Microbiology and Molecular Biology Reviews最新文献_第2页

How fungi see the world: fungal photoreceptors and their role in the regulation of fungal biology. 真菌如何看世界：真菌光感受器及其在真菌生物学调节中的作用。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-09-25 Epub Date: 2025-08-11 DOI: 10.1128/mmbr.00149-22

Luis M Corrochano, Gabriel Gutiérrez, María Corrochano-Luque, Antonio Franco-Cano, David Cánovas

{"title":"How fungi see the world: fungal photoreceptors and their role in the regulation of fungal biology.","authors":"Luis M Corrochano, Gabriel Gutiérrez, María Corrochano-Luque, Antonio Franco-Cano, David Cánovas","doi":"10.1128/mmbr.00149-22","DOIUrl":"10.1128/mmbr.00149-22","url":null,"abstract":"SUMMARYFungi use light as a signal for the regulation of development, to guide the growth of reproductive structures, and to protect the fungal cell from DNA damage produced by light and UV radiation. Light perception requires the activity of photoreceptors that relay the light signal through transduction pathways into the cellular response. Fungi can see and react to a wide range of colors, but most fungi use blue light as their primary signal to regulate its photobiology. Examples of fungal perception of UV, green, and red light, like plants, have been documented and, in most cases, the photoreceptors responsible for these responses have been identified. Blue light is perceived through the activity of light-regulated transcription factors, the WC proteins, first identified in Neurospora crassa. Red light is perceived by phytochromes, a photoreceptor characterized in detail in Aspergillus nidulans. A novel type of rhodopsin, rhodopsin guanylyl cyclase (RGS) has been identified in the zoosporic fungus Blastocladiella emersonii. These types of photoreceptors, together with the blue-light photoreceptor cryptochrome, are widespread in fungi, suggesting that the ancestor of the fungi could see a wide range of colors. Gene duplication and specialization have allowed specific use of fungal photoreceptors in the regulation of fungal biology.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0014922"},"PeriodicalIF":7.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EcoSal Plus will become a part of Microbiology and Molecular Biology Reviews. EcoSal Plus将成为微生物学和分子生物学评论的一部分。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-09-25 Epub Date: 2025-07-23 DOI: 10.1128/mmbr.00185-25

Corrella Detweiler, Susan Lovett, Michael E Lerman

引用次数: 0

Molecular pathogenesis of Haemophilus ducreyi infection in human volunteers. 人类志愿者杜氏嗜血杆菌感染的分子发病机制。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-09-25 Epub Date: 2025-08-22 DOI: 10.1128/mmbr.00055-24

Stanley M Spinola, Kate R Fortney, Susan Ofner, Netsanet Gebregziabher, Julie A Brothwell, Barry P Katz

{"title":"Molecular pathogenesis of Haemophilus ducreyi infection in human volunteers.","authors":"Stanley M Spinola, Kate R Fortney, Susan Ofner, Netsanet Gebregziabher, Julie A Brothwell, Barry P Katz","doi":"10.1128/mmbr.00055-24","DOIUrl":"10.1128/mmbr.00055-24","url":null,"abstract":"SUMMARYHaemophilus ducreyi is a Gram-negative coccobacillus that forms a distinct lineage with Aggregatibacter pleuropneumoniae and Mannheimia haemolytica within the Pasteurellaceae. H. ducreyi causes chancroid, which is characterized by painful genital ulcers (GU) and inguinal lymphadenitis, and facilitates the transmission of HIV. Although once thought to be exclusively sexually transmitted, H. ducreyi is now recognized as a major cause of non-sexually transmitted cutaneous ulcers (CU) on the lower legs of children who live in yaws-endemic areas. Due to the impact of chancroid on global health, the lack of human specimens, and the need to understand H. ducreyi pathogenesis, in 1993, we developed a model in which healthy adult volunteers are infected on the skin overlying the deltoid with the GU strain 35000HP and its isogenic mutants. This review summarizes 31 years of clinical experience with inoculating 429 unique participants and the behavior of strain 35000HP in the model. We examine sex and host effects on the outcome of initial inoculations and the results of second challenges of 53 participants, which together indicate that there is differential host susceptibility to infection, and explore the immunological basis for this phenomenon. We describe the evaluation of candidate bacterial virulence determinants in disease as determined in 38 mutant vs. parent comparison trials and the identification of potential vaccine candidates, which may be needed to control CU. We provide aggregate information on adverse events so that others can replicate this model. This review should also serve as a template for the ethical development of additional human infection models.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0005524"},"PeriodicalIF":7.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular protein quality control in viral myocarditis: molecular mechanisms and therapeutic implication. 病毒性心肌炎的细胞蛋白质量控制：分子机制及其治疗意义。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-09-25 Epub Date: 2025-08-20 DOI: 10.1128/mmbr.00177-25

Yasir Mohamud, Jingfei Carly Lin, Sinwoo Wendy Hwang, Amirhossein Bahreyni, Honglin Luo

