Nutrition ResearchPub Date : 2024-06-27DOI: 10.1016/j.nutres.2024.06.007
Antonio Orlando Farias Martins-Filho , Lilia Schug de Moraes , Cristina Bossle de Castilhos , Leonardo Pozza Santos , Ana Maria Pandolfo Feoli , Fernanda Michielin Busnello , Lúcia Rota Borges , Anne y Castro Marques , Renata Torres Abib Bertacco
{"title":"Eating behavior and dietary practices are associated with age, sex, body mass index, and body fat in individuals with type 2 diabetes and/or hypertension in Brazil","authors":"Antonio Orlando Farias Martins-Filho , Lilia Schug de Moraes , Cristina Bossle de Castilhos , Leonardo Pozza Santos , Ana Maria Pandolfo Feoli , Fernanda Michielin Busnello , Lúcia Rota Borges , Anne y Castro Marques , Renata Torres Abib Bertacco","doi":"10.1016/j.nutres.2024.06.007","DOIUrl":"10.1016/j.nutres.2024.06.007","url":null,"abstract":"<div><p>Type 2 diabetes (T2DM), hypertension, and obesity are major contributors to global mortality. This study aimed to evaluate eating behavior and dietary practices among individuals with T2DM and/or hypertension, examining their associations with sociodemographic and anthropometric characteristics. We hypothesized that these factors may contribute to body mass index (BMI) and body fat (BF) levels in these individuals. In a cross-sectional study, adults/older individuals diagnosed with T2DM and/or hypertension were included. Eating behavior was evaluated via <em>Three-factor Eating Questionnaire-R21</em>. Dietary practices were assessed using the <em>Dietary Guidelines for the Brazilian Population</em> (DGBP) questionnaire. Poisson regression examined associations between eating behaviors, dietary practices, and sociodemographic factors. Linear regressions were employed to analyze relationships between eating behavior, dietary practices, BMI, and BF. The study included 275 primarily female (70.5%) participants under 60 years old (54.2%). Male and older participants had a lower prevalence of high scores in the 'emotional eating' (EE; PR: 0.40 [0.25;0.63]) and 'uncontrolled eating' (UE; PR: 0.68 [0.50;0.92]) domains. In contrast, older patients had a higher prevalence of adherence to the DGBP recommendations (PR:1.53 [1.20;1.94]). A positive association was observed between high EE (β:3.71 [1.98;5.44]) and UE (β:2.85 [1.15;4.55]) scores and BMI, whereas higher dietary practice scores (β:-2.19 [-3.88;-0.50]) were negatively associated with BMI. High EE (β:2.20 [0.38;4.02]) and UE (β:1.92 [0.17;3.67]) scores were positively associated with BF regardless of the confounding factors included. Higher scores on the dietary practices were inversely associated with BF (β:-1.94 [-3.67;-0.21]). Understanding dietary behaviors and practices can facilitate a more comprehensive and effective treatment approach.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"128 ","pages":"Pages 50-59"},"PeriodicalIF":3.4,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-06-17DOI: 10.1016/j.nutres.2024.06.005
Henrique José Cavalcanti Bezerra Gouveia , Márcia Maria da Silva , Raul Manhães de Castro , Luan Kelwyny Thaywã Marques da Silva , Caio Matheus Santos da Silva Calado , Eulália Rebeca da Silva Araújo , Mariana de Almeida Cruz Silva , Ana Elisa Toscano
{"title":"Vitamin D supplementation does not alter inflammatory markers in overweight and obese individuals: A systematic review and meta-analysis of randomized controlled trials","authors":"Henrique José Cavalcanti Bezerra Gouveia , Márcia Maria da Silva , Raul Manhães de Castro , Luan Kelwyny Thaywã Marques da Silva , Caio Matheus Santos da Silva Calado , Eulália Rebeca da Silva Araújo , Mariana de Almeida Cruz Silva , Ana Elisa Toscano","doi":"10.1016/j.nutres.2024.06.005","DOIUrl":"10.1016/j.nutres.2024.06.005","url":null,"abstract":"<div><p>Chronic low-grade inflammation is a common feature of obesity and plays a crucial role in the progression of its complications. Vitamin D (VitD) plays an important role in modulating the immune response and regulating inflammation. Thus, this systematic review and meta-analysis aimed to evaluate