Effect of Adjuvant Mitomycin-C on Recurrent Rhegmatogenous Retinal Detachment With Proliferative Vitreoretinopathy Managed by Relaxing Retinotomy and Retinectomy.
İhsan Gökhan Gürelik, Hüseyin Baran Özdemir, Beste Gizem Köse, Ahmet Burak Acar
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引用次数: 0
Abstract
Purpose: To evaluate the role of adjuvant mitomycin-C (MMC) use in cases of recurrent rhegmatogenous retinal detachment (RRD) complicated by proliferative vitreoretinopathy (PVR) managed by relaxing retinotomy and retinectomy (RR). Methods: A retrospective analysis of consecutive patients undergoing vitreoretinal surgery with RR for RD and PVR was conducted. Patients were divided into two groups: those receiving 20 μg/0.1 mL MMC via the MMC sandwich method (Group 1) and those who did not (Group 2).Demographics, surgical characteristics, visual outcomes, and complications that may related to MMC were analysed. Results: A total of 28 patients (14 eyes per group) were included in the study. Differences in baseline variables between groups were not significant (p > 0.05). The mean follow-up was 15.2 ± 12.2 months. In Group 1, mean preoperative best-corrected visual acuity (BCVA) improved from 2.72 ± 0.70 logMAR to 1.59 ± 0.61 logMAR postoperatively (p=0.001). In Group 2, mean preoperative BCVA increased from 2.06 ± 0.80 logMAR to 1.77 ± 0.94 logMAR (p=0.261). Re-surgery rates were significantly lower in Group 1 (21.4%) than in Group 2 (92.8%, p=0.001). Final retinal attachment was achieved in 100% of eyes in both groups. Postoperative mean intraocular pressure (IOP) was 16.29 ± 4.46 mmHg in Group 1 and 13.92 ± 1.44 mmHg in Group 2 (p=0.081). No MMC-related toxicity was observed clinically. Conclusions: MMC, applied via the sandwich technique, appears safe and is associated with high anatomical and functional success rates while reducing re-operations.
期刊介绍:
Journal of Ophthalmology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the anatomy, physiology and diseases of the eye. Submissions should focus on new diagnostic and surgical techniques, instrument and therapy updates, as well as clinical trials and research findings.