Nutrition Research最新文献

{"title":"High prediagnostic dietary intake of vitamin B2 and vitamin B6 is associated with favorable prognosis of colorectal cancer among Chinese colorectal cancer patients","authors":"Xue Li ,&nbsp;Yujing Fang ,&nbsp;Ruolin Zhou ,&nbsp;Huan Xu ,&nbsp;Qingjian Ou ,&nbsp;Kexin Tu ,&nbsp;Yifan Wang ,&nbsp;Yuanyuan Chen ,&nbsp;Ruhua Zhou ,&nbsp;Caixia Zhang","doi":"10.1016/j.nutres.2024.12.006","DOIUrl":"10.1016/j.nutres.2024.12.006","url":null,"abstract":"<div><div>The potential impact of one-carbon metabolism (OCM)-related B vitamins (vitamin B₂, B₆, B₁₂, and folate) on colorectal cancer survival warrants investigation but research is sparse. This cohort study examined the association between the prediagnostic dietary intakes of OCM-related B vitamins and colorectal cancer survival. A total of 2799 colorectal cancer patients from the Guangdong Colorectal Cancer Cohort, enrolled at baseline in 2010, were followed for mortality outcomes through 2023. Dietary data were collected from patients using a food frequency questionnaire for the year prior to their diagnosis. Multivariable Cox proportional hazards regression models were applied to calculate hazard ratios (HR) and 95% confidence intervals (95% CI) to examine the association between OCM-related B vitamins and colorectal cancer survival. Restricted cubic spline analyses and stratified analysis were performed. During the follow-up period of approximately 60.33 months, 639 deaths were documented, of which 574 were colorectal cancer-specific deaths. Dietary vitamin B₂ and B₆ intake was significantly associated with survivals. The adjusted HRs in the highest versus the lowest quartile of vitamin B₂ intake were 0.77 (0.62-0.97) for overall survival and 0.71 (0.55-0.90) for colorectal cancer-specific survival, and vitamin B₆ intake were 0.79 (0.64-0.99) for overall survival and 0.75 (0.59-0.94) for colorectal cancer-specific survival. Nonlinear associations were observed between vitamin B₆ intake and both overall survival and colorectal cancer-specific survival. However, no significant association was found between vitamin B₁₂ or folate intake and survivals. These results suggest that high prediagnostic intake of vitamin B₂ and B₆ may be associated with improved survivals in colorectal cancer patients.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Pages 24-38"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low folate biomarker concentrations are associated with increase the risk and severity of periodontitis in adults: A cross–sectional study based on the National Health and Nutrition Examination Survey 2009–2014","authors":"Lai-Xi Zhao ,&nbsp;Cheng-Yang Hu ,&nbsp;Zhen-Hua Li ,&nbsp;Meng-Ci Shao ,&nbsp;Jia-Jia Liu ,&nbsp;Xiao-Rong Yan ,&nbsp;Jiong Li ,&nbsp;Wen-Hua Xu ,&nbsp;Xiu-Jun Zhang","doi":"10.1016/j.nutres.2024.12.003","DOIUrl":"10.1016/j.nutres.2024.12.003","url":null,"abstract":"<div><div>We sought to test the hypothesis that adult folate biomarker concentrations are negatively associated with the risk and severity of periodontitis. Data were pooled from the National Health and Nutrition Examination Survey (NHANES) 2009 to 2014. A total of 9252 dentate adult subjects aged 30 years and older who received a periodontal examination and had complete folate biomarker data were included in the analysis. Both logistic regression and linear regression models were built to analyze the associations between folate biomarker concentrations and periodontitis, followed by multisubgroup and sensitivity analyses. In addition, restricted cubic spline models were applied to observe the shape of the associations. We found negative associations between serum folate and periodontitis status (odds ratio [OR] = 0.775, 95% CI: 0.691-0.869), periodontal probing depth (PPD) (β = -0.048, 95% CI: -0.069 to -0.027), and clinical attachment loss (CAL) (β = -0.061, 95% CI: -0.098 to -0.025). A negative association was also found between red blood cell folate and periodontitis status (OR = 0.727, 95% CI: 0.613-0.861), PPD (β = -0.055, 95% CI: -0.086 to -0.024), and CAL (β = -0.084, 95% CI: -0.128 to -0.040). Subgroup and sensitivity analyses showed robust results. Restricted cubic spline models demonstrated significant linearity for associations. Folate biomarker concentrations were negatively associated with periodontitis in adults aged 30 years and older, indicating that folate may have a restrictive effect on the risk and severity of periodontitis. This finding may provide a clinical target for preventive and interventional measures to promote periodontal nutrition and health.