Nutrition Research最新文献

{"title":"Ethnicity modifies the relationship between added sugars and fructose exposure in the first 1000 days and offspring body composition at 24 months","authors":"Sara A. Fortin-Miller ,&nbsp;Byron J. Gajewski ,&nbsp;Susan E. Carlson ,&nbsp;John A. Colombo ,&nbsp;Danielle N. Christifano ,&nbsp;Debra K. Sullivan ,&nbsp;Holly R. Hull","doi":"10.1016/j.nutres.2025.04.009","DOIUrl":"10.1016/j.nutres.2025.04.009","url":null,"abstract":"<div><div>Added sugars (AS) and fructose intake are linked to obesity. Hispanic populations experience high AS intake and obesity rates. It is underexplored if early sugars exposure influences offspring growth, especially across ethnic groups. This secondary analysis examined if AS and fructose intake during pregnancy, infancy, and toddlerhood influenced offspring adiposity at 24 months, and if ethnicity modified outcomes. We hypothesized that higher sugars exposure would predict increased adiposity. Mother-child pairs from a prenatal docosahexaenoic acid supplementation RCT and the offspring follow-up study were included. Dietary intake was assessed at 12 to 20 weeks gestation, and offspring intake at 2 weeks, 6 months, 12 months, and 24 months. Intake was averaged across infancy (Year 1: 2 weeks/6 months) and toddlerhood (Year 2: 12 months/24 months). Anthropometric (<em>n</em> = 130) and dual-energy X-ray absorptiometry (<em>n</em> = 42) data were collected at 24 months. Multiple hierarchical regression examined associations, with interaction terms testing ethnic differences. Higher AS intake in Year 1 predicted higher weight, fat-free mass, and total adiposity. Compared to non-Hispanic offspring, the association of Year 1 fructose intake with weight and Year 2 AS intake with fat-free mass and central fat mass, were weaker in Hispanic offspring. No other significant associations were observed. The relationships between early AS and fructose intake with body composition are dynamic over time and vary by ethnicity. Our findings highlight the potential risks of early sugars exposure on obesity and metabolic health, underscoring the need for further research to inform early-life dietary interventions and public health policies.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"139 ","pages":"Pages 1-15"},"PeriodicalIF":3.4,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The metabolic effects of intermittent fasting in patients with type 2 diabetes exist in the short term but disappear after its discontinuation: A systematic review and meta-analysis of randomized controlled trials","authors":"Fangjun Liu ,&nbsp;Zhengxin Zhang ,&nbsp;Wenjie Sun ,&nbsp;Tao Li","doi":"10.1016/j.nutres.2025.04.008","DOIUrl":"10.1016/j.nutres.2025.04.008","url":null,"abstract":"<div><div>This meta-analysis aimed to determine the short- (&lt; 3 months) and long-term (≥ 3 months) metabolic effects of IF in patients with type 2 diabetes. We hypothesized that IF is non-inferior to other dietary control methods (including continuous energy restriction, standard diet, Mediterranean diet and ad libitum diet) in terms of both short-term and long-term metabolic impacts in patients with type 2 diabetes. We searched for studies in the MEDLINE, EMBASE, and Cochrane Library until August 20, 2023. Studies with non-type 2 diabetes patients, interventions other than IF, no control group, or non-randomized clinical trial designs were excluded. A meta-analysis was then conducted with a random effects model. The Risk of Bias was assessed using the Cochrane risk-of-bias tool (ROB 2). 12 articles with a total of 966 participants were included. IF significantly decreased glycated hemoglobin A1c (HbA1c) (standardized mean difference [SMD]: –0.93; 95% confidence interval [CI]: –1.64, –0.22; P = 0.01), fasting plasma glucose (FPG) (SMD: –0.73; 95% CI: –0.92, –0.54; P &lt; 0.00001) and body weight (SMD: –1.11; 95% CI: –1.92, –0.31; P = 0.007) in the short term compared to control interventions, but showed a similar effect to control interventions in the long term. Substantial heterogeneity existed among our studies. Over the intervention period, long-term IF may safely and feasibly help patients with type 2 diabetes effectively manage blood sugar and reduce body weight, but the metabolic benefits of IF don't endure after its discontinuation. Therefore, continual long-term IF may provide more lasting metabolic benefits.