the effects of isolated VitD supplementation on main inflammatory markers in overweight and obese individuals with no comorbidities and with VitD deficiency. We hypothesized that the increase in serum VitD concentrations after supplementation would significantly reduce the concentrations of inflammatory markers. The search was conducted in Medline/PubMed, SCOPUS, EMBASE, and Web of Science. Eleven randomized placebo-controlled studies were included in the final analysis, with a total of 504 participants and daily (1000-7000 international units) or bolus (100,000-200,000 international units) doses of VitD lasting from 2 to 26 weeks. The VitD supplementation did not influence C-reactive protein (mean difference [MD]: 0.01; 95% confidence interval [CI] –0.37, 0.39; <em>P</em> = .97), interleukin-6 (MD: –0.34; 95% CI –1.09, 0.42; <em>P</em> = .38), and tumor necrosis factor concentrations (MD: –0.02; 95% CI –0.23, 0.19; <em>P</em> = .85). In the analysis considering the studies with a significant increase in serum VitD concentrations, VitD supplementation also did not influence C-reactive protein (MD: –0.17; 95% CI –0.88, 0.54; <em>P</em> = .64), interleukin-6 (MD: –0.47; 95% CI –1.31, 0.37; <em>P</em> = .27), and tumor necrosis factor concentrations (MD: 0.01; 95% CI –1.34, 1.37; <em>P</em> = .98). This meta-analysis suggests that VitD supplementation does not significantly alter inflammatory markers in overweight and obese individuals.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"128 ","pages":"Pages 24-37"},"PeriodicalIF":3.4,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-06-13DOI: 10.1016/j.nutres.2024.06.003
{"title":"The relative validity of nutrition assessment methods for estimating infant carotenoid intake differs by assessment tool, nutrient database, and milk carotenoid adjustment method","authors":"","doi":"10.1016/j.nutres.2024.06.003","DOIUrl":"10.1016/j.nutres.2024.06.003","url":null,"abstract":"<div><p>Validated carotenoid assessment methods are needed to study infant carotenoid nutrition. This is a secondary analysis of repeated diet assessments of healthy participants collected at 4- (n = 21), 6- (n = 12), and 8- (n = 9) months of age in Houston, TX between April 2019 and June 2020. Intake was assessed with 3 assessment tools, analyzed with 3 nutrient databases, and underwent 3 adjustments to account for milk composition variability. We hypothesized that manual adjustment of milk carotenoid intake based on laboratory measurements would improve the validity of all assessment approaches and that using a database with greater coverage of infant food carotenoid compositions would improve accuracy. Generalized linear mixed models assessed associations between tool, nutrient database, age, and milk carotenoid adjustment variables with carotenoid, energy, fruit, and vegetable intakes. The effect of the number of food diary days on intake estimate precision was evaluated by testing the correlation between intake estimates derived from 1, 3, or 5, vs. 7 days. Visit age influenced energy intake estimates (<em>p</em> = .029), along with assessment tool (<em>p</em> = .020). Estimates of vegetable intake were influenced by tool (<em>p</em> = .009). Combined fruit and vegetable intake differed by nutrient database (<em>p</em> = .007). Carotenoid intake differed by age (<em>p</em> =<.0001), tool (<em>p</em> = .002), and nutrient database (<em>p</em> = .004). A minimum of 3 food diary days strongly correlated (rho = 0.79-1) with reference estimates across ages. Milk carotenoid adjustment was most influential in estimating 4-month olds’ carotenoid intake, while nutrient database and tool were important for 6- and 8-month-olds’, highlighting the dynamic nature of infant diet assessment validity across feeding stages.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"128 ","pages":"Pages 38-49"},"PeriodicalIF":3.4,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141391482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-06-04DOI: 10.1016/j.nutres.2024.05.009
