Nutrition Research最新文献

{"title":"A low-dose prebiotic fiber supplement reduces lipopolysaccharide-binding protein concentrations in a subgroup of young, healthy adults consuming low-fiber diets","authors":"Eduardo Z. Romo,&nbsp;Brian V. Hong,&nbsp;Joanne K. Agus,&nbsp;Yanshan Jin,&nbsp;Jea Woo Kang,&nbsp;Angela M. Zivkovic","doi":"10.1016/j.nutres.2024.11.013","DOIUrl":"10.1016/j.nutres.2024.11.013","url":null,"abstract":"<div><div>Although the beneficial effects of fiber supplementation on overall health and the gut microbiome are well-known, it is not clear whether fiber supplementation can also alter the concentrations of lipopolysaccharide-binding protein (LBP), a marker of intestinal permeability. A secondary analysis of a previously conducted study was performed. In the randomized-order, placebo-controlled, double-blinded, cross-over study 20 healthy, young participants consuming a low-fiber diet at baseline were administered a daily dose of 12 g of prebiotic fiber compared with a placebo over a period of 4 weeks with a 4-week washout between arms. In this secondary analysis, we hypothesized that the fiber supplement would reduce LBP concentration. We further hypothesized that lecithin cholesterol acyltransferase activity, a measure of high-density lipoprotein functional capacity, would be altered. Fiber supplementation did not significantly alter LBP concentration or lecithin cholesterol acyltransferase activity in the overall cohort. However, in a subgroup of individuals with elevated baseline LBP concentrations, fiber supplementation significantly reduced LBP from 9.27 ± 3.52 to 7.02 ± 2.32 µg/mL (<em>P</em> = .003). Exploratory analyses found positive correlations between microbial genes involved in lipopolysaccharide synthesis and conversely negative correlations with genes involved in antibiotic synthesis and LBP. Positive correlations between LBP and multiple sulfated molecules including sulfated bile acids and perfluorooctanesulfonate, and ibuprofen metabolites were also found. These findings highlight multiple environmental and lifestyle factors such as exposure to industrial chemicals and medication intake, in addition to diet, which may influence the association between the gut microbiome and gut barrier function.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"133 ","pages":"Pages 138-147"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating reliability, quality, and readability of ChatGPT's nutritional recommendations for women with polycystic ovary syndrome","authors":"Elif Ulug ,&nbsp;Irmak Gunesli ,&nbsp;Aylin Acıkgoz Pinar ,&nbsp;Bulent Okan Yildiz","doi":"10.1016/j.nutres.2024.11.005","DOIUrl":"10.1016/j.nutres.2024.11.005","url":null,"abstract":"<div><div>Patients with polycystic ovary syndrome (PCOS) often have many questions about nutrition and turn to chatbots such as Chat Generative Pretrained Transformer (ChatGPT) for advice. This study aims to evaluate the reliability, quality, and readability of ChatGPT's responses to nutrition-related questions asked by women with PCOS. Frequently asked nutrition-related questions from women with PCOS were reviewed in both Turkish and English. The reliability and quality of the answers were independently evaluated by 2 authors and a panel of 10 expert dietitians, using modified DISCERN and global quality score. Additionally, the readability of the answers was calculated using frequently used readability formulas. The mean modified DISCERN scores for English and Turkish versions were 27.6±0.87 and 27.2±0.87, respectively, indicating a fair level of reliability in the responses (16–31 points or 40%–79%). According to the global quality score, 100% of the responses in English and 90.9% of the responses in Turkish were rated as high quality. The readability of responses was classified as “difficult to read” with the readership levels assessed at college level and above for both English and Turkish. The correlation and regression analyses indicated no relationship between reliability, quality, and readability in English. However, a significant relationship was observed between quality and readability indexes in Turkish (<em>P</em> &lt; .05). Our results suggest that ChatGPT's responses to nutrition-related questions about PCOS are generally of high quality, but improvements in both reliability and readability are still necessary. Although ChatGPT can offer general information and guidance on nutrition for PCOS, it should not be considered a substitute for personalized medical advice from health care professionals for effective management of the syndrome.