Microbiology and Molecular Biology Reviews最新文献

Neurotransmitter signaling in molecular and behavioral immune responses to pathogens in C. elegans. 秀丽隐杆线虫对病原体的分子和行为免疫反应中的神经递质信号。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-09-11 DOI: 10.1128/mmbr.00064-25

Benson Otarigho, Alejandro Aballay

引用次数: 0

Peptidoglycan polymerase function and regulation. 肽聚糖聚合酶的功能与调控。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-08-29 DOI: 10.1128/mmbr.00070-25

Mohammed Terrak, Frédéric Kerff

{"title":"Peptidoglycan polymerase function and regulation.","authors":"Mohammed Terrak, Frédéric Kerff","doi":"10.1128/mmbr.00070-25","DOIUrl":"https://doi.org/10.1128/mmbr.00070-25","url":null,"abstract":"SUMMARYMost bacterial species possess two distinct types of glycosyltransferases (GTases or GTs), each with unique structural folds, which catalyze the addition of lipid II monomers to the anomeric reducing end of a growing glycan chain, ultimately forming β-1,4 glycosidic bonds. These bonds link the GlcNAc-MurNAc-peptide disaccharide subunits of the peptidoglycan (PG) polymer. The first type belongs to the carbohydrate-active enzyme (CAZy) GT51 family, which includes a lysozyme-like domain typically associated with a transpeptidase domain in bifunctional class A penicillin-binding proteins (aPBPs) and is occasionally found as a monofunctional GTase in certain bacteria. The second type, a C1-type GTase from the CAZy GT119 family, has a distinctly different structural fold and is composed of polytopic membrane proteins. These proteins also belong to the SEDS (shape, elongation, division, and sporulation) family and are characterized by 10 transmembrane segments and a large extracellular loop. In a single bacterial cell, multiple representatives of each family (aPBPs and SEDS) are typically present, often performing semi-redundant or distinct physiological functions. This review focuses on the structure-activity relationship of these two crucial PG GTases, the coordination between their GTase and the transpeptidase activities, and the regulatory mechanisms controlling these enzymes during cell growth and division within the elongasome and divisome complexes.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0007025"},"PeriodicalIF":7.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular pathogenesis of Haemophilus ducreyi infection in human volunteers. 人类志愿者杜氏嗜血杆菌感染的分子发病机制。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-08-22 DOI: 10.1128/mmbr.00055-24

Stanley M Spinola, Kate R Fortney, Susan Ofner, Netsanet Gebregziabher, Julie A Brothwell, Barry P Katz

{"title":"Molecular pathogenesis of Haemophilus ducreyi infection in human volunteers.","authors":"Stanley M Spinola, Kate R Fortney, Susan Ofner, Netsanet Gebregziabher, Julie A Brothwell, Barry P Katz","doi":"10.1128/mmbr.00055-24","DOIUrl":"https://doi.org/10.1128/mmbr.00055-24","url":null,"abstract":"SUMMARYHaemophilus ducreyi is a Gram-negative coccobacillus that forms a distinct lineage with Aggregatibacter pleuropneumoniae and Mannheimia haemolytica within the Pasteurellaceae. H. ducreyi causes chancroid, which is characterized by painful genital ulcers (GU) and inguinal lymphadenitis, and facilitates the transmission of HIV. Although once thought to be exclusively sexually transmitted, H. ducreyi is now recognized as a major cause of non-sexually transmitted cutaneous ulcers (CU) on the lower legs of children who live in yaws-endemic areas. Due to the impact of chancroid on global health, the lack of human specimens, and the need to understand H. ducreyi pathogenesis, in 1993, we developed a model in which healthy adult volunteers are infected on the skin overlying the deltoid with the GU strain 35000HP and its isogenic mutants. This review summarizes 31 years of clinical experience with inoculating 429 unique participants and the behavior of strain 35000HP in the model. We examine sex and host effects on the outcome of initial inoculations and the results of second challenges of 53 participants, which together indicate that there is differential host susceptibility to infection, and explore the immunological basis for this phenomenon. We describe the evaluation of candidate bacterial virulence determinants in disease as determined in 38 mutant vs. parent comparison trials and the identification of potential vaccine candidates, which may be needed to control CU. We provide aggregate information on adverse events so that others can replicate this model. This review should also serve as a template for the ethical development of additional human infection models.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0005524"},"PeriodicalIF":7.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shiga toxin-producing Escherichia coli, food contamination, and bacteriophages as a control strategy. 产志贺毒素大肠杆菌、食品污染和噬菌体作为控制策略。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-08-21 DOI: 10.1128/mmbr.00244-25

