Cryptococcal nutrient acquisition and pathogenesis: dining on the host.

IF 8 1区 生物学 Q1 MICROBIOLOGY
Microbiology and Molecular Biology Reviews Pub Date : 2025-03-27 Epub Date: 2025-02-10 DOI:10.1128/mmbr.00015-23
John R Perfect, James W Kronstad
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引用次数: 0

Abstract

SUMMARYPathogens must acquire essential nutrients to successfully colonize and proliferate in host tissue. Additionally, nutrients provide signals that condition pathogen deployment of factors that promote disease. A series of transcriptomics experiments over the last 20 years, primarily with Cryptococcus neoformans and to a lesser extent with Cryptococcus gattii, provide insights into the nutritional requirements for proliferation in host tissues. Notably, the identified functions include a number of transporters for key nutrients including sugars, amino acids, metals, and phosphate. Here, we first summarize the in vivo gene expression studies and then discuss the follow-up analyses that specifically test the relevance of the identified transporters for the ability of the pathogens to cause disease. The conclusion is that predictions based on transcriptional profiling of cryptococcal cells in infected tissue are well supported by subsequent investigations using targeted mutations. Overall, the combination of transcriptomic and genetic approaches provides substantial insights into the nutritional requirements that underpin proliferation in the host.

隐球菌的营养获取和发病机制:以宿主为食。
病原体必须获得必需的营养才能在宿主组织中成功定植和增殖。此外,营养物质提供信号,调节病原体部署促进疾病的因素。在过去的20年里,一系列转录组学实验,主要是针对新型隐球菌和较小程度的加蒂隐球菌,提供了对宿主组织中增殖的营养需求的见解。值得注意的是,已确定的功能包括许多关键营养素的转运体,包括糖、氨基酸、金属和磷酸盐。在这里,我们首先总结了体内基因表达研究,然后讨论了后续分析,专门测试鉴定的转运蛋白与病原体致病能力的相关性。结论是,基于感染组织中隐球菌细胞转录谱的预测得到了随后使用靶向突变的研究的很好支持。总的来说,转录组学和遗传方法的结合提供了对支撑宿主增殖的营养需求的实质性见解。
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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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