Microbiology and Molecular Biology Reviews最新文献_第4页

The intersection of host in vivo metabolism and immune responses to infection with kinetoplastid and apicomplexan parasites. 宿主体内新陈代谢与感染奇异寄生虫和类凋亡寄生虫后的免疫反应之间的交叉。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-02-01 DOI: 10.1128/mmbr.00164-22

Sarah Ewald, Azadeh Nasuhidehnavi, Tzu-Yu Feng, Mahbobeh Lesani, Laura-Isobel McCall

{"title":"The intersection of host in vivo metabolism and immune responses to infection with kinetoplastid and apicomplexan parasites.","authors":"Sarah Ewald, Azadeh Nasuhidehnavi, Tzu-Yu Feng, Mahbobeh Lesani, Laura-Isobel McCall","doi":"10.1128/mmbr.00164-22","DOIUrl":"10.1128/mmbr.00164-22","url":null,"abstract":"SUMMARYProtozoan parasite infection dramatically alters host metabolism, driven by immunological demand and parasite manipulation strategies. Immunometabolic checkpoints are often exploited by kinetoplastid and protozoan parasites to establish chronic infection, which can significantly impair host metabolic homeostasis. The recent growth of tools to analyze metabolism is expanding our understanding of these questions. Here, we review and contrast host metabolic alterations that occur in vivo during infection with Leishmania, trypanosomes, Toxoplasma, Plasmodium, and Cryptosporidium. Although genetically divergent, there are commonalities among these pathogens in terms of metabolic needs, induction of the type I immune responses required for clearance, and the potential for sustained host metabolic dysbiosis. Comparing these pathogens provides an opportunity to explore how transmission strategy, nutritional demand, and host cell and tissue tropism drive similarities and unique aspects in host response and infection outcome and to design new strategies to treat disease.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":null,"pages":null},"PeriodicalIF":12.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139651005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal biodeterioration and preservation of cultural heritage, artwork, and historical artifacts: extremophily and adaptation. 真菌生物劣化与文化遗产、艺术品和历史文物的保存：嗜极性与适应性。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-01-05 DOI: 10.1128/mmbr.00200-22

Geoffrey Michael Gadd, Marina Fomina, Flavia Pinzari

{"title":"Fungal biodeterioration and preservation of cultural heritage, artwork, and historical artifacts: extremophily and adaptation.","authors":"Geoffrey Michael Gadd, Marina Fomina, Flavia Pinzari","doi":"10.1128/mmbr.00200-22","DOIUrl":"10.1128/mmbr.00200-22","url":null,"abstract":"SUMMARYFungi are ubiquitous and important biosphere inhabitants, and their abilities to decompose, degrade, and otherwise transform a massive range of organic and inorganic substances, including plant organic matter, rocks, and minerals, underpin their major significance as biodeteriogens in the built environment and of cultural heritage. Fungi are often the most obvious agents of cultural heritage biodeterioration with effects ranging from discoloration, staining, and biofouling to destruction of building components, historical artifacts, and artwork. Sporulation, morphological adaptations, and the explorative penetrative lifestyle of filamentous fungi enable efficient dispersal and colonization of solid substrates, while many species are able to withstand environmental stress factors such as desiccation, ultra-violet radiation, salinity, and potentially toxic organic and inorganic substances. Many can grow under nutrient-limited conditions, and many produce resistant cell forms that can survive through long periods of adverse conditions. The fungal lifestyle and chemoorganotrophic metabolism therefore enable adaptation and success in the frequently encountered extremophilic conditions that are associated with indoor and outdoor cultural heritage. Apart from free-living fungi, lichens are a fungal growth form and ubiquitous pioneer colonizers and biodeteriogens of outdoor materials, especially stone- and mineral-based building components. This article surveys the roles and significance of fungi in the biodeterioration of cultural heritage, with reference to the mechanisms involved and in relation to the range of substances encountered, as well as the methods by which fungal biodeterioration can be assessed and combated, and how certain fungal processes may be utilized in bioprotection.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":null,"pages":null},"PeriodicalIF":12.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RpoS and the bacterial general stress response. RpoS 和细菌的一般应激反应。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-02-27 DOI: 10.1128/mmbr.00151-22

