Journal of Ophthalmology最新文献

{"title":"Visual Outcomes and Patient Satisfaction With a New Trifocal, Toric Intraocular Lens.","authors":"Zachary Zavodni","doi":"10.1155/joph/9983329","DOIUrl":"10.1155/joph/9983329","url":null,"abstract":"<p><strong>Purpose: </strong>Describe visual outcomes, rotational stability, and patient experience with a new, trifocal, toric intraocular lens (IOL), CNWTTx (Alcon, Fort Worth, TX.).</p><p><strong>Patients and methods: </strong>Prospective, cohort study in a private practice in Salt Lake City, UT. Patients 45 years and older with visually significant cataracts, bilateral regular corneal astigmatism requiring a T3-T6 IOL power lens, no other significant eye disease undergoing sequential cataract surgery with Clareon PanOptix Toric IOL (CNWTTx) followed for 3 months postoperatively. Primary endpoints: monocular corrected distance visual acuity (CDVA), distance-corrected intermediate visual acuity (DCIVA), and distance-corrected near visual acuity (DCNVA). Secondary endpoints: rotational position of the IOL and a patient satisfaction survey.</p><p><strong>Results: </strong>Twenty-five patients were recruited into the study and 22 received bilateral Clareon PanOptix Toric IOLs. At 3-month postoperative visit, visions were monocular mean CDVA of LogMAR (LM) 0.004, mean DCIVA of LM 0.110, and mean DCNVA of LM 0.056. 89% of patients had 0.5 diopters or less of residual astigmatism. Mean lens rotation was 1.67° at 1 month, and no lenses had rotated more than 5°. The majority of patients \"never\" used glasses at near (88%), at arm's length (100%) and at a distance (92%). In spite of 25% of patients noting photopic phenomena either \"most of the time\" or \"always,\" a majority (88%) of patients were either \"satisfied\" or \"very satisfied\" with their vision, and 92% would have the same lens implanted again.</p><p><strong>Conclusion: </strong>The CNWTTx lens results in excellent visual acuities at distance, intermediate, and near, leading to high rates of spectacle independence. The lens is rotationally stable, and patients are subjectively satisfied with their visual outcomes.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"9983329"},"PeriodicalIF":2.2,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of OCT Structural Parameters and OCTA-Measured Retinal Vessel Density and Peripapillary Choroidal Microvasculature in Glaucoma and Optic Neuritis From Multiple Sclerosis or Neuromyelitis Optica.","authors":"Glauco Batista Almeida, João Américo Domingos, Marcelo Hatanaka, Leandro Cabral Zacharias, Leonardo Provetti Cunha, Luiz Guilherme Marchesi Mello, Mário Luiz Ribeiro Monteiro","doi":"10.1155/joph/6354194","DOIUrl":"10.1155/joph/6354194","url":null,"abstract":"<p><strong>Aims: </strong>To compare peripapillary retinal nerve fiber layer (pRNFL), choroidal microvascular dropout (CMvD) and vessel density (pVD), as well as macular ganglion cell complex (GCC) and vessel density (mVD) in eyes with glaucoma and optic neuritis (ON) due to multiple sclerosis (MS-ON) or neuromyelitis optica spectrum disorder (NMOSD-ON) using OCT and OCT angiography (OCTA), and to assess its correlations with visual acuity and visual field (VF) parameters.</p><p><strong>Methods: </strong>Thirty-one eyes (16 patients) with glaucomatous optic neuropathy (GON), 26 eyes (16 patients) with MS-ON, 19 eyes (12 patients) with NMOSD-ON, and 53 healthy eyes (27 subjects) underwent 24-2 VF, OCT, and OCTA. The pRNFL thickness, pVD, and CMvD, as well as macular GCC thickness and mVD, were analyzed and compared using generalized estimating equations. Area under the receiver operating characteristic curves was calculated.</p><p><strong>Results: </strong>All disease groups showed significantly reduced structural parameters compared to controls. MS-ON and NMOSD-ON did not differ and demonstrated greater GCC thinning than GON despite similar pRNFL thickness (except nasally). mVD did not significantly differ among disease groups. In contrast, superficial and deep pVD distinguished the disease groups from controls and were significantly lower in nasal and temporal sectors in MS-ON and particularly in NMOSD-ON compared to GON. Although CMvD occurred in all groups, it was significantly more frequent and extensive in GON. Significant correlations were found between OCTA and OCT and visual function parameters in MS-ON and NMOSD-ON but not in GON eyes.</p><p><strong>Conclusions: </strong>OCT and OCTA parameters seem to differentiate GON, MS-ON, and NMOSD-ON from controls, but substantial overlap exists among the diseases. The presence of CMvD, particularly when extensive, was more commonly observed in GON, although its presence in other groups limits its diagnostic specificity. <b>Trial Registration:</b> Brazilian Clinical Trials Registry: 76722517.2.0000.0068.