Journal of Ophthalmology最新文献

{"title":"Comparison and Correlation of the Donor-Recipient Interface Changes and Visual Outcomes Between nDSEK and DSEK.","authors":"Minghai Huang, Thuthuy Hoang, Guina Yin, Yanqing Liang, Zhifeng Wu, Jian Teng, Zhuoyuan Zhang, Dongmei Wei","doi":"10.1155/joph/2066562","DOIUrl":"https://doi.org/10.1155/joph/2066562","url":null,"abstract":"<p><p><b>Purpose:</b> This study aimed to compare the donor-recipient interface changes between non-Descemet stripping endothelial keratoplasty (nDSEK) and Descemet stripping endothelial keratoplasty (DSEK) and assess their correlation with the postoperative best spectacle-corrected visual acuity (BCVA). <b>Methods:</b> This retrospective study collected clinical data on patients with corneal endothelial decompensation who underwent either nDSEK or DSEK between August 2019 and April 2023. The donor-recipient interface particle density, interface haze, visual outcome, and graft dislocation were compared between nDSEK and DSEK groups. <b>Results:</b> A total of 66 eyes from 66 patients (nDSEK <i>n</i>: 31 eyes and DSEK <i>n</i>: 35 eyes) were included. At 12 months postoperatively, nDSEK had a mean interface particle density of 631.97 ± 143.95 particles/mm², significantly higher than DSEK's 518.20 ± 121.72 particles/mm² (<i>p</i>=0.001). The interface haze was also greater in nDSEK (78.16 ± 13.74) compared with DSEK (64.21 ± 14.78) (<i>p</i> < 0.001). BCVA improved similarly in both groups, with nDSEK changing from 1.92 ± 0.26 to 0.37 ± 0.11 and DSEK from 1.85 ± 0.24 to 0.34 ± 0.10 (<i>p</i>=0.149). Correlation analysis revealed a significant association between interface particle density and interface haze in both the nDSEK (correlation coefficient: 0.716, <i>p</i> < 0.001) and DSEK (correlation coefficient: 0.618, <i>p</i> < 0.001) groups. However, there was no significant correlation between interface particle density and postoperative BCVA for either the nDSEK (correlation coefficient: -0.028, <i>p</i>=0.883) or DSEK (correlation coefficient: 0.111, <i>p</i>=0.525) group. Similarly, no significant correlation was found between interface haze and postoperative BCVA in both groups (nDSEK: correlation coefficient: -0.080, <i>p</i>=0.670 and DSEK: correlation coefficient: -0.210, <i>p</i>=0.227). Graft dislocation rates were comparable: 3.2% in nDSEK and 2.9% in DSEK (<i>p</i>=0.931). <b>Conclusion:</b> nDSEK exhibited more interface particles and haze than standard DSEK, but visual outcomes and graft attachment were similarly effective.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"2066562"},"PeriodicalIF":1.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Biomarkers for Patients With Fungal Keratitis From Blood Routine Examination: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio.","authors":"Aizhen Wang, Menghe Jin, Zhanpeng Yang, Shuaibing Zhou, Juan Yue, Susu Liu, Yanting Xie, Hongmin Zhang","doi":"10.1155/joph/5594701","DOIUrl":"10.1155/joph/5594701","url":null,"abstract":"<p><p><b>Purpose:</b> To assess the potential of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as novel diagnostic and prognostic biomarkers in fungal keratitis (FK). <b>Methods:</b> This study was carried out retrospectively in 77 FK patients and 77 matched cataract controls from Henan Eye Hospital. Peripheral venous blood samples were collected via venipuncture and analyzed using complete blood count for routine clinical evaluation. FK patients were classified into three subgroups: <i>Fusarium</i>, <i>Aspergillus</i>, and <i>Candida</i> groups. Inflammation severity was quantified using standardized clinical scoring. The treatment modalities were used to divide the FK patients into enucleation and nonenucleation groups. <b>Results:</b> NLR and PLR were significantly elevated in FK versus controls (<i>p</i> < 0.001). NLR correlated strongly with inflammation scores (<i>r</i> = 0.535, <i>p</i> < 0.0001), exceeding PLR's moderate correlation (<i>r</i> = 0.311, <i>p</i>=0.0059). FK patients in the enucleation group had significantly higher NLR (<i>p</i>=0.012) and PLR (<i>p</i>=0.021) values than those in the nonenucleation group. There were no significant biomarker differences across fungal species (<i>p</i> > 0.05). <b>Conclusion:</b> Elevated NLR and PLR values during routine laboratory testing might serve as supplementary indicators for early suspicion of FK and monitoring inflammatory progression, particularly in resource-limited settings where specialized ophthalmic diagnostics are unavailable.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"5594701"},"PeriodicalIF":1.