The Siphamia-Photobacterium symbiosis: a binary vertebrate model for host-microbe interactions.

Abstract

SUMMARYAs microbial communities are increasingly recognized as central to animal development and health, simplified animal models have become valuable tools for exploring the complex dynamics of these interactions. The mutualism between siphonfish (Siphamia spp.) and the bioluminescent bacterium Photobacterium mandapamensis offers a naturally occurring, binary, gut-associated symbiosis within a vertebrate host that is a promising system for investigating host-microbe interactions. Over the past decade, the application of genomic, ecological, and microbiological approaches has revealed high levels of strain-level variation within this highly specific and stable symbiosis, highlighting its value for exploring host control and microbial diversity in vertebrate systems. These discoveries demonstrate the potential of the Siphamia-P. mandapamensis system as a powerful model for investigating how vertebrate hosts regulate and maintain long-term bacterial associations, particularly within gut-associated partnerships, as well as the eco-evolutionary processes that shape these relationships. This review aims to consolidate recent findings, evaluate their broader implications for vertebrate-microbe interactions, and propose future directions for research using this association as a model system.