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 135-150"},"PeriodicalIF":3.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A digital health-supported Prediabetes Intervention, Management and Evaluation (PRIME) Program improves Healthy Eating Index score: A cluster randomized controlled trial","authors":"Choon Ming Ng ,&nbsp;Kah Woon Teoh ,&nbsp;Chun Wie Chong ,&nbsp;Yi Ling Ng ,&nbsp;J Simon Bell ,&nbsp;Shaun Wen Huey Lee","doi":"10.1016/j.nutres.2025.04.005","DOIUrl":"10.1016/j.nutres.2025.04.005","url":null,"abstract":"<div><div>There has been increasing interest in digital health-supported interventions to facilitate lifestyle change for diabetes prevention. In this secondary analysis of a digital health-supported Prediabetes Intervention, Management and Evaluation (PRIME) cluster randomized controlled trial, we hypothesized that PRIME can improve dietary outcomes among overweight/obese people with prediabetes in Malaysia (<em>n</em> = 82). PRIME Program was only meant for the healthy population without any significant conditions other than prediabetes and metabolic syndrome. The intervention group received the PRIME mobile app equipped with nutrition education modules, online peer support for motivation, nutrition quizzes for reinforcement, and face-to-face personalized counseling sessions by health coaches, supported with real-time health data while control group received usual care. The outcomes included dietary quality, nutrient intake, and food group consumption. Adjusted mixed model analysis showed that the intervention group had a significant improvement in the total healthy eating index score (+7.69%, 95% CI: 3.53-11.85, <em>P</em> &lt; .001), vegetables (+0.68 servings/d, 95% CI: 0.26-1.11, <em>P</em> = .002), refined grains (–0.61 servings/d, 95% CI: –1.01 to –0.21, <em>P</em> = .003) and sodium intake (–436.06 mg, 95% CI: –677.46 to –194.66, <em>P</em> &lt; .001) when compared to the control group. The present study provided data to inform practice directed at supporting the implementation of a digital health-supported lifestyle intervention in complementing and augmenting existing strategies for diabetes prevention among high-risk groups in Malaysia.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 151-161"},"PeriodicalIF":3.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Queen garnet plum juice supplementation does not provide additional cognitive benefits over a group-based memory program in older adults with mild cognitive impairment: A randomized clinical trial","authors":"Naomi May ,&nbsp;Zoe Fitzgerald ,&nbsp;Samantha Broyd ,&nbsp;Vinicius do Rosario ,&nbsp;Steven Roodenrys ,&nbsp;Vida Bliokas ,&nbsp;Susan Thomas ,&nbsp;Jan Potter ,&nbsp;Jenson George ,&nbsp;Katrina Weston-Green ,&nbsp;Karen E. Charlton","doi":"10.1016/j.nutres.2025.04.006","DOIUrl":"10.1016/j.nutres.2025.04.006","url":null,"abstract":"<div><div>Research suggests a role for inflammation and oxidative stress in mild cognitive impairment (MCI) and its progression. Evidence suggests anthocyanin-rich foods may reduce inflammation and oxidative stress and improve cognition but benefits in MCI are unclear. Therefore, it was hypothesized that daily consumption of anthocyanin-rich Queen Garnet Plum (QGP) juice would improve cognition, mood and blood pressure in people with MCI. Participants diagnosed with MCI (<em>N</em> = 42) participated in a double-blind, randomized controlled trial. Participants were administered either QGP juice or apricot juice (comparator) daily for 8-weeks and participated in a 6-week group-based memory program. Cognitive function was assessed using a battery of cognitive tests, including the Rey Auditory Verbal Learning Test (RAVLT), Complex Figure Test (CFT), Royal Prince Alfred-Prospective Memory Test (RPA-ProMem), and Comprehensive Assessment of Prospective Memory self-report (CAPM-self). Mood and blood pressure were also measured pre- and post-intervention. There was a significant effect of TIME for total RAVLT (<em>P = .</em>028, <em>η²</em> = .12), CFT-recall (<em>P = .</em>036, <em>η²</em> = .11), RPA-ProMem (<em>P &lt; .</em>001, <em>η²</em> = .28), and CAPM-self (<em>P = .</em>007, <em>η²</em> = .22) scores. There was a non-significant trend towards an interaction for CFT-recall (<em>p</em> = .063, <em>η</em>^<em>2</em> = .09), where Bonferroni adjusted pairwise comparisons showed that the QGP group, but not comparators, had significantly improved CFT-recall scores (QGP: +13.93%, <em>P = .