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"6354194"},"PeriodicalIF":2.2,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA-200c Promotes Epithelial-Mesenchymal Transition of Lens Epithelial Cells by Activating the Yes-Associated Protein Signaling Pathway.","authors":"Yin-Juan Wei, Yi-An-Zhu Liu, Ying Dai, Li Nan, Hui Song, Jun Li","doi":"10.1155/joph/5384666","DOIUrl":"10.1155/joph/5384666","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study is to investigate the role and possible mechanism of MicroRNA 200c (MiR-200c) in epithelial-mesenchymal transition (EMT) of Posterior Capsule Opacification (PCO).</p><p><strong>Methods: </strong>Human lens epithelial cells (LECs) were treated with TGFβ2 to induce EMT as a model for PCO. The mRNA levels of miR-200c and EMT markers were examined by real-time quantitative polymerase chain reaction (qPCR). Protein expression levels and mRNA levels of EMT-associated protein/transcriptional coactivators and Yes-associated protein (YAP) were also compared between miR-200c transfected and control cells by western blot analysis and qPCR. The scratch test was applied to detect the migration abilities of cells.</p><p><strong>Results: </strong>The expression level of miR-200c was upregulated in TGFβ2-induced EMT of LECs. Enhanced expression of miR-200c via agomir transfection accelerated both cell migration and the transition to a mesenchymal phenotype. Conversely, miR-200c inhibition using an antagomir effectively suppressed TGFβ2-mediated EMT. Bioinformatics analysis revealed that YAP signaling could be positively regulated by miR-200c, as evidenced by increased levels of YAP observed both in TGFβ2-treated groups and transfected with miR-200c agomir. Inhibition of Yap through the use of YAP-TEAD Inhibitor 1 (Peptide 17) effectively prevented the upregulation of key EMT markers such as FN, vimentin, and transcription factor SNAIL during TGFβ2-induced EMT.</p><p><strong>Conclusions: </strong>MiR-200c promotes EMT and migration in LECs by activating the YAP signaling pathway. MiR-200c may be used as a biomarker for the diagnosis or treatment in PCO.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"5384666"},"PeriodicalIF":2.2,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13366100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148447137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Floppy Eyelid Syndrome and Obstructive Sleep Apnea Syndrome: An Umbrella Review.","authors":"Gisela Tan Oh Napoli, Daniel Mendes Lobato, Fátima Rosana Albertini, Almiro José Machado Júnior","doi":"10.1155/joph/6084912","DOIUrl":"10.1155/joph/6084912","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea syndrome (OSAS) is characterized by intermittent partial or complete interruption of airflow due to upper airway collapse during sleep. Increased eyelid elasticity and the presence of a lax tarsus are features that define floppy eyelid syndrome (FES). The prevalence of FES may reach up to 64.5% among patients with OSAS. Despite its strong association with cardiovascular events, OSAS remains largely underdiagnosed. The <i>objective</i> of this study was to evaluate the degree of epidemiological association between FES and OSAS.</p><p><strong>Methods: </strong>Systematic reviews were evaluated to investigate the association between OSAS and FES in adults. This umbrella review was registered in PROSPERO and followed the PICO framework to define the research question. From August 2023 to January 2025, multiple databases were searched using relevant terms. The methodological quality of the included reviews was assessed using the AMSTAR 2 tool. Certainty of evidence was evaluated using a GRADE framework adapted for umbrella reviews, and an overlap analysis was performed.</p><p><strong>Results: </strong>Seven systematic reviews were included. According to AMSTAR 2, most were classified as having low methodological confidence. The final GRADE certainty ranged from low to moderate. Overlap analysis indicated moderate overlap. Nevertheless, the included studies consistently reported an association between FES and OSAS.</p><p><strong>Conclusion: </strong>Consistent with previous literature, this review supports an association between FES and OSAS. Identification of FES or EL during clinical examination may increase suspicion of OSAS. Despite its clinical relevance, this association remains underrecognized, and further studies using standardized diagnostic criteria are needed to strengthen the available evidence.