Ana E Juarez, Alejandra Krüger, Paula M A Lucchesi

{"title":"Shiga toxin-producing Escherichia coli, food contamination, and bacteriophages as a control strategy.","authors":"Ana E Juarez, Alejandra Krüger, Paula M A Lucchesi","doi":"10.1128/mmbr.00244-25","DOIUrl":"https://doi.org/10.1128/mmbr.00244-25","url":null,"abstract":"SUMMARYShiga toxin-producing Escherichia coli (STEC) strains cause diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS) in humans. HUS is a severe systemic illness that can affect individuals of all ages, especially children. There is no specific treatment for HUS, and interventions consist of supportive therapy. STEC infections occur worldwide, and severe illness may occur in sporadic cases or outbreaks. In 2023, STEC was the third most frequently reported zoonotic agent detected in foodborne outbreaks in the EU. In this manuscript, we have focused on STEC reservoirs, STEC contamination of foods, source attribution of STEC infections, and current discussions about the pathogenic potential of STEC strains present in foods. Considering that food contamination with STEC represents a serious threat to public health, that preventive strategies for STEC infection are critical, and natural antimicrobials have gained increasing interest, we also present thoroughly revised information about bacteriophages as a strategy for STEC control. We also discussed the main aspects of the performance of commercial and non-commercial bacteriophages on foods artificially contaminated with STEC.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0024425"},"PeriodicalIF":7.8,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular protein quality control in viral myocarditis: molecular mechanisms and therapeutic implication. 病毒性心肌炎的细胞蛋白质量控制：分子机制及其治疗意义。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-08-20 DOI: 10.1128/mmbr.00177-25

Yasir Mohamud, Jingfei Carly Lin, Sinwoo Wendy Hwang, Amirhossein Bahreyni, Honglin Luo

{"title":"Cellular protein quality control in viral myocarditis: molecular mechanisms and therapeutic implication.","authors":"Yasir Mohamud, Jingfei Carly Lin, Sinwoo Wendy Hwang, Amirhossein Bahreyni, Honglin Luo","doi":"10.1128/mmbr.00177-25","DOIUrl":"https://doi.org/10.1128/mmbr.00177-25","url":null,"abstract":"SUMMARYViral myocarditis, an inflammatory disease of the myocardium caused by viral infections, poses a significant global health concern, particularly in young adults and children. This condition often progresses to dilated cardiomyopathy and heart failure, underscoring the urgent need for a deeper understanding of its underlying mechanisms. Central to its pathogenesis is the disruption of protein quality control (PQC) system, which is essential for maintaining cardiac proteostasis under both physiological and pathological conditions. This system, comprising molecular chaperones, the ubiquitin-proteasome system, and autophagy pathways, collectively ensures cellular homeostasis. In viral myocarditis, viral replication and host immune responses impose substantial stress on cardiomyocytes, overwhelming the PQC mechanisms. Consequently, misfolded and aggregated proteins, as well as damaged organelles, accumulate, further aggravating myocardial injury. Notably, while PQC pathways play a critical role in limiting viral replication and protecting cardiomyocytes, viruses can subvert these systems to enhance their own replication and provoke maladaptive responses, thereby worsening cardiac injury. This review summarizes current knowledge on the complex interplay between PQC system and viral myocarditis, highlights key knowledge gaps, and discusses potential therapeutic strategies to preserve cardiac function and improve clinical outcomes.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0017725"},"PeriodicalIF":7.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational function prediction of bacteria and phage proteins. 细菌和噬菌体蛋白的计算功能预测。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-08-18 DOI: 10.1128/mmbr.00022-25

Susanna R Grigson, George Bouras, Bas E Dutilh, Robert D Olson, Robert A Edwards

引用次数: 0

How fungi see the world: fungal photoreceptors and their role in the regulation of fungal biology. 真菌如何看世界：真菌光感受器及其在真菌生物学调节中的作用。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-08-11 DOI: 10.1128/mmbr.00149-22

Luis M Corrochano, Gabriel Gutiérrez, María Corrochano-Luque, Antonio Franco-Cano, David Cánovas

{"title":"How fungi see the world: fungal photoreceptors and their role in the regulation of fungal biology.","authors":"Luis M Corrochano, Gabriel Gutiérrez, María Corrochano-Luque, Antonio Franco-Cano, David Cánovas","doi":"10.1128/mmbr.00149-22","DOIUrl":"10.1128/mmbr.00149-22","url":null,"abstract":"SUMMARYFungi use light as a signal for the regulation of development, to guide the growth of reproductive structures, and to protect the fungal cell from DNA damage produced by light and UV radiation. Light perception requires the activity of photoreceptors that relay the light signal through transduction pathways into the cellular response. Fungi can see and react to a wide range of colors, but most fungi use blue light as their primary signal to regulate its photobiology. Examples of fungal perception of UV, green, and red light, like plants, have been documented and, in most cases, the photoreceptors responsible for these responses have been identified. Blue light is perceived through the activity of light-regulated transcription factors, the WC proteins, first identified in Neurospora crassa. Red light is perceived by phytochromes, a photoreceptor characterized in detail in Aspergillus nidulans. A novel type of rhodopsin, rhodopsin guanylyl cyclase (RGS) has been identified in the zoosporic fungus Blastocladiella emersonii. These types of photoreceptors, together with the blue-light photoreceptor cryptochrome, are widespread in fungi, suggesting that the ancestor of the fungi could see a wide range of colors. Gene duplication and specialization have allowed specific use of fungal photoreceptors in the regulation of fungal biology.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0014922"},"PeriodicalIF":7.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological relevance of in vitro cellular models to study varicella-zoster virus-host cell interactome: current limitations and future perspectives. 体外细胞模型研究水痘-带状疱疹病毒-宿主细胞相互作用的生物学相关性：目前的局限性和未来的前景。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-08-06 DOI: 10.1128/mmbr.00165-25

