Nutrition Research最新文献_第9页

A response to a letter to the editor: “Claims of group-level accuracy for bioelectrical impedance analysis in paediatric obesity: A cautionary note” 对致编辑的一封信的回应：“声称儿童肥胖的生物电阻抗分析在群体水平上的准确性：一个警告”。

IF 3.1 3区医学

Nutrition Research Pub Date : 2025-10-01 Epub Date: 2025-07-10 DOI: 10.1016/j.nutres.2025.07.004

Camilla Raaby Benjaminsen , Rasmus Møller Jørgensen , Esben Thyssen Vestergaard , Jens Meldgaard Bruun

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Robustness is action, not assertion: Reassessing an isolation attempt reveals methodological breaches in dietary inorganic nitrate research 稳健性是行动，而不是断言：重新评估分离的尝试揭示了饮食无机硝酸盐研究方法上的漏洞

IF 3.1 3区医学

Nutrition Research Pub Date : 2025-10-01 Epub Date: 2025-09-11 DOI: 10.1016/j.nutres.2025.09.005

Jonas Benjamim

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The light is in the details: Transparent methodology and scientific integrity in systematic review design 细节是光明的：系统评价设计的透明方法和科学完整性。

IF 3.1 3区医学

Nutrition Research Pub Date : 2025-10-01 Epub Date: 2025-08-28 DOI: 10.1016/j.nutres.2025.08.007

Daniel Forster , Gustavo Waclawovsky , Giuseppe Potrick Stefani

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Urinary Iodine/Creatinine as an Indicator of Iodine Status in Lactating Women: Optimal Collection Time Between 0-8 Hours 尿碘/肌酐作为哺乳期妇女碘状态的指标：最佳采集时间在0-8小时之间

IF 3.1 3区医学

Nutrition Research Pub Date : 2025-10-01 Epub Date: 2025-08-21 DOI: 10.1016/j.nutres.2025.08.006

Qi Meng , Duan Li , Ting Wang , Qi Jin , Fei Li , Meina Ji , Hexi Zhang , Wenxing Guo , Wanqi Zhang

{"title":"Urinary Iodine/Creatinine as an Indicator of Iodine Status in Lactating Women: Optimal Collection Time Between 0-8 Hours","authors":"Qi Meng , Duan Li , Ting Wang , Qi Jin , Fei Li , Meina Ji , Hexi Zhang , Wenxing Guo , Wanqi Zhang","doi":"10.1016/j.nutres.2025.08.006","DOIUrl":"10.1016/j.nutres.2025.08.006","url":null,"abstract":"<div><div>The urinary iodine/creatinine ratio (UI/Cr) has been recognized as a stable indicator for assessing iodine nutrition status. However, data regarding UI/Cr in lactating women are relatively limited. This study aimed to explore the variation regularity of spot UI/Cr and to provide the optimal time for urine collection. Twenty-two healthy lactating women were recruited for a 7-day iodine metabolism experiment. Daily iodine intake was accurately measured and calculated; all urine samples from each participant were collected separately over the 7-day period, and urinary iodine and urinary creatinine were tested. Spot UI/Cr showed minimal variation between 00:00 and 08:00, with significant changes after 08:00. The 24-hour period was divided into six segments, with the smallest coefficient of variation observed in the 00:00 to 03:59 period. The mixed-effects model analysis revealed that spot UI/Cr during the 0:00 to 3:59 period exhibited the strongest correlation with 24-hour UI/Cr (<em>β</em> = 0.82, <em>P</em> < .001), as well as with 24-hour urinary iodine excretion (<em>β</em> = 0.49, <em>P</em> < .001). Additionally, spot UI/Cr during the 4:00 to 7:59 period demonstrated the strongest correlation with total iodine intake (<em>β</em> = 0.54, <em>P</em> < .001), while spot UI/Cr during the 20:00 to 23:59 period showed the strongest correlation with the total iodine intake of the previous day (<em>β</em> = 0.41, <em>P</em> < .001). As UI/Cr is influenced by dietary iodine and its variation increases after eating, it is recommended that urine collection time for assessing the iodine nutritional status of lactating women using spot UI/Cr be set between 0:00 and 08:00.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"142 ","pages":"Pages 16-22"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Bioaccessible compounds from bean (Phaseolus vulgaris L.) landraces activate PPARγ in transiently transfected HepG2 cells 从豆（Phaseolus vulgaris L.）地方种中提取的生物可及化合物可激活瞬时转染的HepG2细胞中的PPARγ

