Nutrition Research最新文献

{"title":"David Kritchevsky Graduate Student Award for Nutrition Research","authors":"","doi":"10.1016/S0271-5317(24)00137-4","DOIUrl":"10.1016/S0271-5317(24)00137-4","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"130 ","pages":"Page iii"},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial office and Board Members","authors":"","doi":"10.1016/S0271-5317(24)00136-2","DOIUrl":"10.1016/S0271-5317(24)00136-2","url":null,"abstract":"","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"130 ","pages":"Pages i-ii"},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing particle size of oat flours decreases postprandial glycemia and increases appetite in healthy adults","authors":"Corrina Zi Chen Zhou ,&nbsp;G. Harvey Anderson ,&nbsp;Wenxuan Fan ,&nbsp;Shirley Vien ,&nbsp;Yongfeng Ai ,&nbsp;Mehmet Tulbek ,&nbsp;Hrvoje Fabek","doi":"10.1016/j.nutres.2024.07.006","DOIUrl":"10.1016/j.nutres.2024.07.006","url":null,"abstract":"<div><div>Consumption of oats is associated with lowered risks of type 2 diabetes and obesity. However, many oat-based products (e.g., breakfast cereals) use finely milled flours but are associated with health claims based on oats of larger particle sizes. The objective of this study was to test the hypothesis that increasing oat flour particle size will result in lower postprandial glycemia and appetite. Using a randomized-controlled, crossover design, 20 participants (10 males, 10 females; age: 25.3 ± 1.0 years; body mass index: 23.2 ± 0.6 kg/m²) consumed a serving of porridge made using 40 g of coarse (675.7 ± 19.6 µm), whole (443.3 ± 36.2 µm), fine (96.0 ± 2.1 µm), or a commercial (375.9 ± 14.8 µm) oat flour unmatched in available carbohydrate, protein, and dietary fiber content. After a 12-hour overnight fast, blood glucose, insulin, and appetite were measured at 15 to 30-minute intervals over 120 minutes posttreatment consumption. Coarse and whole flours led to lower blood glucose between 30 and 60 minutes (<em>P</em> &lt; .02). Blood glucose area under the curve (AUC) was lower after coarse than fine and commercial oat flours (<em>P</em> &lt; 0.03), and after whole than fine oat flour (<em>P</em> &lt; .002). Both coarse and whole oat flours resulted in lower insulin AUC than finer flours (<em>P</em> &lt; .05). Appetite AUC was lower after the commercial than coarse flour (<em>P</em> &lt; .007). Controlling milling to produce coarser oat flour to add to common foods may have health benefits. This study was registered at ClinicalTrials.gov (NCT05291351).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"130 ","pages":"Pages 81-94"},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota and inflammation analyses reveal the protective effect of medium-chain triglycerides combined with docosahexaenoic acid on cognitive function in APP/PS1 and SAMP8 mice","authors":"Zehao Wang ,&nbsp;Yue Sun ,&nbsp;Dalong Zhang ,&nbsp;Yue Wang ,&nbsp;Dezheng Zhou ,&nbsp;Wen Li ,&nbsp;Jing Yan ,&nbsp;Yongjie Chen ,&nbsp;Suhui Luo ,&nbsp;Zhiyong Qian ,&nbsp;Zhenshu Li ,&nbsp;Guowei Huang","doi":"10.1016/j.nutres.2024.09.015","DOIUrl":"10.1016/j.nutres.2024.09.015","url":null,"abstract":"<div><div>Accumulating evidence has demonstrated that medium-chain triglycerides (MCTs) and docosahexaenoic acid (DHA) positively affect cognitive function. However, it remains unclear whether the improvement is related to the alterations of gut microbiota and inflammation and the impact of the combined intervention. In this study, we hypothesized that the supplementation of MCTs combined with DHA could modulate gut microbiota, inflammation, and improve cognitive function in APPswe/PS1De9 model mice and senescence-accelerated mouse-prone-8, which are two different mouse models used in neurodegeneration research. The mice were divided into four groups: Control group, MCTs group, DHA group, and MCTs + DHA group. The study assessed cognitive function, inflammatory cytokines, and gut microbiota composition. The results showed that supplementation of MCTs + DHA improved spatial learning ability, memory capacity, exploratory behavior; decreased the relative abundance of <em>Proteobacteria</em>; reduced the ratio of <em>Firmicutes</em>/<em>Bacteroidetes</em>; decreased the concentrations of serum interleukin (IL)-2, IL-6, monocyte chemotactic protein-1, tumor necrosis factor-alpha, while increasing the concentration of IL-10. Furthermore, supplementation with MCTs + DHA exhibited significantly superior effects compared to MCTs or DHA alone in reducing inflammation, optimizing gut microbiota composition, and improving cognitive function. In conclusion, supplementation with MCTs + DHA improved cognition function, accompanied with favorable alterations in gut microbiota and inflammation in APPswe/PS1De9 and senescence-accelerated mouse-prone-8 mice.