Journal of Ophthalmology最新文献

{"title":"CHA₂DS₂-VASc Score in Predicting Visual Acuity Outcomes Following Retinal Vein Occlusion.","authors":"Achia Nemet, Raimo Tuuminen, Tzadok Yona, Gilad Plopsky, Michal Katz, Natali Glinkin, Olga Lelchuk, Joseph Pikkel","doi":"10.1155/2024/3054783","DOIUrl":"https://doi.org/10.1155/2024/3054783","url":null,"abstract":"<p><p><b>Purpose:</b> To find whether the CHA₂DS₂-VASc score, a system for stratifying stroke risk among patients with atrial fibrillation, correlates with visual acuity prognosis following retinal vein occlusion (RVO). <b>Participants and Methods:</b> This retrospective study included 83 eyes of 83 patients with a diagnosis of branch or central RVO between June 2017 and August 2022 with at least 12 months of follow-up in Assuta Ashdod Medical Center, Ashdod, Israel. The patients were divided into three groups, with CHA₂DS₂-VASc scores of 0-2 (<i>N</i> = 31), 3-5 (<i>N</i> = 45), or 6-9 (<i>N</i> = 7). The change in best-corrected visual acuity (BCVA) between the groups was examined about 1 year after the presentation of RVO. <b>Results:</b> The patient mean age was 67.9 ± 13.8 years; 38.6% were women. The mean visual acuity was 0.83 ± 0.67 LogMAR units at the first admission and 0.78 ± 0.80 LogMAR units at the last visit. Patients with a CHA₂DS₂-VASc score from 6 to 9 had a significantly poorer BCVA prognosis at 1-year (+0.60 ± 0.94 [-0.27, 1.47] LogMAR units) compared to groups with a CHA₂DS₂-VASc score from 3 to 5 (-0.01 ± 0.65 [-0.20, 0.19] LogMAR units) and a CHA₂DS₂-VASc score from 0 to 2 (-0.12 ± 0.59 [-0.33, 0.10] LogMAR units) (<i>p</i> = 0.038). <b>Conclusions:</b> Following RVO, patients with a CHA₂DS₂-VASc score of 6 or higher had a worse prognosis in their visual acuity than patients with a lower score.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2024 ","pages":"3054783"},"PeriodicalIF":1.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Standard Cross-Linking on the Corneal Optical Density-Age Relationship in Keratoconus After Mechanical Stripping of the Epithelium.","authors":"Maja Bohac, Fanka Gilevska, Alma Biscevic, Ivan Gabric, Kresimir Gabric, Sudi Patel","doi":"10.1155/2024/8827837","DOIUrl":"https://doi.org/10.1155/2024/8827837","url":null,"abstract":"<p><p><b>Background:</b> To determine if cross-linking (CXL) treatment modifies any pre-existing association between corneal optical density (COD) and age in keratoconus free of corneal scarring. <b>Methods:</b> COD was monitored in two groups (i) before and after standard CXL treatment for keratoconus (de-epithelization with a crescent blade, <i>n</i> = 69 eyes) and (ii) age/gender-matched cases without any signs of keratoconus (<i>n</i> = 24 eyes). Seven different markers of COD were quantified using a 0-100 grey scale, supplied with Pentacam™ software. <b>Results:</b> Mean age (±sd, range) in Group I (19 females and 50 males) was 24.2 years (±7.2, 11-44) and in Group II (9 females and 15 males), it was 24.7 years (±7.6, 17-45). COD over the apex and along the depth of the cornea (y, arbitrary scale units) was associated with age (<i>x</i>, in years) in Group I at preop (<i>y</i> = 0.08<i>x</i> + 13.12, <i>r</i> _<i>s</i>  = 0.350 and <i>p</i>=0.003), at 12 months postop (<i>y</i> = 0.08<i>x</i> + 15.15, <i>r</i> _<i>s</i>  = 0.295 and <i>p</i>=0.014) and in Group II, at the start (<i>y</i> = 0.16<i>x</i> + 11.28, <i>r</i> _<i>s</i>  = 0.474 and <i>p</i>=0.019) and 12 months later (<i>y</i> = 0.24<i>x</i> + 8.63, <i>r</i> _<i>s</i>  = 0.600 and <i>p</i>=0.002). The change in COD following CXL was significantly associated with the preop value. <b>Conclusion:</b> CXL initially breaks down the pre-existing relationship between COD and age. This is re-established by 12 months postop. The CXL induced change in COD depends on the preop value but not on the patient's age.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2024 ","pages":"8827837"},"PeriodicalIF":1.