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Democratizing Glaucoma Care: A Framework for AI-Driven Progression Prediction Across Diverse Healthcare Settings.","authors":"Cansu Yuksel Elgin","doi":"10.1155/joph/9803788","DOIUrl":"https://doi.org/10.1155/joph/9803788","url":null,"abstract":"<p><p><b>Purpose:</b> To propose a conceptual framework for an AI-driven personalized glaucoma progression prediction system that integrates diverse data sources to enhance clinical decision-making and improve patient outcomes. This framework is specifically designed to address healthcare disparities in glaucoma care through scalable AI technology that can function across diverse resource settings, from tertiary care centers to remote clinics. The system aims to democratize access to expert-level glaucoma care while addressing challenges of bias, equity, and accessibility. <b>Methods:</b> The paper outlines a comprehensive framework consisting of four main components: (1) data integration and preprocessing, (2) AI model architecture and training, (3) personalized prediction generation, and (4) a clinical decision support interface. The framework leverages multimodal neural networks to analyze structural imaging data, functional test results, clinical measurements, and patient demographics. <b>Results:</b> The proposed framework addresses current limitations in glaucoma progression prediction by capturing complex interactions between various risk factors. Potential benefits include early detection of rapid progressors, optimized treatment strategies, improved patient counseling, and support for clinical research. Implementation challenges such as data quality, model interpretability, workflow integration, regulatory approval, and ethical considerations are discussed along with strategies to address them. <b>Conclusions:</b> The AI-driven framework for glaucoma progression prediction represents a significant advancement in personalized glaucoma management. While challenges remain, the potential benefits in terms of preserved vision, improved quality of life, and more efficient healthcare delivery are substantial. Future research directions include incorporating genetic data, advanced imaging modalities, and federated learning techniques to further enhance the system's capabilities and impact.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"9803788"},"PeriodicalIF":1.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing Factors in Corneal Densitometry Recovery After Accelerated Cross-Linking for Keratoconus.","authors":"Kuan-I Huang, Cyuan-Yi Yeh, Chao-Chien Hu, Sheng-Fu Cheng","doi":"10.1155/joph/9490950","DOIUrl":"https://doi.org/10.1155/joph/9490950","url":null,"abstract":"<p><p>This study examines corneal densitometry recovery and influencing factors following accelerated corneal cross-linking (CXL) for progressive keratoconus. Corneal densitometry, measured using Scheimpflug tomography, provides an objective assessment of corneal clarity, especially in tracking the resolution of postoperative haze. We conducted a retrospective case-control analysis of 24 patients (31 eyes) who underwent CXL with 0.25% riboflavin and 18 mW/cm² irradiation between 2021 and 2023. Variables included patient age, maximum keratometry (<i>K</i> _max), central corneal thickness (CCT), and demarcation line depth (DLD), defined as the depth of the CXL region. Results revealed a significant increase in densitometry values across most corneal zones at 1-month postoperation, followed by a gradual return to baseline by 12 months. Notably, younger patients exhibited a faster recovery, with mean densitometry values returning to baseline in 11.4 months compared to 14.9 months in older patients (<i>p</i>=0.02). Similarly, corneas with deeper DLDs demonstrated faster densitometry recovery, suggesting a potentially more efficient corneal remodeling process. Additional analysis indicated a trend toward higher densitometry values in shallower DLDs at 1 month, although this difference was not statistically significant. These findings support the use of densitometry as a reliable measure of post-CXL healing. While DLD depth and patient age were associated with a faster recovery, they did not directly predict final corneal clarity. Our study suggests that factors such as age and DLD depth should be considered in patient prognosis, although further research is needed to confirm these findings across varying CXL protocols.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"9490950"},"PeriodicalIF":1.