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"132 ","pages":"Pages 27-39"},"PeriodicalIF":3.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High dietary antioxidant index associated with reduced insulin resistance in female Mexican children and adolescents","authors":"Rogelio F. Jiménez-Ortega ,&nbsp;Joacim Meneses-León ,&nbsp;Sonia Hernández ,&nbsp;Priscila Thebar-Moreno ,&nbsp;Diana I. Aparicio-Bautista ,&nbsp;Adriana Becerra-Cervera ,&nbsp;Carlos Aguilar-Salinas ,&nbsp;Jorge Salmerón ,&nbsp;Berenice Rivera-Paredez ,&nbsp;Rafael Velázquez-Cruz","doi":"10.1016/j.nutres.2024.09.016","DOIUrl":"10.1016/j.nutres.2024.09.016","url":null,"abstract":"<div><div>Antioxidant intake is inversely associated with different health outcomes; however, its association with insulin resistance (IR) has not been well documented. We hypothesized that the Dietary Antioxidant Index (DAI) is inversely associated with IR in Mexican children and adolescents. A cross-sectional analysis was performed using data from the Health Workers Cohort Study. A total of 830 children and adolescents aged 7 to 18 years were enrolled. The DAI was evaluated in three categories defined by tertiles using a semiquantitative food frequency questionnaire. IR was defined using previously reported cutoff points in the homeostasis model assessment. This association was evaluated using a multiple logistic regression model. Stratified analysis was performed using body mass index and sex. The prevalence of IR based on the DAI categories (low, medium, high) was 23.8%, 24.2%, and 15.3%, respectively. The IR odds ratio (OR) for participants in the highest DAI category was 0.49 (95% confidence interval [CI]: 0.30-0.80). Notably, female Children and Adolescents in the highest DAI category had significantly lower odds of developing IR than those in the lowest DAI category (OR 0.54, 95% CI 0.29-0.98). Participants with overweight/obesity showed a similar association (OR 0.37, 95% CI 0.18-0.76). These results suggest that the DAI is inversely associated with IR, particularly in females, highlighting the potential role of antioxidants in preventing IR. This underscores the need to establish recommendations for antioxidant consumption in female children and adolescents.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"132 ","pages":"Pages 53-66"},"PeriodicalIF":3.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved metabolic stability in iNOS knockout mice with Lactobacillus supplementation","authors":"Hobby Aggarwal ,&nbsp;Jyoti Gautam ,&nbsp;Sonu Kumar Gupta ,&nbsp;Bhabatosh Das ,&nbsp;Yashwant Kumar ,&nbsp;Kumaravelu Jagavelu ,&nbsp;Madhu Dikshit","doi":"10.1016/j.nutres.2024.09.018","DOIUrl":"10.1016/j.nutres.2024.09.018","url":null,"abstract":"<div><div>Oxidative and nitrosative stress play pivotal roles in normal physiological processes and the pathogenesis of metabolic disorders. Previous studies from our lab demonstrated insulin resistance (IR), and dyslipidemia in iNOS^−/− mice, emphasizing the importance of maintaining optimal redox balance. These mice exhibited altered gut microbiota with decreased <em>Lactobacillus</em>. Therefore, we hypothesized that <em>Lactobacillus</em> supplementation could mitigate metabolic disturbances in iNOS^−/− mice. To test this hypothesis, iNOS^−/− mice and wild-type (WT) mice were divided into four groups: iNOS^−/- with or without Lactobacillus supplementation, WT with or without Lactobacillus supplementation and glucose tolerance, insulin resistance, gluconeogenesis, lipids, gene expression related to glucose and lipid metabolism (qPCR), fecal gut microbiota (16S rRNA sequencing), and serum and caecum metabolomics (LC-MS) were monitored. IR and dyslipidemic iNOS^−/− mice exhibited reduced microbial diversity, diminished presence of <em>Lactobacillus</em>, and altered serum metabolites, indicating metabolic dysregulation. <em>Lactobacillus</em> supplementation in iNOS^−/− mice effectively reversed glucose intolerance, IR, dyslipidemia, and associated metabolic irregularities compared to WT. These improvements correlated with changes in gene expression related to fatty acid synthesis in liver and adipose tissue, lipid oxidation in liver, and lipid efflux in intestinal tissue as compared to untreated iNOS^−/− mice. Despite the positive effects on metabolic markers, <em>Lactobacillus</em> supplementation did not reduce body weight or rectify disrupted energy balance, as evidenced by reduced VCO₂ production, heat generation, and metabolic rates in iNOS^−/− mice. The results suggest that <em>Lactobacillus</em> supplementation ameliorates metabolic disturbances but did not fully restore disrupted energy balance, highlighting complex interactions between the gut microbiome and metabolism.