Microbiology and Molecular Biology Reviews最新文献_第3页

Bacterial cell volume regulation and the importance of cyclic di-AMP. 细菌细胞体积调节和环状二-AMP 的重要性。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-06-10 DOI: 10.1128/mmbr.00181-23

Alexander J Foster, Marco van den Noort, Bert Poolman

{"title":"Bacterial cell volume regulation and the importance of cyclic di-AMP.","authors":"Alexander J Foster, Marco van den Noort, Bert Poolman","doi":"10.1128/mmbr.00181-23","DOIUrl":"10.1128/mmbr.00181-23","url":null,"abstract":"SUMMARYNucleotide-derived second messengers are present in all domains of life. In prokaryotes, most of their functionality is associated with general lifestyle and metabolic adaptations, often in response to environmental fluctuations of physical parameters. In the last two decades, cyclic di-AMP has emerged as an important signaling nucleotide in many prokaryotic lineages, including Firmicutes, Actinobacteria, and Cyanobacteria. Its importance is highlighted by the fact that both the lack and overproduction of cyclic di-AMP affect viability of prokaryotes that utilize cyclic di-AMP, and that it generates a strong innate immune response in eukaryotes. In bacteria that produce the second messenger, most molecular targets of cyclic di-AMP are associated with cell volume control. Besides, other evidence links the second messenger to cell wall remodeling, DNA damage repair, sporulation, central metabolism, and the regulation of glycogen turnover. In this review, we take a biochemical, quantitative approach to address the main cellular processes that are directly regulated by cyclic di-AMP and show that these processes are very connected and require regulation of a similar set of proteins to which cyclic di-AMP binds. Altogether, we argue that cyclic di-AMP is a master regulator of cell volume and that other cellular processes can be connected with cyclic di-AMP through this core function. We further highlight important directions in which the cyclic di-AMP field has to develop to gain a full understanding of the cyclic di-AMP signaling network and why some processes are regulated, while others are not.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0018123"},"PeriodicalIF":8.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hsp90, a team player in protein quality control and the stress response in bacteria. Hsp90，细菌蛋白质质量控制和应激反应的团队成员。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-03-27 DOI: 10.1128/mmbr.00176-22

Anushka C Wickramaratne, Sue Wickner, Andrea N Kravats

引用次数: 0

Structural analysis of resistance-nodulation cell division transporters. 抗性结节细胞分裂转运体的结构分析。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-03-29 DOI: 10.1128/mmbr.00198-23

Philip A Klenotic, Edward W Yu

引用次数: 0

Bacillus subtilis stress-associated mutagenesis and developmental DNA repair. 枯草芽孢杆菌应激相关诱变和 DNA 发育修复

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-03-29 DOI: 10.1128/mmbr.00158-23

Mario Pedraza-Reyes, Karen Abundiz-Yañez, Alejandra Rangel-Mendoza, Lissett E Martínez, Rocío C Barajas-Ornelas, Mayra Cuéllar-Cruz, Hilda C Leyva-Sánchez, Víctor M Ayala-García, Luz I Valenzuela-García, Eduardo A Robleto

{"title":"Bacillus subtilis stress-associated mutagenesis and developmental DNA repair.","authors":"Mario Pedraza-Reyes, Karen Abundiz-Yañez, Alejandra Rangel-Mendoza, Lissett E Martínez, Rocío C Barajas-Ornelas, Mayra Cuéllar-Cruz, Hilda C Leyva-Sánchez, Víctor M Ayala-García, Luz I Valenzuela-García, Eduardo A Robleto","doi":"10.1128/mmbr.00158-23","DOIUrl":"10.1128/mmbr.00158-23","url":null,"abstract":"SUMMARYThe metabolic conditions that prevail during bacterial growth have evolved with the faithful operation of repair systems that recognize and eliminate DNA lesions caused by intracellular and exogenous agents. This idea is supported by the low rate of spontaneous mutations (10-9) that occur in replicating cells, maintaining genome integrity. In contrast, when growth and/or replication cease, bacteria frequently process DNA lesions in an error-prone manner. DNA repairs provide cells with the tools needed for maintaining homeostasis during stressful conditions and depend on the developmental context in which repair events occur. Thus, different physiological scenarios can be anticipated. In nutritionally stressed bacteria, different components of the base excision repair pathway may process damaged DNA in an error-prone approach, promoting genetic variability. Interestingly, suppressing the mismatch repair machinery and activating specific DNA glycosylases promote stationary-phase mutations. Current evidence also suggests that in resting cells, coupling repair processes to actively transcribed genes may promote multiple genetic transactions that are advantageous for stressed cells. DNA repair during sporulation is of interest as a model to understand how transcriptional processes influence the formation of mutations in conditions where replication is halted. Current reports indicate that transcriptional coupling repair-dependent and -independent processes operate in differentiating cells to process spontaneous and induced DNA damage and that error-prone synthesis of DNA is involved in these events. These and other noncanonical ways of DNA repair that contribute to mutagenesis, survival, and evolution are reviewed in this manuscript.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0015823"},"PeriodicalIF":8.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPRi functional genomics in bacteria and its application to medical and industrial research. 细菌的 CRISPRi 功能基因组学及其在医学和工业研究中的应用。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-05-29 DOI: 10.1128/mmbr.00170-22

