Journal of Ophthalmology最新文献

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The Features of Vessel Densities and Hemorheological Parameters in Patients With Central Retinal Vein Occlusion: A Prospective Randomized Case-Control Study. 视网膜中央静脉阻塞患者血管密度和血液流变学参数的特征:一项前瞻性随机病例对照研究。
IF 1.9 4区 医学
Journal of Ophthalmology Pub Date : 2025-10-07 eCollection Date: 2025-01-01 DOI: 10.1155/joph/6634841
Xuan Li, Shuyue Huang, Ziyang Chen, Hang Yuan, Like Xie, Xiaofeng Hao
{"title":"The Features of Vessel Densities and Hemorheological Parameters in Patients With Central Retinal Vein Occlusion: A Prospective Randomized Case-Control Study.","authors":"Xuan Li, Shuyue Huang, Ziyang Chen, Hang Yuan, Like Xie, Xiaofeng Hao","doi":"10.1155/joph/6634841","DOIUrl":"https://doi.org/10.1155/joph/6634841","url":null,"abstract":"<p><p><b>Background:</b> This study analyzed changes in the vessel densities (VDs) and hemorheological parameters of patients with central retinal vein occlusion (CRVO). <b>Methods:</b> A prospective randomized case-control study was conducted, which included 80 CRVO patients (the study group) and 80 participants with normal fundus (the normal control group). Best-corrected visual acuity (BCVA), optic disc and macular VD, and other structural parameters (C/D ratio, RNFL thickness, etc.) were measured with optical coherence tomography angiography. Hemorheological parameters, including whole blood viscosity at low shear rate (LSR-WBV; 5/s) and high shear rate (HSR-WBV; 200/s), and erythrocyte aggregation index (AI), were also measured. <b>Results:</b> LSR-WBV, HSR-WBV, and AI were significantly higher in CRVO patients (9.009 ± 1.595 mPa·s, 4.981 ± 0.617 mPa·s, and 3.405 ± 1.679) than in participants with normal fundus (8.409 ± 1.110 mPa·s, 4.523 ± 0.597 mPa·s, and 2.880 ± 1.517) (all <i>p</i> < 0.05). CRVO eyes had significantly lower visual acuity, smaller C/D and cup volume, thicker peripapillary RNFL, and lower optic disc and macular VD than unaffected eyes and normal eyes (all <i>p</i> < 0.05). VD inside the optic disc and deep capillary plexus in unaffected eyes was markedly decreased when compared with that in normal eyes (all <i>p</i> < 0.05). BCVA in CRVO eyes was particularly correlated with VD inside disc (<i>p</i>=0.001 and <i>r</i> = -0.391). <b>Conclusion:</b> CRVO patients presented with more serious thrombophilia and higher hemorheological parameters, and the blood perfusion was significantly decreased in the optic disc and macula of CRVO eyes and was partially reduced in unaffected eyes. Moreover, optic disc blood perfusion exerted greater impacts on visual acuity, and inside-disc VD might be the greatest risk factor.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"6634841"},"PeriodicalIF":1.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Effects Observation of ICL Implantation With Personalized Surgically Induced Astigmatism for Correcting Low to Moderate Astigmatism With Myopia in Patients. ICL植入术配合个体化手术散光矫正低至中度散光伴近视患者的临床效果观察。
IF 1.9 4区 医学
Journal of Ophthalmology Pub Date : 2025-09-30 eCollection Date: 2025-01-01 DOI: 10.1155/joph/6649909
Ting Huang, Siyi Bao, Ke Li
{"title":"Clinical Effects Observation of ICL Implantation With Personalized Surgically Induced Astigmatism for Correcting Low to Moderate Astigmatism With Myopia in Patients.","authors":"Ting Huang, Siyi Bao, Ke Li","doi":"10.1155/joph/6649909","DOIUrl":"10.1155/joph/6649909","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the clinical effectiveness of personalized surgically induced astigmatism (SIA) combined with ICL implantation for correcting low to moderate astigmatism with myopia in patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective, noncomparative, noninterventional case series. The study included 55 myopic patients (87 eyes) with low to moderate astigmatism who underwent ICL implantation. All patients received a transparent corneal incision at the corneal steep axis, introducing personalized SIA. Preoperative