Heaji Lee , Yunju Eo , Sun Yeou Kim , Yunsook Lim
{"title":"Guava leaf extract attenuated muscle proteolysis in dexamethasone induced muscle atrophic mice via ubiquitin proteasome system, mTOR-autophagy, and apoptosis pathway","authors":"Heaji Lee , Yunju Eo , Sun Yeou Kim , Yunsook Lim","doi":"10.1016/j.nutres.2024.05.009","DOIUrl":"10.1016/j.nutres.2024.05.009","url":null,"abstract":"<div><p>Muscle atrophy is the waste or loss of muscle mass and is caused by physical inactivity, aging, or diseases such as diabetes, cancer, and heart failure. The number of patients suffering from musculoskeletal disorders is expected to increase in the future. However, intervention for muscle atrophy is limited, so research on treatment for muscle wasting is needed. This study hypothesized that guava leaf (<em>Psidium guajava L.</em> [GL]) would have ameliorative effects on muscle atrophy by regulation of protein degradation pathways in a dexamethasone (DEX)-induced muscle atrophy mice model. Muscle atrophy was induced by DEX injection for 28 days in 7 week-old-male ICR mice. Then, low-dose GL (LGL, 200 mg/kg) or high-dose GL (HGL, 500 mg/kg) extract (GLE) was supplemented by oral gavage for 21 days. Muscle strength, calf thickness, and body composition were analyzed. Histopathological changes in the gastrocnemius muscle were examined using hematoxylin and eosin staining, and molecular pathways related to muscle degradation were analyzed by western blots. GLE treatment regardless of dose increased muscle strength in mice with muscle atrophy accompanied by attenuating autophagy related pathway in the DEX-induced muscle atrophy mice. Moreover, a high dose of GLE treatment ameliorated ubiquitin proteasome system and apoptosis in the DEX-induced muscle atrophy mice. This study suggested that GLE could be helpful to improve muscle health and alleviate proteolysis by regulation of the ubiquitin–proteasome system, autophagy, and apoptosis, which are involved in muscle degradation. In conclusion, GLE could be a potential nutraceutical to prevent muscle atrophy.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"127 ","pages":"Pages 97-107"},"PeriodicalIF":3.4,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141281636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-05-29DOI: 10.1016/j.nutres.2024.05.005
Da-Young Kim , Seungjun Oh , Hae-Sun Ko , Sanghee Park , Young-Jun Jeon , Jihoe Kim , Dong Kwon Yang , Kye Won Park
{"title":"Sesamolin suppresses adipocyte differentiation through Keap1-dependent Nrf2 activation in adipocytes","authors":"Da-Young Kim , Seungjun Oh , Hae-Sun Ko , Sanghee Park , Young-Jun Jeon , Jihoe Kim , Dong Kwon Yang , Kye Won Park","doi":"10.1016/j.nutres.2024.05.005","DOIUrl":"10.1016/j.nutres.2024.05.005","url":null,"abstract":"<div><p>Sesamolin, a lignan isolated from sesame oils, has been found to possess neuroprotective, anticancer, and free radical scavenging properties. We hypothesized that sesamolin could stimulate the activity of nuclear factor erythroid-derived 2-like 2 (Nrf2) and inhibit adipocyte differentiation of preadipocytes. The objective of this study was to investigate effects of sesamolin on adipocyte differentiation and its underlying molecular mechanisms. In this study, we determined the effects of treatment with 25 to 100 µM sesamolin on adipogenesis in cell culture systems. Sesamolin inhibited lipid accumulation and suppressed the expression of adipocyte markers during adipocyte differentiation of C3H10T1/2, 3T3-L1, and primary preadipocytes. Mechanism studies revealed that sesamolin increased Nrf2 protein expression without inducing its mRNA, leading to an increase in the expression of Nrf2 target genes such as heme oxygenase 1 and NAD(P)H:quinone oxidoreductase 1 (Nqo1) in C3H10T1/2 adipocytes and mouse embryonic fibroblasts. These effects were significantly attenuated in Nrf2 knockout (KO) mouse embryonic fibroblasts, indicating that effects of sesamolin were dependent on Nrf2. In H1299 human lung cancer cells with KO of Kelch like-ECH-associated protein 1 (Keap1), a negative regulator of Nrf2, sesamolin failed to further increase Nrf2 protein expression. However, upon reexpressing Keap1 in Keap1 KO cells, the ability of sesamolin to elevate Nrf2 protein expression was restored, highlighting the crucial role of Keap1 in sesamolin-induced Nrf2 activation. Taken together, these findings show that sesamolin can inhibit adipocyte differentiation through Keap1-mediated Nrf2 activation.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"128 ","pages":"Pages 14-23"},"PeriodicalIF":3.4,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-05-26DOI: 10.1016/j.nutres.2024.05.004
