Microbiology and Molecular Biology Reviews最新文献_第2页

How human papillomavirus (HPV) targets DNA repair pathways for viral replication: from guardian to accomplice. 人乳头瘤病毒（HPV）如何针对病毒复制的DNA修复途径：从监护人到帮凶。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-03-27 Epub Date: 2025-01-27 DOI: 10.1128/mmbr.00153-23

Arushi Vats, Laimonis Laimins

{"title":"How human papillomavirus (HPV) targets DNA repair pathways for viral replication: from guardian to accomplice.","authors":"Arushi Vats, Laimonis Laimins","doi":"10.1128/mmbr.00153-23","DOIUrl":"10.1128/mmbr.00153-23","url":null,"abstract":"SUMMARYHuman papillomaviruses (HPVs) are small DNA viruses that are responsible for significant disease burdens worldwide, including cancers of the cervix, anogenital tract, and oropharynx. HPVs infect stratified epithelia at a variety of body locations and link their productive life cycles to the differentiation of the host cell. These viruses have evolved sophisticated mechanisms to exploit cellular pathways, such as DNA damage repair (DDR), to regulate their life cycles. HPVs activate key DDR pathways such as ATM, ATR, and FA, which are critical for maintaining genomic integrity but are often dysregulated in cancers. Importantly, these DDR pathways are essential for HPV replication in undifferentiated cells and amplification upon differentiation. The ability to modulate these DDR pathways not only enables HPV persistence but also contributes to cellular transformation. In this review, we discuss the recent advances in understanding the mechanisms by which HPV manipulates the host DDR pathways and how these depend upon enhanced topoisomerase activity and R-loop formation. Furthermore, the strategies to manipulate DDR pathways utilized by high-risk HPVs are compared with those used by other DNA viruses that exhibit similarities and distinct differences.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0015323"},"PeriodicalIF":8.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vesicular mechanisms of drug resistance in apicomplexan parasites. 顶复体寄生虫的囊泡耐药机制。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-03-27 Epub Date: 2025-01-24 DOI: 10.1128/mmbr.00010-24

Kasturi Haldar, Souvik Bhattacharjee

{"title":"Vesicular mechanisms of drug resistance in apicomplexan parasites.","authors":"Kasturi Haldar, Souvik Bhattacharjee","doi":"10.1128/mmbr.00010-24","DOIUrl":"10.1128/mmbr.00010-24","url":null,"abstract":"SUMMARYVesicular mechanisms of drug resistance are known to exist across prokaryotes and eukaryotes. Vesicles are sacs that form when a lipid bilayer 'bends' to engulf and isolate contents from the cytoplasm or extracellular environment. They have a wide range of functions, including vehicles of communication within and across cells, trafficking of protein intermediates to their rightful organellar destinations, and carriers of substrates destined for autophagy. This review will provide an in-depth understanding of vesicular mechanisms of apicomplexan parasites, Plasmodium and Toxoplasma (that respectively cause malaria and toxoplasmosis). It will integrate mechanistic and evolutionarily insights gained from these and other pathogenic eukaryotes to develop a new model for plasmodial resistance to artemisinins, a class of drugs that have been the backbone of modern campaigns to eliminate malaria worldwide. We also discuss extracellular vesicles that present major vesicular mechanisms of drug resistance in parasite protozoa (that apicomplexans are part of). Finally, we provide a broader context of clinical drug resistance mechanisms of Plasmodium, Toxoplasma, as well as Cryptosporidium and Babesia, that are prominent members of the phyla, causative agents of cryptosporidiosis and babesiosis and significant for human and animal health.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0001024"},"PeriodicalIF":8.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryptococcal nutrient acquisition and pathogenesis: dining on the host. 隐球菌的营养获取和发病机制：以宿主为食。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-03-27 Epub Date: 2025-02-10 DOI: 10.1128/mmbr.00015-23

John R Perfect, James W Kronstad

{"title":"Cryptococcal nutrient acquisition and pathogenesis: dining on the host.","authors":"John R Perfect, James W Kronstad","doi":"10.1128/mmbr.00015-23","DOIUrl":"10.1128/mmbr.00015-23","url":null,"abstract":"SUMMARYPathogens must acquire essential nutrients to successfully colonize and proliferate in host tissue. Additionally, nutrients provide signals that condition pathogen deployment of factors that promote disease. A series of transcriptomics experiments over the last 20 years, primarily with Cryptococcus neoformans and to a lesser extent with Cryptococcus gattii, provide insights into the nutritional requirements for proliferation in host tissues. Notably, the identified functions include a number of transporters for key nutrients including sugars, amino acids, metals, and phosphate. Here, we first summarize the in vivo gene expression studies and then discuss the follow-up analyses that specifically test the relevance of the identified transporters for the ability of the pathogens to cause disease. The conclusion is that predictions based on transcriptional profiling of cryptococcal cells in infected tissue are well supported by subsequent investigations using targeted mutations. Overall, the combination of transcriptomic and genetic approaches provides substantial insights into the nutritional requirements that underpin proliferation in the host.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0001523"},"PeriodicalIF":8.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple sclerosis and infection: history, EBV, and the search for mechanism. 多发性硬化症和感染：历史、EBV和机制的研究。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-03-27 Epub Date: 2025-01-16 DOI: 10.1128/mmbr.00119-23

