Nutrition Research最新文献

{"title":"High prevalence of xerophthalmia linked to socio-demographic and nutritional factors among vitamin A-deficient rural primary schoolchildren in Malaysia","authors":"Katherine Boon Hwei Seng ,&nbsp;Pei Yee Tan ,&nbsp;Chuan Chun Lim ,&nbsp;Radhika Loganathan ,&nbsp;Yvonne Ai-Lian Lim ,&nbsp;Kim-Tiu Teng ,&nbsp;Kanga Rani Selvaduray ,&nbsp;Syahirah Nadiah Mohd Johari ,&nbsp;Norlina Mohd Ramli","doi":"10.1016/j.nutres.2024.07.003","DOIUrl":"10.1016/j.nutres.2024.07.003","url":null,"abstract":"<div><div>Vitamin A deficiency (VAD) remains a major health issue in developing nations, contributing to preventable childhood blindness. However, there is lack of recent data on xerophthalmia, especially among school-aged children in Malaysia. We hypothesized that xerophthalmia persists among rural schoolchildren in Malaysia and potentially associated with socio-demographic status and malnutrition. We conducted a cross-sectional study on 596 schoolchildren (8-12 years) from ten rural primary schools located in five states across Malaysia. Children meeting the criteria for xerophthalmia assessment included those diagnosed with vitamin A deficiency (VAD) (plasma retinol &lt; 0.70 µmol/L) and marginal VAD (plasma retinol 0.70 to &lt; 1.05 µmol/L). The overall prevalence of xerophthalmia was 48.8%, with the most common ocular sign being conjunctival xerosis (38.9%). The occurrence of xerophthalmia was negatively associated with retinol-binding protein 4 (RPB4) (<em>P</em>=0.003), alpha-carotene (<em>P</em>=0.04), hemoglobin (<em>P</em>=0.004), weight (<em>P</em>=0.02), body mass index (BMI) (<em>P</em>=0.04) and WAZ (weight-for-age z-score) (<em>P</em>=0.04) status. Based on multivariate logistic regression analysis, a higher risk of xerophthalmia was observed in boys (Adjusted odd ratio [AOR]: 1.7, 95% confidence interval [CI]: 1.2-2.5) and Orang Asli (OA, indigenous) schoolchildren (AOR: 2.0, 95% CI: 1.3-3.0), while schoolchildren with overweight/obesity status (AOR: 0.5, 95% CI: 0.3-0.8) were associated with a reduced risk of xerophthalmia. The present study unveils a high prevalence of xerophthalmia among vitamin A-deficient primary schoolchildren in rural areas of Malaysia, especially among the indigenous community. The identified socio-demographic and nutritional factors associated to xerophthalmia would facilitate the implementation of more targeted interventions in addressing these issues.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"131 ","pages":"Pages 14-26"},"PeriodicalIF":3.4,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141785703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intact fruit intake is nonlinear inversely associated with visceral adipose tissue area in U.S. adults: a cross-sectional study","authors":"Xi Gu ,&nbsp;Ping Gao ,&nbsp;Ying Shen ,&nbsp;Leiqun Lu","doi":"10.1016/j.nutres.2024.07.001","DOIUrl":"10.1016/j.nutres.2024.07.001","url":null,"abstract":"<div><p>Excess visceral adipose tissue (VAT) plays a crucial role in leading to obesity-related diseases. However, the association between fruit intake (excluding fruit juice) and VAT is not well-known. We aim to further explore this association in a large population. We hypothesized that higher intact fruit intake would be inversely associated with VAT. A total of 9582 adult participants from the National Health and Nutrition Examination Survey and the Food Patterns Equivalents Database 2011-2018 were included. Weighted linear regression models were utilized to evaluate the association between intact fruit intake (from two 24-hour dietary recalls) and VAT area (measured by dual-energy X-ray absorptiometry). Subgroup analysis was conducted to test the robustness of the results. Restricted cubic spline analysis was performed to find the nonlinear association. The median of intact fruit intake was 0.32 cup-equivalent (eq)/d, and the mean of VAT was 104.87 ± 1.23 cm². Intact fruit intake (increased by 1 cup-eq/d) demonstrated an inverse association with VAT area across three adjusted models, with <em>β</em>(95% confidence interval) values of –7(–8.49, –5.51), –6(–7.50, –4.51), and –3.02(–4.11, –1.94) in model 1, model 2, and model 3, respectively. Subgroup analysis revealed no interactions were found among age, sex, ethnicity, body mass index, and physical activity subgroups. Restricted cubic spline revealed the inverse association was more significant when intact fruit intake was less than 1.7 cups-eq/d. These findings suggest that increasing intact fruit consumption could be an effective public health strategy to mitigate VAT accumulation and associated health risks, advancing our understanding of dietary impacts on adiposity.