and postoperative visual acuity, intraocular pressure (IOP), refractive diopter, corneal curvature, corneal astigmatism (CA), astigmatism axis, and aberrations were evaluated. Preoperative and postoperative data changes were analyzed, and CA vector analysis was performed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The uncorrected distance visual acuity (UDVA) at 1 week and 6 months postoperatively were similar to the preoperative corrected distance visual acuity (CDVA) (&lt;i&gt;p&lt;/i&gt;1 = 0.870, &lt;i&gt;p&lt;/i&gt;2 = 0.043), and better than the estimated corrected distance visual acuity (EsCDVA) (&lt;i&gt;p&lt;/i&gt;1 &lt; 0.001, &lt;i&gt;p&lt;/i&gt;2 &lt; 0.001). The postoperative UDVA remained stable over time (&lt;i&gt;p&lt;/i&gt;=0.054). The ocular refractive astigmatism (RA) decreased by -0.43 D and approximately 51.81% (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) at 1 w postoperatively, and by -0.32 D and approximately 38.55% (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) at 6 m postoperatively. CA decreased by -0.38 D and approximately 30.65% (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) at 1 w postoperatively, and by -0.27 D and approximately 21.77% (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) at 6 m postoperatively. The postoperative regression in RA was approximately -0.11 D (&lt;i&gt;p&lt;/i&gt;=0.011), and in CA, it was approximately -0.11 D (&lt;i&gt;p&lt;/i&gt;=0.094). The postoperative total corneal aberrations and low-order aberration (LOA) were decreased (&lt;i&gt;p&lt;/i&gt; &lt; 0.05, &lt;i&gt;p&lt;/i&gt; &lt; 0.05), and high-order aberration (HOA) was increased (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). As time progressed postoperatively, the corrective results tended to regress. The postoperative vertical coma was decreased (&lt;i&gt;p&lt;/i&gt; &gt; 0.05), and the horizontal coma and the spherical aberration were increased (&lt;i&gt;p&lt;/i&gt; &gt; 0.05, &lt;i&gt;p&lt;/i&gt; &gt; 0.05). As time progressed postoperatively, the postoperative variation tended to be obvious. The SIA values at 1 week and 6 months postoperatively were -0.41 D ∗ 89 (mean -0.52 D) and -0.28 D ∗ 88 (mean -0.42 D), the target induced astigmatism (TIA) values were -0.25 D ∗ 87 (mean -0.43 D) and -0.23 D ∗ 87 (mean -0.32 D), and the correlations between TIA and SIA were &lt;i&gt;y&lt;/i&gt; = 0.44&lt;i&gt;x&lt;/i&gt; + 0.33, &lt;i&gt;R&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt; = 0.24 and &lt;i&gt;y&lt;/i&gt; = 0.32&lt;i&gt;x&lt;/i&gt; + 0.31, &lt;i&gt;R&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt; = 0.19. The difference vector (DV) values were -0.16 D ∗ 2 (mean -0.50 D) and -0.05 D ∗ 4 (mean -0.41 D). The postoperative correction index (CI) values were all greater than 1, indicating mild overcorrection. Notably, the effect of overcorrection was more pronounced at 1 w postoperatively than 6 m. The index of success ","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"6649909"},"PeriodicalIF":1.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetically Prioritized Plasma Proteins as Candidate Therapeutic Targets for Dry Age-Related Macular Degeneration. 遗传优先的血浆蛋白作为干性年龄相关性黄斑变性的候选治疗靶点。
IF 1.9 4区 医学
Journal of Ophthalmology Pub Date : 2025-09-30 eCollection Date: 2025-01-01 DOI: 10.1155/joph/3972293
Jiabao Hou, Ju Guo, Wenlong Shen, Dejian Xie, Ping Li, Yan Zhang, Zhihu Zhao