</em>007; comparators: +0.84%, <em>P = .</em>855). Overall, QGP consumption during a group-based memory rehabilitation program did not result in additional cognitive benefits in older adults with MCI. This trial was registered at the Australian New Zealand Clinical Trials Registry as ACTRN12618001184268.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 107-121"},"PeriodicalIF":3.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pro-inflammatory diet is associated with higher body adiposity in kidney transplant recipients","authors":"Mariana Silva da Costa ,&nbsp;Mariana Ribeiro Costa Portugal ,&nbsp;Jenneffer Rayane Braga Tibaes ,&nbsp;Larissa Santos Maciel de Azevedo Bianchi ,&nbsp;Karine Scanci da Silva Pontes ,&nbsp;Ana Paula Medeiros Menna Barreto ,&nbsp;Lucas Boechat Caparelli ,&nbsp;Maria Inês Barreto Silva ,&nbsp;Márcia Regina Simas Torres Klein","doi":"10.1016/j.nutres.2025.04.007","DOIUrl":"10.1016/j.nutres.2025.04.007","url":null,"abstract":"<div><div>The dietary inflammatory index (DII) has been associated with obesity and cardiovascular risk factors (CVRF) in the general population. We hypothesized that in kidney transplant recipients (KTR), a positive relationship between DII, body adiposity and CVRF would also be observed. To test this hypothesis, we conducted a cross-sectional study with adult KTR. Body mass index (BMI), body adiposity index (BAI) and waist circumference (WC) were assessed. Total fat mass (FM), trunk FM, and load-capacity index (LCI) were evaluated using dual-energy X-ray absorptiometry. Energy-adjusted DII (E-DII) was estimated based on three 24-h recalls and stratified as anti-inflammatory (E-DII&lt;0) and pro-inflammatory (E-DII&gt;0). CVRF included hypertension, diabetes, dyslipidemia, and metabolic syndrome. A total of 170 KTR, 59% male, with 49.5 (42-57) years and E-DII from -2.89 to 4.78 were evaluated. KTR with E-DII&gt;0, compared to those with E-DII&lt;0, exhibited significantly higher values of BAI, total FM (kg), and LCI. In multiple adjusted linear regression, E-DII was significantly associated with WC, total FM (kg), and trunk FM (kg). Logistic regression analysis indicated that E-DII&gt;0 was significantly associated with obesity, as assessed by BAI. E-DII was not associated with CVRF. The present study suggests that a pro-inflammatory diet is associated with higher total and central body adiposity in KTR. Interventions targeting an anti-inflammatory diet may contribute to reducing excessive body adiposity in this population.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 122-134"},"PeriodicalIF":3.4,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional status reshapes gut microbiota composition in adolescent Afghan refugees in Peshawar, Pakistan","authors":"Muhammad Shahzad ,&nbsp;Muhammad Arshad ,&nbsp;Habab Ali Ahmad ,&nbsp;Ishawu Iddrissu ,&nbsp;Elizabeth H. Bailey ,&nbsp;Nizar Dru ,&nbsp;Shabir Khan ,&nbsp;Haris Khan ,&nbsp;Simon C. Andrews","doi":"10.1016/j.nutres.2025.04.004","DOIUrl":"10.1016/j.nutres.2025.04.004","url":null,"abstract":"<div><div>Although the human gut microbiome, and its role in health and disease, have been extensively studied in different populations, a comprehensive assessment of gut microbiome composition has not been performed in vulnerable refugee populations. In this study, we hypothesized that overall nutritional status, as indicated by serum micronutrients concentrations, is an important driver of variations in gut microbiome composition. Therefore, gut-microbiome diversity and associated demographic, health and nutritional factors were assessed in adolescent Afghan refugees (n=206). Blood and faecal samples were collected and analysed for nutrition status markers and 16S rRNA gene amplicon-based community profiling, respectively. Bioinformatics and statistical analysis were performed using SPSS, QIIME and R. Overall, 56 distinct phyla, 117 families and 252 genera were identified in the faecal samples. Bacterial diversity (alpha and beta diversity) and the <em>Firmicutes:Bacteroidetes</em> (F/B) ratio were significantly higher in the 15 to 19 year old age group (cf. the 10-14 age group) but were lower in the underweight and vitamin D deficient groups. Furthermore, LEfSe analysis identified