The Combined Utilization of Epithelial Thickness and Tomographic Parameters in Keratoconus Detection.

IF 1.8 4区 医学 Q3 OPHTHALMOLOGY
Journal of Ophthalmology Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI:10.1155/joph/6647993
Abdelrahman Salman, Mayank Nanavaty, Rana Omran, Marwan Ghabra, Obeda Kailani, Rafea Shaaban, Taym Darwish, Buraa Kubaisi, Zein Baradi, Mohamed Khallouf, Omar Badla
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引用次数: 0

Abstract

Purpose: To evaluate the performance of the anterior segment optical coherence tomography (AS-OCT) and Scheimpflug-Placido tomographic (SPT) indices in differentiating suspect keratoconus (SKC) from normal (N). Methods: In this cross-sectional study, one eye of each patient was scanned on AS-OCT and SPT. Following, 5 regression analysis models were developed: Model 1: combined AS-OCT corneal thickness (CT); Model 2: combined AS-OCT epithelial thickness (ET); Model 3: Models 1 + 2; Model 4: SPT indices (symmetry index front [SIf], symmetry index back [SIb], keratoconus vertex back [KVb], and minimum CT [ThkMin]); Model 5: Models 3 + 4. The areas under the curve (AUC) of receiver operator characteristic (ROC) curves were compared across groups to estimate their performance accuracy. Results: Two hundred and five N eyes, 56 SKC eyes, and 89 keratoconus (KC) eyes were scanned with AS-OCT and SPT. For Models 1 and 2, no individual metric yielded an AUC > 0.84. For Model 3, the AUC was 0.96 (R2 Nagelkerke: 0.69) with 90.28% cases correctly identified as SKC. For Model 4, the AUC was 0.99 (R2 Nagelkerke: 0.87), with 95.58% of cases correctly classified as SKC. For Model 5, the diagnostic accuracy did not improve compared to Model 4. Conclusion: Both combined AS-OCT indices and combined SPT indices provided excellent diagnostic power to differentiate SKC from N eyes. The combined SPT model showed a superior value compared to the AS-OCT model. Furthermore, combined AS-OCT and SPT data did not perform better than the combined SPT data alone.

上皮厚度和层析参数在圆锥角膜检测中的联合应用。
目的:评价前段光学相干断层扫描(AS-OCT)和Scheimpflug-Placido断层扫描(SPT)指标在鉴别疑似圆锥角膜(SKC)和正常角膜(N)中的作用。方法:在本横断面研究中,对每位患者的一只眼进行AS-OCT和SPT扫描。建立5个回归分析模型:模型1:AS-OCT联合角膜厚度(CT);模型2:AS-OCT联合上皮厚度(ET);模型3:模型1 + 2;模型4:SPT指数(前对称指数[SIf],后对称指数[SIb],圆锥角膜顶点后对称指数[KVb],最小CT值[ThkMin]);模型5:模型3 + 4。比较各组受试者操作特征曲线的曲线下面积(AUC),以估计其表现准确性。结果:用AS-OCT和SPT扫描N眼205只,SKC眼56只,圆锥角膜(KC) 89只。对于模型1和2,没有单独的度量产生AUC bb0 0.84。对于模型3,AUC为0.96 (R2 Nagelkerke: 0.69), 90.28%的病例正确识别为SKC。对于模型4,AUC为0.99 (R2 Nagelkerke: 0.87), 95.58%的病例被正确分类为SKC。对于模型5,与模型4相比,诊断准确率没有提高。结论:AS-OCT联合指标和SPT联合指标对N眼SKC有较好的诊断价值。与AS-OCT模型相比,联合SPT模型显示出优越的价值。此外,联合AS-OCT和SPT数据并不比单独联合SPT数据表现更好。
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来源期刊
Journal of Ophthalmology
Journal of Ophthalmology MEDICINE, RESEARCH & EXPERIMENTAL-OPHTHALMOLOGY
CiteScore
4.30
自引率
5.30%
发文量
194
审稿时长
6-12 weeks
期刊介绍: Journal of Ophthalmology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the anatomy, physiology and diseases of the eye. Submissions should focus on new diagnostic and surgical techniques, instrument and therapy updates, as well as clinical trials and research findings.
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