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"133 ","pages":"Pages 46-53"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"David Kritchevsky Graduate Student Award for Nutrition Research","authors":"","doi":"10.1016/S0271-5317(25)00011-9","DOIUrl":"10.1016/S0271-5317(25)00011-9","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"133 ","pages":"Page iii"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Processed and ultra-processed foods are associated with depression and anxiety symptoms in a cross-sectional sample of urban Lebanese adults","authors":"Lamia Ghernati ,&nbsp;Hani Tamim ,&nbsp;Fatima Al Zahraa Chokor ,&nbsp;Mandy Taktouk ,&nbsp;Batoul Assi ,&nbsp;Lara Nasreddine ,&nbsp;Martine Elbejjani","doi":"10.1016/j.nutres.2024.11.011","DOIUrl":"10.1016/j.nutres.2024.11.011","url":null,"abstract":"<div><div>While low dietary quality has been linked to poor mental health, evidence on more direct relations of specific dietary quality indicators, namely degrees of food processing, with mental health disorders remains limited. This study aims to investigate the association between food groups’ intakes, defined based on their degree of food processing, with depression and anxiety symptoms in a sample of Lebanese adults. We hypothesized that higher intakes of ultra-processed foods (UPF) will be related to higher risk of depression and anxiety while an opposite association will be observed for unprocessed or minimally processed foods (MPF). Data come from a Lebanese cross-sectional study (n = 188 adults). The NOVA classification was adopted for evaluating the intakes of the 4 food groups: unprocessed or minimally processed foods (MPF); processed culinary ingredients (PCI); processed foods (PF) and ultra-processed foods (UPF). Associations between food group intakes in quartiles with depression and anxiety symptoms were analyzed using multivariable regression analyses adjusted for several confounders. Median energy intake was 2481.65 (2617.2) kcal/d, with 36.12% of Total Energy Intakes coming from MPF, 29.71% from PF, 25.25% from UPF, and 5.75% from PCI. Among participants, 33% and 27.7% had elevated depression and anxiety symptoms, respectively. Higher PF intake was associated with significantly lower odds of both depression and anxiety symptoms while a higher UPF intake was associated with higher odds of depression. Results confirm the hypothesized links between UPF and adverse mental health outcomes and highlight the need for further studies on PF intakes and mental health given the culture-specific nature of foods constituting this group.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"133 ","pages":"Pages 172-189"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderate-to-vigorous physical activity modulates the association between serum 25-hydroxyvitamin D and bone stiffness in European children and adolescents","authors":"Lan Cheng ,&nbsp;Hermann Pohlabeln ,&nbsp;Maike Wolters ,&nbsp;Wolfgang Ahrens ,&nbsp;Alfonso Siani ,&nbsp;Toomas Veidebaum ,&nbsp;Michael Tornaritis ,&nbsp;Dénes Molnár ,&nbsp;Gabriele Eiben ,&nbsp;Monica Hunsberger ,&nbsp;Stefaan De Henauw ,&nbsp;Luis A Moreno ,&nbsp;Antje Hebestreit ,&nbsp;the IDEFICS and I.Family consortia","doi":"10.1016/j.nutres.2024.10.003","DOIUrl":"10.1016/j.nutres.2024.10.003","url":null,"abstract":"<div><div>It remains unclear how serum 25-hydroxyvitamin D (25(OH)D) concentrations relate to childhood bone health. We hypothesized that 25(OH)D was inversely associated with bone turnover biomarkers and positively associated with bone stiffness. Cross-sectional analyses were performed using data from participants (2-15-year-old, 51% boys) from the <em>Identification and Prevention of Dietary- and Lifestyle-induced Health Effects in Children and Infants Study</em> (IDEFICS)/I.Family cohort, comprising 3,638 serum 25(OH)D measurements collected in 2007-2008 and 2012-2013 across eight European countries. A biomarker of bone formation (serum osteocalcin), a biomarker of bone resorption (serum C-terminal telopeptides of type I collagen [CTx]), and stiffness index measured using calcaneal quantitative ultrasound were considered outcomes. Linear mixed-effects models were used to adjust for confounders (i.e., age, sex, parental education, time spent in sports club, dairy products consumption, sedentary behavior, height and weight <em>z</em>-scores), the cluster effect of country and repeated measurements. Interactions of calcium intake, moderate-to-vigorous physical activity (MVPA) and weight status with 25(OH)D on outcomes were tested. Only 1 in 3 participants reached the sufficient 25(OH) D concentration of 20 ng/mL. Sufficient 25(OH)D was associated with higher stiffness index if participants had MVPA ≥60 min/day (β = 12.14, <em>P</em> &lt; .05). Moreover, 25(OH)D was inversely associated with CTx (β = –7.09, <em>P</em> &lt; .05); this association was positive but not statistically significant among primary school children living with overweight/obesity. No interaction was observed for calcium intake. In conclusion, serum 25(OH)D and CTx were inversely associated. MVPA interacted with the positive association between 25(OH)D and bone stiffness, highlighting the importance of promoting MVPA guidelines in future vitamin D and bone health interventions.