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"132 ","pages":"Pages 95-111"},"PeriodicalIF":3.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary metals are associated with obesity in U.S. children and adolescents: A cross-sectional study","authors":"Xinyun Zhou,&nbsp;Hongliang Jin,&nbsp;Yan Zhang","doi":"10.1016/j.nutres.2024.09.017","DOIUrl":"10.1016/j.nutres.2024.09.017","url":null,"abstract":"<div><div>Heavy metals are pervasive in the environment, and exposure to these metals may contribute to obesity in children and adolescents. We hypothesized that metal exposures are associated with obesity in children and adolescents. Data were drawn from children and adolescents aged 6 to 19 years from the 2007 to 2018 National Health and Nutrition Examination Survey. We employed weighted multivariate logistic regression and restricted cubic spline to explore the effects of individual metal exposures on obesity, and weighted quantile sum regression, quantile g-computed regression, and Bayesian kernel machine regression to explore the effects of mixed metal exposures on obesity. Subgroup analyses by gender were also performed. All models were adjusted for age, gender, race, poverty to income ratio, and serum cotinine. Among the 3,650 children and adolescents studied, 21.04% had obesity. Logistic regression revealed positive associations between barium (OR = 1.23, 95% CI: 1.07-1.40) and thallium (OR = 1.55, 95% CI: 1.23-2.15) with obesity, while cadmium (OR = 0.74, 95% CI: 0.61-0.89), cobalt (OR = 0.51, 95% CI: 0.41-0.62), and lead (OR = 0.70, 95% CI: 0.57-0.86) were negatively associated with obesity. Restricted cubic spline indicated a nonlinear relationship between lead and thallium and obesity. Quantile g-computed regression demonstrated that mixed metal exposure was negatively associated with obesity (OR = 0.50, 95% CI: 0.42-0.59). Subgroup analyses revealed a gender-specific effect for mercury (<em>P</em> for interaction = 0.03), which was negatively associated with obesity in females (OR = 0.83, 95% CI: 0.69-0.99). In conclusion, metal exposures are associated with obesity in children and adolescents, with gender differences.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"132 ","pages":"Pages 40-52"},"PeriodicalIF":3.4,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher sweet beverage consumption was associated with increased gestational weight gain and birth weight: A Chinese cohort study","authors":"Shuang Zhang,&nbsp;Cuiping Zhang,&nbsp;Jia Guo,&nbsp;Baojuan Li,&nbsp;Weiqin Li,&nbsp;Jinnan Liu,&nbsp;Lingyan Feng,&nbsp;Peng Wang","doi":"10.1016/j.nutres.2024.09.013","DOIUrl":"10.1016/j.nutres.2024.09.013","url":null,"abstract":"<div><div>Diet during pregnancy is crucial to maternal metabolism and fetal development, so exploring the most potent food risk factor could improve maternal and child health. In this study, we investigated the diet and lifestyle of 833 healthy pregnant women in the second trimester from November 2020 to August 2021. Based on the Tianjin Antenatal Care System in China, we followed up with these women and recorded their gestational weight gain (GWG) and newborn birth weight. We conducted a dietary survey through FFQ based on the food groups recommended by the Chinese Dietary Guidelines and included common ultra-processed foods. We collected 219 semi-quantitative FFQs and 614 self-reported FFQs for analysis. According to the consumption frequency of 12 food groups, 4 dietary patterns were extracted by principal component analysis. We analyzed the associations of food energy, consumption frequency, and dietary patterns with GWG and birth weight, especially GWG in the first and second trimesters (f-GWG). The results showed that f-GWG was positively correlated with food energy. Beverage consumption was associated with f-GWG (<em>r</em> = 0.288, <em>P</em> = .026) in obese pregnant women. A dietary pattern that favors high consumption of ultra-processed foods (fried foods, baked desserts, and sweet beverages) was associated with increased GWGs. Non-obesity women with high consumption of baked desserts and sweet beverages had higher GWGs (<em>P</em> &lt; .05). After adjusting for confounding factors (including total energy, physical activity, and sleep quality), only sweet beverage consumption was associated with f-GWG (<em>β</em> 0.498, 95%CI 0.153-0.843) and birth weight (<em>β</em> 0.124, 95%CI 0.009-0.240). Sweet beverage consumption is a key adjustable risk factor for prenatal care.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"132 ","pages":"Pages 15-26"},"PeriodicalIF":3.