Nutrition Research最新文献

{"title":"The combined indicator of vitamin B12 status calculated using 3-parameters (3cB12) is negatively associated with mortality among US adults: NHANES 1999 to 2004","authors":"Yanmei Li,&nbsp;Huifen Wang,&nbsp;Shuo Chen,&nbsp;Qilu Wei,&nbsp;Yini Liu,&nbsp;Zhenmei Song,&nbsp;Shiyu Du","doi":"10.1016/j.nutres.2025.02.008","DOIUrl":"10.1016/j.nutres.2025.02.008","url":null,"abstract":"<div><div>The association between vitamin B₁₂ status and the risk of mortality is controversial. The combined indicator calculated using 3 traditional parameters (3cB₁₂) can be used to indicate vitamin B₁₂ status. We hypothesize that vitamin B₁₂ deficiency indicated by 3cB₁₂ may be related to high mortality risks. To evaluate the association between 3cB₁₂ and all-cause, cardiovascular disease (CVD) and cancer-related mortality, we used Cox proportional hazard models, cumulative Kaplan–Meier curves, and smooth curve fitting to assess data from NHANES 1999 to 2004. A total of 12,103 adults (20 years and older) were included in the analyses and 3595 participants were determined as deceased. The median follow-up duration was 202 months. In the fully adjusted model, all three mortality rates decreased along with the increase in 3cB₁₂ scores, with hazard ratio (HR) [95% confidence interval (CI)]: 0.81 (0.75, 0.87) for all-cause mortality, HR (95% CI): 0.83 (0.72, 0.95) for CVD mortality, and HR (95% CI): 0.79 (0.66, 0.96) for cancer-related mortality. When 3cB₁₂ was divided into two groups, individuals in the lower 3cB₁₂ group (3cB₁₂ &lt; −0.5) showed increased risks of all-cause mortality [HR (95% CI): 1.73 (1.48, 2.02)] and CVD mortality [HR (95% CI): 1.84 (1.31, 2.59)], as compared to the higher 3cB₁₂ group (3cB₁₂ ≥ −0.5). The smooth fitting curves represented a negative linear relationship between 3cB₁₂ and all three types of mortality (<em>P</em> for nonlinearity &gt;.05). In conclusion, the extrapolation of 3cB₁₂ from conventional metrics affords a novel perspective for evaluating B₁₂ nutritional status and mortality risk.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 53-63"},"PeriodicalIF":3.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial office and Board Members","authors":"","doi":"10.1016/S0271-5317(25)00037-5","DOIUrl":"10.1016/S0271-5317(25)00037-5","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages i-ii"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher dietary vegetable and fruit intake along with their biomarkers is inversely associated with all-cause mortality among cancer survivors","authors":"Mianmian Jiang,&nbsp;Caixia Zhang","doi":"10.1016/j.nutres.2025.02.001","DOIUrl":"10.1016/j.nutres.2025.02.001","url":null,"abstract":"<div><div>The association between dietary vegetable and fruit (VF) intake and survival outcomes among cancer survivors remains unclear, with limited research available on the association between VF-related biomarkers and mortality in this population. We hypothesized that there were inverse relationships between dietary VF intake, serum carotenoids, serum vitamin C, composite biomarker score and both all-cause and cancer-specific mortality among cancer survivors. This study analyzed cancer survivors from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2018 cycles for VF intake (n = 4326), and from NHANES III, 2003 to 2006, and 2017 to 2018 cycles for serum carotenoids (n = 2187), serum vitamin C (n = 2267), and composite biomarker score (n = 2131). Weighted multivariable Cox proportional hazards regression models were used to assess the associations between exposures and mortality, computing hazard ratio (HR) and 95% CI. Dietary VF intake was significantly associated with a lower risk of all-cause mortality (HR = 0.80, 95% CI: 0.67−0.96) over a median follow-up of 6.9 years. For serum biomarkers, higher concentration of total carotenoids (median follow-up: 10.0 years), vitamin C (median follow-up: 9.4 years) and higher composite biomarker score (median follow-up: 10.1 years) were associated with lower risks of all-cause mortality, with HRs (95% CIs) of 0.73 (0.58−0.92), 0.73 (0.56−0.95), and 0.73 (0.57−0.95), respectively. Additionally, only vitamin C was linked to cancer-specific mortality, with HRs (95% CIs) of 0.55 (0.37−0.81). Higher VF intake and their associated biomarkers are associated with a lower risk of all-cause mortality among U.S. cancer survivors.