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"129 ","pages":"Pages 28-37"},"PeriodicalIF":3.4,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141697524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current understanding of free fatty acids and their receptors in colorectal cancer treatment","authors":"Agata Binienda,&nbsp;Jakub Fichna","doi":"10.1016/j.nutres.2024.05.007","DOIUrl":"10.1016/j.nutres.2024.05.007","url":null,"abstract":"<div><p>Colorectal cancer (CRC) is one of the leading causes of cancer-related death. Currently, dietary factors are being emphasized in the pathogenesis of CRC. There is strong evidence that fatty acids (FAs) and free FA receptors (FFARs) are involved in CRC. This comprehensive review discusses the role of FAs and their receptors in CRC pathophysiology, development, and treatment. In particular, butyrate and n-3 polyunsaturated fatty acids have been found to exert anticancer properties by, among others, inhibiting proliferation and metastasis and inducing apoptosis in tumor cells. Consequently, they are used in conjunction with conventional therapies. Furthermore, <em>FFAR</em> gene expression is down-regulated in CRC, suggesting their suppressive character. Recent studies showed that the FFAR4 agonist, GW9508, can inhibit tumor growth. In conclusion, natural as well as synthetic FFAR ligands are considered promising candidates for CRC therapy.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"127 ","pages":"Pages 133-143"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0271531724000757/pdfft?md5=48796a3662ee199e27dbe148e3f50027&pid=1-s2.0-S0271531724000757-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141275035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary vitamin D3 supplementation enhances splenic NK cell activity in healthy and diabetic male mice","authors":"Minha Oh ,&nbsp;Sohee Jung ,&nbsp;Yoon-ah Kim ,&nbsp;Ga Young Lee ,&nbsp;Sung Nim Han","doi":"10.1016/j.nutres.2024.06.004","DOIUrl":"10.1016/j.nutres.2024.06.004","url":null,"abstract":"<div><p>Type 2 diabetes mellitus negatively affects the immune system, resulting in reduced natural killer (NK) cell activity. Vitamin D has been shown to regulate innate and adaptive immune cells. However, the effects of vitamin D on NK cells remain inconclusive, especially in the context of diabetes. We hypothesized that dietary vitamin D₃ supplementation can enhance NK cell activity in diabetic mice. Therefore, we investigated the effects of dietary vitamin D₃ on NK cell activity in control and diabetic mice and explored the mechanisms of NK cell activity modulation by vitamin D₃. Control (CON) and diabetic mice (db/db) were randomly divided into 2 groups, then fed either a control diet (948 IU vitamin D₃/kg diet, vDC) or a diet supplemented with vitamin D₃ (9,477 IU vitamin D₃/kg diet, vDS) for 8 weeks. Diabetic mice exhibited lower NK cell activity than control mice. The vDS group had significantly higher NK cell activity than the vDC group in both control and diabetic mice. The vDS group had a higher percentage of CD11b single-positive NK cells than the vDC group (CON-vDS 34%; db/db-vDS 30%; CON-vDC 27%; db/db-vDC 22%). The intracellular expression of splenic TGF-β was significantly higher in the db/db group than in the CON group. Overall, vDS group had higher <em>Bcl2</em> and <em>Tbx21</em> mRNA expressions than the vDC group. In conclusion, the present study shows that NK cell activity is impaired under diabetic conditions, possibly due to the reduced percentage of mature NK cells. Moreover, NK activity is enhanced by dietary supplementation in both control and diabetic mice that may be associated with changes in the proportion of mature NK cells.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"127 ","pages":"Pages 144-155"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141391059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"David Kritchevsky Graduate Student Award for Nutrition Research","authors":"","doi":"10.1016/S0271-5317(24)00095-2","DOIUrl":"10.1016/S0271-5317(24)00095-2","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"127 ","pages":"Page iii"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0271531724000952/pdfft?md5=de4c3eeb253df3f55e2d723912e50701&pid=1-s2.0-S0271531724000952-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial office and Board Members","authors":"","doi":"10.1016/S0271-5317(24)00094-0","DOIUrl":"10.1016/S0271-5317(24)00094-0","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"127 ","pages":"Pages i-ii"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0271531724000940/pdfft?md5=a5514f0da90cba454aa2d29d3ca08331&pid=1-s2.0-S0271531724000940-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suboptimal diet quality is associated with the incidence of type 2 diabetes mellitus