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplementation of spermidine at 40 mg/day has minimal effects on circulating polyamines: An exploratory double-blind randomized controlled trial in older men","authors":"Patrick Keohane ,&nbsp;Jeremy R. Everett ,&nbsp;Rui Pereira ,&nbsp;Chad M. Cook ,&nbsp;Traci M. Blonquist ,&nbsp;Eunice Mah","doi":"10.1016/j.nutres.2024.09.012","DOIUrl":"10.1016/j.nutres.2024.09.012","url":null,"abstract":"<div><div>This study represents the first investigation into the safety of a novel, high-purity spermidine trihydrochloride supplement (hpSPD) in humans. Spermidine, a natural compound found in various foods, has demonstrated potential health benefits in animal and epidemiological studies. However, evidence from clinical trials and safety evaluations of spermidine supplements is limited because pure spermidine for human administration has not been available. In this randomized, double-blind, within-subject and placebo-controlled trial, 37 healthy men (age 50–70 years; body mass index, 18.5–28 kg/m²) were administered either hpSPD or a placebo. We hypothesized that 7-day and 28-day dosing of 40 mg/day of hpSPD would have minimal effects on safety, although metabolic and polyamine homeostasis has not previously been examined at this dosage level. Consistent with our hypothesis, 40 mg/day hpSPD did not result in any significant changes in clinical, lipids, chemistry, or hematological parameters compared to placebo. Compliance was high, and no study product-related adverse events were reported. Substantial changes in serum and urine polyamine concentrations were not observed following hpSPD supplementation, suggesting effective homeostatic control of full-dose highly purified spermidine supplements with no evidence of adaptation of spermidine metabolism at 40 mg/day. These findings suggest that hpSPD at 40 mg/day for up to 28 days is safe and well-tolerated in healthy older men. The study is consistent with preclinical results and provides important evidence supporting the safety of high-purity spermidine supplementation, enabling further research with single-molecule spermidine to investigate its potential biology for improving human health. This trial was registered at clinicaltrials.gov (NCT05459961).</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"132 ","pages":"Pages 1-14"},"PeriodicalIF":3.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and transcriptome data identify association between iron overload and metabolic dysfunction-associated steatotic liver disease and hepatic fibrosis","authors":"Chunling Li ,&nbsp;Mengqi Qu ,&nbsp;Xiangfeng Tian ,&nbsp;Wenyi Zhuang ,&nbsp;Meng Zhu ,&nbsp;Shengxia Lv ,&nbsp;Yongsheng Zhang ,&nbsp;Feiye Zhu","doi":"10.1016/j.nutres.2024.09.011","DOIUrl":"10.1016/j.nutres.2024.09.011","url":null,"abstract":"<div><div>The primary objective of this study was to examine the association between iron overload (IO), metabolic dysfunction-associated steatotic liver disease (MASLD), and hepatic fibrosis. We hypothesized that there is a significant association. Data from the NHANES (2017-2020) were analyzed to explore IO's impact on MASLD and hepatic fibrosis in U.S. adults. We assessed serum ferritin, controlled attenuation parameter (CAP), liver stiffness measurement (LSM), and various covariates. Gene expression data were sourced from the FerrDb V2 and GEO databases. Differential gene expression analysis, Protein-Protein Interaction (PPI) Network construction, and Gene Ontology (GO) and KEGG pathway enrichment analyses were performed. The study verified the link between MASLD, hepatic fibrosis, and iron overload hub genes. This study of 5927 participants, averaging 46.78 years of age, revealed significant correlations between serum ferritin and CAP, LSM, after adjusting for covariates. Threshold effect analysis indicated nonlinear associations between serum ferritin and CAP, LSM, with distinct patterns observed by age and gender. Moreover, the area under the ROC curve for serum ferritin with MASLD and hepatic fibrosis was 0.8272 and 0.8376, respectively, demonstrating its performance in assessing these conditions. Additionally, molecular analyses identified potential hub genes associated with iron overload and MASLD, and hepatic fibrosis, revealing the underlying mechanisms. Our study findings reveal an association between iron overload, MASLD, and hepatic fibrosis. Additionally, the hub genes may be implicated in iron overload and subsequently contribute to the progression of MASLD and hepatic fibrosis. These findings support precision nutrition strategies.</div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"131 ","pages":"Pages 121-134"},"PeriodicalIF":3.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}