IF 3.1 3区医学

Nutrition Research Pub Date : 2025-10-01 Epub Date: 2025-09-04 DOI: 10.1016/j.nutres.2025.09.001

Pia Eckhof , Nélida Nina , Sarah Bauer , Thomas A Kufer , Jan Frank , Felipe Jiménez-Aspee

{"title":"Bioaccessible compounds from bean (Phaseolus vulgaris L.) landraces activate PPARγ in transiently transfected HepG2 cells","authors":"Pia Eckhof , Nélida Nina , Sarah Bauer , Thomas A Kufer , Jan Frank , Felipe Jiménez-Aspee","doi":"10.1016/j.nutres.2025.09.001","DOIUrl":"10.1016/j.nutres.2025.09.001","url":null,"abstract":"<div><div>Common beans (<em>Phaseolus vulgaris</em> L.) are a nutrient-dense staple food associated with a reduced risk of noncommunicable chronic diseases. One proposed mechanism involves the modulation of nuclear receptors, particularly peroxisome proliferator-activated receptors (PPARs), which are key regulators of lipid and carbohydrate metabolism. In this study, we evaluated the effects of <em>in vitro</em> digested flours, secondary metabolite-enriched extracts (SMEEs), their fractions, and selected representative phytochemicals from 14 landraces and 2 commercial <em>P. vulgaris</em> samples to directly activate PPARs and other nuclear receptors using a luciferase reporter assay in transiently transfected HepG2 cells. We hypothesized that bioaccessible compounds from the digested landraces would directly activate PPARγ in HepG2 cells. Digested flours from landraces such as Magnum and Peumo significantly activated both PPARγ1 and PPARγ2, reaching values up to 1.54-fold higher than the controls (<em>P</em> < .05). Corresponding SMEEs showed stronger activities, with up to 2.32-fold activation compared to the controls (<em>P</em> < .05). In contrast, none of the polarity-based fractions or the major identified phytochemicals (kaempferol-3-O-glycoside, sojasaponin Ba and Bb) showed significant effects. These findings demonstrate that digested <em>P. vulgaris</em> matrices contain bioaccessible compounds capable of directly activating PPARγ in HepG2 cells, likely through synergistic interactions or unidentified constituents. This mechanistic evidence supports the functional relevance of traditional bean landraces in precision nutrition strategies targeting metabolic health.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"142 ","pages":"Pages 33-45"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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David Kritchevsky Graduate Student Award for Nutrition Research 大卫·克里切夫斯基营养研究研究生奖

IF 3.1 3区医学

Nutrition Research Pub Date : 2025-09-01 Epub Date: 2025-09-12 DOI: 10.1016/S0271-5317(25)00114-9

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Dietary vitamin E intake is associated with lower mortality among individuals with metabolic dysfunction-associated steatotic liver disease 在代谢功能障碍相关的脂肪变性肝病患者中，膳食维生素E摄入量与较低的死亡率相关

IF 3.1 3区医学

Nutrition Research Pub Date : 2025-09-01 Epub Date: 2025-08-06 DOI: 10.1016/j.nutres.2025.08.001

