{"title":"Cardamom consumption may improve cardiovascular metabolic biomarkers in adults: A systematic review and meta-analysis of randomized controlled trials","authors":"Xiaofeng Zhang, Caixia Wang, Ruixue Min, Qilun Zhou, Yue Qi, Jianming Fan","doi":"10.1016/j.nutres.2024.03.002","DOIUrl":"10.1016/j.nutres.2024.03.002","url":null,"abstract":"<div><p>The bioactive compounds in cardamom have been found to enhance cardiovascular health by improving blood lipids and inflammation. We hypothesized that cardamom consumption might ameliorate cardiovascular metabolic biomarkers in adults; however, there is still debate regarding its impact on cardiac metabolism. This research was therefore designed to determine if cardamom consumption had a favorable impact on lipid profiles, inflammatory markers, and oxidative stress indices as they related to cardiovascular diseases. A comprehensive search was conducted through PubMed, Scopus, Embase, Web of Science, and the Cochrane Library on July 4, 2023. Using a random-effects model pooled the weighted mean difference (WMD) and 95% confidence interval (CI). The final 12 trials containing 989 participants were included. The results illustrated that cardamom consumption could improve total cholesterol (WMD = –8.56 mg/dL; 95% CI, –14.90 to –2.22), triglycerides (WMD = –14.09 mg/dL; 95% CI, –24.01 to –4.17), high-sensitivity C-reactive protein (WMD = –1.01 ng/mL; 95% CI, –1.81 to –0.22), and interleukin-6 (WMD = –1.81 pg/mL; 95% CI, –3.06 to –0.56). However, it did not have significant influences on high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and some indicators of oxidative stress. In conclusion, cardamom consumption can improve specific cardiovascular metabolic biomarkers and potentially confer protective effects on cardiovascular health. However, more large-scale clinical research with better designs would further validate the findings, which will offer substantial evidence of cardamom as nutritional and functional products.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"125 ","pages":"Pages 101-112"},"PeriodicalIF":4.5,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140278390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-03-11DOI: 10.1016/j.nutres.2024.03.001
Shu-Fang Xia , Yuan Liu , Yue Chen , Zi-Yuan Li , Lan Cheng , Jian-Yun He , Ling Hang , Gusonghan Maitiniyazi , Xin-Xin Cheng , Shi-Ru Sun , Dan-Feng Gu
{"title":"Association between dietary inflammatory potential and frailty is mediated by inflammation among patients with colorectal cancer: A cross-sectional study","authors":"Shu-Fang Xia , Yuan Liu , Yue Chen , Zi-Yuan Li , Lan Cheng , Jian-Yun He , Ling Hang , Gusonghan Maitiniyazi , Xin-Xin Cheng , Shi-Ru Sun , Dan-Feng Gu","doi":"10.1016/j.nutres.2024.03.001","DOIUrl":"10.1016/j.nutres.2024.03.001","url":null,"abstract":"<div><p>Patients with colorectal cancer (CRC) are at high risk of frailty, leading to reduced quality of life and survival. Diet is associated with frailty in the elderly through regulating inflammation. Thus, we hypothesized that dietary inflammatory potential (as assessed by dietary inflammatory index [DII]) might be associated with frailty in patients with CRC through regulating inflammatory biomarkers. A total of 231 patients with CRC were included in this cross-sectional study. Dietary intake was evaluated by 3-day, 24-hour dietary recalls, and frailty status was assessed in accordance with the Fried frailty criteria. Plasma inflammatory cytokines were determined in 126 blood samples. A total of 67 patients (29.0%) were frail, with significantly higher DII scores than nonfrail patients, accompanied with significantly increased interleukin-6 (IL-6) and decreased interleukin-10 (IL-10) concentrations. Each 1-point increase of DII was related to a 25.0% increased risk of frailty. IL-6 was positively correlated with frailty and DII, whereas IL-10 was negatively correlated. After adjusting for age, sex, body mass index, education level, smoking status, and energy, mediation analysis revealed that the association between DII and frailty was significantly mediated by IL-6 (average causal mediation effect [ACME], 0.052; 95% confidence interval, 0.020–0.087; <em>P</em> = .002) and IL-10 (ACME, 0.025; 95% confidence interval, 0.004–0.063; <em>P</em> = .016). The ρ values for the sensitivity measure at which estimated ACMEs were zero were 0.3 and –0.2 for IL-6 and IL-10, respectively. Therefore, a pro-inflammatory diet was associated with frailty in patients with CRC possibly in part by affecting circulating IL-6 and IL-10 concentrations.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"125 ","pages":"Pages 79-90"},"PeriodicalIF":4.5,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140107290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-03-01DOI: 10.1016/j.nutres.2023.05.001
Manisha Rao , Emily L. Zumbro , Kenneth Shane Broughton , Monique J. LeMieux