Sophie Bouillet, Taran S Bauer, Susan Gottesman

引用次数: 0

Interplay between group A Streptococcus and host innate immune responses. A 群链球菌与宿主先天性免疫反应之间的相互作用。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-03-07 DOI: 10.1128/mmbr.00052-22

Marcia Shu-Wei Su, Yi-Lin Cheng, Yee-Shin Lin, Jiunn-Jong Wu

{"title":"Interplay between group A Streptococcus and host innate immune responses.","authors":"Marcia Shu-Wei Su, Yi-Lin Cheng, Yee-Shin Lin, Jiunn-Jong Wu","doi":"10.1128/mmbr.00052-22","DOIUrl":"10.1128/mmbr.00052-22","url":null,"abstract":"SUMMARYGroup A Streptococcus (GAS), also known as Streptococcus pyogenes, is a clinically well-adapted human pathogen that harbors rich virulence determinants contributing to a broad spectrum of diseases. GAS is capable of invading epithelial, endothelial, and professional phagocytic cells while evading host innate immune responses, including phagocytosis, selective autophagy, light chain 3-associated phagocytosis, and inflammation. However, without a more complete understanding of the different ways invasive GAS infections develop, it is difficult to appreciate how GAS survives and multiplies in host cells that have interactive immune networks. This review article attempts to provide an overview of the behaviors and mechanisms that allow pathogenic GAS to invade cells, along with the strategies that host cells practice to constrain GAS infection. We highlight the counteractions taken by GAS to apply virulence factors such as streptolysin O, nicotinamide-adenine dinucleotidase, and streptococcal pyrogenic exotoxin B as a hindrance to host innate immune responses.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":null,"pages":null},"PeriodicalIF":12.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking human milk oligosaccharide metabolism and early life gut microbiota: bifidobacteria and beyond. 将母乳寡糖代谢与生命早期肠道微生物群联系起来：双歧杆菌及其他。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-01-11 DOI: 10.1128/mmbr.00094-23

Cathy Lordan, Aoife K Roche, Dianne Delsing, Arjen Nauta, Andre Groeneveld, John MacSharry, Paul D Cotter, Douwe van Sinderen

{"title":"Linking human milk oligosaccharide metabolism and early life gut microbiota: bifidobacteria and beyond.","authors":"Cathy Lordan, Aoife K Roche, Dianne Delsing, Arjen Nauta, Andre Groeneveld, John MacSharry, Paul D Cotter, Douwe van Sinderen","doi":"10.1128/mmbr.00094-23","DOIUrl":"10.1128/mmbr.00094-23","url":null,"abstract":"SUMMARYHuman milk oligosaccharides (HMOs) are complex, multi-functional glycans present in human breast milk. They represent an intricate mix of heterogeneous structures which reach the infant intestine in an intact form as they resist gastrointestinal digestion. Therefore, they confer a multitude of benefits, directly and/or indirectly, to the developing neonate. Certain bifidobacterial species, being among the earliest gut colonizers of breast-fed infants, have an adapted functional capacity to metabolize various HMO structures. This ability is typically observed in infant-associated bifidobacteria, as opposed to bifidobacteria associated with a mature microbiota. In recent years, information has been gleaned regarding how these infant-associated bifidobacteria as well as certain other taxa are able to assimilate HMOs, including the mechanistic strategies enabling their acquisition and consumption. Additionally, complex metabolic interactions occur between microbes facilitated by HMOs, including the utilization of breakdown products released from HMO degradation. Interest in HMO-mediated changes in microbial composition and function has been the focal point of numerous studies, in recent times fueled by the availability of individual biosynthetic HMOs, some of which are now commonly included in infant formula. In this review, we outline the main HMO assimilatory and catabolic strategies employed by infant-associated bifidobacteria, discuss other taxa that exhibit breast milk glycan degradation capacity, and cover HMO-supported cross-feeding interactions and related metabolites that have been described thus far.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":null,"pages":null},"PeriodicalIF":12.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the gut microbiota by considering human evolution: a story of fire, cereals, cooking, molecular ingenuity, and functional cooperation. 通过考虑人类进化来了解肠道微生物群：一个关于火、谷物、烹饪、分子智慧和功能合作的故事。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2023-12-21 DOI: 10.1128/mmbr.00127-22