Amy L Enright, William J Heelan, Ryan D Ward, Jason M Peters

引用次数: 0

Insights into the enigma of oral streptococci in carcinogenesis. 洞察口腔链球菌致癌之谜。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-03-20 DOI: 10.1128/mmbr.00095-23

Sangeetha Senthil Kumar, Michael D L Johnson, Justin E Wilson

{"title":"Insights into the enigma of oral streptococci in carcinogenesis.","authors":"Sangeetha Senthil Kumar, Michael D L Johnson, Justin E Wilson","doi":"10.1128/mmbr.00095-23","DOIUrl":"10.1128/mmbr.00095-23","url":null,"abstract":"SUMMARYThe genus Streptococcus consists of a taxonomically diverse group of Gram-positive bacteria that have earned significant scientific interest due to their physiological and pathogenic characteristics. Within the genus Streptococcus, viridans group streptococci (VGS) play a significant role in the oral ecosystem, constituting approximately 80% of the oral biofilm. Their primary role as pioneering colonizers in the oral cavity with multifaceted interactions like adherence, metabolic signaling, and quorum sensing contributes significantly to the complex dynamics of the oral biofilm, thus shaping oral health and disease outcomes. Perturbations in oral streptococci composition drive oral dysbiosis and therefore impact host-pathogen interactions, resulting in oral inflammation and representing VGS as an opportunistic pathogen. The association of oral streptococci in tumors across distant organs, spanning the esophagus, stomach, pancreas, and colon, illuminates a potential association between oral streptococci, inflammation, and tumorigenesis. This finding emphasizes the need for further investigations into the role of oral streptococci in mucosal homeostasis and their involvement in carcinogenesis. Hence, here, we review the significance of oral streptococci in biofilm dynamics and how the perturbation may impact mucosal immunopathogenesis in the context of cancer, with a vision of exploiting oral streptococci for cancer intervention and for the development of non-invasive cancer diagnosis.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0009523"},"PeriodicalIF":8.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White-opaque switching in Candida albicans: cell biology, regulation, and function. 白色念珠菌中的不透明白色切换：细胞生物学、调节和功能。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-03-28 DOI: 10.1128/mmbr.00043-22

David R Soll

{"title":"White-opaque switching in Candida albicans: cell biology, regulation, and function.","authors":"David R Soll","doi":"10.1128/mmbr.00043-22","DOIUrl":"10.1128/mmbr.00043-22","url":null,"abstract":"SUMMARYCandida albicans remains a major fungal pathogen colonizing humans and opportunistically invading tissue when conditions are predisposing. Part of the success of C. albicans was attributed to its capacity to form hyphae that facilitate tissue invasion. However, in 1987, a second developmental program was discovered, the \"white-opaque transition,\" a high-frequency reversible switching system that impacted most aspects of the physiology, cell architecture, virulence, and gene expression of C. albicans. For the 15 years following the discovery of white-opaque switching, its role in the biology of C. albicans remained elusive. Then in 2002, it was discovered that in order to mate, C. albicans had to switch from white to opaque, a unique step in a yeast mating program. In 2006, three laboratories simultaneously identified a putative master switch gene, which led to a major quest to elucidate the underlying mechanisms that regulate white-opaque switching. Here, the evolving discoveries related to this complicated phenotypic transition are reviewed in a quasi-chronological order not only to provide a historical perspective but also to highlight several unique characteristics of white-opaque switching, which are fascinating and may be important to the life history and virulence of this persistent pathogen. Many of these characteristics have not been fully investigated, in many cases, leaving intriguing questions unresolved. Some of these include the function of unique channeled pimples on the opaque cell wall, the capacity to form opaque cells in the absence of the master switch gene WOR1, the formation of separate \"pathogenic\" and \"sexual\" biofilms, and the possibility that a significant portion of natural strains colonizing the lower gastrointestinal tract may be in the opaque phase. This review addresses many of these characteristics with the intent of engendering interest in resolving questions that remain unanswered.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0004322"},"PeriodicalIF":8.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Candida albicans and Candida glabrata: global priority pathogens. 白色念珠菌和光滑念珠菌：全球优先病原体。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-06-04 DOI: 10.1128/mmbr.00021-23

Myrto Katsipoulaki, Mark H T Stappers, Dhara Malavia-Jones, Sascha Brunke, Bernhard Hube, Neil A R Gow

