Viral factors underlying the pandemic potential of influenza viruses.

IF 8 1区生物学 Q1 MICROBIOLOGY

Microbiology and Molecular Biology Reviews Pub Date : 2025-05-09 DOI:10.1128/mmbr.00066-24

Gabriele Neumann, Amie J Eisfeld, Yoshihiro Kawaoka

引用次数: 0

Abstract

SUMMARYOver the past 25 years, there has been an increasing number of mammalian (including human) infections caused by avian influenza A viruses that resulted in mild to severe illnesses. These viruses typically did not spread between mammals through aerosols in nature or in experimental settings. However, recently, this has changed, with several avian influenza A viruses exhibiting aerosol transmissibility among mammals, indicating that these viruses may pose a greater pandemic risk. In this review, we examine the current situation and discuss the mutations that may be necessary for avian influenza A viruses to efficiently replicate in mammals and transmit among them via aerosols.

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流感病毒具有大流行潜力的病毒因素。

在过去的25年里，甲型禽流感病毒引起的哺乳动物（包括人类）感染的数量不断增加，这些感染导致了轻微到严重的疾病。这些病毒通常不会在自然界或实验环境中通过气溶胶在哺乳动物之间传播。然而，最近这种情况发生了变化，一些甲型禽流感病毒在哺乳动物中表现出气溶胶传播能力，这表明这些病毒可能造成更大的大流行风险。在这篇综述中，我们研究了目前的情况，并讨论了禽流感病毒在哺乳动物中有效复制并通过气溶胶在它们之间传播所必需的突变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiology and Molecular Biology Reviews 生物-微生物学

CiteScore

18.80

自引率

0.80%

发文量

期刊介绍： Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.