Microbiology and Molecular Biology Reviews最新文献_第5页

From isotopically labeled DNA to fluorescently labeled dynamic pili: building a mechanistic model of DNA transport to the cytoplasmic membrane. 从同位素标记的 DNA 到荧光标记的动态纤毛虫：建立 DNA 向细胞质膜运输的机理模型。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-03-11 DOI: 10.1128/mmbr.00125-23

Jason D Zuke, Briana M Burton

{"title":"From isotopically labeled DNA to fluorescently labeled dynamic pili: building a mechanistic model of DNA transport to the cytoplasmic membrane.","authors":"Jason D Zuke, Briana M Burton","doi":"10.1128/mmbr.00125-23","DOIUrl":"10.1128/mmbr.00125-23","url":null,"abstract":"SUMMARYNatural competence, the physiological state wherein bacteria produce proteins that mediate extracellular DNA transport into the cytosol and the subsequent recombination of DNA into the genome, is conserved across the bacterial domain. DNA must successfully translocate across formidable permeability barriers during import, including the cell membrane(s) and the cell wall, that are normally impermeable to large DNA polymers. This review will examine the mechanisms underlying DNA transport from the extracellular space to the cytoplasmic membrane. First, the challenges inherent to DNA movement through the cell periphery will be discussed to provide context for DNA transport during natural competence. The following sections will trace the development of a comprehensive model for DNA translocation to the cytoplasmic membrane, highlighting the crucial studies performed over the last century that have contributed to building contemporary DNA import models. Finally, this review will conclude by reflecting on what is still unknown about the process and the possible solutions to overcome these limitations.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0012523"},"PeriodicalIF":12.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological adventures in Candida albicans: farnesol and ubiquinones. 白色念珠菌的生理探险：法呢醇和泛醌。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-03-04 DOI: 10.1128/mmbr.00081-22

Kenneth W Nickerson, Daniel J Gutzmann, Cory H T Boone, Ruvini U Pathirana, Audrey L Atkin

{"title":"Physiological adventures in Candida albicans: farnesol and ubiquinones.","authors":"Kenneth W Nickerson, Daniel J Gutzmann, Cory H T Boone, Ruvini U Pathirana, Audrey L Atkin","doi":"10.1128/mmbr.00081-22","DOIUrl":"10.1128/mmbr.00081-22","url":null,"abstract":"SUMMARYFarnesol was first identified as a quorum-sensing molecule, which blocked the yeast to hyphal transition in Candida albicans, 22 years ago. However, its interactions with Candida biology are surprisingly complex. Exogenous (secreted or supplied) farnesol can also act as a virulence factor during pathogenesis and as a fungicidal agent triggering apoptosis in other competing fungi. Farnesol synthesis is turned off both during anaerobic growth and in opaque cells. Distinctly different cellular responses are observed as exogenous farnesol levels are increased from 0.1 to 100 µM. Reported changes include altered morphology, stress response, pathogenicity, antibiotic sensitivity/resistance, and even cell lysis. Throughout, there has been a dearth of mechanisms associated with these observations, in part due to the absence of accurate measurement of intracellular farnesol levels (Fi). This obstacle has recently been overcome, and the above phenomena can now be viewed in terms of changing Fi levels and the percentage of farnesol secreted. Critically, two aspects of isoprenoid metabolism present in higher organisms are absent in C. albicans and likely in other yeasts. These are pathways for farnesol salvage (converting farnesol to farnesyl pyrophosphate) and farnesylcysteine cleavage, a necessary step in the turnover of farnesylated proteins. Together, these developments suggest a unifying model, whereby high, threshold levels of Fi regulate which target proteins are farnesylated or the extent to which they are farnesylated. Thus, we suggest that the diversity of cellular responses to farnesol reflects the diversity of the proteins that are or are not farnesylated.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0008122"},"PeriodicalIF":12.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages. 细菌和噬菌体中 7-脱氮鸟嘌呤衍生物的生物合成和功能。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-02-29 DOI: 10.1128/mmbr.00199-23

Valérie de Crécy-Lagard, Geoffrey Hutinet, José D D Cediel-Becerra, Yifeng Yuan, Rémi Zallot, Marc G Chevrette, R M Madhushi N Ratnayake, Marshall Jaroch, Samia Quaiyum, Steven Bruner

{"title":"Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages.","authors":"Valérie de Crécy-Lagard, Geoffrey Hutinet, José D D Cediel-Becerra, Yifeng Yuan, Rémi Zallot, Marc G Chevrette, R M Madhushi N Ratnayake, Marshall Jaroch, Samia Quaiyum, Steven Bruner","doi":"10.1128/mmbr.00199-23","DOIUrl":"10.1128/mmbr.00199-23","url":null,"abstract":"SUMMARYDeazaguanine modifications play multifaceted roles in the molecular biology of DNA and tRNA, shaping diverse yet essential biological processes, including the nuanced fine-tuning of translation efficiency and the intricate modulation of codon-anticodon interactions. Beyond their roles in translation, deazaguanine modifications contribute to cellular stress resistance, self-nonself discrimination mechanisms, and host evasion defenses, directly modulating the adaptability of living organisms. Deazaguanine moieties extend beyond nucleic acid modifications, manifesting in the structural diversity of biologically active natural products. Their roles in fundamental cellular processes and their presence in biologically active natural products underscore their versatility and pivotal contributions to the intricate web of molecular interactions within living organisms. Here, we discuss the current understanding of the biosynthesis and multifaceted functions of deazaguanines, shedding light on their diverse and dynamic roles in the molecular landscape of life.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0019923"},"PeriodicalIF":12.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biogenesis, germination, and pathogenesis of Cryptococcus spores. 隐球菌孢子的生物生成、萌发和致病机理。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-03-05 DOI: 10.1128/mmbr.00196-23