Sondos M. Flieh , Antje Hebestreit , Hermann Pohlabeln , María L. Miguel-Berges , Esther M. González-Gil , Paola Russo , Dénes Molnár , Kathleen Wijnant , Lauren Lissner , Stefanie Do , Tonia Solea , Toomas Veidebaum , Luis A. Moreno , IDEFICS/I.Family Consortium
{"title":"Longitudinal associations between psychosomatic and emotional status and selected food portion sizes in European children and adolescents: IDEFICS/I.Family study","authors":"Sondos M. Flieh , Antje Hebestreit , Hermann Pohlabeln , María L. Miguel-Berges , Esther M. González-Gil , Paola Russo , Dénes Molnár , Kathleen Wijnant , Lauren Lissner , Stefanie Do , Tonia Solea , Toomas Veidebaum , Luis A. Moreno , IDEFICS/I.Family Consortium","doi":"10.1016/j.nutres.2024.05.004","DOIUrl":"10.1016/j.nutres.2024.05.004","url":null,"abstract":"<div><p>This study aims to investigate the influence of psychosomatic and emotional status on food portion sizes (PSs) consumption from high energy-dense food groups in European children and adolescents. We hypothesized that psychosomatic and emotional status would have a significant association with the PS selection of energy-dense food. The study included 7355 children aged between 2 and 9.9 years at baseline (T0) (48.8% females); 3869 after 2 years (T1) (48.2% females), and 2971 (51.8% females) after 6 years of follow-up (T3). Psychosomatic and emotional status were measured using emotional well-being during the last week score (KINDL) and Strengths and Difficulties Questionnaire. PS was calculated from daily food intake recorded in 24-hour dietary recalls. The associations between emotional status indicators and PS from selected energy-dense food groups were assessed by multilevel linear regression models. In the cross-sectional analysis, we observed that higher KINDL scores were linked to lower PS consumption from sweet bakery products and savory snacks in both genders. Moreover, we found that adolescent females with high emotional and peer problem scores tended to consume larger PS of carbohydrate-rich and sugar-fatty food items (<em>P</em> < .017). Longitudinally, higher peer problem scores were associated with increased PS from bread and rolls, margarine and lipids, and dairy products in all genders and age groups (<em>P</em>< .017). In adolescents, psychosomatic and emotional status could be a trigger for consuming large PS from carbohydrate-rich and sugar-fatty energy-dense foods. Thus, nutritional interventions should consider emotional status to decrease unhealthy dietary habits in children and adolescents.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"127 ","pages":"Pages 84-96"},"PeriodicalIF":4.5,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0271531724000708/pdfft?md5=d9bb79fa041addde8bef9182eee8f4f6&pid=1-s2.0-S0271531724000708-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-05-25DOI: 10.1016/j.nutres.2024.05.006
Chan Yoon Park , Sunhye Shin
