Subnuclear Phacoemulsification to Reduce Corneal Injury in Nuclear Cataract Surgery: Evidence From a Randomized Controlled Trial.

IF 1.8 4区 医学 Q3 OPHTHALMOLOGY
Journal of Ophthalmology Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI:10.1155/joph/1737599
Han Wang, Rubing Liu, Rong Wang, Xuyang Wang, Furong Luo, Jifa Kuang, Zebin Li, Chengwu Yang, Mingbing Zeng
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Abstract

Objects: To assess the safety and effectiveness of subnuclear phacoemulsification (SNP), a new technique for reducing corneal injury in nuclear cataract surgery. Methods: This randomized controlled trial (RCT) was designed in March 2020 and carried it out from April 1 to September 30, 2020, including a 3 months' follow-up. We recruited 256 age-related hard nucleus cataract patients and randomly assigned them to two groups: the experimental group receiving SNP, and the control group receiving conventional phacoemulsification (CP). A single surgeon performed all the surgeries. We compared the two groups on the cumulative dissipated energy (CDE), phacoemulsification ultrasound time (UST), and complications for safety, as well as at multiple postsurgery follow-up timepoints on three major outcomes for effectiveness: visual acuity, central corneal thickness, and central corneal endothelial cell density. Results: The two groups were well-matched in terms of demographics, nuclear density, and safety measures (ultrasound energy, phacoemulsification time, and complications). For effectiveness after surgery, compared to the CP group, the SNP group had better visual acuity and thinner central cornea postsurgery within 1 week and had higher central corneal endothelial cell density at the 1- and 3-month follow-up. Conclusions: Compared to CP, SNP is more effective for reducing corneal injury in cataract surgery. The widespread application of this technology will greatly improve the safety of cataract surgery, especially hard cataract surgery. Trial Registration: Chinese Clinical Trial Registry: ChiCTR2000031114.

亚核超声乳化术减少核性白内障手术中角膜损伤:来自随机对照试验的证据。
目的:评价核性白内障手术中减少角膜损伤的新技术——亚核超声乳化术(SNP)的安全性和有效性。方法:随机对照试验(RCT)于2020年3月设计,于2020年4月1日至9月30日进行,随访3个月。选取年龄相关性硬核性白内障患者256例,随机分为两组:实验组接受SNP治疗,对照组接受常规超声乳化术治疗。一名外科医生完成了所有的手术。我们比较了两组的累积耗散能量(CDE)、超声乳化超声时间(UST)和安全性并发症,并在多个术后随访时间点比较了三个主要疗效指标:视力、角膜中央厚度和角膜中央内皮细胞密度。结果:两组在人口统计学、核密度、安全措施(超声能量、超声乳化时间、并发症)方面匹配良好。术后疗效方面,与CP组相比,SNP组术后1周内视力更好,角膜中央更薄,随访1个月和3个月时角膜中央内皮细胞密度更高。结论:与CP相比,SNP能更有效地减少白内障手术中角膜的损伤。该技术的广泛应用将大大提高白内障手术特别是硬白内障手术的安全性。试验注册:中国临床试验注册:ChiCTR2000031114。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Ophthalmology
Journal of Ophthalmology MEDICINE, RESEARCH & EXPERIMENTAL-OPHTHALMOLOGY
CiteScore
4.30
自引率
5.30%
发文量
194
审稿时长
6-12 weeks
期刊介绍: Journal of Ophthalmology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the anatomy, physiology and diseases of the eye. Submissions should focus on new diagnostic and surgical techniques, instrument and therapy updates, as well as clinical trials and research findings.
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