significant differences in the relative abundance of bacterial genera based on age, BMI and micronutrient (vitamins and minerals) status. These results were further scrutinised by correlation analysis which confirmed that age, BMI and micronutrient status show significant correlations with F/B ratio and the relative abundance of specific bacterial taxa. Collectively, our study provides the first indication of how the gut-microbiota profile of adolescent Afghan refugees is associated with a range of nutrition-status factors. These findings can thus provide a basis for translational microbiota research aimed at improving the health of such understudied and vulnerable populations.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 55-67"},"PeriodicalIF":3.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota-induced inflammation mediates the impacts of a Western diet on hippocampal-dependent memory","authors":"Eden Crain ,&nbsp;Dulce M. Minaya ,&nbsp;Claire B. de La Serre","doi":"10.1016/j.nutres.2025.04.002","DOIUrl":"10.1016/j.nutres.2025.04.002","url":null,"abstract":"<div><div>Obesity is associated with impaired hippocampal-dependent memory, but the mechanisms driving this pathology are not fully understood. Western diets (WD) contribute to obesity, and previous reviews have described a role for WD in impaired hippocampal-dependent memory. However, there is need for a more detailed description of the pathways by which WD may impair memory. The short vs long-term effect of specific dietary components on brain structure and functions as well as the precise mechanism and molecular pathways involved are still not fully understood. This review focuses on the mechanisms and effects of gut microbiota-driven neuroinflammation. WD leads to changes and imbalance in bacterial taxa abundances that are deleterious to the host health (gut dysbiosis) and studies in rodent models show these changes are sufficient to impair hippocampal-dependent memory. Here, we discuss a variety of proposed mechanisms linking microbiota composition to hippocampal function, with a focus on neuroinflammation. Gut microbiota impacts gastrointestinal barrier function, leading to increased circulating proinflammatory bacterial products, increased blood-brain barrier permeability, and neuroinflammation.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 89-106"},"PeriodicalIF":3.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-restricted eating increases hunger in adults with overweight and obesity: A systematic review and meta-analysis of randomized controlled studies","authors":"Amarilis D. Silva ,&nbsp;Kisian C. Guimarães ,&nbsp;Ricardo A. Oliveira ,&nbsp;Daniel A. Rosa ,&nbsp;Cibele A. Crispim","doi":"10.1016/j.nutres.2025.04.003","DOIUrl":"10.1016/j.nutres.2025.04.003","url":null,"abstract":"<div><div>Time-Restricted Eating (TRE) is an intermittent fasting approach that holds promise in managing obesity and appears to influence hunger. We hypothesized that the effects of TRE would be due to a lower caloric intake imposed, as with any other type of dietary intervention. However, it remains unclear whether these effects are attributed to the chrononutrition protocol itself or the caloric restriction resulting from the intervention. Our primary aim was to examine the impact of TRE on hunger compared to isocaloric strategies in adults with overweight or obesity. We conducted a systematic review of randomized clinical trials, with inclusion criteria comprising adults aged 18 years and older with overweight/obesity. A literature search was conducted from the earliest available article up to January 2025, with no restrictions on time, region, or language. The search encompassed major electronic databases, including CENTRAL, MEDLINE, LILACS, EMBASE, Google Scholar, and OpenGrey. Of the 14 studies included, four met the eligibility criteria for the primary meta-analysis, which evaluated hunger in 323 participants. The findings revealed that TRE resulted in an increase in hunger (MD 2.05, 95% CI 1.46, 2.64; I² = 0%) compared to the isocaloric control group. In conclusion, the TRE protocol was associated with elevated hunger compared to isocaloric strategies, which may warrant further investigation into its long-term feasibility in weight loss programs.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 76-88"},"PeriodicalIF":3.