Elliott D SoRelle, Micah A Luftig

引用次数: 0

A call for the United States to continue investing in science. 呼吁美国继续对科学进行投资。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-03-27 Epub Date: 2025-02-27 DOI: 10.1128/mmbr.00072-25

Ira Blader, Felicia Goodrum, Michael J Imperiale, Arturo Casadevall, Cesar A Arias, Andreas Baumler, Carey-Ann D Burnham, Christina A Cuomo, Corrella S Detweiler, Graeme N Forrest, Jack A Gilbert, Susan Lovett, Stanley Maloy, Alexander McAdam, Irene Newton, Gemma Reguera, George A O'Toole, Patrick D Schloss, Ashley Shade, Marvin Whiteley

引用次数: 0

O-antigen polysaccharides in Klebsiella pneumoniae: structures and molecular basis for antigenic diversity. 肺炎克雷伯菌的o抗原多糖：抗原多样性的结构和分子基础。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-03-21 DOI: 10.1128/mmbr.00090-23

Chris Whitfield, Steven D Kelly, Tom D Stanton, Kelly L Wyres, Bradley R Clarke, Taylor J B Forrester, Agnieszka Kowalczyk

{"title":"O-antigen polysaccharides in Klebsiella pneumoniae: structures and molecular basis for antigenic diversity.","authors":"Chris Whitfield, Steven D Kelly, Tom D Stanton, Kelly L Wyres, Bradley R Clarke, Taylor J B Forrester, Agnieszka Kowalczyk","doi":"10.1128/mmbr.00090-23","DOIUrl":"10.1128/mmbr.00090-23","url":null,"abstract":"SUMMARYKlebsiella pneumoniae is a gram-negative species, whose isolates are found in the environment and as commensals in the human gastrointestinal tract. This bacterium is among the leading causes of a range of nosocomial and community-acquired infections, particularly in immunocompromised individuals, where it can give rise to pneumonia, urinary tract infections, septicemia, and liver abscesses. Treatment of K. pneumoniae infections is compromised by the emergence of isolates producing carbapenemase and extended-spectrum β-lactamase enzymes, making it a high priority for new therapeutic approaches including vaccination and immunoprophylaxis. One potential target for these strategies is the O-antigen polysaccharide component of lipopolysaccharides, which are important virulence determinants for K. pneumoniae. Consideration of immunotherapeutic opportunities requires a comprehensive and fundamental understanding of O-polysaccharide structures, distribution of particular O serotypes in clinical isolates, and the potential for antigenic diversification. The number of recognized K. pneumoniae O-polysaccharide antigens has varied over time, complicated by the observation that some examples share similar structural (and potentially antigenically cross-reactive) elements, and by the existence of genetic loci for which corresponding O-polysaccharide structures have yet to be determined. Here, we provide a comprehensive integration of the current carbohydrate structures and genetic information, together with a proposal for an updated classification system for K. pneumoniae O-antigens, that is being implemented in Kaptive for molecular serotyping. The accumulated insight into O-polysaccharide assembly pathways is used to describe the molecular basis for O-antigen diversity in K. pneumoniae.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0009023"},"PeriodicalIF":8.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coinfection by multiple Trypanosoma cruzi clones: a new perspective on host-parasite relationship with consequences for pathogenesis and management of Chagas disease. 多重克氏锥虫克隆的共同感染：宿主-寄生虫关系与恰加斯病发病机制和管理后果的新视角

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-03-21 DOI: 10.1128/mmbr.00242-24

Yves Carlier, Eric Dumonteil, Claudia Herrera, Etienne Waleckx, Michel Tibayrenc, Pierre Buekens, Carine Truyens, Eric Muraille

{"title":"Coinfection by multiple Trypanosoma cruzi clones: a new perspective on host-parasite relationship with consequences for pathogenesis and management of Chagas disease.","authors":"Yves Carlier, Eric Dumonteil, Claudia Herrera, Etienne Waleckx, Michel Tibayrenc, Pierre Buekens, Carine Truyens, Eric Muraille","doi":"10.1128/mmbr.00242-24","DOIUrl":"https://doi.org/10.1128/mmbr.00242-24","url":null,"abstract":"SUMMARYChagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi (Tc), infecting 6-7 million people. It is transmitted by insect vectors, orally, through infected tissues, or congenitally. Tc infection can progress toward chronic cardiac and/or digestive severe and fatal CD in 20%-40% of patients. Tc exhibits an important genetic and phenotypic intraspecies diversity and a preponderant clonal population structure. The impact of multiclonal coinfections has been little studied in CD patients. Relationships between the currently used discrete typing unit (DTU)-based classification of Tc lineages and the occurrence of the different clinical forms of CD, its congenital transmission, as well as the efficacy of trypanocidal molecules (benznidazole and nifurtimox) could not be established. In this review, we revisit the different aspects of Tc diversity and analyze the impact of infections with multiple clones and their variants on the dynamic and pathogenesis of CD and its maternal-fetal transmission. We propose to call \"cruziome\" all the Tc clones and their variants infecting a given host and provide strong evidence that (i) multiclonal Tc infections are likely the rule rather than the exception; (ii) each \"cruziome\" is associated with a unique combination of virulence factors, tissular tropisms, and host immune responses; (iii) accordingly, some particularly harmful \"cruziomes\" likely trigger the occurrence and progression of CD and might also favor the congenital transmission of parasites. We propose that our concept of \"cruziome\" should be taken into consideration because of its practical consequences in epidemiological studies, laboratory diagnosis, clinical management, and treatment of CD.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0024224"},"PeriodicalIF":8.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host specificity of gut microbiota associated with social bees: patterns and processes. 与群居蜜蜂相关的肠道微生物群宿主特异性：模式和过程。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-03-20 DOI: 10.1128/mmbr.00080-23