{"title":"Genetically Prioritized Plasma Proteins as Candidate Therapeutic Targets for Dry Age-Related Macular Degeneration.","authors":"Jiabao Hou, Ju Guo, Wenlong Shen, Dejian Xie, Ping Li, Yan Zhang, Zhihu Zhao","doi":"10.1155/joph/3972293","DOIUrl":"10.1155/joph/3972293","url":null,"abstract":"<p><strong>Background: </strong>Dry age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly, yet effective treatments remain limited. This study aimed to identify putative causal plasma proteins linked to dry AMD through proteome-wide Mendelian randomization (MR) and genetic pleiotropy analyses.</p><p><strong>Methods: </strong>We performed proteome-wide MR analyses using protein quantitative trait loci (pQTL) data from the UK Biobank Pharma Proteomics Project (UKB-PPP) and genetic summary statistics for dry AMD from FinnGen R11. Replication analyses were conducted using pQTL data from the deCODE Genetics cohort and dry AMD GWAS data from the Million Veteran Program (MVP), all in individuals of European ancestry. To enhance robustness, we conducted additional sensitivity analyses using colocalization and summary data-based MR (SMR) approaches. Cell-type-specific expression profiles derived from single-cell RNA sequencing (scRNA-seq) data were used to prioritize candidate drug targets based on tissue relevance and druggability.</p><p><strong>Results: </strong>Discovery MR analysis identified 22 plasma proteins putatively associated with dry AMD. Replication MR tests and genetic pleiotropy analyses prioritized 12 proteins. Two retinal cell-specific genes were validated through scRNA-seq analysis. Druggability assessment confirmed C3 as an established AMD target and identified MASP1 and CFHR2 as complement pathway components with partial druggability. Notably, the remaining nine proteins represent novel pathways in dry AMD pathogenesis, four of which offer immediate drug-repurposing opportunities with approved agents, while five represent previously unexplored therapeutic candidates with high mechanistic plausibility.</p><p><strong>Conclusions: </strong>This study provides genetically supported therapeutic candidates for dry AMD and prioritizes candidates with high clinical potential, advancing therapeutic strategies for dry AMD.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"3972293"},"PeriodicalIF":1.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Between COVID-19 and Retinal Vein Occlusions. COVID-19与视网膜静脉闭塞的关系
IF 1.9 4区 医学
Journal of Ophthalmology Pub Date : 2025-09-29 eCollection Date: 2025-01-01 DOI: 10.1155/joph/6507997
Tetsuya Muto, Shigeki Machida, Shinichiro Imaizumi, Koju Kamoi
{"title":"Relationship Between COVID-19 and Retinal Vein Occlusions.","authors":"Tetsuya Muto, Shigeki Machida, Shinichiro Imaizumi, Koju Kamoi","doi":"10.1155/joph/6507997","DOIUrl":"10.1155/joph/6507997","url":null,"abstract":"<p><p>The relationship between coronavirus disease 2019 (COVID-19) infection or vaccination and retinal vein occlusions (RVOs) remains controversial. RVOs include central and branch RVOs. Previous studies have indicated a link between RVOs and COVID-19. RVOs develop when the retinal blood vessels are clogged by thrombin or lipid deposition. The retina, an important component of the visual apparatus, relays the visual information to the brain after light stimulation. When retinal veins are clogged, the damage can range from slightly reduced vision to complete blindness. SARS-CoV-2, the causative agent for COVID-19, leads to endothelial dysfunction and increased von Willebrand factor (VWF) antigen levels in the blood, which activate the coagulation process and platelet aggregation. Activation of tissue factors initiates the coagulation cascade, leading to fibrin formation through thrombin. Because arteries and veins sometimes cross in the retina, the vein, with its thin vessel wall, may be compressed. As a result, blood flow slows due to venous constriction, and clotting is more likely to occur at the crossing point. RVO ultimately develops through these processes. Patients with COVID-19 have significantly elevated levels of VWF antigen and activity, which likely contribute to the increased risk of thrombosis observed in COVID-19-associated coagulopathy. As RVOs align with conventional approaches, ophthalmologists should consider COVID-19 as a potential etiological factor when evaluating patients presenting with acute vision loss. Enhanced awareness of this association may facilitate timely diagnosis and tailored patient care in affected populations.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"6507997"},"PeriodicalIF":1.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Visual Field Fluctuation Between Myopic and Emmetropic Glaucoma Patients. 近视眼与屈光性青光眼患者视野波动的比较。