in middle-aged and older populations in China: evidence from a population-based cross-sectional study","authors":"Xiaojun Ma ,&nbsp;Pengfei Li ,&nbsp;Yu Liu ,&nbsp;Lu Liu ,&nbsp;Jingjing Xu ,&nbsp;Xixiang Wang ,&nbsp;Shaobo Zhou ,&nbsp;Xiuwen Ren ,&nbsp;Ying Wang ,&nbsp;Linhong Yuan","doi":"10.1016/j.nutres.2024.05.008","DOIUrl":"10.1016/j.nutres.2024.05.008","url":null,"abstract":"<div><p>The association between dietary quality and type 2 diabetes mellitus (T2DM) based on the Chinese Dietary Balance Index (DBI-16) is seldom reported. We hypothesized that poor dietary quality might increase the risk of T2DM in the middle-aged and older populations. A total of 1816 individuals (≥50 years) were included in the study. Demographic characteristics and dietary intake data were collected. Logistic regression and restricted cubic spline (RCS) analyses were conducted to explore the association between DBI-16 indexes and the risk of T2DM. The insufficient intake of vegetables and dairy might decrease the risk of T2DM (<em>OR_Vegetable</em> = 0.77, <em>95% CI</em> = 0.60-0.97; <em>OR_Dairy</em> = 0.58, <em>95% CI</em> = 0.35-0.96), but the individuals with insufficient intake of fruit were more likely to have a higher risk of T2DM (<em>OR_fruit</em> = 2.26, <em>95% CI</em> = 1.69-3.06). Compared with the subjects with the lowest quartile of Low Bound Score (LBS) or Diet Quality Distance (DQD), the individuals with Q2 and Q3 level of LBS (<em>OR_Q2</em> = 1.40, <em>95% CI</em> = 1.03-1.90, <em>P</em> = .033; <em>OR_Q3 =</em> 1.52, <em>95% CI</em> = 1.11-2.08, <em>P</em> &lt; .01) or DQD (<em>OR_Q2</em> = 1.45, <em>95% CI</em> = 1.06-1.99, <em>P</em> = .021; <em>OR_Q3 =</em> 1.64, <em>95% CI</em> = 1.20-2.24, <em>P</em> &lt; .01) showed increased risk of T2DM with a nonlinear association observed by RCS analysis. We concluded that imbalanced dietary intake, especially insufficient daily fruit intake, might predict an increased risk of T2DM in the middle-aged and elderly Chinese.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"127 ","pages":"Pages 123-132"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141275320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upcycled canola meal extract mitigates UVB-induced skin wrinkling by regulating photoaging-related biomarkers in hairless mice","authors":"Gi-Cheol Park ,&nbsp;Inil Lee ,&nbsp;Jisuk Yun ,&nbsp;Jae Sung Hwang ,&nbsp;Dae-Ok Kim","doi":"10.1016/j.nutres.2024.06.002","DOIUrl":"10.1016/j.nutres.2024.06.002","url":null,"abstract":"<div><p>Canola meal, a by-product of processing canola into oil, reportedly contains high amounts of phenolic compounds and proteins. However, as canola meal is primarily used as feed for livestock, advances in multiple research fields are required to broaden its potential applications. Photoaging is caused by continuous exposure to ultraviolet (UV) radiation from sunlight. UV radiation generates reactive oxygen species and destroys collagen in the skin, thickening the epidermis, reducing elasticity, and causing wrinkles. We hypothesized that canola meal extract (CME) can mitigate the damage to skin associated with wrinkles induced by exposure to UVB radiation. To evaluate the anti-wrinkle effect, we administered CME orally to 40 female Hos:HR-1 hairless mice divided into 5 groups: (1) control mice, (2) a UVB group, and (3−5) CME-treated groups (CME−250, 500, and 1000 mg/kg body weight/day, respectively). All groups except the controls were irradiated with UVB 3 times a week to create wrinkles due to photoaging. CME administration inhibited the increase of the number, mean length, and mean depth of wrinkles induced by UVB radiation as assessed using a skin replica. Histopathological image analysis revealed that CME administration resulted in a decrease in epidermal thickness and an increase in collagen content, while increasing catalase activity and hydroxyproline content in skin tissues. CME administration inhibited the phosphorylation of mitogen-activated protein kinase and decreased the production of collagenase and gelatinase. These results suggest that CME, an upcycled material, has the potential to develop into a healthful and functional food ingredient with anti-wrinkling effects.