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"6084912"},"PeriodicalIF":2.2,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13366405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148447425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Standardized Classification of Uveal Injury.","authors":"Tianjing Yang, Hua Yan","doi":"10.1155/joph/8878849","DOIUrl":"10.1155/joph/8878849","url":null,"abstract":"<p><strong>Purpose: </strong>Mechanical ocular injury involving the uvea poses significant surgical challenges and risks of irreversible visual impairment. Currently, there is no standardized classification to guide the management and prognosis of uveal injuries. This study aims to establish such a classification system.</p><p><strong>Methods: </strong>A methodological proposal for a novel classification was developed based on the most posterior location of uveal laceration/rupture and the extent of quadrant involvement. The classification was informed by clinical data with uveal injury. The system is designed to be determinable during clinical examination, emergency repair, or vitrectomy.</p><p><strong>Results: </strong>This study proposes a novel, standardized classification system for uveal injury based on the most posterior location of uveal laceration or rupture: Zone I (iris), Zone II (ciliary body), Zone III (choroid anterior to the equator), and Zone IV (choroid posterior to the equator), each subdivided (a-d) by extent of quadrant involvement. The system defines reproducible surgical approaches per zone.</p><p><strong>Conclusion: </strong>This novel classification is presented as a proposal to standardize the assessment of uveal injury, addressing a critical gap in existing ocular trauma systems. It provides a structured framework to guide surgical decision-making and anatomical restoration and to facilitate future research in the management of severe ocular trauma.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"8878849"},"PeriodicalIF":2.2,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxychloroquine Retinopathy in Systemic Lupus Erythematosus: Risk Factors, Screening, and Emerging Biomarkers.","authors":"Yehya Tlaiss, Ali Harajli, Ehab Al Mashtoub, Atef Salame Nasreddine, Tony Badawi, Alaa Tarchichi, Mohamad Tlais","doi":"10.1155/joph/8124348","DOIUrl":"10.1155/joph/8124348","url":null,"abstract":"<p><p>Hydroxychloroquine (HCQ) is a cornerstone therapy for systemic lupus erythematosus (SLE) because of its immunomodulatory and anti-inflammatory benefits. However, long-term exposure can cause HCQ-induced retinopathy, a potentially irreversible adverse effect in which early detection is critical. This review summarizes the literature on the reported prevalence of HCQ-related retinal toxicity in SLE, highlights consistently supported risk modifiers (including higher daily dose relative to real body weight, longer duration/cumulative exposure, and renal impairment), and synthesizes current screening strategies centered on multimodal structural and functional testing. Spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), standard automated perimetry, and multifocal electroretinography (mfERG) are frequently emphasized as complementary tools for earlier detection, while emerging approaches such as OCT angiography-derived metrics and pharmacokinetic measures remain exploratory. Real-world screening adherence is often suboptimal, underscoring the need for implementation strategies that align dosing, risk stratification, and ophthalmic monitoring. Future work should standardize diagnostic definitions, clarify optimal screening intervals across risk strata, and prospectively validate promising biomarkers and automated screening workflows.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"8124348"},"PeriodicalIF":2.2,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Tilt and Decentration of Intraocular Lens After Combined Femtosecond Laser-Assisted Cataract Surgery and Vitrectomy.","authors":"Tomoyuki Watanabe, Takeru Tuboi, Koki Honzawa, Hiroshi Horiguchi, Akira Watanabe, Tadashi Nakano","doi":"10.1155/joph/6845362","DOIUrl":"10.1155/joph/6845362","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the changes in tilt and decentration prior to and following microincision vitrectomy and femtosecond laser-assisted cataract surgery (FLACS) using a 7 mm intraocular lens (IOL).