IF 1.9 4区 医学
Journal of Ophthalmology Pub Date : 2025-09-21 eCollection Date: 2025-01-01 DOI: 10.1155/joph/9948265
Molly Barten, Louis B Cantor
{"title":"Comparison of Visual Field Fluctuation Between Myopic and Emmetropic Glaucoma Patients.","authors":"Molly Barten, Louis B Cantor","doi":"10.1155/joph/9948265","DOIUrl":"10.1155/joph/9948265","url":null,"abstract":"<p><p><b>Background:</b> Conflicting studies suggest that myopia may both increase and decrease the risk of developing glaucomatous visual field loss. To provide appropriate treatment, one must distinguish between visual field fluctuation, where variability occurs over days to weeks not due to pathological change, and true visual field progression. <b>Objective:</b> A retrospective, observational clinical study tests the hypothesis that myopic glaucoma patients demonstrate more long-term visual field fluctuation than emmetropic glaucoma patients. <b>Methods:</b> Four or more Humphrey visual field tests over several clinic visits were analyzed in 156 eyes. The visual field index (VFI) plot, mean deviation (MD), and threshold sensitivity on the glaucoma progression analysis were collected to quantify fluctuation. The sample had two groups: (1) emmetropic glaucoma eyes with a spherical equivalent refraction between +2 and -2 diopters and (2) high myopic glaucoma eyes with a spherical equivalent refraction ≤ -5 diopters. Two sample -tests and one-way analysis of variance (ANOVA) tests with random effect on subject using root mean square error of approximation (RMSEA) were used to compare fluctuation. <b>Results:</b> RMSEA two sample -tests between 78 myopic and 78 emmetropic glaucoma eyes found that myopic glaucoma eyes demonstrated significant fluctuation for MD (<i>p</i> = 0.006) and VFI (<i>p</i> = 0.035) compared with emmetropic eyes. Although myopic eyes showed greater fluctuation in MD (1.504 ± 1.016) and VFI (0.037 ± 0.045) compared with emmetropic glaucoma eyes (MD = 1.125 ± 0.652) (VFI = 0.026 ± 0.019), threshold sensitivity analyses did not reach statistically significant differences (<i>p</i> = 0.054) between myopic (1.609 ± 1.022) and emmetropic glaucoma eyes (1.339 ± 0.687). One-way ANOVA tests found statistically significant MD and VFI fluctuation difference (MD = -0.29, <i>p</i> value = 0.01) (VFI = -0.30, <i>p</i> value = 0.03) but not threshold sensitivity fluctuation difference = -0.19 (<i>p</i> value = 0.11). <b>Conclusion:</b> The results for MD and VFI, but not threshold sensitivity, are consistent with the hypothesis that myopic patients demonstrate more visual field fluctuation than emmetropic glaucoma patients.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"9948265"},"PeriodicalIF":1.9,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Collagen Cross-Linking Alone to 1% Povidone-Iodine Treatment of Refractory Corneal Ulcers: A Randomized Clinical Trial. 单独胶原交联与1%聚维酮碘治疗难治性角膜溃疡的比较:一项随机临床试验。
IF 1.9 4区 医学
Journal of Ophthalmology Pub Date : 2025-09-21 eCollection Date: 2025-01-01 DOI: 10.1155/joph/9559107
Mohammad-Hosein Validad, Soroush Jamshidian, Tahereh Rakhshandadi, Monireh Mahjoob
{"title":"Comparison of Collagen Cross-Linking Alone to 1% Povidone-Iodine Treatment of Refractory Corneal Ulcers: A Randomized Clinical Trial.","authors":"Mohammad-Hosein Validad, Soroush Jamshidian, Tahereh Rakhshandadi, Monireh Mahjoob","doi":"10.1155/joph/9559107","DOIUrl":"10.1155/joph/9559107","url":null,"abstract":"<p><p><b>Background:</b> Corneal ulcer is one of the most common causes of corneal opacities. This study compared the effects of topical 1% povidone-iodine (PI) and corneal collagen cross-linking in patients with therapy-resistant corneal ulcers. <b>Methods:</b> This single-blind randomized clinical trial included patients referred to Al-Zahra