Sébastien C Ortiz, Christina M Hull

引用次数: 0

Hemophore-like proteins of the HmuY family in the oral and gut microbiome: unraveling the mystery of their evolution 口腔和肠道微生物群中的 HmuY 家族血孔样蛋白：揭开其进化之谜

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2024-02-02 DOI: 10.1128/mmbr.00131-23

Teresa OlczakMichał ŚmigaSvetlana V. AntonyukJohn W. Smalley1Laboratory of Medical Biology, Faculty of Biotechnology, University of Wrocław, Wrocław, Poland2Molecular Biophysics Group, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, the University of Liverpool, Liverpool, United Kingdom3Institute of Life Course and Medical Sciences, School of Dentistry, the University of Liverpool, Liverpool, United Kingdom, Corrella S. Detweiler

引用次数: 0

Programmed chromosome fragmentation in ciliated protozoa: multiple means to chromosome ends. 纤毛原生动物的程序性染色体断裂:通往染色体末端的多种途径。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2023-12-20 Epub Date: 2023-11-27 DOI: 10.1128/mmbr.00184-22

Mireille Bétermier, Lawrence A Klobutcher, Eduardo Orias

{"title":"Programmed chromosome fragmentation in ciliated protozoa: multiple means to chromosome ends.","authors":"Mireille Bétermier, Lawrence A Klobutcher, Eduardo Orias","doi":"10.1128/mmbr.00184-22","DOIUrl":"10.1128/mmbr.00184-22","url":null,"abstract":"SUMMARYCiliated protozoa undergo large-scale developmental rearrangement of their somatic genomes when forming a new transcriptionally active macronucleus during conjugation. This process includes the fragmentation of chromosomes derived from the germline, coupled with the efficient healing of the broken ends by de novo telomere addition. Here, we review what is known of developmental chromosome fragmentation in ciliates that have been well-studied at the molecular level (Tetrahymena, Paramecium, Euplotes, Stylonychia, and Oxytricha). These organisms differ substantially in the fidelity and precision of their fragmentation systems, as well as in the presence or absence of well-defined sequence elements that direct excision, suggesting that chromosome fragmentation systems have evolved multiple times and/or have been significantly altered during ciliate evolution. We propose a two-stage model for the evolution of the current ciliate systems, with both stages involving repetitive or transposable elements in the genome. The ancestral form of chromosome fragmentation is proposed to have been derived from the ciliate small RNA/chromatin modification process that removes transposons and other repetitive elements from the macronuclear genome during development. The evolution of this ancestral system is suggested to have potentiated its replacement in some ciliate lineages by subsequent fragmentation systems derived from mobile genetic elements.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0018422"},"PeriodicalIF":12.9,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138445289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the origin of the nucleus: a hypothesis. 关于原子核的起源:一个假说。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2023-12-20 Epub Date: 2023-11-29 DOI: 10.1128/mmbr.00186-21

Buzz Baum, Anja Spang

引用次数: 0

2023 Acknowledgment of MMBR Reviewers. 2023 感谢 MMBR 评审员。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2023-12-20 DOI: 10.1128/mmbr.00162-23

Corrella Detweiler

引用次数: 0

Bacterial heterogeneity and antibiotic persistence: bacterial mechanisms utilized in the host environment. 细菌异质性和抗生素持久性:宿主环境中利用的细菌机制。

IF 5.4 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2023-12-20 Epub Date: 2023-11-14 DOI: 10.1128/mmbr.00174-22

Katherine L Cotten, Kimberly Michele Davis

{"title":"Bacterial heterogeneity and antibiotic persistence: bacterial mechanisms utilized in the host environment.","authors":"Katherine L Cotten, Kimberly Michele Davis","doi":"10.1128/mmbr.00174-22","DOIUrl":"10.1128/mmbr.00174-22","url":null,"abstract":"SUMMARYAntibiotic persistence, or the ability of small subsets of bacteria to survive prolonged antibiotic treatment, is an underappreciated cause of antibiotic treatment failure. Over the past decade, researchers have discovered multiple different stress responses and mechanisms that can promote antibiotic persistence. However, many of these studies have been completed in culture-based systems that fail to truly replicate the complexities of the host environment, and it is unclear whether the mechanisms defined in in vitro studies are applicable during host infection. In this review, we focus our discussion on recent studies that utilize a mixture of ex vivo culture systems and animal models to understand what stressors in the host environment are important for inducing antibiotic persistence. Different host stressors are involved depending on the anatomical niche the bacteria reside in and whether the host immune system is primed to generate a more robust response against bacteria, which can result in differing downstream effects on antibiotic susceptibility. Bacterial pathogens can also utilize specific strategies to reprogram their metabolism, which is vital for transitioning into an antibiotic-persistent state within host tissues. Importantly, we highlight that more attention is needed to establish guidelines for in vivo work on antibiotic persistence, particularly when identifying antibiotic-persistent subpopulations and distinguishing these phenotypes from antibiotic tolerance. Studying antibiotic persistence in the context of the host environment will be crucial for developing tools and strategies to target antibiotic-persistent bacteria and increase the efficacy of antibiotic treatment.","PeriodicalId":18520,"journal":{"name":"Microbiology and Molecular Biology Reviews","volume":" ","pages":"e0017422"},"PeriodicalIF":5.4,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92155196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction for Zhu and Zheng, "The Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1". 更正朱、郑：“单纯疱疹病毒1型宿主抗病毒天然免疫与免疫逃避策略的竞争”。

IF 12.9 1区生物学

Microbiology and Molecular Biology Reviews Pub Date : 2023-12-20 Epub Date: 2023-10-16 DOI: 10.1128/mmbr.00103-23

Huifang Zhu, Chunfu Zheng

引用次数: 0