</p><p><strong>Methods: </strong>Patients were grouped by surgical method: conventional phacoemulsification surgery and vitrectomy without gas (Group A: 27 eyes), conventional phacoemulsification surgery and vitrectomy with gas (Group B: 72 eyes), FLACS and vitrectomy without gas (Group C: 29 eyes), and FLACS and vitrectomy with gas (Group D: 25 eyes). In the femtosecond-laser group, a 5.6 mm capsulotomy was created. 7 mm IOL was inserted in all cases. IOL tilt and decentration were compared using swept-source anterior segment optical coherence tomography for up to 12 months postoperatively.</p><p><strong>Results: </strong>On postoperative Day 1, the IOL tilt increased in all groups compared to the preoperative values, with a significantly greater increase observed in Groups B and D. Moreover, in Groups B and D, the tilt decreased substantially after Day 1 and gradually declined at 12 months. Similarly, Groups A and C also showed a decrease in tilt after Day 1, with a gradual decline at 12 months. Groups B and D showed greater initial decentration, which decreased over time. In contrast, Groups A and C exhibited more stable decentration values throughout the follow-up period.</p><p><strong>Conclusion: </strong>In combined cataract surgery and vitrectomy, no difference was observed in the tilt and decentration of the 7 mm IOL between 5.6 mm anterior capsulotomy created by FLACS and continuous curvilinear capsulorhexis, regardless of gas tamponade. Combining FLACS with vitrectomy is an equivalent technique when combined with conventional phacoemulsification surgery and vitrectomy is performed.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"6845362"},"PeriodicalIF":2.2,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Proximal Nasolacrimal Abnormalities on the Surgical Outcomes of Punctal Stenosis.","authors":"Emre Ayintap, Mehmet Ali Doran, Hasan Aytogan","doi":"10.1155/joph/7692939","DOIUrl":"10.1155/joph/7692939","url":null,"abstract":"<p><strong>Purpose: </strong>Punctoplasty is the standard surgical treatment for punctal stenosis; however, underlying canalicular abnormalities may significantly impact functional outcomes. This study evaluates the frequency and nature of proximal canalicular pathologies in patients with severe punctal stenosis (Grade 0 or 1) undergoing snip punctoplasty without stent or plug implantation and explores their relationship with surgical success.</p><p><strong>Methods: </strong>This retrospective study included patients with Grade 0 or 1 punctal stenosis who underwent snip punctoplasty at Izmir Tepecik Training and Research Hospital between 2017 and 2023. Patients with systemic diseases, prior lacrimal surgeries, or nasolacrimal duct obstructions beyond the common were excluded. Punctoplasty was performed using the three-snip technique without the use of punctal plugs or Mini-Monoka stents. Intraoperative probing and lacrimal lavage were used to evaluate canalicular patency.</p><p><strong>Results: </strong>A total of 312 patients (516 eyes) were included. Surgical success was achieved in 396 eyes (76.74%). Failure occurred in 120 eyes (23.26%), with proximal canalicular stenosis being the most common associated pathology (38.33%), followed by mid-canalicular (26.67%) obstructions. Since we exclusively included patients with Grade 0-1 punctal stenosis, the relatively lower functional success observed in our cohort may reflect a higher underlying prevalence of canalicular pathology in this subgroup. This supports the hypothesis that advanced punctal stenosis is frequently accompanied by additional proximal lacrimal abnormalities, potentially contributing to surgical failure. Failure was significantly associated with increasing age, especially in patients ≥ 60 years (28.7%) compared to patients < 60 years (15.2%). Gender was not a significant factor.</p><p><strong>Conclusions: </strong>Although anatomical patency can be achieved with snip punctoplasty, functional success is often compromised by unrecognized canalicular abnormalities-particularly in patients with severe punctal stenosis. Chronic ocular inflammation and fibrosis may affect both the punctum and canalicular pathway. Adjunctive use of Mini-Monoka stents should be considered to address deeper canalicular disease. Future prospective studies with standardized symptom scores and extended follow-up are warranted.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"7692939"},"PeriodicalIF":2.2,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Visual Outcomes of Toric and Nontoric Intraocular Lenses Featuring Combined Diffractive Extended Depth of Focus and Multifocal Designs.","authors":"Laureano A Rementería-Capelo, Inés Contreras, Laura Mariñas-García, Vanesa Blázquez, Javier Ruiz-Alcocer","doi":"10.1155/joph/3788361","DOIUrl":"10.1155/joph/3788361","url":null,"abstract":"<p><strong>Purpose: </strong>To assess and compare visual quality and subjective outcomes of the toric and nontoric versions of a trifocal intraocular lens (IOL) combining a diffractive extended depth of focus (EDoF) profile with a diffractive multifocal pattern.