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and Vascular Features of Macula Related to the Recurrence of Macular Edema in Central Retinal Vein Occlusion After Anti-VEGF Therapy.","authors":"Dazhuang Ren, Cece Zhao, Gaoxu Wei, Xiaoyun Hou, Chang Li, Zhiqing Li","doi":"10.1155/joph/8824342","DOIUrl":"10.1155/joph/8824342","url":null,"abstract":"<p><p><b>Purpose:</b> To identify the structural and vascular features of the macula related to the recurrence of macular edema (ME) in central retinal vein occlusion (CRVO) after intravitreal anti-VEGF injections. <b>Methods:</b> This was a cross-sectional study including CRVO patients without ME and age-matched individuals. CRVO patients were divided into the ME-resolved group and the ME-recurrence group on the basis of whether ME recurred within 3 months. All subjects provided a detailed history and underwent a comprehensive ophthalmological examination. Measurements of the macula by swept-source optical coherence tomography angiography (SS-OCTA) were recorded. We also created the Δparameter, which represents the difference in OCTA parameters between CRVO-affected eyes and their fellow eyes. <b>Results:</b> The study included 13 ME-resolved CRVO patients, 20 ME-recurrence CRVO patients, and 24 age-matched controls. Compared with the ME-recurrence group, the ME-resolved group had a longer CRVO duration, more previous intravitreal anti-VEGF injections, and a higher proportion of previous retinal photocoagulation (all <i>p</i> < 0.05). Additionally, retinal thickness (RT) and choroidal thickness (CT) were thinner in the ME-resolved group than in the ME-recurrence and control groups (all <i>p</i> < 0.01). The ME-resolved group also had significantly lower vessel density (VD) in both superficial and deep vascular complexes (SVC/DVC) and larger foveal avascular zone area (FAZa) in SVC and DVC than the ME-recurrence group and the control group (all <i>p</i> < 0.01). The results were the same with the Δparameters. Multivariate logistic regression revealed that ΔVD and ΔFAZa in SVC and DVC were independently associated with ME recurrence after adjusting for the effects of CRVO duration, previous anti-VEGF injections, and retinal photocoagulation (all <i>p</i> < 0.05). <b>Conclusion:</b> With prolonged CRVO duration, more anti-VEGF injections, and more retinal photocoagulation procedures, retinal, choroidal, and vascular atrophy in the macula occurs in CRVO eyes, making ME less likely to recur. Macular vascular atrophy is vital for the resolution of ME and might be a manifestation of capillary remodeling.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"8824342"},"PeriodicalIF":1.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting the Outcome of Vitrectomy With Internal Limiting Membrane Peeling for Myopic Foveoschisis.","authors":"Lie Yang, Jialin Wang, Lu Zhao, Zhuohua Zhou, Yingxiang Huang, Yanling Wang","doi":"10.1155/joph/2774963","DOIUrl":"10.1155/joph/2774963","url":null,"abstract":"<p><p><b>Purpose:</b> To evaluate the short- and long-term effect of pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling on visual acuity and macular morphology in myopic foveoschisis (MF) patients and to identify potential prognostic factors. <b>Methods:</b> We retrospectively analyzed the clinical data of patients with MF who underwent PPV with ILM peeling by the same senior fundus surgeon at Beijing Friendship Hospital from January 2016 to December 2022. The peeling was strategically centered on the macular fovea, extending to encompass the superotemporal and inferotemporal vascular arcades. Univariate analysis and multivariate logistic regression analysis were conducted to screen out the prognostic factors. <b>Results:</b> 36 eyes of 36 consecutive patients were analyzed in total. Best-corrected visual acuity (BCVA) improved significantly from 1.10 ± 0.61 logMAR to 0.78 ± 0.58 logMAR (<i>p</i>=0.031). 23 eyes (63.89%) had postoperative BCVA improved ≥ 2 Snellen lines. The mean central fovea thickness (CFT) decreased from 427.14 ± 255.91 μm to 155.85 ± 67.33 μm (<i>p</i> < 0.001). 18 and 16 eyes achieved partial and complete retinal reattachment, respectively, as follows. The twelfth month postoperatively was a threshold to influence the resolution of MF significantly, but it did not affect the visual outcome. Multiple logistic regression showed CFT (OR = 1.007, 95% CI = 1.001, 1.013, <i>p</i> value = 0.034) remained significant to predict the complete retina resolution. For visual acuity, integrated ellipsoid zone (EZ) band (OR = 0.239, 95% CI = 0.073, 0.783, <i>p</i> value = 0.018) might be a significant predictive factor. Subgroup analysis further indicated that in eyes with an intact EZ band, a poorer baseline BCVA was associated with an increase in postoperative BCVA (<i>p</i>=0.015). Conversely, in those with disrupted EZ band, all included factors showed no significant difference. <b>Conclusion:</b> The study observed trends in the recovery pattern of the retina following surgery and suggested potential factors that may be associated with improvements in both visual acuity and retinal reattachment. The findings may offer some guidance to ophthalmic surgeons in considering the timing of surgery, although further research is needed to confirm these trends as definitive predictors.