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"127 ","pages":"Pages 108-122"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141412030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eating behavior and dietary practices are associated with age, sex, body mass index, and body fat in individuals with type 2 diabetes and/or hypertension in Brazil","authors":"Antonio Orlando Farias Martins-Filho ,&nbsp;Lilia Schug de Moraes ,&nbsp;Cristina Bossle de Castilhos ,&nbsp;Leonardo Pozza Santos ,&nbsp;Ana Maria Pandolfo Feoli ,&nbsp;Fernanda Michielin Busnello ,&nbsp;Lúcia Rota Borges ,&nbsp;Anne y Castro Marques ,&nbsp;Renata Torres Abib Bertacco","doi":"10.1016/j.nutres.2024.06.007","DOIUrl":"10.1016/j.nutres.2024.06.007","url":null,"abstract":"<div><p>Type 2 diabetes (T2DM), hypertension, and obesity are major contributors to global mortality. This study aimed to evaluate eating behavior and dietary practices among individuals with T2DM and/or hypertension, examining their associations with sociodemographic and anthropometric characteristics. We hypothesized that these factors may contribute to body mass index (BMI) and body fat (BF) levels in these individuals. In a cross-sectional study, adults/older individuals diagnosed with T2DM and/or hypertension were included. Eating behavior was evaluated via <em>Three-factor Eating Questionnaire-R21</em>. Dietary practices were assessed using the <em>Dietary Guidelines for the Brazilian Population</em> (DGBP) questionnaire. Poisson regression examined associations between eating behaviors, dietary practices, and sociodemographic factors. Linear regressions were employed to analyze relationships between eating behavior, dietary practices, BMI, and BF. The study included 275 primarily female (70.5%) participants under 60 years old (54.2%). Male and older participants had a lower prevalence of high scores in the 'emotional eating' (EE; PR: 0.40 [0.25;0.63]) and 'uncontrolled eating' (UE; PR: 0.68 [0.50;0.92]) domains. In contrast, older patients had a higher prevalence of adherence to the DGBP recommendations (PR:1.53 [1.20;1.94]). A positive association was observed between high EE (β:3.71 [1.98;5.44]) and UE (β:2.85 [1.15;4.55]) scores and BMI, whereas higher dietary practice scores (β:-2.19 [-3.88;-0.50]) were negatively associated with BMI. High EE (β:2.20 [0.38;4.02]) and UE (β:1.92 [0.17;3.67]) scores were positively associated with BF regardless of the confounding factors included. Higher scores on the dietary practices were inversely associated with BF (β:-1.94 [-3.67;-0.21]). Understanding dietary behaviors and practices can facilitate a more comprehensive and effective treatment approach.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"128 ","pages":"Pages 50-59"},"PeriodicalIF":3.4,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D supplementation does not alter inflammatory markers in overweight and obese individuals: A systematic review and meta-analysis of randomized controlled trials","authors":"Henrique José Cavalcanti Bezerra Gouveia ,&nbsp;Márcia Maria da Silva ,&nbsp;Raul Manhães de Castro ,&nbsp;Luan Kelwyny Thaywã Marques da Silva ,&nbsp;Caio Matheus Santos da Silva Calado ,&nbsp;Eulália Rebeca da Silva Araújo ,&nbsp;Mariana de Almeida Cruz Silva ,&nbsp;Ana Elisa Toscano","doi":"10.1016/j.nutres.2024.06.005","DOIUrl":"10.1016/j.nutres.2024.06.005","url":null,"abstract":"<div><p>Chronic low-grade inflammation is a common feature of obesity and plays a crucial role in the progression of its complications. Vitamin D (VitD) plays an important role in modulating the immune response and regulating inflammation. Thus, this systematic review and meta-analysis aimed to evaluate the effects of isolated VitD supplementation on main inflammatory markers in overweight and obese individuals with no comorbidities and with VitD deficiency. We hypothesized that the increase in serum VitD concentrations after supplementation would significantly reduce the concentrations of inflammatory markers. The search was conducted in Medline/PubMed, SCOPUS, EMBASE, and Web of Science. Eleven randomized placebo-controlled studies were included in the final analysis, with a total of 504 participants and daily (1000-7000 international units) or bolus (100,000-200,000 international units) doses of VitD lasting from 2 to 26 weeks. The VitD supplementation did not influence C-reactive protein (mean difference [MD]: 0.01; 95% confidence interval [CI] –0.37, 0.39; <em>P</em> = .97), interleukin-6 (MD: –0.34; 95% CI –1.09, 0.42; <em>P</em> = .38), and tumor necrosis factor concentrations (MD: –0.02; 95% CI –0.23, 0.19; <em>P</em> = .85). In the analysis considering the studies with a significant increase in serum VitD concentrations, VitD supplementation also did not influence C-reactive protein (MD: –0.17; 95% CI –0.88, 0.54; <em>P</em> = .64), interleukin-6 (MD: –0.47; 95% CI –1.31, 0.37; <em>P</em> = .27), and tumor necrosis factor concentrations (MD: 0.01; 95% CI –1.34, 1.37; <em>P</em> = .98). This meta-analysis suggests that VitD supplementation does not significantly alter inflammatory markers in overweight and obese individuals.</p></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"128 ","pages":"Pages 24-37"},"PeriodicalIF":3.4,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}