</p><p><strong>Methods: </strong>This prospective cohort study included patients bilaterally implanted with the TECNIS Synergy or TECNIS Synergy Toric II IOL. At 3 months postoperatively, monocular and binocular uncorrected distance visual acuity (UDVA), corrected visual acuity (VA) at 100%, 50%, and 10% contrast, and binocular defocus curves were evaluated. A five-point Likert scale questionnaire assessed satisfaction at different distances, perception of halos, and willingness to choose the same lens again.</p><p><strong>Results: </strong>A total of 114 eyes (52 nontoric and 62 toric) were analyzed. Monocular UDVA was 0.02 ± 0.07 logMAR (nontoric) and 0.08 ± 0.11 logMAR (toric) (<i>p</i> = 0.02), while binocular UDVA was -0.05 ± 0.06 logMAR and -0.02 ± 0.10 logMAR, respectively (<i>p</i> = 0.13). Defocus curves showed VA better than 0.1 logMAR from +1.0 to -2.5 D in both groups. No significant differences in contrast sensitivity were observed between groups at any level (<i>p</i> > 0.05). Over 80% of patients in each group reported being satisfied or very satisfied at all distances. Halos were described as not or only slightly bothersome by 42% of patients. A small percentage expressed a low likelihood of choosing the same lens again (4% nontoric, 9% toric).</p><p><strong>Conclusion: </strong>Both IOL models provided similar and effective visual restoration from distance to near. Despite some reported visual disturbances, patient satisfaction and visual quality were high and comparable between the toric and nontoric lenses when appropriately aligned.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"3788361"},"PeriodicalIF":2.2,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13325403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Interocular Flicker ERG Asymmetry in Acute Postoperative Endophthalmitis After Intraocular Surgery: A Pilot Study.","authors":"Ying Zheng, Simon Dulz, Vasyl Druchkiv, Martin Stephan Spitzer, Christos Skevas","doi":"10.1155/joph/2982435","DOIUrl":"10.1155/joph/2982435","url":null,"abstract":"<p><strong>Background/objectives: </strong>Postoperative endophthalmitis remains a vision-threatening complication despite advances in treatment. Current prognostic markers (Gram stain and initial visual acuity) have limited predictive values for real-time retinal neuronal function assessment and visual recovery. The purpose of this pilot study was to explore whether photopic electroretinograms might be used to forecast the endophthalmitis prognosis following intravitreal injection or phacoemulsification intraocular lens implantation.</p><p><strong>Subjects/methods: </strong>This prospective observational study included 11 consecutive patients with acute postoperative endophthalmitis following phacoemulsification with IOL implantation (3 eyes) or intravitreal injections (8 eyes). ERGs were recorded using a portable RETeval™ system under nonmydriatic conditions. R Core Team (2019) was used to assess the preoperative electroretinogram outcomes, duration until the onset of endophthalmitis, procedure types of original surgeries, and pre- and postoperative best-corrected visual acuity.</p><p><strong>Results: </strong>Mean patient age was 79.23 years (range 62-88). A significant correlation was found between interocular photopic flicker latency difference and BCVA improvement (<i>p</i> = 0.04, < 0.05). Patients with ≤ 8 ms latency difference showed significantly better visual recovery (≥ 2-line gain). No significant correlations were found with diabetes status, original surgical procedure types, or time to symptom onset.</p><p><strong>Conclusion: </strong>In this hypothesis-generating pilot study of acute postoperative endophthalmitis, a smaller interocular flicker ERG latency difference at presentation is associated with better visual recovery. These preliminary findings suggest that this rapid, noninvasive functional test may have potential as a prognostic biomarker and warrants further validation in larger cohorts, complementing existing clinical and microbiological parameters in the management of this sight-threatening infection.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"2982435"},"PeriodicalIF":2.2,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}