{"title":"Candida albicans and Candida glabrata: global priority pathogens.","authors":"Myrto Katsipoulaki, Mark H T Stappers, Dhara Malavia-Jones, Sascha Brunke, Bernhard Hube, Neil A R Gow","doi":"10.1128/mmbr.00021-23","DOIUrl":"10.1128/mmbr.00021-23","url":null,"abstract":"SUMMARYA significant increase in the incidence of Candida-mediated infections has been observed in the last decade, mainly due to rising numbers of susceptible individuals. Recently, the World Health Organization published its first fungal pathogen priority list, with Candida species listed in medium, high, and critical priority categories. This review is a synthesis of information and recent advances in our understanding of two of these species-Candida albicans and Candida glabrata. Of these, C. albicans is the most common cause of candidemia around the world and is categorized as a critical priority pathogen. C. glabrata is considered a high-priority pathogen and has become an increasingly important cause of candidemia in recent years. It is now the second most common causative agent of candidemia in many geographical regions. Despite their differences and phylogenetic divergence, they are successful as pathogens and commensals of humans. Both species can cause a broad variety of infections, ranging from superficial to potentially lethal systemic infections. While they share similarities in certain infection strategies, including tissue adhesion and invasion, they differ significantly in key aspects of their biology, interaction with immune cells, host damage strategies, and metabolic adaptations. Here we provide insights on key aspects of their biology, epidemiology, commensal and pathogenic lifestyles, interactions with the immune system, and antifungal resistance.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0002123"},"PeriodicalIF":8.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genotypic diversity, virulence, and molecular genetic tools in Histoplasma. 组织胞浆菌的基因型多样性、毒力和分子遗传工具。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-05-31 DOI: 10.1128/mmbr.00076-23

Victoria E Sepúlveda, William E Goldman, Daniel R Matute

{"title":"Genotypic diversity, virulence, and molecular genetic tools in Histoplasma.","authors":"Victoria E Sepúlveda, William E Goldman, Daniel R Matute","doi":"10.1128/mmbr.00076-23","DOIUrl":"10.1128/mmbr.00076-23","url":null,"abstract":"SUMMARYHistoplasmosis is arguably the most common fungal respiratory infection worldwide, with hundreds of thousands of new infections occurring annually in the United States alone. The infection can progress in the lung or disseminate to visceral organs and can be difficult to treat with antifungal drugs. Histoplasma, the causative agent of the disease, is a pathogenic fungus that causes life-threatening lung infections and is globally distributed. The fungus has the ability to germinate from conidia into either hyphal (mold) or yeast form, depending on the environmental temperature. This transition also regulates virulence. Histoplasma and histoplasmosis have been classified as being of emergent importance, and in 2022, the World Health Organization included Histoplasma as 1 of the 19 most concerning human fungal pathogens. In this review, we synthesize the current understanding of the ecological niche, evolutionary history, and virulence strategies of Histoplasma. We also describe general patterns of the symptomatology and epidemiology of histoplasmosis. We underscore areas where research is sorely needed and highlight research avenues that have been productive.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0007623"},"PeriodicalIF":8.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IS26 and the IS26 family: versatile resistance gene movers and genome reorganizers. IS26 和 IS26 家族：多功能抗性基因移动者和基因组重组者。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-03-04 DOI: 10.1128/mmbr.00119-22

Christopher J Harmer, Ruth M Hall

{"title":"IS26 and the IS26 family: versatile resistance gene movers and genome reorganizers.","authors":"Christopher J Harmer, Ruth M Hall","doi":"10.1128/mmbr.00119-22","DOIUrl":"10.1128/mmbr.00119-22","url":null,"abstract":"SUMMARYIn Gram-negative bacteria, the insertion sequence IS26 is highly active in disseminating antibiotic resistance genes. IS26 can recruit a gene or group of genes into the mobile gene pool and support their continued dissemination to new locations by creating pseudo-compound transposons (PCTs) that can be further mobilized by the insertion sequence (IS). IS26 can also enhance expression of adjacent potential resistance genes. IS26 encodes a DDE transposase but has unique properties. It forms cointegrates between two separate DNA molecules using two mechanisms. The well-known copy-in (replicative) route generates an additional IS copy and duplicates the target site. The recently discovered and more efficient and targeted conservative mechanism requires an IS in both participating molecules and does not generate any new sequence. The unit of movement for PCTs, known as a translocatable unit or TU, includes only one IS26. TU formed by homologous recombination between the bounding IS26s can be reincorporated via either cointegration route. However, the targeted conservative reaction is key to generation of arrays of overlapping PCTs seen in resistant pathogens. Using the copy-in route, IS26 can also act on a site in the same DNA molecule, either inverting adjacent DNA or generating an adjacent deletion plus a circular molecule carrying the DNA segment lost and an IS copy. If reincorporated, these circular molecules create a new PCT. IS26 is the best characterized IS in the IS26 family, which includes IS257/IS431, ISSau10, IS1216, IS1006, and IS1008 that are also implicated in spreading resistance genes in Gram-positive and Gram-negative pathogens.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0011922"},"PeriodicalIF":8.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0