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"133 ","pages":"Pages 64-77"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compared to dual-energy X-ray absorptiometry, bioelectrical impedance effectively monitors longitudinal changes in body composition in children and adolescents with obesity during a lifestyle intervention","authors":"Camilla Raaby Benjaminsen ,&nbsp;Rasmus Møller Jørgensen ,&nbsp;Esben Thyssen Vestergaard ,&nbsp;Jens Meldgaard Bruun","doi":"10.1016/j.nutres.2024.11.003","DOIUrl":"10.1016/j.nutres.2024.11.003","url":null,"abstract":"<div><div>Accurate and efficient body composition assessment is essential for diagnosing and monitoring childhood obesity in clinical and research settings. This study evaluated the agreement between bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) in assessing body composition and its changes during a long-term lifestyle intervention in children and adolescents with obesity. We hypothesized that BIA is comparable to DXA in tracking longitudinal changes in body composition in this population. The study included 92 children and adolescents 5 to 17 years of age (mean 10.5 ± 2.9 years) classified as obese at the time of measurement (body mass index-standard deviation score ≥ 2 SD). From January 1, 2014, to December 31, 2017, they participated in a lifestyle intervention at Randers Regional Hospital. Body composition was assessed using BIA and DXA at baseline and follow-up (mean 20.5 ± 9.3 months). Bland–Altman plots, correlation- and concordance analyses were used to evaluate the agreement between methods. Bland–Altman plots demonstrated wide limits of agreement without significant bias for longitudinal changes in fat mass (FM), FM%, fat-free mass (FFM), and FFM% (0.39 kg (CI –0.14, 0.93), –0.39% (CI –1.06, 0.26), –0.21 kg (CI –0.73, 0.31), and 0.39% (CI –0.27, 1.05), respectively). Correlations between methods for changes in FM, FM%, FFM, and FFM% were 0.93, 0.83, 0.88, and 0.83, respectively. In cross-sectional assessments, BIA underestimated FM and FM% and overestimated FFM and FFM% compared to DXA. Conclusively, BIA effectively monitors longitudinal changes in body composition at a group level in a pediatric population with obesity. However, caution is needed for individual assessments.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"133 ","pages":"Pages 1-12"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NTR Reviewer Thank You","authors":"","doi":"10.1016/S0271-5317(25)00009-0","DOIUrl":"10.1016/S0271-5317(25)00009-0","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"133 ","pages":"Pages iv-vi"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suboptimal vitamin D status and overweight/obesity are associated with gut integrity and inflammation in minority children and adolescents: A cross-sectional analysis from the MetA-bone trial","authors":"Jacqueline Hernandez,&nbsp;Jose Bastida Rodriguez,&nbsp;Maria Angelica Trak-Fellermeier,&nbsp;Rodolfo Galvan,&nbsp;Alison Macchi,&nbsp;Preciosa Martinez-Motta,&nbsp;Cristina Palacios","doi":"10.1016/j.nutres.2024.11.006","DOIUrl":"10.1016/j.nutres.2024.11.006","url":null,"abstract":"<div><div>Preserving gut integrity is essential to preventing the development of chronic diseases. Several factors are associated with gut integrity and inflammation in adults. However, there is limited evidence in healthy children. This study evaluated the factors associated with gut integrity and inflammation in healthy children participating in the MetA-Bone trial. We hypothesized that age, sex, race/ethnicity, diet, vitamin D, and body composition will be associated with gut integrity and inflammation. Socio-demographic variables were collected with a questionnaire. Measures included markers of gut integrity (Intestinal Fatty Acid Binding Protein; I-FABP), and inflammation (IL-17 and calprotectin) determined by ELISA in 24-h urine and serum; serum 25(OH)D concentration (commercial lab), BMI percentile, and diet (24-h recalls). Analyses included descriptive statistics, chi-square, and adjusted logistic regressions. Participants (n=138) median age was 12.4 (11.1-13.3), 53.6% were male, 9.4% were Black/African American, and 71.1% were Hispanic/Latino. Children with suboptimal vitamin D were 3.35 times more likely to present gut integrity damage (elevated I-FABP) than those with optimal status (<em>P</em> = .005). Overweight/obesity and fructose intake were associated with inflammation (elevated calprotectin) (<em>P</em> &lt; .05). Those with lower gut integrity damage had lower odds of having higher inflammation (<em>P</em> = .021). Other factors were not associated with inflammation. Suboptimal vitamin D status, overweight/obesity and inflammation may compromise the gut integrity in healthy children, suggesting an impairment on the intestinal barrier repair system. More research with a longitudinal design is needed to gain a deeper understanding of the role of additional factors linked to gut integrity and inflammation in healthy children.