Gerald W Tannock

{"title":"Understanding the gut microbiota by considering human evolution: a story of fire, cereals, cooking, molecular ingenuity, and functional cooperation.","authors":"Gerald W Tannock","doi":"10.1128/mmbr.00127-22","DOIUrl":"10.1128/mmbr.00127-22","url":null,"abstract":"SUMMARYThe microbial community inhabiting the human colon, referred to as the gut microbiota, is mostly composed of bacterial species that, through extensive metabolic networking, degrade and ferment components of food and human secretions. The taxonomic composition of the microbiota has been extensively investigated in metagenomic studies that have also revealed details of molecular processes by which common components of the human diet are metabolized by specific members of the microbiota. Most studies of the gut microbiota aim to detect deviations in microbiota composition in patients relative to controls in the hope of showing that some diseases and conditions are due to or exacerbated by alterations to the gut microbiota. The aim of this review is to consider the gut microbiota in relation to the evolution of Homo sapiens which was heavily influenced by the consumption of a nutrient-dense non-arboreal diet, limited gut storage capacity, and acquisition of skills relating to mastering fire, cooking, and cultivation of cereal crops. The review delves into the past to gain an appreciation of what is important in the present. A holistic view of \"healthy\" microbiota function is proposed based on the evolutionary pathway shared by humans and gut microbes.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":null,"pages":null},"PeriodicalIF":12.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A bird's-eye view of the endoplasmic reticulum in filamentous fungi. 鸟瞰丝状真菌的内质网。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-02-19 DOI: 10.1128/mmbr.00027-23

Juan M Martínez-Andrade, Robert W Roberson, Meritxell Riquelme

引用次数: 0

Molecular mechanisms that govern infection and antifungal resistance in Mucorales. 真菌感染和抗真菌耐药性的分子机制。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-03-06 DOI: 10.1128/mmbr.00188-22

Carlos Lax, Francisco E Nicolás, Eusebio Navarro, Victoriano Garre

{"title":"Molecular mechanisms that govern infection and antifungal resistance in Mucorales.","authors":"Carlos Lax, Francisco E Nicolás, Eusebio Navarro, Victoriano Garre","doi":"10.1128/mmbr.00188-22","DOIUrl":"10.1128/mmbr.00188-22","url":null,"abstract":"SUMMARYThe World Health Organization has established a fungal priority pathogens list that includes species critical or highly important to human health. Among them is the order Mucorales, a fungal group comprising at least 39 species responsible for the life-threatening infection known as mucormycosis. Despite the continuous rise in cases and the poor prognosis due to innate resistance to most antifungal drugs used in the clinic, Mucorales has received limited attention, partly because of the difficulties in performing genetic manipulations. The COVID-19 pandemic has further escalated cases, with some patients experiencing the COVID-19-associated mucormycosis, highlighting the urgent need to increase knowledge about these fungi. This review addresses significant challenges in treating the disease, including delayed and poor diagnosis, the lack of accurate global incidence estimation, and the limited treatment options. Furthermore, it focuses on the most recent discoveries regarding the mechanisms and genes involved in the development of the disease, antifungal resistance, and the host defense response. Substantial advancements have been made in identifying key fungal genes responsible for invasion and tissue damage, host receptors exploited by the fungus to invade tissues, and mechanisms of antifungal resistance. This knowledge is expected to pave the way for the development of new antifungals to combat mucormycosis. In addition, we anticipate significant progress in characterizing Mucorales biology, particularly the mechanisms involved in pathogenesis and antifungal resistance, with the possibilities offered by CRISPR-Cas9 technology for genetic manipulation of the previously intractable Mucorales species.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":null,"pages":null},"PeriodicalIF":12.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140039775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From isotopically labeled DNA to fluorescently labeled dynamic pili: building a mechanistic model of DNA transport to the cytoplasmic membrane. 从同位素标记的 DNA 到荧光标记的动态纤毛虫：建立 DNA 向细胞质膜运输的机理模型。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-03-11 DOI: 10.1128/mmbr.00125-23