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of a Trifocal Versus an Extended Depth of Field Intraocular Lens in Chinese Patients With Cataract: A Prospective Cohort Study.","authors":"Qingzhong Chen, Guangbin Zhang","doi":"10.1155/2024/5571802","DOIUrl":"https://doi.org/10.1155/2024/5571802","url":null,"abstract":"<p><p><b>Purpose:</b> To compare the standard outcomes between the PanOptix and Symfony multifocal intraocular lenses (MIOLs) in Chinese patients. <b>Methods:</b> This prospective observational cohort study enrolled patients with cataracts between April 2021 and December 2021 at Xiamen Eye Center Affiliated to Xiamen University. The patients were grouped in the PanOptix (TIOL group) and Symfony (EDF group) according to the IOLs implanted. Uncorrected distant, corrected distance, binocular uncorrected intermediate, and near visual acuity (UNVA), distance-corrected intermediate and near VA (DCNVA) , defocus curve, spectacle independence, contrast sensitivity (CS), and visual disturbances were evaluated after 3 months. <b>Results:</b> Forty patients (80 eyes) were enrolled in the study (20/group). Three months after the operation, UNVA (0.13 ± 0.16) and DCNVA (0.08 ± 0.08) were better in the TIOL group than in the EDF group (0.22 ± 0.08 and 0.22 ± 0.08, respectively, <i>p</i>=0.003 and <i>p</i> < 0.001, respectively). The TIOL group achieved a better-than-0.15-logMAR VA from +0.5 D to -2.5 D (40 cm). VAs of the TIOL group from -1 D (100 cm) to -4 D (25 cm) were better than in the EDF group (<i>p</i> < 0.05). There were no significant differences in the intermediate and far vision outcomes (<i>p</i> > 0.05). Total near-vision spectacle independence was higher in the TIOL group (80%) than in the EDF group (50%) (<i>p</i>=0.039). <b>Conclusion:</b> Compared with EDF, TIOL leads to better near-vision outcomes without significant differences for intermediate and distant vision outcomes. <b>Trial Registration:</b> ClinicalTrials.gov identifier: ChiCTR2100044558.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2024 ","pages":"5571802"},"PeriodicalIF":1.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subthreshold Micropulse Laser (577 nm) Therapy with an Individual Approach for Power Titration in Patients with Chronic Central Serous Chorioretinopathy (Pilot Study).","authors":"Taras Kustryn, Oleg Zadorozhnyy, Illia Nasinnyk, Nataliya Pasyechnikova, Andrii Korol","doi":"10.1155/2024/9750395","DOIUrl":"https://doi.org/10.1155/2024/9750395","url":null,"abstract":"<p><strong>Purpose: </strong>To study the safety and effectiveness of subthreshold micropulse (SML) 577 nm laser therapy with an individual power titration in treating patients with chronic central serous chorioretinopathy (CSC).</p><p><strong>Methods: </strong>The study was a prospective, single-centre observation of 30 patients (30 eyes) with chronic CSC. All patients with chronic CSC were treated with a 577 nm micropulse laser. Individual power parameters for each patient were titrated in a micropulse mode. The primary outcome measure was best-corrected visual acuity (BCVA) at 6-month follow-up. The secondary outcome measures were as follows: central retinal thickness (CRT) and maximum subretinal fluid height (SRFH) according to optical coherence tomography, number of laser sessions, and treatment safety at 6-month follow-up.</p><p><strong>Results: </strong>Before treatment, the mean BCVA was 0.35 ± 0.16, the mean CRT was 285 ± 76 µm, and the mean SRFH was 311 ± 85 µm. Six months after 577 nm SML therapy, there was a statistically significant increase in the mean BCVA with the maximum correction to 0.45 ± 0.15 (<i>p</i> = 0.001). The mean CRT and SRFH decreased significantly to 236 ± 45 <i>μ</i>m (<i>p</i> = 0.003) and 45 ± 25 <i>μ</i>m (<i>p</i> = 0.001), respectively. At the end of the follow-up, complete resorption of the subretinal fluid was noted in 50% (15 eyes), and in 43% (13 eyes), a decrease in the SRFH was observed. During the entire observation period, 25 patients underwent 1 session of 577 nm SML therapy, 2 patients underwent 2 sessions, and 3 patients underwent the intervention three times.</p><p><strong>Conclusion: </strong>SML 577 nm therapy with individual selection of laser power in a micropulse mode is a safe and effective method of treating patients with chronic CSC. Further studies are needed to test the long-term safety and efficacy of 577 nm SML therapy with individual power settings in chronic CSC.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2024 ","pages":"9750395"},"PeriodicalIF":1.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Optical Coherence Tomography Angiography in True and Pseudo-Optic Disc Swelling.","authors":"Kaveh Abri Aghdam, Ali Aghajani, Amin Zand, Samira Chaibakhsh, Pasha Anvari, Fatemeh Zahra Ijadi, Khalil Ghasemi Falavarjani","doi":"10.1155/2024/1164635","DOIUrl":"https://doi.org/10.1155/2024/1164635","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated the optic disc microvasculature in healthy subjects and patients with optic nerve head drusen (ONHD), active papilledema, and acute nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCTA).</p><p><strong>Methods: </strong>This prospective, comparative case series included sixteen eyes with ONHD, thirty-one eyes with active papilledema, sixteen eyes with acute NAION, and thirty-two healthy eyes. The Optovue AngioVue OCT and OCTA Imaging System recorded peripapillary retinal nerve fiber layer (RNFL) thickness and vessel density maps from the radial peripapillary capillary (RPC) slab.</p><p><strong>Results: </strong>Average RNFL thicknesses were greater in eyes with ONHD, papilledema, and NAION compared to control eyes (all <i>Ps</i> < 0.001), but this parameter did not differ among patient groups. The mean peripapillary vessel density did not differ between the ONHD and control groups (<i>P</i>=1.000), nor between the NAION and papilledema groups (<i>P</i>=0.216). However, this value in the ONHD and control groups was significantly higher than in the NAION and papilledema groups (all <i>Ps</i> < 0.05).</p><p><strong>Conclusion: </strong>RPC density is influenced during the progression of conditions such as ONHD, papilledema, and NAION. Although a decrease in vessel density values has been observed in cases of true disc edema, further research is necessary to assess the potential of OCTA in differentiating between true and pseudo-optic disc edema.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2024 ","pages":"1164635"},"PeriodicalIF":1.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Biometric and Optical Coherence Tomography Parameters in Former Preterm Children: A Cohort Study.","authors":"Marzieh Najjaran, Siamak Zarei-Ghanavati, Hadi Ostadimoghaddam, Abbasali Yekta, Nasser Shoeibi, Armin Hemmati, Mojtaba Abrishami, Saeed Akhlaghi, Mohammed Ziaei","doi":"10.1155/2024/2381582","DOIUrl":"https://doi.org/10.1155/2024/2381582","url":null,"abstract":"<p><strong>Purpose: </strong>To compare biometric and optical coherence tomography parameters as well as refractive status in preterm children aged 4-8 years with or without retinopathy of prematurity (ROP), and evaluate their correlations with age and gender-matched full-term children.</p><p><strong>Methods: </strong>Retrospective comparative cohort study of four groups of children. Children with a history of preterm birth, including ROP who received intravitreal bevacizumab (IVB) treatment, children with a history of ROP that regressed without treatment and those with no history of ROP were compared to age and gender-matched full-term children as a control group. Best corrected visual acuity (BCVA), spherical equivalent of refraction (SE), macular and choroidal thickness, as well as biometric parameters was measured.</p><p><strong>Results: </strong>A total of 120 eyes of 120 children (30 children in each group) were included. There was no significant difference in BCVA, SE, and subjective cylinder between groups (<i>p</i>=0.05, <i>p</i>=0.3, <i>p</i>=0.6, respectively). Axial length was significantly shorter, and the cornea was steeper in both ROP groups than in other groups (<i>p</i>=0.001, <i>p</i> < 0.001, respectively). The central macular thickness was significantly thicker in the treated, regressed ROP and preterm groups than in full-term children (<i>p</i> < 0.001). The gestational age was negatively correlated with macular thickness in both treated and regressed ROP groups (<i>r</i> = -0.517; <i>p</i>=0.003, <i>r</i> = - 0.490; <i>p</i>=0.006, respectively).</p><p><strong>Conclusions: </strong>Children with a history of ROP had a shorter axial length, steeper cornea, and thicker macula that correlated with lower gestational age.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2024 ","pages":"2381582"},"PeriodicalIF":1.