Ophthalmology Hospital in Zahedan, Iran, from 2022 to 2024, who had corneal ulcers resistant to standard therapy. Participants were divided into two groups using stratified permuted block randomization method: one group received 1% PI and the other underwent corneal collagen cross-linking. Signs and symptoms were recorded before treatment and on days 1, 3, 7, and 28 posttreatment. Statistical analysis was performed using generalized estimating equations and repeated measures analysis of variance (ANOVA). <b>Results:</b> Thirty patients, with a mean age of 52.23 ± 2.34 years, participated in this study. Both corneal collagen cross-linking and 1% PI treatments significantly reduced the wound area, stromal infiltration, hypopyon, corneal edema, eye itching, eye burning, and eye pain (<i>p</i> < 0.05). However, no statistically significant differences were observed between the two treatments (<i>p</i> > 0.09). The improvement rate was 73.3% in the 1% PI group and 60% in the corneal collagen cross-linking group. <b>Conclusions:</b> Corneal collagen cross-linking and 1% PI demonstrated comparable efficacy in promoting healing of refractory corneal ulcers. Therefore, both methods may be considered for managing corneal ulcers that are resistant to standard therapy. <b>Trial Registration:</b> Iranian Registry of Clinical Trials (IRCT): IRCT20221230056988N1.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"9559107"},"PeriodicalIF":1.9,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laser Photocoagulation Subsequent to Intravitreal Ranibizumab for Retinopathy of Prematurity Long-Term Efficacy in Extremely Low Birth Weight Twins. 雷尼单抗玻璃体注射后激光光凝治疗极低出生体重双胞胎早产儿视网膜病变的长期疗效
IF 1.9 4区 医学
Journal of Ophthalmology Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI: 10.1155/joph/8213936
Jin-Guo Chen, Xin Hong, Qing-Qing Huang, Ke-Xin Mo, Jing-Jin Zhang
{"title":"Laser Photocoagulation Subsequent to Intravitreal Ranibizumab for Retinopathy of Prematurity Long-Term Efficacy in Extremely Low Birth Weight Twins.","authors":"Jin-Guo Chen, Xin Hong, Qing-Qing Huang, Ke-Xin Mo, Jing-Jin Zhang","doi":"10.1155/joph/8213936","DOIUrl":"10.1155/joph/8213936","url":null,"abstract":"<p><p><b>Purpose:</b> To evaluate the long-term efficacy of laser photocoagulation (LP) subsequent to intravitreal ranibizumab (IVR) for retinopathy of prematurity (ROP) in extremely low birth weight (ELBW) twins. <b>Methods:</b> In this matched case-control retrospective study, ELBW (birth weight < 1000 g) twins developed Type I ROP or AROP who received IVR and LP consecutively (IVR + LP) grouped between July 2019 and May 2022 were reviewed. Primary structural outcome was assessed at 12 months postoperatively. Physical assessments, comprising ophthalmic, systemic, and neurodevelopmental evaluations were performed at a chronological age of 24-36 months. Children with spontaneous regression of ROP, matched by sex and age (±3 months) to the IVR + LP group in a 1:1 ratio, were defined as the control group. The independent <i>t</i>-test and Wilcoxon rank-sum test were used to analyze and describe the demography, morphology, and treatment outcomes. <b>Results:</b> Twenty-four twins (48 eyes) with the mean gestational age (GA) and body weight (BW) at birth of 27.5 ± 1.7 weeks and 831.4 ± 140.9 g, respectively, were analyzed. Aggressive ROP in Zone I was observed in 8 eyes (16.7%). Stage 3+ disease was observed in 2 eyes (4.1%) in Zone I and 17 eyes (35.4%) in Zone II posterior. The median duration between IVR and LP was 197.5 days (range: 28-237 days). The reduction of cumulative clock hours (CCH) of ROP lesion showed a statistically significant difference after IVR (<i>p</i> < 0.05). The median laser spots count was 204 (range: 139-503), and the laser power ranged from 100 to 130 mW. Long-term follow-up physical examinations, including ophthalmic, systemic, and neurodevelopmental assessments, revealed no statistically significant differences between the IVR + LP and control groups. Notably, there were no differences in axial length (AL) and spherical equivalent (SE) (<i>p</i> < 0.05). <b>Conclusion:</b> LP following IVR treatment provides long-term effective outcomes for ROP in ELBW twins, without affecting ophthalmic, systemic, or neurological development, and reduces the risk of myopia compared to LP monotherapy.