{"title":"Cellular protein quality control in viral myocarditis: molecular mechanisms and therapeutic implication.","authors":"Yasir Mohamud, Jingfei Carly Lin, Sinwoo Wendy Hwang, Amirhossein Bahreyni, Honglin Luo","doi":"10.1128/mmbr.00177-25","DOIUrl":"10.1128/mmbr.00177-25","url":null,"abstract":"SUMMARYViral myocarditis, an inflammatory disease of the myocardium caused by viral infections, poses a significant global health concern, particularly in young adults and children. This condition often progresses to dilated cardiomyopathy and heart failure, underscoring the urgent need for a deeper understanding of its underlying mechanisms. Central to its pathogenesis is the disruption of protein quality control (PQC) system, which is essential for maintaining cardiac proteostasis under both physiological and pathological conditions. This system, comprising molecular chaperones, the ubiquitin-proteasome system, and autophagy pathways, collectively ensures cellular homeostasis. In viral myocarditis, viral replication and host immune responses impose substantial stress on cardiomyocytes, overwhelming the PQC mechanisms. Consequently, misfolded and aggregated proteins, as well as damaged organelles, accumulate, further aggravating myocardial injury. Notably, while PQC pathways play a critical role in limiting viral replication and protecting cardiomyocytes, viruses can subvert these systems to enhance their own replication and provoke maladaptive responses, thereby worsening cardiac injury. This review summarizes current knowledge on the complex interplay between PQC system and viral myocarditis, highlights key knowledge gaps, and discusses potential therapeutic strategies to preserve cardiac function and improve clinical outcomes.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0017725"},"PeriodicalIF":7.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets. 朊病毒和蛋白质聚集作为病原体、自我繁殖结构、生物标志物和治疗靶点。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-09-25 DOI: 10.1128/mmbr.00007-25

Byron Caughey, Efrosini Artikis, Daniel Shoup, Christina D Orrú, Parvez Alam, Sabiha Parveen, Samantha King, Jakub Soukup, Andrew G Hughson, Suzette A Priola

{"title":"Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets.","authors":"Byron Caughey, Efrosini Artikis, Daniel Shoup, Christina D Orrú, Parvez Alam, Sabiha Parveen, Samantha King, Jakub Soukup, Andrew G Hughson, Suzette A Priola","doi":"10.1128/mmbr.00007-25","DOIUrl":"https://doi.org/10.1128/mmbr.00007-25","url":null,"abstract":"SUMMARYMany mammalian diseases appear to be caused primarily by the abnormal accumulation of self-propagating assemblies of specific host proteins such as Aβ and tau in Alzheimer's disease, α-synuclein (aSyn) in Parkinson's disease, and prion protein (PrP) in classical prion diseases. Most proteinopathies involve a prion-like spreading of the aggregates from localized sites of initiation within the host and, sometimes, between individuals. Often, the pathological assemblies take the form of amyloid fibrils, the cores of many of which have been solved by cryo-electron microscopy, revealing disease-specific, strain-like conformers of the given protein. Amyloids grow via seeded polymerization, a mechanism that is being widely exploited to develop ultrasensitive and specific amplification assays for pathological seeds as biomarkers. Such assays can aid fundamental research, diagnostics, prognostics, and clinical trials for multiple proteinopathies that have been challenging to diagnose and treat. Here, we review the structural biology, transmissibilities, spreading mechanisms, and detection of proteopathic aggregates as well as therapeutic approaches to limiting their accumulation.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0000725"},"PeriodicalIF":7.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of bacterial host-to-host transmission. 细菌宿主间传播的机制。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-09-25 Epub Date: 2025-07-01 DOI: 10.1128/mmbr.00259-24

M Ammar Zafar, Giovanna E Hernandez, Kimberly A Walker

{"title":"Mechanisms of bacterial host-to-host transmission.","authors":"M Ammar Zafar, Giovanna E Hernandez, Kimberly A Walker","doi":"10.1128/mmbr.00259-24","DOIUrl":"10.1128/mmbr.00259-24","url":null,"abstract":"SUMMARYBacterial pathogens must navigate complex host environments to thrive, replicate, and ultimately transmit to new hosts. Effective transmission is critical for pathogen propagation and often requires overcoming host defenses and exploiting environmental conditions. The mechanisms used by bacterial pathogens to cause disease have been studied for decades, and numerous virulence factors have been identified and characterized through the use of genetic tools and animal models. While insightful, these discoveries have only scratched the surface of our understanding of disease mechanisms. Even less well understood is how pathogens move from an infected host to colonize and establish infection in a new host. Pathogens can move between hosts via direct and indirect modes, relying on numerous routes, such as respiratory, fecal-oral, direct contact, vector-borne, and vertical transmission. Recent advances in animal models for the study of bacterial transmission have enabled a more accurate recapitulation of transmission between humans. This review summarizes the current knowledge of bacterial transmission factors and animal models of transmission, and how these tools are advancing our understanding of the transmission mechanisms used by bacterial pathogens.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0025924"},"PeriodicalIF":7.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implications of morphological variation in influenza viruses. 流感病毒形态变异的意义。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-09-25 Epub Date: 2025-06-20 DOI: 10.1128/mmbr.00015-25