Florent Mazel, Aiswarya Prasad, Philipp Engel

{"title":"Host specificity of gut microbiota associated with social bees: patterns and processes.","authors":"Florent Mazel, Aiswarya Prasad, Philipp Engel","doi":"10.1128/mmbr.00080-23","DOIUrl":"https://doi.org/10.1128/mmbr.00080-23","url":null,"abstract":"SUMMARYGut microbes provide benefits to some animals, but their distribution and effects across diverse hosts are still poorly described. There is accumulating evidence for host specificity (i.e., a pattern where different microbes tend to associate with distinct host lineages), but the causes and consequences of this pattern are unclear. Combining experimental tests in the laboratory with broad surveys in the wild is a promising approach to gaining a comprehensive and mechanistic understanding of host specificity prevalence, origin, and importance. Social bees represent an ideal testbed for this endeavor because they are phylogenetically and functionally diverse, with host-specific, stable, and tractable gut microbiota. Furthermore, the western honeybee (Apis mellifera) is an emerging experimental model system for studying microbiota-host interactions. In this review, we summarize data on the prevalence and strength of host specificity of the social bee gut microbiota (bumblebees, stingless bees, and honeybees), as well as the potential and proven ecological and molecular mechanisms that maintain host specificity. Overall, we found that host specificity in bees is relatively strong and likely results from several processes, including host filtering mediated by the immune system and priority effects. However, more research is needed across multiple social bee species to confirm these findings. To help future research, we summarize emerging hypotheses in the field and propose several experimental and comparative tests. Finally, we conclude this review by highlighting the need to understand how host specificity can influence host health.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0008023"},"PeriodicalIF":8.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycobiome: an underexplored kingdom in cancer. 霉菌生物群：一个未被充分探索的癌症王国。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-03-14 DOI: 10.1128/mmbr.00261-24

Yan-Yan Sun, Ning-Ning Liu

引用次数: 0

The multifaceted roles of phosphoethanolamine-modified lipopolysaccharides: from stress response and virulence to cationic antimicrobial resistance. 磷脂酰乙醇胺修饰的脂多糖的多方面作用：从应激反应和毒力到阳离子抗菌性。

IF 8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-12-18 Epub Date: 2024-10-09 DOI: 10.1128/mmbr.00193-23

Anna Schumann, Ahmed Gaballa, Martin Wiedmann

{"title":"The multifaceted roles of phosphoethanolamine-modified lipopolysaccharides: from stress response and virulence to cationic antimicrobial resistance.","authors":"Anna Schumann, Ahmed Gaballa, Martin Wiedmann","doi":"10.1128/mmbr.00193-23","DOIUrl":"10.1128/mmbr.00193-23","url":null,"abstract":"SUMMARYLipopolysaccharides (LPS) are an integral part of the outer membrane of Gram-negative bacteria and play essential structural and functional roles in maintaining membrane integrity as well as in stress response and virulence. LPS comprises a membrane-anchored lipid A group, a sugar-based core region, and an O-antigen formed by repeating oligosaccharide units. 3-Deoxy-D-manno-octulosonic acid-lipid A (Kdo2-lipid A) is the minimum LPS component required for bacterial survival. While LPS modifications are not essential, they play multifaceted roles in stress response and host-pathogen interactions. Gram-negative bacteria encode several distinct LPS-modifying phosphoethanolamine transferases (PET) that add phosphoethanolamine (pEtN) to lipid A or the core region of LPS. The pet genes differ in their genomic locations, regulation mechanisms, and modification targets of the encoded enzyme, consistent with their various roles in different growth niches and under varied stress conditions. The discovery of mobile colistin resistance genes, which represent lipid A-modifying pet genes that are encoded on mobile elements and associated with resistance to the last-resort antibiotic colistin, has led to substantial interest in PETs and pEtN-modified LPS over the last decade. Here, we will review the current knowledge of the functional diversity of pEtN-based LPS modifications, including possible roles in niche-specific fitness advantages and resistance to host-produced antimicrobial peptides, and discuss how the genetic and structural diversities of PETs may impact their function. An improved understanding of the PET group will further enhance our comprehension of the stress response and virulence of Gram-negative bacteria and help contextualize host-pathogen interactions.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0019323"},"PeriodicalIF":8.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0