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"2774963"},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Myopic Progression and Quality of Life Wearing Either DIMs Lenses or Single-Vision Myopia Correcting Spectacles.","authors":"Xiaoying Li, Wei Ma, Yutong Song, Maurice Yap, Longqian Liu","doi":"10.1155/joph/9959251","DOIUrl":"10.1155/joph/9959251","url":null,"abstract":"<p><p><b>Purpose:</b> To assess the efficacy of the Defocus Incorporated Multiple Segments (DIMS) spectacle lens for myopia control and its impact on vision-related quality of life in Chinese children over a 1-year period. <b>Methods:</b> This randomized double-blind prospective controlled clinical trial enrolled 176 myopic subjects aged between seven and 14 years who were randomly assigned into the DIMS group or the control single-vision (SV) group. Refractive error and axial length measurements at baseline, three-, six-, nine-, and 12-month follow-up visits were monitored. The Quality of Life Impact of Refractive Correction (QIRC) questionnaire was used to evaluate the vision-related quality of life at baseline and at 12 months postintervention. <b>Results:</b> Of the initial cohort, a total of 151 children successfully completed the study (DIMS <i>n</i> = 72; SV <i>n</i> = 79). Baseline characteristics were similar between both groups. Average axial elongation and myopia progression after 1 year were 0.17 (95% CI 0.13-0.20) mm and -0.27 (95% CI -0.36 to -0.18) D in the DIMS group and 0.30 (95% CI 0.26-0.33) mm and -0.55 (95% CI -0.64 to -0.47) D in the SV group. The mean differences in axial elongation and myopia progression were 0.13 mm (95% CI 0.08-0.18 mm, <i>p</i> < 0.001) and -0.28 D (95% CI -0.41 to -0.15 D, <i>p</i> < 0.001) between the two groups. No significant difference in the QIRC score was found between the DIMS and SV groups (55.30 (95% CI 53.17-56.90) versus 54.20 (95% CI 51.99-56.41), <i>p</i>=0.854)). <b>Conclusion:</b> The use of DIMS lenses in children was found to slow down myopia progression compared to SV lenses, without negatively affecting their overall quality of life. <b>Trial Registration:</b> Clinical Trial Registry identifier: ChiCTR2000037443.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"9959251"},"PeriodicalIF":1.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Axial Length Prediction Model in Children With Congenital Cataract and Intraocular Lens Implantation.","authors":"Jialin Xu, Yunhui Yu, Yaqi Wang, Shenrong Zhang, Enze Liu, Wenjing Wang, Chenyuan Zhu, Jin Li","doi":"10.1155/joph/9948890","DOIUrl":"10.1155/joph/9948890","url":null,"abstract":"<p><p><b>Purpose:</b> To develop a prediction model for postoperative axial length (AL) in Asian children with congenital cataracts undergoing primary/secondary intraocular lens (IOL) implantation. <b>Design:</b> Retrospective observational study. <b>Methods:</b> Data were collected from children who underwent cataract surgery for congenital cataracts at the Eye Hospital of Wenzhou Medical University between 2006 and 2020. All participants completed preoperative and at least 1-year of postoperative follow-up. SPSS 26.0 software was used to analyze the variable factors affecting AL growth and the interactions among these factors. A generalized estimating equation (GEE) was employed to assess the correlation between the AL and related univariates over time. The univariate model was applied to build a multivariate model to predict the postoperative AL. Two validation sets were used to verify the accuracy of the formula. <b>Results:</b> The study involved 86 children, accounting for 148 eyes. The median age at the time of surgery was 3.00 years, with a median age of 9.50 years at the final follow-up visit. The median duration of follow-up was 5.00 years. The preoperative and final follow-up mean ALs were 21.79 ± 1.77 and 23.36 ± 1.90 mm, respectively. Taking the predicted AL (<i>Y</i>) as the dependent variable and the age at surgery (<i>X</i> ₁), age at review (<i>X</i> ₂), and preoperative AL (<i>X</i> ₃) as the independent variables, the prediction model was established as <i>Y</i> = 0.20 - 0.473 × <i>X</i> ₁ + 0.446 × <i>X</i> ₂ + 0.993 × <i>X</i> ₃ - 0.014 × (<i>X</i> ₂ - <i>X</i> ₁)∗<i>X</i> ₂. <b>Conclusions:</b> This model predicts AL growth in children following congenital cataract surgery and IOL implantation, helping ophthalmologists select appropriate IOL power.