{"title":"Low dietary vitamin C intake is associated with low muscle strength among elderly Korean women","authors":"Chan Yoon Park , Sunhye Shin","doi":"10.1016/j.nutres.2024.05.006","DOIUrl":"10.1016/j.nutres.2024.05.006","url":null,"abstract":"<div><p>Although vitamin C is one of the most important antioxidants, its effect on muscle quality is not fully understood. Therefore, we hypothesized that low dietary vitamin C intake is associated with low muscle strength. To test the hypothesis, a single 24-h dietary recall and handgrip strength test of 10,883 younger adults 19-64 y and 3,961 older adults ≥65 y from the seventh Korea National Health and Examination Survey (KNHANES VII 2016-2018) was analyzed by multivariable linear and logistic regression models, and low muscle strength was defined as handgrip strength <28 kg for men and <18 kg for women. Approximately 15.5% of Korean adults met the recommended intake of dietary vitamin C, and those with higher dietary vitamin C intake had higher total energy and protein intake. After adjusting for confounding variables, including age, body mass index, total energy intake, household income, alcohol consumption, smoking, resistance exercise, medical condition, and dietary intake of protein, vitamin E, and β-carotene, dietary vitamin C was correlated with maximal handgrip strength in younger women 19-64 y (β = 0.002; SE = 0.001; <em>P</em>-value = .026) and older women ≥65 y (β = 0.005; SE = 0.002; <em>P</em>-value = .013). Among older women ≥65 y, those in the lowest quartile of dietary vitamin C intake had a higher risk of low muscle strength compared to those in the highest quartile after adjustment of confounding factors (odds ratio, 2.16; 95% confidence interval, 1.49-3.15). These results imply that adequate dietary vitamin C intake may reduce the risk of sarcopenia in older Korean women.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"127 ","pages":"Pages 75-83"},"PeriodicalIF":4.5,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutrition ResearchPub Date : 2024-05-23DOI: 10.1016/j.nutres.2024.05.002
Berenice Rivera-Paredez , Anna D. Argoty-Pantoja , Rafael Velázquez-Cruz , Jorge Salmerón , Aida Jiménez-Corona , Clicerio González-Villalpando , Martin Lajous , Juan Tamayo , Andrés Catzin-Kuhlmann , Robert Nelson , Ricardo Correa-Rotter , Edgar Denova-Gutiérrez
{"title":"Dietary inflammatory index and lower glomerular filtration rate in Mexican adults","authors":"Berenice Rivera-Paredez , Anna D. Argoty-Pantoja , Rafael Velázquez-Cruz , Jorge Salmerón , Aida Jiménez-Corona , Clicerio González-Villalpando , Martin Lajous , Juan Tamayo , Andrés Catzin-Kuhlmann , Robert Nelson , Ricardo Correa-Rotter , Edgar Denova-Gutiérrez","doi":"10.1016/j.nutres.2024.05.002","DOIUrl":"10.1016/j.nutres.2024.05.002","url":null,"abstract":"<div><p>We hypothesized that higher scores on the dietary inflammatory index (DII) would be associated with a lower glomerular filtration rate (GFR). This cross-sectional study included 2098 participants from Mexican Teachers Cohort Study, the Health Workers Cohort Study, and the Comitán Study belonging to the RenMex consortium. Energy-adjusted DII scores were estimated using a semi-quantitative food frequency questionnaire (FFQ). eGFR was estimated by the CKD Epidemiology Collaboration equation. Quantile regression models and ordered regression models were estimated to assess the associations of interest. Median age of study participants was 47 years, median eGFR was 102.9 mL/min/1.73m<sup>2</sup>, and the median energy-adjusted DII was 0.89 (range, -2.25, +4.86). The median eGFR was lower in participants in the highest percentile of DII compared to those in the lowest percentile (103.8 vs 101.4). We found that continuous and categorical energy-adjusted DII scores were associated with lower eGFR, especially at the lower percentiles. In adjusted ordered logistic regression, we found that the highest DII category was associated with 1.80 times the odds of belonging to the mildly decreased eGFR category or moderately decreased eGFR category compared lowest DII category (OR: 1.80, 95%CI 1.35, 2.40). A high DII score was associated with a lower eGFR among the Mexican population. Additional studies are crucial to validate these findings and explore potential strategies to reduce the consumption of pro-inflammatory foods as a preventive approach for chronic kidney disease (CKD).</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"127 ","pages":"Pages 53-62"},"PeriodicalIF":4.5,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141134730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}