Threats from the Candida parapsilosis complex: the surge of multidrug resistance and a hotbed for new emerging pathogens.

IF 8 1区 生物学 Q1 MICROBIOLOGY
Microbiology and Molecular Biology Reviews Pub Date : 2024-12-18 Epub Date: 2024-11-07 DOI:10.1128/mmbr.00029-23
Toni Gabaldón
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引用次数: 0

Abstract

SUMMARYCandida parapsilosis is a common agent of candidiasis that has gained increased attention in recent years, culminating with its recent consideration as a high-priority fungal pathogen by the World Health Organization. Reasons for this classification are the recent surge in incidence and the alarmingly growing rates of drug and multidrug resistance. In addition, several closely related species such as Candida metapsilosis and Candida orthopsilosis may represent recently emerged opportunistic pathogens originated from environmental niches through interspecies hybridization. Here, I review recent research focused on the potential origin and spread of drug resistance and of emerging species in this complex. I will also discuss open questions regarding the possible implications of human activities in these two epidemiological phenomena.

来自副丝状念珠菌复合体的威胁:多重耐药性的激增和新出现病原体的温床。
摘要副丝状念珠菌是念珠菌病的一种常见病原体,近年来日益受到关注,世界卫生组织最近将其列为高度优先的真菌病原体。之所以将其列为高度优先真菌病原体,是因为其发病率近来急剧上升,而且耐药性和多重耐药性的比率也在惊人地增长。此外,几种密切相关的菌种,如甲硅质念珠菌和正硅质念珠菌,可能是最近出现的机会性病原体,通过种间杂交起源于环境壁龛。在此,我将回顾最近的研究,重点是这一复合体中耐药性和新出现物种的潜在起源和传播。我还将讨论人类活动在这两种流行病学现象中可能产生的影响。
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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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