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Human Induced Pluripotent Stem Cell-Based Model for Retinal Pigment Epithelial Cells to Reveal Possible Disease Mechanisms for Macular Degeneration in Pseudoxanthoma Elasticum.","authors":"Taina Viheriälä, Heidi Hongisto, Lyydia Saari, Marika Oksanen, Tanja Ilmarinen, Suvi Väärämäki, Hannu Uusitalo, Pasi Nevalainen, Heli Skottman","doi":"10.1155/2024/6939920","DOIUrl":"https://doi.org/10.1155/2024/6939920","url":null,"abstract":"<p><p>Pseudoxanthoma elasticum (PXE) is a rare metabolic disease with autosomal recessive inheritance. The manifestation in PXE is represented by retinal complications, pseudoxanthomas of the skin folding areas, and arterial calcification. The retinal complications are caused by the calcification of Bruch's membrane beneath retinal pigment epithelial cells (RPE) that can lead to retinal macular degeneration. The exact mechanism for the retinal pathophysiology is not known, and patients have variable symptoms and findings. Two induced pluripotent stem cell (hiPSC) lines from a patient carrying the common homozygous mutation c.3421C > T, p.Arg1141X in the ATP-binding cassette transporter gene (<i>ABCC6</i>; OMIM264800) were established and fully characterized. Then, RPE cells were differentiated, and molecular and functional characterization was conducted as a comparison to healthy controls. Data demonstrated that PXE-specific high-quality hiPSC lines can be established from a skin biopsy regardless of the skin-related disease phenotype and disease-specific RPE differentiation is feasible. The molecular and functional assessment of the PXE-specific RPE indicated increased pigmentation and reduced epithelial barrier functions as well as phagocytosis activity as compared to healthy controls. Although preliminary data, this indicates possible RPE-dependent factors that might explain the individual vulnerability of the retinas for macular degeneration in PXE. Future validation of the novel findings with additional PXE patients will be important.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2024 ","pages":"6939920"},"PeriodicalIF":1.8,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors and VEGF, hs-CRP, and ESR in Central Serous Chorioretinopathy.","authors":"Lingjuan Sun, Li Yin, Shurui Wang, Haiyan Wang","doi":"10.1155/2024/9322594","DOIUrl":"https://doi.org/10.1155/2024/9322594","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the risk factors associated with central serous chorioretinopathy (CSC) and analyze the relationship between vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and CSC.</p><p><strong>Methods: </strong>A total of 109 patients diagnosed with CSC (CSC group) at our ophthalmology clinic from February 2017 to February 2021 were included, with 103 volunteers from our hospital's health examination center serving as the control group. Additionally, the new multimodal imaging classification of 109 CSC patients was further divided into simple CSC (57 cases) and complex CSC (52 cases). Demographic data, underlying diseases, medical history, and medication history were collected. Levels of VEGF, hs-CRP, and ESR were measured, and multifactorial logistic regression analysis was performed to identify factors influencing CSC. Receiver operating characteristic (ROC) curve analysis was conducted to assess the diagnostic value of VEGF, hs-CRP, and ESR in CSC.</p><p><strong>Results: </strong>The CSC group showed a higher proportion of males, smoking history, alcohol consumption, comorbid obstructive sleep apnea, hypothyroidism, renal disease, <i>Helicobacter pylori</i> infection, steroid use, and shift work compared to the control group (<i>P</i> < 0.05). VEGF, hs-CRP, and ESR levels were significantly higher in the CSC group than in the control group (<i>P</i> < 0.05). The levels of VEGF, hs-CRP, and ESR in the complex CSC group were higher than those in the simple CSC group (<i>P</i> < 0.05). Male gender, shift work, <i>Helicobacter pylori</i> infection, hypothyroidism, elevated VEGF, hs-CRP, and ESR were identified as risk factors for CSC (<i>P</i> < 0.05). The combined diagnostic value of VEGF, hs-CRP, and ESR (area under the ROC curve: 0.886) was higher than that of individual markers (0.722, 0.728, and 0.703, respectively) (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Male gender, shift work, <i>Helicobacter pylori</i> infection, hypothyroidism, and elevated levels of VEGF, hs-CRP, and ESR are risk factors for CSC. The combined use of VEGF, hs-CRP, and ESR demonstrates higher diagnostic efficiency in identifying CSC.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2024 ","pages":"9322594"},"PeriodicalIF":1.