conclusion, the outcomes of this meta-analysis showed that prenatal DHA supplementation (450-800 mg/day) may reduce the risk of preterm births and increase infant birth weight.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"128 ","pages":"Pages 82-93"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141709550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-08-01DOI: 10.1016/j.nutres.2024.06.009
Yaozong Zhang , Songxian Rao , Xiaoyu Zhang , Zhaohong Peng , Wen Song , Shaoyu Xie , Hongjuan Cao , Zhuang Zhang , Wanshui Yang
{"title":"Dietary and circulating branched chain amino acids are unfavorably associated with body fat measures among Chinese adults","authors":"Yaozong Zhang , Songxian Rao , Xiaoyu Zhang , Zhaohong Peng , Wen Song , Shaoyu Xie , Hongjuan Cao , Zhuang Zhang , Wanshui Yang","doi":"10.1016/j.nutres.2024.06.009","DOIUrl":"10.1016/j.nutres.2024.06.009","url":null,"abstract":"<div><p>Animal studies showed a detrimental effect of dietary branched chain amino acids (BCAAs) on metabolic health, while epidemiological evidence on dietary BCAAs and obesity is limited and inconclusive. We hypothesized that high dietary and circulating BCAAs are unfavorably associated with obesity in community-dwelling adults. We evaluated the 1-year longitudinal associations of dietary BCAA intake and circulating BCAAs with body fat measures. Body weight, height, and circumferences of the waist (WC) and hip (HC) were measured at baseline and again after 1-year. Body composition and liver fat [indicated by controlled attenuation parameter (CAP)] were also assessed after 1-year. Serum BCAA concentrations at baseline were quantified by liquid chromatography mass spectrometry. Diet was collected using 4 quarterly 3-day recalls during the 1-year. The correlation coefficients between dietary and serum BCAAs were 0.12 (<em>P</em> = .035) for total dietary BCAAs, and ranged from -0.02 (soy foods, <em>P</em> = .749) to 0.18 (poultry, <em>P</em> = .001). Total dietary BCAA intake was associated with increase in body weight (<em>β</em> = 0.044, <em>P</em> = .022) and body mass index (BMI, <em>β</em> = 0.047, <em>P</em> = .043). BCAAs from animal foods were associated with increase in HC, while BCAAs from soy foods were associated with weight gain and higher CAP (all <em>P</em> < .05). Serum BCAAs were associated with higher WC, HC, BMI, body fat mass, visceral fat level, and CAP (all <em>P</em> < .05). These results support that dietary and circulating BCAAs are positively associated with the risk of obesity. More cohort studies with validated dietary assessment tools and long-term follow-up among diverse populations are needed to confirm our findings.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"128 ","pages":"Pages 94-104"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}