Jonas Govaerts, Charlotte Goethals, Elise Van Breedam, Catherine Sadzot-Delvaux, Peter Delputte, Benson Ogunjimi, Marielle Lebrun, Peter Ponsaerts

{"title":"Biological relevance of in vitro cellular models to study varicella-zoster virus-host cell interactome: current limitations and future perspectives.","authors":"Jonas Govaerts, Charlotte Goethals, Elise Van Breedam, Catherine Sadzot-Delvaux, Peter Delputte, Benson Ogunjimi, Marielle Lebrun, Peter Ponsaerts","doi":"10.1128/mmbr.00165-25","DOIUrl":"10.1128/mmbr.00165-25","url":null,"abstract":"SUMMARYWith varicella-zoster virus (VZV) being a strictly human-specific pathogen, in vitro cell culture models to study the VZV-host cell interactome predominantly rely on the use of primary human cells, immortalized cell lines, and-more recently-stem cell-derived models. In this work, based on literature reports published within the past 15 years, we attempted to summarize major lessons learned from in vitro VZV research, with a specific focus on whether and how a variety of host cells respond upon VZV infection at the cellular level. Following this specific approach, we describe the cellular events occurring following VZV infection in a neural cell type context, an immune cell type context, and a skin cell type context. Highly relevant, and for sure subject to the development of future VZV research, cell types within each of the three compartments reviewed display similarities but also significant differences in cellular response to VZV infection. Clearly, these need further clarification on a cell-type and/or VZV strain-specific level. Finally, to increase physiological relevance, we propose an integrated approach for future VZV-host cell interactome studies on a systems level by using advanced human-induced pluripotent stem cell-derived skin, peripheral, and central nervous system compartments that can be complemented with an isogenic immune cell component. Combined with the implementation of state-of-the-art multi-omics analyses, as well as electrophysiological recordings, this next-generation toolbox for advanced virus-host cell interactome studies may help to elucidate important aspects of VZV biology, including the suggested link between VZV pathology and neurodegenerative diseases.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0016525"},"PeriodicalIF":7.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EcoSal Plus will become a part of Microbiology and Molecular Biology Reviews. EcoSal Plus将成为微生物学和分子生物学评论的一部分。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-07-23 DOI: 10.1128/mmbr.00185-25

Corrella Detweiler, Susan Lovett, Michael E Lerman

引用次数: 0

Polio virotherapy provokes MDA5 signaling and CD4⁺ T cell help to mediate cancer in situ vaccination. 脊髓灰质炎病毒治疗激发MDA5信号和CD4+ T细胞帮助介导癌症原位疫苗接种。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-07-08 DOI: 10.1128/mmbr.00040-24

Matthias Gromeier, Michael C Brown

{"title":"Polio virotherapy provokes MDA5 signaling and CD4+ T cell help to mediate cancer in situ vaccination.","authors":"Matthias Gromeier, Michael C Brown","doi":"10.1128/mmbr.00040-24","DOIUrl":"10.1128/mmbr.00040-24","url":null,"abstract":"SUMMARYThere is overwhelming evidence that antitumor CD8+ T cell responses can mediate effective tumor control. CD8+ T cell responses are quintessential defensive measures directed against categorically intracellular pathogens. It is thus intuitively obvious that viruses hold unique potential to mediate cancer in situ vaccination, the process whereby endogenous immune responses are provoked to empower antitumor immunity. Numerous attenuated viruses have been derived from diverse virus families and tested as intratumor \"cancer virotherapies.\" However, the mechanistic understanding of how viruses mediate cancer in situ vaccination -including whether such attenuated viruses maintain the capacity to subvert antigen presentation and T cell priming, a common, defining feature of their wild-type precursors that may limit in situ vaccination, as well as the role of innate and adaptive antiviral immune responses in mediating overall therapy benefit-remains largely undefined. In this review, we provide a comprehensive overview of the molecular mechanisms, the unexpected benefit of profound attenuation, and the central role of both innate and adaptive antiviral immune responses in mediating polio virotherapy. In doing so, we aim to highlight the need for unraveling the enormous complexity and depth of virus:host interactions for devising rational strategies to leverage them for cancer immunotherapy.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0004024"},"PeriodicalIF":7.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0