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"133 ","pages":"Pages 13-21"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression is associated with lower diet quality in both pre- and post-menopausal U.S. women: NHANES 2007-2018","authors":"Bridget A. Owens ,&nbsp;Alexandra B. Larcom ,&nbsp;Maya Vadiveloo","doi":"10.1016/j.nutres.2024.11.007","DOIUrl":"10.1016/j.nutres.2024.11.007","url":null,"abstract":"<div><div>Depression has been associated with adverse diet-related outcomes and women are particularly vulnerable to depression around the menopause transition. Therefore, we hypothesized that depression and postmenopausal status would be associated with lower diet quality, and that depression would be associated with lower diet quality in both pre- and post-menopausal women, but that the association would be stronger in postmenopausal women. Data from 5,634 nonpregnant women age &gt; 20 years from the National Health and Nutrition Examination Survey from 2007-2018 were analyzed. Diet quality was determined using the Healthy Eating Index 2020 (HEI-2020). Multivariable linear regression was used to examine the association between depression and diet quality, menopause and diet quality, and depression and diet quality by menopause status, adjusting for covariates. Mean age was 49.6 ± 0.4; 12% of women were classified as depressed and 46% as postmenopausal. In multivariable-adjusted models, depression was associated with lower HEI-2020 total (β = -3.33, <em>P</em> &lt; .001) and adequacy scores (β = -2.41, <em>P</em> &lt; .0001) but not moderation scores. Postmenopausal women had higher HEI-2020 total (β = 2.48, <em>P</em> &lt; .0001), moderation (Β = 1.19, <em>P</em> &lt; .0001), and adequacy (β = 0.81, <em>P</em> &lt; .01) scores than premenopausal women. In a nationally representative sample of U.S. women, depression was associated with lower diet quality across all women and in both pre- and post-menopause. Further research is needed to better understand the relationship between depression and diet quality throughout the menopause transition, when hormonal changes could make women more vulnerable to depression.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"133 ","pages":"Pages 35-45"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of fish intake on dyslipidemia likelihood by cooking method: Results from the Hellenic National Nutrition and Health Survey","authors":"Sotiria Kotopoulou ,&nbsp;Antonis Zampelas ,&nbsp;Emmanuella Magriplis","doi":"10.1016/j.nutres.2024.11.004","DOIUrl":"10.1016/j.nutres.2024.11.004","url":null,"abstract":"<div><div>Nutritional guidelines emphasize fish consumption due to its reported health benefits, although the potential differential effects based on the cooking method used have not been well investigated. Hypothesizing that fish consumption and preparation method may affect lipid concentrations, we aimed to examine fish consumption per dietary guidelines adherence and assess the association between fish intake and dyslipidemia likelihood in Greek adults. Fish consumers were identified using 24-hour recalls and a validated Food Propensity Questionnaire from 3742 adults (aged ≥19 years, 59.3% females). Dyslipidemia likelihood was estimated using adjusted logistic regression models, for total intake, and for nonfried and fried-fish consumers. Prevalence of fish consumers was 17.9% (<em>n</em> = 668), and 20.8% (<em>n</em> = 139) reported frying it. Based on the Food Propensity Questionnaire, and in combination with the two 24-hour recalls, 67.7% of fish consumers and 66.9% of fried-fish consumers consumed it less than once per month, resulting in a median weekly intake of 23.7 (13.7, 56.7) g and 26.2 (15.0, 70.4) g, respectively. For each gram of total fish intake, the odds of dyslipidemia decreased by 3% but consuming fried fish 1 to 3 times /month compared to &lt;1 per month, increased the odds by 3.6% (odds ratio, 3.6; 95% confidence interval, 1.19–10.70). Greek adults do not adhere to the dietary guidelines for fish consumption in terms of weekly intake and a large proportion consume it fried. Both factors may lead to a further increased likelihood of dyslipidemia and not to a protective effect. Public health educational awareness programs are required to increase the frequency of fish consumption, with emphasis given on cooking methods.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"133 ","pages":"Pages 22-34"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}