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 141-157"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"David Kritchevsky Graduate Student Award for Nutrition Research","authors":"","doi":"10.1016/S0271-5317(25)00038-7","DOIUrl":"10.1016/S0271-5317(25)00038-7","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Page iii"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bugs got milk? Exploring the potential of lactose as a prebiotic ingredient for the human gut microbiota of lactose-tolerant individuals","authors":"Rita de Cassia Pessotti ,&nbsp;Mathilde Guerville ,&nbsp;Laira Lorraine Agostinho ,&nbsp;Cristina Stewart Bittencourt Bogsan ,&nbsp;Mateus Kawata Salgaço ,&nbsp;Amandine Ligneul ,&nbsp;Miller Nunes de Freitas ,&nbsp;Cristiano Ruch Werneck Guimarães ,&nbsp;Katia Sivieri","doi":"10.1016/j.nutres.2025.02.006","DOIUrl":"10.1016/j.nutres.2025.02.006","url":null,"abstract":"<div><div>Milk consumption is important to help meet daily nutrient requirements. However, lactose—present in dairy products—has been associated with digestive discomfort in individuals who are lactose intolerant or have inadequate lactase activity. Yet, a new perspective on this dietary component has emerged: its potential as a prebiotic for the lactose-tolerant population. We hypothesized that ingestion of lactose may improve the microbial community structure and metabolism of the gut microbiota from healthy adults. First, we assessed the acute impact of lactose ingestion on the gut microbiota of adults using a short-duration <em>in vitro</em> batch colonic model. Subsequently, we employed a long-duration <em>in vitro</em> dynamic multivessel colonic model to evaluate the effects of lactose chronic ingestion. In both cases, a mixture of lactose/galactose/glucose was administered in a defined proportion to mimic lactose metabolism and galactose/glucose absorption in lactose-tolerant adults. The hypothesis was confirmed, as a modulatory prebiotic effect was revealed on the microbial community structure and metabolism of the microbiota upon treatments simulating the ingestion of three doses of lactose, equivalent to half a glass, one glass, and two glasses of cow's milk. The long-duration model confirmed this potential, increasing the relative abundance of the beneficial genera <em>Lactobacillus, Akkermansia</em>, and <em>Faecalibacterium</em>, while the usually detrimental genus <em>Clostridium</em> decreased. Additionally, the health-promoting microbial metabolites acetate, propionate, and lactate were increased. Therefore, lactose ingestion could positively modulate the gut microbiota in healthy lactose-tolerant adults, thereby promoting gut health and shedding light on the dietary benefits of consuming milk.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 64-80"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and inflammatory potential of diet is associated with risk of asthma-chronic obstructive pulmonary disease overlap: Findings from NHANES (2003-2018)","authors":"Yuhuan Wei ,&nbsp;Li Qin ,&nbsp;Xiaoling Wang ,&nbsp;Yuan Cui ,&nbsp;Yunhua Zhao ,&nbsp;Shaoye Huo ,&nbsp;Lihong Wang ,&nbsp;Teng Li ,&nbsp;Chunhai Shao","doi":"10.1016/j.nutres.2025.01.010","DOIUrl":"10.1016/j.nutres.2025.01.010","url":null,"abstract":"<div><div>Previous studies have explored the connection between the dietary inflammation index (DII) and asthma-COPD Overlap (ACO); however, the relationship between diet and the risk of ACO from an antioxidant perspective remains unexamined. We hypothesized that a proinflammatory diet may increase the risk of ACO by promoting inflammation, whereas an antioxidant diet may reduce the risk by mitigating inflammation. To test this hypothesis, we conducted a cross-sectional study utilizing data from the National Health and Nutrition Examination Survey (NHANES) in 2003-2018, including 23,050 participants. The study employed propensity score matching (PSM), logistic regression, restricted cubic splines (RCS), and mediation analysis. Pre-PSM and post-PSM RCS analyses indicated a positive correlation between DII and ACO, while the composite dietary antioxidant index (CDAI) demonstrated a negative association (<em>P-overall</em> &lt;0 .05). Pre-PSM and post-PSM logistic regression results showed that higher DII scores were associated with an increased risk of ACO, while higher CDAI scores correlated with a reduced risk of ACO (<em>P</em> &lt;0 .05). Mediation analysis further indicated that pro-inflammatory diets increased ACO risk through elevated levels of white blood cells (WBC), eosinophil counts (EC), systemic immune-inflammation index (SII), and system inflammation response index (SIRI) (<em>P</em> &lt; 0.05). In contrast, antioxidant diets reduced the risk of ACO events by decreasing the levels of these inflammatory markers (<em>P</em> &lt; 0.05). In conclusion, higher DII scores may increase the risk of ACO, while higher CDAI scores may decrease it. Both DII and CDAI mediate their effects through inflammatory markers, including WBC, EC, SII, and SIRI.