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"9948890"},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractive Accuracy of a Novel Swept-Source OCT in Patients With Short and Long Eyes.","authors":"Laureano A Rementería-Capelo, Inés Contreras, Jorge L García-Pérez, Javier Ruiz-Alcocer","doi":"10.1155/joph/9987580","DOIUrl":"10.1155/joph/9987580","url":null,"abstract":"<p><p><b>Purpose:</b> To analyze the refractive accuracy of a novel swept-source optical coherence biometer (SS-OCT), that uses individual refractive indices to measure axial length, in short and long eyes implanted with monofocal intraocular lenses (IOLs). <b>Methods:</b> This retrospective comparative study considered eyes with short axial length (AL) (< 22.5 mm) or long AL (> 26 mm) bilaterally implanted with the Acrysof IQ monofocal IOL. All eyes were preoperatively analyzed with the Argos biometer and IOL calculations were made using the Barrett Universal II (BUII). One month after the surgery, refractive and visual outcomes and refractive prediction errors were calculated. Furthermore, a back calculation of the prediction errors based on the Barrett True Axial Length (BTAL) formula was also performed and the results of both formulas were compared. <b>Results:</b> Sixty eyes of 60 patients (30 with AL < 22.5 mm (short) and 30 with AL > 26 mm (long)) were included. After surgery, monocular UDVA was 0.03 ± 0.10 and 0.10 ± 0.15 logMAR for short-eye and long-eye groups, respectively. For short eyes, mean prediction error (MPE) with BUII and BTAL were 0.19 ± 0.34 D and 0.00 ± 0.35 D, respectively (<i>p</i>  <  0.001). Mean absolute error (MAE) was 0.32 ± 0.22 D with the BUII and 0.29 ± 0.20 D with the BTAL formula (<i>p</i>=0.21). For long eyes, MPE with BUII was -0.15 ± 0.35 D and -0.13 ± 0.36 D with BTAL (<i>p</i>=0.08), while MAE was 0.31 ± 0.21 D and 0.32 ± 0.20 D with BUII and BTAL, respectively (<i>p</i>=0.33). The percentage of eyes with a prediction error within ±0.5 D predicted postop spherical equivalent was > 75% for both groups and both formulas (<i>p</i> > 0.05 for all situations). <b>Conclusions:</b> The novel SS-OCT biometer using individual refractive indices to measure AL showed an overall good refractive accuracy using the BUII. The results were similar or better with the optimized BTAL formula, suggesting that formulas purposely designed for biometric measurements with this novel technology are a promising tool for eyes with extreme AL.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"9987580"},"PeriodicalIF":1.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifitegrast in Treatment of Dry Eye Disease-A Practical, Narrative Expert Review.","authors":"Erlend C S Landsend, Mads Istre, Tor P Utheim","doi":"10.1155/joph/6504111","DOIUrl":"10.1155/joph/6504111","url":null,"abstract":"<p><p><b>Purpose:</b> Dry eye disease (DED) is a multifactorial disorder affecting millions worldwide. Inflammation plays a central role in DED. The aim of this review is to critically evaluate the literature concerning the efficacy and safety of lifitegrast, a small molecule immunomodulator that blocks the action of lymphocyte function-associated antigen-1. <b>Methods:</b> Studies were identified using PubMed and ClinicalTrials.gov. Fourteen studies met the inclusion criteria, six of which were randomized controlled trials. The articles were assessed regarding the effect of lifitegrast on symptoms and signs of DED, its usefulness compared to other treatments, and potential adverse events. <b>Results:</b> The analysis demonstrated positive effects of lifitegrast on subjective and objective parameters of DED in the selected studies. However, despite promising results, the included studies did not provide enough evidence to conclude that lifitegrast could outperform other treatments of DED. No major side effects were reported. <b>Conclusions:</b> Based on the current literature, we conclude that lifitegrast could improve various parameters of DED. Still, larger controlled trials are required to establish additional benefits of this medication beyond those of other DED treatments.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2025 ","pages":"6504111"},"PeriodicalIF":1.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}