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Pages 73-87"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variants in GHRL, RETN, and PLIN1 are associated with obesity, diabetes, and metabolic syndrome, and influence food consumption in adults with obesity","authors":"Marina Aparecida dos Santos ,&nbsp;Raul Hernandes Bortolin ,&nbsp;Alvaro Cerda ,&nbsp;Raquel de Oliveira ,&nbsp;Tamires Invencioni Moraes Stefani ,&nbsp;Cristina Moreno Fajardo ,&nbsp;Egídio Lima Dorea ,&nbsp;Márcia Martins Silveira Bernik ,&nbsp;Nágila Raquel Teixeira Damasceno ,&nbsp;Mario Hiroyuki Hirata ,&nbsp;Rosario Dominguez Crespo Hirata","doi":"10.1016/j.nutres.2024.12.005","DOIUrl":"10.1016/j.nutres.2024.12.005","url":null,"abstract":"<div><div>Genetic and environmental factors have important role in the pathogenesis of obesity and metabolic diseases. We hypothesized that genes involved in energy intake, cellular lipid metabolism and pro-inflammatory adipokines influence obesity-related metabolic disturbances and food intake. We explored the association of <em>GHRL</em> (rs26311G&gt;C and rs4684677A&gt;T), <em>PLIN1</em> (rs2289487G&gt;A and rs894160G&gt;A), <em>RETN</em> (rs3745367C&gt;T and rs7408174G&gt;A), and <em>NAMPT</em> (rs1319501T&gt;C) variants with obesity, metabolic and inflammatory markers, and food intake composition. Clinical, anthropometric, and laboratory data were obtained from 237 adults. Genomic DNA was extracted and genetic variants were analyzed by real-time polymerase chain reaction. Food intake was assessed in 81 subjects with obesity, who underwent a 9-week nutritional orientation program. Multivariate logistic regression analysis adjusted by covariates showed association of <em>GHRL</em> rs26311-G and rs4684677-A alleles with risk of type 2 diabetes (T2D) and/or metabolic syndrome (<em>P</em> &lt; .05), and <em>RETN</em> rs7408174-C allele with risk of T2D and obesity (<em>P</em> &lt; .05). Covariate-adjusted multivariate linear regression analysis showed association of <em>PLIN1</em> rs894160-G allele with increased waist-to-hip ratio (<em>P</em> = .003). The nutritional orientation program reduced carbohydrate and total fat intake, in subjects with obesity (<em>P</em> &lt; .05). Analysis of basal data revealed associations of <em>PLIN1</em> rs894160-G with increased body mass index, <em>PLIN1</em> rs2289487-A with reduced intake of total fat, monosaturated fatty acids and cholesterol, and <em>RETN</em> rs3745367-A with increased intake of protein and saturated fatty acids (<em>P</em> &lt; .05). <em>GHRL</em> rs26311-G was associated with increased postprogram protein intake (<em>P</em> = .044). In conclusion, variants in <em>GHRL, RETN,</em> and <em>PLIN1</em> are associated with obesity, T2D, metabolic syndrome, and increased waist-to-hip ratio, and influence food consumption in adults with obesity.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Pages 13-23"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"l-theanine: From tea leaf to trending supplement – does the science match the hype for brain health and relaxation?","authors":"Roderick Dashwood ,&nbsp;Francesco Visioli","doi":"10.1016/j.nutres.2024.12.008","DOIUrl":"10.1016/j.nutres.2024.12.008","url":null,"abstract":"<div><div><span>l</span>-Theanine is a unique non-protein amino acid found abundantly in tea leaves. Interest in its potential use as a dietary supplement has surged recently, especially claims related to promoting relaxation and cognitive enhancement. This review surveys the chemistry, metabolism, and purported biological activities of <span>l</span>-theanine. It is well absorbed from the intestine and can cross the blood-brain barrier. Some studies suggest <span>l</span>-theanine may increase alpha waves in the brain associated with relaxation and selective attention, reduce stress and anxiety, and improve sleep quality, though findings are often inconsistent. Potential neuroprotective and anti-seizure effects have also been reported in animal models. When combined with caffeine, <span>l</span>-theanine may improve cognitive performance, alertness and focus. However, the evidence supporting many health claims remains limited, especially the lack of rigorous human clinical trials. While <span>l</span>-theanine exhibits a good safety profile based on toxicology studies, caution is warranted regarding the purported health benefits, until stronger scientific substantiation emerges. Overall, the mechanisms of action and therapeutic potential of <span>l</span>-theanine require further investigation, given the current interest and increasing popularity of this nutraceutical supplement marketed for brain health and relaxation. In the absence of well-designed and carefully controlled human clinical trials, we would urge caution in the use of <span>l</span>-theanine supplements at pharmacologic doses by the wider population, and believe that the science does not yet match the hype behind this trending supplement for brain health and relaxation.