{"title":"Retraction notice to “Whey protein preload enhances the aGLP-1 response and reduces circulating glucose in women with polycystic ovarian syndrome” [Nutrition Research 92 (2021) 84–98]","authors":"Manisha Rao , Emily L. Zumbro , Kenneth Shane Broughton , Monique J. LeMieux","doi":"10.1016/j.nutres.2023.05.001","DOIUrl":"10.1016/j.nutres.2023.05.001","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"123 ","pages":"Page 130"},"PeriodicalIF":4.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0271531723000374/pdfft?md5=2213ac040084c4921b29a9ef92269637&pid=1-s2.0-S0271531723000374-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9545940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-03-01DOI: 10.1016/j.nutres.2023.05.002
Richard S. Bruno, Katie Zamary
{"title":"Reemergence from the pandemic, annual awards, and editorial office updates: from the desk of the Editor-in-Chief, Nutrition Research","authors":"Richard S. Bruno, Katie Zamary","doi":"10.1016/j.nutres.2023.05.002","DOIUrl":"10.1016/j.nutres.2023.05.002","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"123 ","pages":"Pages 131-136"},"PeriodicalIF":4.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9836352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-03-01DOI: 10.1016/j.nutres.2024.02.010
Ruixiang Hu , Yipu Huang , Xin Jiang , Yi Xu , Zhirui Zheng , Yuansen Shi , Yun Liu
{"title":"Maternal dietary copper deficiency induces cardiomyopathy and liver injury in mice by activating autophagy","authors":"Ruixiang Hu , Yipu Huang , Xin Jiang , Yi Xu , Zhirui Zheng , Yuansen Shi , Yun Liu","doi":"10.1016/j.nutres.2024.02.010","DOIUrl":"10.1016/j.nutres.2024.02.010","url":null,"abstract":"<div><p>Maternal nutritional deficiencies during pregnancy result in birth defects and elevate the risk of cardiovascular diseases and metabolic diseases. Accumulating evidence suggests that deficiency of copper, a fundamental trace element involved in several pivotal physiological processes, promotes the onset of multiple diseases, notably heart and liver diseases. Yet, exploration into the effects of maternal copper deficiency (CuD) on offspring is still limited. In this study, we hypothesized that maternal CuD induced cardiomyopathy and liver injury in offspring through the activation of autophagy. We established a maternal CuD mouse model by feeding pregnant C57BL/6 mice with a CuD diet until the end of the experiment. Echocardiography, histological analysis, western blotting, and quantitative polymerase chain reaction were performed on offspring at postnatal day 14. We found that maternal CuD caused growth retardation and early postnatal death in the offspring. Furthermore, our results revealed that CuD induced cardiac systolic dysfunction, cardiac hypertrophy, hepatic steatosis, and liver injury. Moreover, higher expression of LC3 and lower expression of p62 were observed in the heart tissues and liver tissues of CuD mice compared with the control group, indicating that CuD induced autophagy activation. In conclusion, maternal CuD caused severely deleterious effects on the heart and liver of the offspring via activating autophagy.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"126 ","pages":"Pages 1-10"},"PeriodicalIF":4.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140043950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-02-29DOI: 10.1016/j.nutres.2024.02.007
Ana Laura Benevenuto de Amorim , Ester Ferreira Rodrigues , Elizandra Lopes Sussi , Lenycia de Cassya Lopes Neri
{"title":"Carbohydrate restriction during lactation: A systematic review","authors":"Ana Laura Benevenuto de Amorim , Ester Ferreira Rodrigues , Elizandra Lopes Sussi , Lenycia de Cassya Lopes Neri","doi":"10.1016/j.nutres.2024.02.007","DOIUrl":"10.1016/j.nutres.2024.02.007","url":null,"abstract":"<div><p>The quality of a mother's diet is important to ensure child growth and development and keep women healthy. This systematic review aimed to identify the outcomes of a carbohydrate-restricted diet during lactation. PubMed, EMBASE, Scopus, Web of Science, and LILACS were searched for studies published between 2012 and 2023; 16 studies were selected, all of them case reports or care series. The carbohydrate restriction described in the papers mainly was ketogenic, low-carb, low-carbohydrate and high-fat, and modified ketogenic diets. The main goal of women undertaking these diets was weight loss, with therapeutic purposes (monitored and supervised by health professionals) in only 2 cases: (1) ketogenic diet therapy for treatment of seizures in the infant and (2) to reduce symptoms of mother's gastroesophageal reflux. Most articles reported that lactating women were hospitalized, experiencing symptoms such as vomiting, muscle weakness, nausea, abdominal pain, general malaise, and fatigue. However, articles did not mention poor outcomes for the infants. Most of the studies in this review were published in the past 3 years, indicating a possible increase in cases of women practicing carbohydrate restriction during lactation for weight loss caused by body dissatisfaction. In conclusion, carbohydrate restriction during lactation may be harmful to the lactating woman and contribute to the state of lactational ketoacidosis, but infant outcomes are mainly a change in feeding patterns. Thus, education on food and nutrition is necessary for this population.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"125 ","pages":"Pages 91-100"},"PeriodicalIF":4.5,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0271531724000265/pdfft?md5=e5ece036be72d277bbb2686921eae95a&pid=1-s2.0-S0271531724000265-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140044042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-02-29DOI: 10.1016/j.nutres.2024.02.009