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"8213936"},"PeriodicalIF":1.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12443513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OCT Biomarkers in a Cohort of Patients With PRPF31-Associated Retinitis Pigmentosa. prpf31相关色素性视网膜炎患者的OCT生物标志物研究
IF 1.9 4区 医学
Journal of Ophthalmology Pub Date : 2025-09-07 eCollection Date: 2025-01-01 DOI: 10.1155/joph/6629368
Jan-Philipp Bodenbender, Katarina Stingl, Susanne Kohl, Laura Kühlewein
{"title":"OCT Biomarkers in a Cohort of Patients With <i>PRPF31</i>-Associated Retinitis Pigmentosa.","authors":"Jan-Philipp Bodenbender, Katarina Stingl, Susanne Kohl, Laura Kühlewein","doi":"10.1155/joph/6629368","DOIUrl":"10.1155/joph/6629368","url":null,"abstract":"<p><p><b>Purpose:</b> With degeneration of the photoreceptors in retinitis pigmentosa (RP), the reflectivity of the ellipsoid zone (EZ) decreases. We aimed to study characteristics of the EZ and its reflectivity in a cohort of patients with <i>PRPF31</i>-associated autosomal-dominant RP (<i>PRPF31</i>-adRP) and a possible relationship to EZ width and best-corrected visual acuity (BCVA). <b>Methods:</b> EZ width and relative EZ reflectivity (rEZR) were assessed in 32 patients with <i>PRPF31</i>-adRP. EZ width was measured on a horizontal SD-OCT scan through the fovea of the right eye. On the same OCT scans, rEZR was measured at the foveola, temporal and nasal parafoveola and fovea. <b>Results:</b> Total EZ width revealed a significant negative correlation with age (<i>r</i> <sub><i>s</i></sub>  = -0.418, <i>p</i>=0.017). Foveolar rEZR revealed a significant negative correlation with age (<i>r</i> <sub><i>s</i></sub>  = -0.403, <i>p</i>=0.022), but was not significantly correlated with BCVA (foveolar: <i>r</i> <sub><i>s</i></sub>  = -0.151, <i>p</i>=0.410), in contrast to parafoveolar rEZR (<i>r</i> <sub><i>s</i></sub>  = -0.365, <i>p</i>=0.0399), which was significantly correlated with BCVA. The ratio of foveal and parafoveolar rEZR correlated significantly with total EZ width (<i>r</i> <sub><i>s</i></sub>  = 0.358, <i>p</i>=0.044). <b>Conclusions:</b> The EZ reflectivity (EZR) can be measured reliably using freely available software. The correlation we observed between rEZR and BCVA leads us to the conclusion that rEZR may be an additional marker in observational and therapeutic trials.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"6629368"},"PeriodicalIF":1.9,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Ocular Torsion in Exotropic Patients Following Horizontal Strabismus Surgery: A Comparative Analysis Using Conventional Color Fundus Photography and Spectralis Optical Coherence Tomography. 水平斜视手术后外斜视患者眼扭转的评估:常规彩色眼底摄影和光谱光学相干断层扫描的比较分析。
IF 1.9 4区 医学
Journal of Ophthalmology Pub Date : 2025-09-07 eCollection Date: 2025-01-01 DOI: 10.1155/joph/1477145
Kaveh Abri Aghdam, Zahra-Alsadat Abtahi, Amin Zand, Mostafa Soltan Sanjari, Ali Sadeghi, Vahid Zare Hosseinabadi, Seyed Ali Sonbolestan
{"title":"Assessment of Ocular Torsion in Exotropic Patients Following Horizontal Strabismus Surgery: A Comparative Analysis Using Conventional Color Fundus Photography and Spectralis Optical Coherence Tomography.","authors":"Kaveh Abri Aghdam, Zahra-Alsadat Abtahi, Amin Zand, Mostafa Soltan Sanjari, Ali Sadeghi, Vahid Zare Hosseinabadi, Seyed Ali Sonbolestan","doi":"10.1155/joph/1477145","DOIUrl":"10.1155/joph/1477145","url":null,"abstract":"<p><p><b>Purpose:</b> To objectively evaluate ocular cycloposition using conventional color fundus photography (CFP) and Spectralis optical coherence tomography (OCT) in exotropic patients undergoing horizontal