Hepatitis B virus entry, assembly, and egress.

IF 8 1区 生物学 Q1 MICROBIOLOGY
Yu-Chen Chuang, J-H James Ou
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Abstract

SUMMARYHepatitis B virus (HBV) is an important human pathogen that chronically infects approximately 250 million people in the world, resulting in ~1 million deaths annually. This virus is a hepatotropic virus and can cause severe liver diseases including cirrhosis and hepatocellular carcinoma. The entry of HBV into hepatocytes is initiated by the interaction of its envelope proteins with its receptors. This is followed by the delivery of the viral nucleocapsid to the nucleus for the release of its genomic DNA and the transcription of viral RNAs. The assembly of the viral capsid particles may then take place in the nucleus or the cytoplasm and may involve cellular membranes. This is followed by the egress of the virus from infected cells. In recent years, significant research progresses had been made toward understanding the entry, the assembly, and the egress of HBV particles. In this review, we discuss the molecular pathways of these processes and compare them with those used by hepatitis delta virus and hepatitis C virus , two other hepatotropic viruses that are also enveloped. The understanding of these processes will help us to understand how HBV replicates and causes diseases, which will help to improve the treatments for HBV patients.

乙型肝炎病毒的进入、聚集和排出。
摘要乙型肝炎病毒(HBV)是一种重要的人类病原体,全世界约有 2.5 亿人长期感染该病毒,每年约有 100 万人因此死亡。该病毒是一种致肝病毒,可导致严重的肝脏疾病,包括肝硬化和肝细胞癌。HBV 进入肝细胞是由其包膜蛋白与其受体相互作用开始的。随后,病毒核壳被送入细胞核,释放其基因组 DNA 并转录病毒 RNA。然后,病毒衣壳颗粒可能在细胞核或细胞质中组装,也可能涉及细胞膜。随后,病毒从受感染的细胞中排出。近年来,人们在了解 HBV 颗粒的进入、组装和排出方面取得了重大研究进展。在这篇综述中,我们将讨论这些过程的分子途径,并将它们与其他两种同样具有包膜的肝毒性病毒--乙型肝炎病毒和丙型肝炎病毒--的分子途径进行比较。了解这些过程将有助于我们理解 HBV 如何复制和致病,从而有助于改进对 HBV 患者的治疗。
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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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