Yajie Peng , Wanhong Wu , Lin Chen , Chao Xu , Xuelian Xiong

{"title":"Dietary vitamin E intake is associated with lower mortality among individuals with metabolic dysfunction-associated steatotic liver disease","authors":"Yajie Peng , Wanhong Wu , Lin Chen , Chao Xu , Xuelian Xiong","doi":"10.1016/j.nutres.2025.08.001","DOIUrl":"10.1016/j.nutres.2025.08.001","url":null,"abstract":"<div><div>Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a prominent global health issue within the realm of chronic liver diseases. Dietary interventions are of utmost importance in its management. This research, grounded in data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999-2018 and the National Death Index (NDI), was designed to clarify the association between dietary vitamin E intake and mortality among MASLD patients. Our hypothesis proposed that higher dietary vitamin E intake might be inversely associated with a lower risk of mortality in this population. A total of 7883 MASLD patients were enrolled. Their dietary vitamin E intake was accurately measured via the USDA's standardized method, and numerous confounding factors were comprehensively taken into account. The findings indicated that a higher dietary vitamin E intake was significantly linked to a decreased risk of both all-cause and cardiovascular disease (CVD) mortality in MASLD patients. Kaplan-Meier curves and Cox regression models vividly depicted this inverse correlation. Subgroup and sensitivity analyses further verified the reliability of the results, showing that nonsedentary patients were more sensitive to the protective effects of vitamin E. Notably, the improvement of mortality was particularly significant in patients with increased total bilirubin and fibrotic liver. This study offers valuable perspectives on the potential role of dietary vitamin E in MASLD management. It suggests that increasing dietary vitamin E intake could be a promising preventive approach.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"141 ","pages":"Pages 96-108"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Skipping breakfast and its wide-ranging health consequences: A systematic review from multiple metabolic disruptions to socioeconomic factors 不吃早餐及其广泛的健康后果：从多种代谢紊乱到社会经济因素的系统回顾

IF 3.1 3区医学

Nutrition Research Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1016/j.nutres.2025.07.006

Tatiana Palotta Minari, Luciana Pellegrini Pisani

{"title":"Skipping breakfast and its wide-ranging health consequences: A systematic review from multiple metabolic disruptions to socioeconomic factors","authors":"Tatiana Palotta Minari, Luciana Pellegrini Pisani","doi":"10.1016/j.nutres.2025.07.006","DOIUrl":"10.1016/j.nutres.2025.07.006","url":null,"abstract":"<div><div>Skipping breakfast has been widely debated due to its potential health consequences across multiple domains. This systematic review evaluates literature from 2010 to 2025, analyzing 66 studies to assess its associations with obesity, diabetes, gut microbiome alterations, neurodegenerative diseases, cancer, sports performance, psychiatric disorders, cognitive health, and socioeconomic factors. The hypothesis suggests that breakfast omission is linked to various adverse health effects. Evidence highlights associations with obesity and weight gain due to altered hormonal responses influencing hunger and energy balance. Additionally, skipping breakfast negatively affects gut microbiota, contributing to systemic inflammation and metabolic dysfunction. Research suggests potential links to increased cancer risk through inflammatory pathways, while cognitive decline, mood disorders, and impaired athletic performance are also observed. Psychiatric disorders, including anxiety and depression, may be exacerbated by irregular meal patterns, influencing neurotransmitter regulation. Emerging studies indicate that breakfast consumption plays a role in bone mineral density, as prolonged fasting periods may affect calcium metabolism and skeletal health. Socioeconomic disparities impact breakfast consumption, affecting diet quality and overall health outcomes. While some individuals experience neutral or even beneficial effects, meal timing and caloric distribution play critical roles in metabolic and cardiovascular health. However, causality remains complex due to confounding factors like diet quality, physical activity, and socioeconomic status. Current studies face limitations, including small sample sizes and short intervention periods, requiring further research to refine conclusions and explore long-term mechanisms behind breakfast omission’s health impacts.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"141 ","pages":"Pages 34-45"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low serum 25 hydroxyvitamin D Is associated with severe metabolic dysfunction-associated steatotic liver disease in individuals with overweight/obesity: A cross-sectional study 低血清25羟维生素D与超重/肥胖患者严重代谢功能障碍相关的脂肪变性肝病相关：一项横断面研究

IF 3.1 3区医学

Nutrition Research Pub Date : 2025-09-01 Epub Date: 2025-08-08 DOI: 10.1016/j.nutres.2025.08.004

Yan Li , Minglan Yang , Jiang Yue , Jie Chen , Zixuan Wang , Yicheng Qi , Qianjing Liu , Qing Lu , Jing Ma