Jason D Zuke, Briana M Burton

{"title":"From isotopically labeled DNA to fluorescently labeled dynamic pili: building a mechanistic model of DNA transport to the cytoplasmic membrane.","authors":"Jason D Zuke, Briana M Burton","doi":"10.1128/mmbr.00125-23","DOIUrl":"10.1128/mmbr.00125-23","url":null,"abstract":"SUMMARYNatural competence, the physiological state wherein bacteria produce proteins that mediate extracellular DNA transport into the cytosol and the subsequent recombination of DNA into the genome, is conserved across the bacterial domain. DNA must successfully translocate across formidable permeability barriers during import, including the cell membrane(s) and the cell wall, that are normally impermeable to large DNA polymers. This review will examine the mechanisms underlying DNA transport from the extracellular space to the cytoplasmic membrane. First, the challenges inherent to DNA movement through the cell periphery will be discussed to provide context for DNA transport during natural competence. The following sections will trace the development of a comprehensive model for DNA translocation to the cytoplasmic membrane, highlighting the crucial studies performed over the last century that have contributed to building contemporary DNA import models. Finally, this review will conclude by reflecting on what is still unknown about the process and the possible solutions to overcome these limitations.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":null,"pages":null},"PeriodicalIF":12.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological adventures in Candida albicans: farnesol and ubiquinones. 白色念珠菌的生理探险：法呢醇和泛醌。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-03-04 DOI: 10.1128/mmbr.00081-22

Kenneth W Nickerson, Daniel J Gutzmann, Cory H T Boone, Ruvini U Pathirana, Audrey L Atkin

{"title":"Physiological adventures in Candida albicans: farnesol and ubiquinones.","authors":"Kenneth W Nickerson, Daniel J Gutzmann, Cory H T Boone, Ruvini U Pathirana, Audrey L Atkin","doi":"10.1128/mmbr.00081-22","DOIUrl":"10.1128/mmbr.00081-22","url":null,"abstract":"SUMMARYFarnesol was first identified as a quorum-sensing molecule, which blocked the yeast to hyphal transition in Candida albicans, 22 years ago. However, its interactions with Candida biology are surprisingly complex. Exogenous (secreted or supplied) farnesol can also act as a virulence factor during pathogenesis and as a fungicidal agent triggering apoptosis in other competing fungi. Farnesol synthesis is turned off both during anaerobic growth and in opaque cells. Distinctly different cellular responses are observed as exogenous farnesol levels are increased from 0.1 to 100 µM. Reported changes include altered morphology, stress response, pathogenicity, antibiotic sensitivity/resistance, and even cell lysis. Throughout, there has been a dearth of mechanisms associated with these observations, in part due to the absence of accurate measurement of intracellular farnesol levels (Fi). This obstacle has recently been overcome, and the above phenomena can now be viewed in terms of changing Fi levels and the percentage of farnesol secreted. Critically, two aspects of isoprenoid metabolism present in higher organisms are absent in C. albicans and likely in other yeasts. These are pathways for farnesol salvage (converting farnesol to farnesyl pyrophosphate) and farnesylcysteine cleavage, a necessary step in the turnover of farnesylated proteins. Together, these developments suggest a unifying model, whereby high, threshold levels of Fi regulate which target proteins are farnesylated or the extent to which they are farnesylated. Thus, we suggest that the diversity of cellular responses to farnesol reflects the diversity of the proteins that are or are not farnesylated.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":null,"pages":null},"PeriodicalIF":12.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0