Chidiebere F Uchechukwu, Nicole C Robb

引用次数: 0

Y-box binding proteins in immunity and RNA virus infection. 免疫与RNA病毒感染中的Y-box结合蛋白。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-09-23 DOI: 10.1128/mmbr.00191-24

Tania Strilets, Mariano A Garcia-Blanco

引用次数: 0

Archaeal RNA processing and regulation: expanding the functional landscape. 古细菌RNA加工和调控：扩展功能景观。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-09-23 DOI: 10.1128/mmbr.00318-24

Yueting Liang, Wen Qi, Xiuzhu Dong, Jie Li

{"title":"Archaeal RNA processing and regulation: expanding the functional landscape.","authors":"Yueting Liang, Wen Qi, Xiuzhu Dong, Jie Li","doi":"10.1128/mmbr.00318-24","DOIUrl":"https://doi.org/10.1128/mmbr.00318-24","url":null,"abstract":"SUMMARYRNA processing governs RNA function and gene regulation across all domains of life. In Archaea, recent advances in transcriptomics, genetics, and structural biology have uncovered a strikingly complex landscape of RNA processing and regulation. This review provides an up-to-date and comprehensive synthesis of archaeal RNA biology, covering the processing of ribosomal RNA (rRNA), transfer RNA (tRNA), and small noncoding RNAs, including C/D box and H/ACA box sRNAs, SRP RNA, and CRISPR RNAs, as well as emerging insights into mRNA processing and decay. We emphasize the growing knowledge of regulatory sRNAs, including tRNA-derived fragments (tRFs), which introduce new layers of archaeal RNA-based gene control. We also describe the roles of key ribonucleases and RNA chaperones in coordinating RNA processing and post-transcriptional control. These discoveries expand our understanding of how archaea employ RNA-centric strategies to orchestrate gene expression with remarkable specificity and adaptability. By integrating mechanistic insights with evolutionary context, this review provides a new framework for understanding archaeal RNA biology and its relevance to the modular evolution of RNA-based regulation. We also identify major knowledge gaps and propose future research priorities, emphasizing the potential of next-generation approaches to drive the next wave of discovery.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0031824"},"PeriodicalIF":7.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial plastic degradation: enzymes, pathways, challenges, and perspectives. 微生物塑料降解：酶，途径，挑战和观点。

IF 7.8 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2025-09-19 DOI: 10.1128/mmbr.00087-24

Pablo Pérez-García, Katharina Sass, Sasipa Wongwattanarat, Johannes Amann, Golo Feuerriegel, Tabea Neumann, Nico Bäse, Laura S Schmitz, Robert F Dierkes, Marno F Gurschke, Alan Wypych, Hadjira Bounabi, Marcella de Divitiis, Christel Vollstedt, Wolfgang R Streit

{"title":"Microbial plastic degradation: enzymes, pathways, challenges, and perspectives.","authors":"Pablo Pérez-García, Katharina Sass, Sasipa Wongwattanarat, Johannes Amann, Golo Feuerriegel, Tabea Neumann, Nico Bäse, Laura S Schmitz, Robert F Dierkes, Marno F Gurschke, Alan Wypych, Hadjira Bounabi, Marcella de Divitiis, Christel Vollstedt, Wolfgang R Streit","doi":"10.1128/mmbr.00087-24","DOIUrl":"10.1128/mmbr.00087-24","url":null,"abstract":"SUMMARYSynthetic polymers have transformed modern life, giving rise to a wide spectrum of versatile materials commonly known as plastics. They are essential to industries including packaging, medical devices, automotive, textiles, and many consumer goods. However, significant environmental challenges have emerged because of the same properties that make plastics so useful. Of the estimated 400-450 million tons (Mt) of plastics produced each year, nearly 80 percent end up in the environment. Many of these plastics will persist in nature for hundreds or even thousands of years because they are mostly not biodegradable or poorly biodegradable. The identification of polymer-active microorganisms and enzymes that target most fossil fuel-based plastics is one of the greatest challenges microbiologists are facing today. Currently, more than 255 functionally verified plastic-active enzymes from more than 11 microbial phyla are known. Here, we summarize current knowledge on the microbial pathways and enzymes involved in the degradation of polyethylene terephthalate (PET), polyamide (PA) oligomers, ester-based polyurethane (PUR), and polycarbonates (PC), as well as some of the most widely used bioplastics. We also highlight the challenges microbiologists face in identifying microorganisms acting on highly persistent commodity polymers such as polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), ether-based PUR, PA, polystyrene (PS), epoxy resins, and synthetic rubber (SR), for which no truly efficient degraders are currently known. We highlight methods used to discover novel microorganisms and enzymes involved in biodegradation and measure and quantify their activities. Finally, we will review the biotechnological applications of microbial-driven plastics recycling.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0008724"},"PeriodicalIF":7.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0