{"title":"Low serum 25 hydroxyvitamin D Is associated with severe metabolic dysfunction-associated steatotic liver disease in individuals with overweight/obesity: A cross-sectional study","authors":"Yan Li , Minglan Yang , Jiang Yue , Jie Chen , Zixuan Wang , Yicheng Qi , Qianjing Liu , Qing Lu , Jing Ma","doi":"10.1016/j.nutres.2025.08.004","DOIUrl":"10.1016/j.nutres.2025.08.004","url":null,"abstract":"<div><div>The role of vitamin D status in metabolic dysfunction-associated steatotic liver disease (MASLD) remains controversial. Furthermore, research evaluating the relationship between vitamin D status and abdominal fat distribution is limited. Therefore, we hypothesized that serum vitamin D is inversely associated with the severity of liver fat content (LFC) in populations with overweight/obesity. A total of 201 subjects with body mass index ≥23 kg/m<sup>2</sup> were classified by 25 hydroxyvitamin D (25 (OH) D) concentration as either vitamin D deficiency (<20 ng/mL) or vitamin D normal (≥20 ng/mL). Magnetic resonance imaging-proton density fat fraction was used to measure fat accumulation in the liver, pancreas, and abdomen subcutaneous and visceral. The LFC and subcutaneous adipose tissue (SAT) were significantly higher in the vitamin D deficient group compared to the normal vitamin D group (<em>P < .</em>05). However, there were no significant differences in visceral adipose tissue or pancreatic fat content between the 2 groups. Additionally, as the severity of LFC and SAT increases in individuals with overweight/obesity, serum 25 (OH) D concentration significantly decreases (<em>P < .</em>05). Further multivariate-adjusted logistic regression analysis revealed that individuals in the highest tertile of 25 (OH) D exposure exhibited lower risks of severe hepatic steatosis compared to those in the lowest tertile (T3 vs. T1, OR 0.26, 95% CI 0.10-0.67, <em>P = .</em>01). Our results identify a significant inverse association between serum 25 (OH) D concentration and severe MASLD in individuals with overweight/obesity. Further research is needed to explore the metabolic mechanisms underlying this association and their implications for liver protection.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"141 ","pages":"Pages 60-69"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing dietary polyunsaturated fatty acids through gut microbiota to enhance ferroptosis in breast cancer therapy 利用膳食多不饱和脂肪酸通过肠道菌群增强乳腺癌治疗中的铁下垂

IF 3.1 3区医学

Nutrition Research Pub Date : 2025-09-01 Epub Date: 2025-07-25 DOI: 10.1016/j.nutres.2025.07.007

Yara Adel Haroun , Abdulrahman Abdulla Alzyoud , Mohammad Taha Alizadeh , Nashwa Ahmed Mohamed , Riyad Bendardaf , Sameh S.M. Soliman

{"title":"Harnessing dietary polyunsaturated fatty acids through gut microbiota to enhance ferroptosis in breast cancer therapy","authors":"Yara Adel Haroun , Abdulrahman Abdulla Alzyoud , Mohammad Taha Alizadeh , Nashwa Ahmed Mohamed , Riyad Bendardaf , Sameh S.M. Soliman","doi":"10.1016/j.nutres.2025.07.007","DOIUrl":"10.1016/j.nutres.2025.07.007","url":null,"abstract":"<div><div>Breast cancer remains a leading global health challenge, with treatment resistance posing significant obstacles to effective therapy. Emerging research highlights the pivotal role of dietary polyunsaturated fatty acids (PUFAs) and gut microbiota in modulating breast cancer progression and therapeutic outcomes. This review explores the interplay and potential relevance of the PUFA–microbiota–ferroptosis axis in breast cancer progression and therapy. Omega-3 PUFAs, abundant in diets like the Mediterranean, exhibit anti-inflammatory properties, promote beneficial gut microbiota, and enhance ferroptosis, thereby reducing tumor proliferation and resistance. Conversely, omega-6 PUFAs, prevalent in Western diets, can exacerbate inflammation and tumor aggressiveness when imbalanced. Gut microbiota, through the production of short-chain fatty acids and PUFA-derived metabolites, further regulate ferroptosis sensitivity and systemic inflammation. We are evaluating the mechanisms by which omega-3 PUFAs and probiotics restore gut dysbiosis, modulate the tumor microenvironment, and synergize with treatments like chemotherapy and immune checkpoint inhibitors. Taken together and considering the generally favorable safety profile of omega-3 PUFAs, these findings suggest that the PUFA–microbiota–ferroptosis axis may represent a promising avenue for further investigation as a complementary strategy to address treatment resistance and improve outcomes. This warrants further translational research to optimize its clinical utility in personalized breast cancer management. Regulatory frameworks are also crucial to ensuring the safe and ethical implementation of PUFA-based interventions in global breast cancer care.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"141 ","pages":"Pages 10-33"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0