Bacterial acquisition of host fatty acids has far-reaching implications on virulence.

IF 8 1区 生物学 Q1 MICROBIOLOGY
Jack K Waters, Bart A Eijkelkamp
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引用次数: 0

Abstract

SUMMARYThe lipid homeostasis pathways of bacterial pathogens have been studied comprehensively for their biochemical functionality. However, new and refined technologies have supported the interrogation of bacterial lipid and fatty acid homeostasis mechanisms in more complex environments, such as mammalian host niches. In particular, emerging findings on the breadth and depth of host fatty acid uptake have demonstrated their importance beyond merely fatty acid utilization for membrane synthesis, as they can contribute to virulence factor regulation, pathogenesis, and group-based behaviors. Lipid homeostasis is also intertwined with other metabolic and physiological processes in the bacterial cells, which appear to be largely unique per species, but overarching themes can be derived. This review combines the latest biochemical and structural findings and places these in the context of bacterial pathogenesis, thereby shedding light on the far-reaching implications of lipid homeostasis on bacterial success.

细菌获取宿主脂肪酸对毒力有深远影响。
摘要 细菌病原体的脂质平衡途径已被全面研究,以了解其生化功能。然而,新的精炼技术支持了对细菌在哺乳动物宿主龛位等更复杂环境中的脂质和脂肪酸平衡机制的研究。特别是,关于宿主脂肪酸摄取的广度和深度的新发现表明,脂肪酸的重要性不仅限于利用脂肪酸进行膜合成,它们还有助于毒力因子调节、致病机理和群体行为。脂质平衡还与细菌细胞中的其他代谢和生理过程交织在一起,这些过程似乎在很大程度上因物种而异,但也可以从中得出一些总体性的主题。这篇综述结合了最新的生化和结构研究成果,并将其置于细菌致病机理的背景下,从而揭示了脂质平衡对细菌成功的深远影响。
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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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