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained and Efficient Delivery of Antivascular Endothelial Growth Factor by the Adeno-associated Virus for the Treatment of Corneal Neovascularization: An Outlook for Its Clinical Translation.","authors":"Mengzhen Xie,Lixiang Wang,Yingping Deng,Ke Ma,Hongbo Yin,Xiaolan Zhang,Xingye Xiang,Jing Tang","doi":"10.1155/2024/5487973","DOIUrl":"https://doi.org/10.1155/2024/5487973","url":null,"abstract":"Corneal diseases represent 5.1% of all eye defects and are the fourth leading cause of blindness globally. Corneal neovascularization can arise from all conditions of chronic irritation or hypoxia, which disrupts the immune-privileged state of the healthy cornea, increases the risk of rejection after keratoplasty, and leads to opacity. In the past decades, significant progress has been made for neovascular diseases of the retina and choroid, with plenty of drugs getting commercialized. In addition, to overcome the barriers of the short duration and inadequate penetration of conventional formulations of antivascular endothelial growth factor (VEGF), multiple novel drug delivery systems, including adeno-associated virus (AAV)-mediated transfer have gone through the full process of bench-to-bedside translation. Like retina neovascular diseases, corneal neovascularization also suffers from chronicity and a high risk of recurrence, necessitating sustained and efficient delivery across the epithelial barrier to reach deep layers of the corneal stroma. Among the explored methods, adeno-associated virus-mediated delivery of anti-VEGF to treat corneal neovascularization is the most extensively researched and most promising strategy for clinical translation although currently although, it remains predominantly at the preclinical stage. This review comprehensively examines the necessity, benefits, and risks of applying AAV vectors for anti-VEGF drug delivery in corneal vascularization, including its current progress and challenges in clinical translation.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"36 1","pages":"5487973"},"PeriodicalIF":1.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Indicators for Assessing the Risk of Progression from PACS to APAC and the Degree of Intraocular Pressure Elevation in APAC Using AS-OCT.","authors":"Rumin Zhao,Qiaofang Du,Yunlong Wu,Wenhui Geng,Zijian Zhang,Bojun Zhao","doi":"10.1155/2024/8368315","DOIUrl":"https://doi.org/10.1155/2024/8368315","url":null,"abstract":"ObjectiveThe aim of this study is to quantify anterior chamber parameters to provide potential risk indicators for evaluating the progression of primary angle-closure suspect (PACS) eyes to acute primary angle closure (APAC) and the degree of intraocular pressure elevation in patients with APAC utilizing anterior segment optical coherence tomography (AS-OCT).MethodsTomey CASIA2 AS-OCT was used to quantitatively measure various anterior chamber parameters, including anterior chamber depth (ACD), anterior chamber volume (ACV), lens thickness (LT), lens vault (LV), iris-trabecular contact index (ITC), iris thickness (IT), iris volume (IV), iris curvature (IC), iris area (IA), and iris thickness (IT), in APAC eyes (30 eyes) and contralateral PACS eyes (30 eyes) of 30 patients. The differences in these parameters between the two groups and their relationship with intraocular pressure were analyzed.ResultsCompared to the PACS group, the APAC group exhibited significantly smaller IA and IC, and significantly larger pupil diameter (PD) and ITC (P < 0.05). There were no statistically significant differences in ACV, ACD, ACW, ACA, LV, IV, and IT750/2000 between the two groups. In APAC eyes, multivariable linear regression analysis showed a significant negative correlation between intraocular pressure and IV (β = -1.85; 95% confidence interval: -2.77 to -0.93; P=0.001), while no correlation was found in PACS eyes. In all 60 eyes, LT showed a negative correlation with ACV, ACD, ACA, and nasal IT750, and a positive correlation with LV and nasal IC.ConclusionAS-OCT has multiple advantages in evaluating various anterior chamber parameters in patients with glaucoma. IA may serve as a predictive indicator of the progression of eyes from PAC or APAC. A significant negative correlation was found between intraocular pressure and IV during APAC attacks. LT can be considered a predictive factor for the occurrence of primary angle-closure disease.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"17 1","pages":"8368315"},"PeriodicalIF":1.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}