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 128-140"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full-fat versus non-fat yogurt consumption improves glucose homeostasis and metabolic hormone regulation in individuals with prediabetes: A randomized-controlled trial","authors":"Victoria M. Taormina ,&nbsp;Simonne Eisenhardt ,&nbsp;Matthew P. Gilbert ,&nbsp;Matthew E. Poynter ,&nbsp;C. Lawrence Kien ,&nbsp;Jana Kraft","doi":"10.1016/j.nutres.2025.02.005","DOIUrl":"10.1016/j.nutres.2025.02.005","url":null,"abstract":"<div><div>Dietary guidance recommends consuming low- or non-fat dairy foods for metabolic health, yet observational research indicates full-fat yogurt intake may not detrimentally affect type 2 diabetes risk. Randomized-controlled trials are needed to further explore this relationship. Our aim was to evaluate the effect of substituting full-fat (3.25%) yogurt for non-fat yogurt on type 2 diabetes risk in individuals with prediabetes. We hypothesized beneficial effects on measures of glucose homeostasis, insulin sensitivity, and metabolic hormone response following short-term consumption of 3 full-fat yogurt servings daily. Thirteen individuals completed the 8-week randomized, double-masked crossover controlled-feeding trial comprised 2, 3-week experimental diet periods in which participants consumed 3 daily servings of full-fat or non-fat yogurt; a 1-week control preceded each diet period. Following each diet period, changes in whole-body glucose handling and metabolic hormone concentrations were measured using mixed meal and oral glucose tolerance tests. Our primary outcome measure was the blood glucose concentration at the 120-minute time point during the oral glucose tolerance test. Though differences in the primary outcome measure were not observed, the full-fat yogurt diet resulted in lower concentrations of blood fructosamine, a marker of average blood glucose concentrations over 2 to 3 weeks. Further, fasting glucagon-like peptide-1 and post-prandial glucose-dependent insulinotropic polypeptide concentrations were greater following the full-fat yogurt diet. Our preliminary results indicate that short-term consumption of full-fat relative to non-fat yogurt beneficially affected aspects of glucose homeostasis and metabolic hormone regulation in individuals with prediabetes, warranting further randomized-controlled research. This trial is registered at clinicaltrials.gov (NCT03577119).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 39-52"},"PeriodicalIF":3.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dairy consumption is associated with breast cancer risk: a comprehensive meta-analysis stratified by hormone receptor and menopausal status, and age","authors":"Seokyung An ,&nbsp;Madhawa Gunathilake ,&nbsp;Jeongseon Kim","doi":"10.1016/j.nutres.2025.02.003","DOIUrl":"10.1016/j.nutres.2025.02.003","url":null,"abstract":"<div><div>Breast cancer (BC) is a prevalent global health concern, with various risk factors contributing to its heterogeneity. This comprehensive meta-analysis aims to explore the association between dairy consumption and BC risk, stratified by hormone receptor, menopausal status, and age. To assess the association between dairy consumption and BC risk, a systematic literature review based on studies published until December 2024 retrieved from PubMed, SCOPUS, Web of Science, and Cochrane Library. Summary relative risks (RRs) with corresponding 95% confidence intervals (CIs) were calculated and then aggregated using random-effects models. Summary RR from 51 studies with 62,602 BC cases showed that overall dairy consumption is inversely associated with BC risk (RR = 0.91, 95% CI: 0.84-0.98, <em>I</em>² = 75%), particularly among individuals aged over 45 (RR = 0.81, 95% CI: 0.68-0.98, <em>I</em>² = 0%). Notably, higher intake of low-fat dairy products showed potential protective effects (RR = 0.91, 95% CI: 0.84-0.98, <em>I</em>² = 56%), especially in premenopausal women (skimmed milk, RR = 0.86, 95% CI: 0.76-0.97, <em>I</em>² = 0%). Fermented dairy products, including yogurt, exhibited a decreased BC risk, particularly in postmenopausal women (RR = 0.91, 95% CI: 0.87-0.96, <em>I</em>² = 0%). However, a positive association was observed between total milk intake and the risk of estrogen receptor-negative BC (RR = 1.31, 95% CI: 1.08-1.59, <em>I</em>² = 0%). This meta-analysis provides comprehensive insights into the association between specific dairy product consumption and BC risk. The findings highlight the protective impact of specific dairy products on different subtypes, offering valuable insights for BC prevention.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"138 ","pages":"Pages 68-75"},"PeriodicalIF":3.