strabismus surgery and to assess the agreement between these methods. Additionally, we aimed to determine whether surgery alters ocular torsion in pure exotropia. <b>Methods:</b> In this prospective, single-center study, 42 eyes from 21 patients with exotropia requiring bilateral lateral rectus muscle recession were evaluated. The disc-center fovea angle (DFA) was measured pre- and postoperatively using CFP (Topcon fundus camera) and Spectralis OCT with fovea-to-disc (FoDi) alignment software. <b>Results:</b> The angle of exodeviation improved significantly postoperatively, from 35.10 ± 7.89 to 3.76 ± 3.73 prism diopters (<i>p</i> < 0.001). Both CFP- and OCT-derived DFA values remained stable in both eyes at 6 months (<i>p</i> > 0.05 for all comparisons). No significant differences were observed between CFP and OCT measurements at baseline or postoperatively (<i>p</i> > 0.05). Preoperative intraclass correlation coefficient (ICC) between methods was strong (right eye: 0.765; left eye: 0.750), decreasing postoperatively to moderate levels (right eye: 0.618; left eye: 0.661). <b>Conclusion:</b> Horizontal strabismus surgery does not significantly alter ocular torsion in pure exotropia. Spectralis OCT reliably quantifies cyclotorsion but may yield marginally lower DFA values compared to CFP, despite no statistical difference.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"1477145"},"PeriodicalIF":1.9,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Various Body and Head Positions on Intraocular Pressure in Cataract Patients With Limited Mobility. 活动受限白内障患者不同体位和头位对眼压的影响。
IF 1.9 4区 医学
Journal of Ophthalmology Pub Date : 2025-09-02 eCollection Date: 2025-01-01 DOI: 10.1155/joph/2019418
Yanxia Tong, Jing Yuan, Tingting Peng, Huafang Guo, Biyue Tu, Haifeng Jiang, Yong Wang
{"title":"Effect of Various Body and Head Positions on Intraocular Pressure in Cataract Patients With Limited Mobility.","authors":"Yanxia Tong, Jing Yuan, Tingting Peng, Huafang Guo, Biyue Tu, Haifeng Jiang, Yong Wang","doi":"10.1155/joph/2019418","DOIUrl":"10.1155/joph/2019418","url":null,"abstract":"<p><p><b>Purpose:</b> To assess the impact of various body and head positions on intraocular pressure (IOP) in cataract patients aged over 40 years with limited mobility. <b>Methods:</b> This cross-sectional study was conducted between August and December 2023 at Aier Eye Hospital of Wuhan University. The IOP was measured using a handheld tonometer (iCare IC200 rebound tonometer) in various head positions (forward, tilted left, and tilted right) and body positions: supine, semirecumbent, sitting, and prone. <b>Results:</b> In the supine position, the IOP measurements for the head positioned forward, right, and left were (13.80 ± 3.62) mmHg, (14.25 ± 3.66) mmHg, and (13.78 ± 3.40) mmHg, respectively. In the semirecumbent position, the corresponding IOPs were (12.08 ± 3.34) mmHg, (12.12 ± 3.22) mmHg, and (12.04 ± 3.38) mmHg. In the sitting position, the IOPs were recorded as (11.73 ± 3.29) mmHg, (11.73 ± 3.22) mmHg, and (11.59 ± 3.17) mmHg. Lastly, in the prone position, the IOPs were (14.19 ± 3.73) mmHg, (14.42 ± 3.93) mmHg, and (14.74 ± 3.81) mmHg, respectively. In each position group, there was no statistically significant difference in IOP among the three head positions. Regardless of the head position, the IOP is lowest in the sitting position, followed by semirecumbent and supine positions, with the prone position having the highest IOP. The analyses revealed that central corneal thickness (CCT) was correlated with an IOP value (<i>p</i> < 0.05) when patients were in different positions. <b>Conclusion:</b> IOP is influenced by body position. As the body transitions from upright to horizontal, IOP tends to increase. The position of the head, however, has no effect on IOP.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"2019418"},"PeriodicalIF":1.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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