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Pages 39-48"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cashew nut consumption reduces waist circumference and oxidative stress in adolescents with obesity: A randomized clinical trial","authors":"Luis Felipe Nunes de Oliveira ,&nbsp;Carla Soraya Costa Maia ,&nbsp;Maria Dinara de Araújo Nogueira ,&nbsp;Thaynan dos Santos Dias ,&nbsp;Matheus Aragão Dias Firmino ,&nbsp;Ana Paula de Melo Loureiro ,&nbsp;Elisabete Leide Marzola ,&nbsp;Paulo Iury Gomes Nunes ,&nbsp;Flávia Almeida Santos ,&nbsp;Walter Breno de Souza Freire ,&nbsp;Rodrigo Soares Fortunato ,&nbsp;Adriano César Carneiro Loureiro","doi":"10.1016/j.nutres.2024.12.009","DOIUrl":"10.1016/j.nutres.2024.12.009","url":null,"abstract":"<div><div>Previous evidence suggests that certain types of nuts, when included in a healthy diet pattern, may provide health benefits. Therefore, we hypothesize that the consumption of cashew nuts associated with a healthy diet may enhance antioxidant defenses and improve anthropometric and body composition parameters in individuals with obesity. We conducted a 12-week randomized clinical trial, divided into 4 sessions, involving adolescents randomly assigned to receive either 30 g of roasted cashew nuts together with nutrition education (cashew nut group-CNG) or only nutrition education (control group-CG). The total number of participants who started the study was 142, with 77 in the CNG and 65 in the CG. Data on anthropometry, body composition, and oxidative stress were collected at baseline (0-week) and endpoint (12-week). The main post-intervention findings in the CNG showed decreases in waist circumference (WC), thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) at 60 minutes in the CNG, while neck circumference (NC) increased. However, the CG showed an increase in TBARS and percentage of lean body mass (LBM), along with reduction in TAC at 60 minutes. After 12 weeks, the consumption of cashew nuts seemed to assist in WC reduction, even without a decrease in other anthropometric parameters, thereby decreasing the cardiometabolic risk. Furthermore, the consumption of cashew nuts demonstrated the ability to decrease overall oxidative damage as assessed by TBARS, a finding that reinforces the effects of this nut consumption against systemic oxidative stress associated with obesity.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"134 ","pages":"Pages 60-72"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study protocol, menu design, and rationale for a study testing the effects of a whole fruit-rich diet on glycemic control, liver fat, pancreatic fat, and cardiovascular health in adults with type 2 diabetes","authors":"Cody J. Hanick ,&nbsp;Kelly J. Berg ,&nbsp;W. Timothy Garvey ,&nbsp;Amy M. Goss ,&nbsp;Felicia L. Steger ,&nbsp;Joshua S. Richman ,&nbsp;Courtney M. Peterson","doi":"10.1016/j.nutres.2025.01.008","DOIUrl":"10.1016/j.nutres.2025.01.008","url":null,"abstract":"<div><div>Dietary interventions such as very-low-calorie diets and low-carbohydrate diets can improve glycemic control and even induce type 2 diabetes (T2D) remission. However, less is known about the effects of carbohydrate-rich whole foods, such as whole fruit, in people with T2D. Therefore, the aim of this pilot study is to investigate the effects of a whole fruit-rich diet on glycemic control, ectopic fat, and cardiovascular risk factors in adults with T2D. In this pilot study, sixteen adults aged 20 to 70 years with insulin-independent T2D for ≤6 years will complete a 12-week controlled-feeding intervention while maintaining their weight. During the ramp-up phase (weeks 1-4), participants progressively consume more whole fruit. During weeks 5 to 12, participants eat a fruit-rich Mediterranean diet providing 50% of calories as whole fruit (∼16.4 servings/day). All outcomes are measured at weeks 0, 4, and 12. The