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yeast mannans promote laxation and specifically modulate microbiota composition in older adults: An open-label pilot study","authors":"Melissa L. Moreno ,&nbsp;Pieter Van den Abbeele ,&nbsp;Aurélien Baudot ,&nbsp;Thomas A. Tompkins ,&nbsp;Diana H. Taft ,&nbsp;Runzhe Yao ,&nbsp;Jeremie Auger ,&nbsp;James Colee ,&nbsp;Wendy J. Dahl","doi":"10.1016/j.nutres.2025.02.004","DOIUrl":"10.1016/j.nutres.2025.02.004","url":null,"abstract":"<div><div>Yeast mannans (YM) are potential prebiotics that may improve laxation. The aim was to evaluate the effects of YM on gastrointestinal symptoms, with a hypothesis of high tolerance. A secondary aim assessed stool frequency. Fecal microbiota composition (16S rRNA gene amplicon sequencing) and targeted urine metabolites (LC-MS/MS) were explored. An <em>ex vivo</em> simulation of digestion and fermentation (6 donors) compared YM to the reference prebiotic inulin followed by an open-label pilot study, with a 1-week baseline and 2-week intervention of 15 g/d of YM. <em>Ex vivo</em> findings showed increased <em>Bacteroides faecis, B. ovatus, Parabacteroides merdae, P. distasonis, Blautia faecis</em>, and <em>Bifidobacterium</em> spp. in response to YM. Participants (<em>n</em> = 20, 71.4 ± 11.0 y) reported no change with YM for burping, constipation, diarrhea, flatulence/gas, nausea, reflux/heartburn, or rumblings/noise, rated from 0 for none to 3 for severe symptoms. Cramping/pain marginally increased from baseline (0.02 ± 0.01) to intervention (0.05 ± 0.02; <em>P</em> = .046), as did distention/bloating (baseline, 0.07 ± 0.03; intervention week 2, 0.15 ± 0.05; <em>P</em> = .037). This high tolerability was explained by the <em>ex vivo</em> finding that YM induced less gas production than inulin (–45%). Stool frequency trended higher with YM (1.53 ± 0.15 stools/d) compared to baseline (1.35 ± 0.11) (<em>P</em> = .079); participants with ≤1 stools/d (<em>n</em> = 8) showed an increase (0.84 ± 0.14 to 1.19 ± 0.32; <em>P</em> = .016). <em>In vivo</em> compositional changes in fecal microbiota suggest increased <em>B. faecis, B. ovatus, P. merdae,</em> and <em>P. distasonis</em> levels in response to YM. Overall, YM elicited specific microbiota modulation with minimal gastrointestinal symptoms and the potential to increase stool frequency, supporting its prebiotic potential. This trial was registered at clinicaltrials.gov (NCT05939336).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 15-27"},"PeriodicalIF":3.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-processed food intake is associated with a displacement of the traditional diet of Costa Rican adolescents","authors":"Kenny Mendoza ,&nbsp;Rafael Monge-Rojas ,&nbsp;Rulamán Vargas-Quesada ,&nbsp;Josiemer Mattei","doi":"10.1016/j.nutres.2025.02.002","DOIUrl":"10.1016/j.nutres.2025.02.002","url":null,"abstract":"<div><div>Ultra-processed food (UPF) intake is high among adolescent populations worldwide. This study aimed to characterize the UPF intake and assess its contribution to the traditional diet of Costa Rican adolescents. Using cross-sectional data from 3-day food records obtained from 818 adolescents (13-18 years) from San José, Costa Rica, we calculated the daily % of total energy intake (TEI) from Nova-defined UPF, the Traditional Costa Rica Adolescents Diet Score (TCRAD; higher score reflecting higher traditional adherence), other nutrients, and fiber. The multivariable-adjusted mean UPF intakes were compared across participants’ characteristics, mealtime, and days of the week, and assessed for association with TCRAD (continuous score and by adherence categories) and dietary components. UPF intake represented 35.9% of the TEI and was higher on weekdays (<em>vs.</em> weekends), among female adolescents (vs males), urban areas (<em>vs.</em> rural), and higher socioeconomic status. UPF were consumed mostly as snacks (43.5%), in the morning: (58.5%) and afternoon (41.5%). Each 10-percentage-point increase in the total UPF energy contribution was associated with -0.44 (SE = 0.04; <em>P</em> &lt; .0001) lower TCRAD score. UPF was inversely associated with fiber and beneficial micronutrients, and directly associated with added sugars and <em>trans</em> fats. The multivariable-adjusted UPF intake was lower at moderate (38.5%, <em>P</em> &lt; .0001) and high (29.9%, <em>P</em> &lt; .0001) adherence to the TCRAD, compared with low adherence (43.9%). Our results support widespread trends of UPF displacing healthy diets. Strategies to reduce UPF consumption, especially during school hours, and encourage healthy traditional diets, are needed for Costa Rican adolescents.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"136 ","pages":"Pages 1-14"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}