New Biomarkers for Patients With Fungal Keratitis From Blood Routine Examination: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio.

IF 1.8 4区 医学 Q3 OPHTHALMOLOGY
Journal of Ophthalmology Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI:10.1155/joph/5594701
Aizhen Wang, Menghe Jin, Zhanpeng Yang, Shuaibing Zhou, Juan Yue, Susu Liu, Yanting Xie, Hongmin Zhang
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引用次数: 0

Abstract

Purpose: To assess the potential of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as novel diagnostic and prognostic biomarkers in fungal keratitis (FK). Methods: This study was carried out retrospectively in 77 FK patients and 77 matched cataract controls from Henan Eye Hospital. Peripheral venous blood samples were collected via venipuncture and analyzed using complete blood count for routine clinical evaluation. FK patients were classified into three subgroups: Fusarium, Aspergillus, and Candida groups. Inflammation severity was quantified using standardized clinical scoring. The treatment modalities were used to divide the FK patients into enucleation and nonenucleation groups. Results: NLR and PLR were significantly elevated in FK versus controls (p < 0.001). NLR correlated strongly with inflammation scores (r = 0.535, p < 0.0001), exceeding PLR's moderate correlation (r = 0.311, p=0.0059). FK patients in the enucleation group had significantly higher NLR (p=0.012) and PLR (p=0.021) values than those in the nonenucleation group. There were no significant biomarker differences across fungal species (p > 0.05). Conclusion: Elevated NLR and PLR values during routine laboratory testing might serve as supplementary indicators for early suspicion of FK and monitoring inflammatory progression, particularly in resource-limited settings where specialized ophthalmic diagnostics are unavailable.

真菌性角膜炎患者血常规检查的新生物标志物:中性粒细胞与淋巴细胞比率和血小板与淋巴细胞比率。
目的:评估中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)作为真菌性角膜炎(FK)新的诊断和预后生物标志物的潜力。方法:回顾性分析河南省眼科医院77例FK患者和77例对照白内障患者。静脉穿刺采集外周静脉血,全血细胞计数分析,用于常规临床评价。FK患者分为三个亚组:镰刀菌组、曲霉菌组和念珠菌组。采用标准化临床评分对炎症严重程度进行量化。采用治疗方式将FK患者分为去核组和非去核组。结果:FK组NLR和PLR较对照组显著升高(p < 0.001)。NLR与炎症评分呈正相关(r = 0.535, p < 0.0001),超过PLR的中度相关(r = 0.311, p=0.0059)。去核组FK患者NLR (p=0.012)和PLR (p=0.021)值显著高于非去核组。不同菌种间生物标志物差异无统计学意义(p < 0.05)。结论:常规实验室检测中NLR和PLR值升高可作为早期怀疑FK和监测炎症进展的补充指标,特别是在资源有限且无法获得专业眼科诊断的地区。
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来源期刊
Journal of Ophthalmology
Journal of Ophthalmology MEDICINE, RESEARCH & EXPERIMENTAL-OPHTHALMOLOGY
CiteScore
4.30
自引率
5.30%
发文量
194
审稿时长
6-12 weeks
期刊介绍: Journal of Ophthalmology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the anatomy, physiology and diseases of the eye. Submissions should focus on new diagnostic and surgical techniques, instrument and therapy updates, as well as clinical trials and research findings.
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