primary outcome is glycemic control, assessed hierarchically by whether participants achieve nondiabetic glucose concentrations without antihyperglycemic medications; the total dose of antihyperglycemic medications; mean glucose during a three-hour oral glucose tolerance test; and mean 24-hour glucose from continuous glucose monitoring. Secondary outcomes include intrahepatic lipid, pancreatic fat, blood pressure, heart rate, and serum lipids. We hypothesize that a fruit-rich diet will improve glycemic control, reduce the need for antihyperglycemic medications, decrease ectopic fat, and improve cardiovascular risk factors. This novel study will help determine the effects of a whole fruit-rich diet on glycemic control and liver fat and whether diabetes remission may be possible without losing weight. This study was registered at ClinicalTrials.gov (NCT03758742).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 82-100"},"PeriodicalIF":3.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary inflammatory index predicts cancer mortality in male patients but not female patients: Results from NHANES 1999 to 2014","authors":"Junyi Shen ,&nbsp;Anqi Lin ,&nbsp;Aimin Jiang ,&nbsp;Zhenyu Xie ,&nbsp;Quan Cheng ,&nbsp;Jing Zhang ,&nbsp;Jian Zhang ,&nbsp;Peng Luo","doi":"10.1016/j.nutres.2025.01.007","DOIUrl":"10.1016/j.nutres.2025.01.007","url":null,"abstract":"<div><div>This study explored sex differences between dietary inflammatory index (DII) and cancer prognosis and their mechanisms. We hypothesized that association between dietary inflammatory index and cancer prognosis differs by sex. The study included 2874 adults with cancer from the National Health and Nutrition Examination Survey covering 1999 to 2014. Mortality status was linked to National Death Index mortality data through 31 December 2019. Cox proportional hazards regression models were applied to calculate hazard risk and 95% confidence intervals (Cis) in male patients and female patients. Sex-specific cancer and nonsex-specific cancer subgroup analyses were performed, and the role of C-reactive protein in sex differences was analyzed. The Cancer Genome Atlas pan-cancer transcriptome data were combined to explore the biological mechanisms of the sex differences. Multivariate Cox regression showed higher DII in male patients correlated with increased all-cause mortality (hazard risk highest vs lowest quartile = 1.57 [95% confidence intervals 1.24-1.98]; <em>P</em> for trend &lt;.01), but not in female patients (<em>P</em> = .44). For sex-specific cancers, higher DII potentially correlated with increased mortality in prostate cancer (unadjusted <em>P</em> for trend = .04), but not in breast (<em>P</em> = .83), ovarian (<em>P</em> = .49), or cervical cancers (<em>P</em> = .91). In melanoma and colon cancer, higher DII correlated with increased mortality in male patients but not female patients. Serum C-reactive protein, interleukin-1 binding, interleukin-35 pathway, and programmed cell death protein 1 pathway may contribute to these sex differences. In conclusion, sex differences exist between DII and mortality risk in cancer patients.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 52-66"},"PeriodicalIF":3.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma metabolomics differentiating and predicting prognosis of coronary artery disease patients with distinct nutritional status","authors":"Chengyang Lai ,&nbsp;Yangchen Li ,&nbsp;Wenwei Luo ,&nbsp;Bin Zhang ,&nbsp;Chen Liu ,&nbsp;Liming Peng ,&nbsp;Hanping Li ,&nbsp;Ju-e Liu ,&nbsp;Xiao Xiao ,&nbsp;Shilong Zhong","doi":"10.1016/j.nutres.2025.01.004","DOIUrl":"10.1016/j.nutres.2025.01.004","url":null,"abstract":"<div><div>This study investigated the metabolic mechanisms underlying the association between malnutrition and poor prognosis in coronary artery disease (CAD). We hypothesized that specific metabolites associated with nutritional status impact all-cause mortality and Major Adverse Cardiovascular Events in CAD patients. To test this hypothesis, we evaluated the nutritional status of 5182 CAD patients from multiple centers using three nutritional risk screening tools and analyzed the impact on CAD outcomes with restricted cubic splines and Cox regression. Poor nutritional status was found to be linked to increased adverse outcomes. Further analysis using multiple linear regression and mediation analysis identified elevated concentrations of β-pseudouridine and dulcitol, and decreased concentrations of <span>l</span>-tryptophan and LPC (18:2/0:0), among other metabolites, as mediators of this association. Employing Least Absolute Shrinkage and Selection Operator for variable selection, we integrated these metabolites with clinical variables, which significantly improved the predictive accuracy for adverse outcomes. Our results highlight significant metabolic disparities in CAD patients based on nutritional status and provide novel insights into the role of nutrition-associated metabolites in CAD prognosis. These findings suggest that customized nutritional interventions targeting these metabolites could positively influence the progression of CAD.