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition outweighs sarcopenia and adiposity as a predictor of survival in colorectal cancer patients","authors":"Mylena Pinto dos Santos ,&nbsp;Mariana Vieira Barbosa ,&nbsp;Nilian Carla Souza ,&nbsp;Renata Brum Martucci","doi":"10.1016/j.nutres.2025.04.001","DOIUrl":"10.1016/j.nutres.2025.04.001","url":null,"abstract":"<div><div>Colorectal cancer (CRC) patients often face nutritional disturbances, including malnutrition, changes in skeletal muscle index (SMI), and adipose tissue. We hypothesized that malnutrition, sarcopenia and nutritional disorders, as low muscle strength, low SMI, and reduced adipose tissue can negatively impact survival. This study aimed to assess the impact of malnutrition, SMI, muscle strength, sarcopenia, and adipose tissue on CRC patient survival. We analyzed 2 cohorts of CRC patients in this longitudinal study. Nutritional status was assessed by Patient-Generated Subjective Global Assessment (PG-SGA) and those classified as B and C were considered with malnutrition. Computed tomography (CT) scans of the third lumbar vertebra (L3) measured SMI and various adipose tissue fractions (visceral, subcutaneous, intramuscular, and total). Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2). The primary outcome was 5-year overall survival. Of 266 patients (mean age 60.7 years, 53.0% male), 11.3% had sarcopenia, 27.0% were malnourished, and 40.0% died. After adjusting for clinical variables, Cox regression analysis showed that only Malnutrition (HR: 1.96; CI: 1.35-2.84; <em>P</em> ≤ .001) significantly impacted survival. In CRC patients, Malnutrition outweighs sarcopenia and adiposity as a predictor of survival in colorectal cancer patients.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 45-54"},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variants in vitamin D metabolism-related genes are associated with vitamin D status and adiposity markers","authors":"Adriana Becerra‑Cervera ,&nbsp;Rogelio F. Jiménez-Ortega ,&nbsp;Diana I. Aparicio-Bautista ,&nbsp;Tania V. López-Pérez ,&nbsp;Nelly Patiño ,&nbsp;Manuel Castillejos-López ,&nbsp;Alberto Hidalgo‑Bravo ,&nbsp;Edgar Denova‑Gutiérrez ,&nbsp;Jorge Salmerón ,&nbsp;Berenice Rivera‑Paredez ,&nbsp;Rafael Velázquez‑Cruz","doi":"10.1016/j.nutres.2025.02.009","DOIUrl":"10.1016/j.nutres.2025.02.009","url":null,"abstract":"<div><div>Single nucleotide variants (SNVs) in vitamin D (VD) metabolism genes have been shown to be associated with serum 25(OH)D concentrations. Although these associations have been reported in other populations, they are less studied in Mexico, a country with high vitamin D deficiency (VDD) despite ample sun exposure. Therefore, we investigate the association between VD-metabolism related SNVs, serum 25(OH)D concentrations, and their impact on VDD and adiposity indicators. We hypothesized that SNVs are associated with serum 25(OH)D concentrations in the Mexican population. We included 1977 individuals (597 males and 1380 females) from the Health Worker Cohort Study. Nine genetic variants: rs10741657 (<em>CYP2R1</em>), rs6013897 (<em>CYP24A1</em>), rs10877012 (<em>CYP27B1</em>), rs10783219 and rs4516035 (<em>VDR</em>), rs4588 and rs7041 (<em>GC</em>), rs4944957 and rs3794060 (<em>NADSYN1</em>), in VD metabolism-related genes were genotyped. Linear and logistic regression models were used to assess the association of interest. In our study, 7 genetic variants were associated with serum 25(OH)D concentrations and VDD. A genetic risk score was created using variants rs6013897 (<em>CYP24A1</em>), rs4516035 (<em>VDR</em>), and rs4588 (<em>GC</em>), which were associated with lower serum 25(OH)D concentrations, higher VDD prevalence, and increased odds of VDD. A second GRS using all 9 variants showed weaker associations. Gene-gene interactions between rs3794060-rs4944957 (<em>NADSYN1</em>), and rs10877012(<em>CYP27B1</em>)-rs7041(<em>GC</em>), were associated with serum 25(OH)D concentrations and VDD, respectively. Additionally, SNV interactions with body mass index, waist circumference, and body fat distribution were identified. These findings suggest that SNVs influence serum 25(OH)D concentrations and adiposity indicators, with potential clinical implications for obesity management.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 105-119"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}