Donya Poursalehi , Saeideh Mirzaei , Ali Asadi , Masoumeh Akhlaghi , Keyhan Lotfi , Parvane Saneei
{"title":"Total dietary fiber intake is inversely associated with metabolically unhealthy status in adolescents with excess weight","authors":"Donya Poursalehi , Saeideh Mirzaei , Ali Asadi , Masoumeh Akhlaghi , Keyhan Lotfi , Parvane Saneei","doi":"10.1016/j.nutres.2024.02.009","DOIUrl":"10.1016/j.nutres.2024.02.009","url":null,"abstract":"<div><p>Little is known about the relationship between dietary fiber and metabolic health status in adolescents. This study was performed to investigate total dietary fiber intake and metabolic health status in a sample of Iranian adolescents with overweight/obesity. We hypothesized that higher total dietary fiber intake would reduce odds of metabolically unhealthy status. In this cross-sectional study, 203 adolescents (aged 12–18 years) with overweight/obesity were randomly recruited from several educational areas with different socioeconomic statuses using a multistage cluster sampling approach. Dietary intakes were evaluated by a validated food frequency questionnaire. Demographic, anthropometric, and cardiometabolic data were gathered through standard methods. Adolescents were categorized as having either metabolically healthy overweight/obesity or metabolically unhealthy overweight/obesity (MUO) phenotypes according to the International Diabetes Federation (IDF) and IDF/Homeostasis Model Assessment Insulin Resistance (HOMA-IR) criteria. Subjects had mean age of 13.97 (years) and mean fiber intake of 19.5 (g/d). After considering potential confounders, adolescents with the highest fiber intake, compared with the lowest intake, had decreased odds of MUO based on IDF (odds ratio [OR] = 0.14; 95% confidence interval [CI], 0.04–0.46) and IDF/HOMA-IR (OR = 0.16; 95% CI, 0.04–0.56) definitions. Also, each additional unit of total dietary fiber intake (1 g/d) was associated with lower chance of MUO phenotype considering IDF and IDF/HOMA-IR criteria. Individuals with higher intakes of dietary fiber were also less likely to have hyperglycemia (in fully adjusted model: OR = 0.17; 95% CI, 0.06–0.52). We found that consumption of total dietary fiber was inversely associated with odds of MUO among Iranian adolescents. Further prospective studies are required for confirming our results.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"125 ","pages":"Pages 69-78"},"PeriodicalIF":4.5,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140043872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-02-28DOI: 10.1016/j.nutres.2024.02.008
Marina Vilar Geraldi , Ágatta Caroline de Souza , Marina Maintinguer Norde , Paulo Roberto Berni , Lívia Mateus Reguengo , Bruno Geloneze , Mario Roberto Marostica
{"title":"Jaboticaba peel improves postprandial glucose and inflammation: A randomized controlled trial in adults with metabolic syndrome","authors":"Marina Vilar Geraldi , Ágatta Caroline de Souza , Marina Maintinguer Norde , Paulo Roberto Berni , Lívia Mateus Reguengo , Bruno Geloneze , Mario Roberto Marostica","doi":"10.1016/j.nutres.2024.02.008","DOIUrl":"https://doi.org/10.1016/j.nutres.2024.02.008","url":null,"abstract":"<div><p>The modulation of glucose metabolism through dietary sources has been recognized as 1 of the most sustainable approaches for preventing of cardiometabolic diseases. Although fibers and phenolic compounds derived from jaboticaba (<em>Plinia jaboticaba</em>) peel have demonstrated improvements in metabolic pathways in preclinical models, their beneficial effects in clinical trials remain to be fully determined. This study aimed to assess the impact of jaboticaba peel (JP) powder supplementation on glucose metabolism compared with a placebo in individuals with metabolic syndrome (MetS). A single-blind, parallel, randomized, placebo-controlled trial involving 49 individuals with MetS was conducted. Participants were assigned to receive either a JP supplement (15 g/day) or a matched placebo. Anthropometry measurements, body composition, blood pressure, metabolic and inflammatory parameters, and a mixed-meal tolerance test were assessed at weeks 0 and 5. Daily intake of JP improved the area under the curve of glucose (<em>P</em> = .025) and the interleukin-6 (IL-6) (<em>P</em> = .045). No significant time × treatment effects were observed for blood pressure, body weight, body composition, lipid metabolism, glucagon-like peptide-1, inflammatory cytokines (tumor necrosis factor-α, IL-1β), C-reactive protein, and insulin sensitivity and resistance indexes. JP supplementation may be a promising approach for managing MetS disorders, potentially by reducing the area under the curve for glucose and the proinflammatory cytokine IL-6. This research is registered at the Brazilian Registry of Clinical Trials (RBR-8wwq9t).</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"125 ","pages":"Pages 36-49"},"PeriodicalIF":4.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140141744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}