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"137 ","pages":"Pages 1-13"},"PeriodicalIF":3.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles","authors":"Hend Al-Jaber ,&nbsp;Rim Bacha ,&nbsp;Wafaa A. Al-Mannai ,&nbsp;Layla Al-Mansoori","doi":"10.1016/j.nutres.2025.01.006","DOIUrl":"10.1016/j.nutres.2025.01.006","url":null,"abstract":"<div><div>Breastfeeding is widely recognized for its essential nutritional benefits and broader biological impacts. Beyond providing infants with a balanced mix of vitamins, proteins, and fats critical for growth and development, breast milk contains bioactive extracellular vesicles (BMEVs). These membrane-bound particles, rich in proteins, lipids, and nucleic acids, play a pivotal role in immune modulation, intercellular communication, and the overall development of the infant's immune system. This review explores the emerging therapeutic potential of BMEVs, highlighting their capacity to modulate recipient cell functions, influence immune responses, and contribute to overall infant health. Preclinical evidence suggests that these vesicles can prevent and manage conditions such as necrotizing enterocolitis, allergies, and viral infections, which are common in early childhood. Furthermore, BMEVs offer promise as vehicles for targeted drug delivery, enhancing the efficacy of therapeutic interventions. Despite the growing body of evidence, challenges such as the need for standardized isolation methods, characterization techniques, and larger-scale clinical studies persist, hindering the translation of this research into clinical practice. This review addresses these challenges and discusses future directions, emphasizing the need for comprehensive mechanistic studies to fully realize the potential of BMEVs as novel therapeutic agents and biomarkers of health. Ultimately, these vesicles represent a promising frontier in maternal and child health, with potential applications extending far beyond traditional nutrition. By harnessing their unique properties, BMEVs could revolutionize infant care, offering new strategies for disease prevention and innovative therapeutic interventions that enhance infant health outcomes.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 42-51"},"PeriodicalIF":3.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the link between magnesium and diabetic neuropathy: Evidence from in vitro to clinical studies","authors":"Kannika Smithiseth ,&nbsp;Prangmalee Leurcharusmee ,&nbsp;Passakorn Sawaddiruk ,&nbsp;Nipon Chattipakorn ,&nbsp;Siriporn Chattipakorn","doi":"10.1016/j.nutres.2025.01.005","DOIUrl":"10.1016/j.nutres.2025.01.005","url":null,"abstract":"<div><div>Diabetic neuropathy (DN) is one of the major complications of diabetes and the most common cause of neuropathic pain. Although the underlying pathological mechanisms remain unclear, several studies have produced conflicting results regarding the link between magnesium (Mg) concentration and DN. This ambiguity raises questions about the potential benefits of Mg supplementation in individuals with DN. Therefore, this comprehensive review summarizes and discusses the evidence from clinical, <em>in vitro</em>, and <em>in vivo</em> studies on the association between Mg and DN. Several findings indicate that Mg depletion is linked to the presence of neuropathy in diabetic patients. Additionally, low Mg concentration may contribute to the onset or worsening of DN by promoting axonal degeneration through various pathways. Furthermore, multiple studies have shown that Mg supplementation can have neuroprotective effects. These findings suggest potential as an alternative or complementary therapy for preventing and treating DN in the future.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"135 ","pages":"Pages 13-31"},"PeriodicalIF":3.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}