Journal of Food Biochemistry最新文献

{"title":"Berberine Liposome Nanoparticles as a Potential Therapeutic Strategy for Managing Ischemic Stroke Through PTGS2 Inhibition","authors":"Peng Xie,&nbsp;Mingyan Xia,&nbsp;Wenpeng Cao,&nbsp;Dongfen Guo,&nbsp;Zhenkui Ren,&nbsp;Wenfeng Yu","doi":"10.1155/jfbc/8896885","DOIUrl":"https://doi.org/10.1155/jfbc/8896885","url":null,"abstract":"<div>\u0000 <p>Pyroptosis following cerebral ischemia–reperfusion injury (CIRI) is a key driver of long-term neuronal damage and poor functional recovery. Microglia, the primary immune cells of the central nervous system (CNS), play a pivotal role in regulating pyroptosis and orchestrating neuroinflammation. In this study, we observed significant upregulation of prostaglandin endoperoxide synthase-2/cyclooxygenase-2 (PTGS2/COX-2) in ischemic stroke patients, as well as in both in vivo and in vitro CIRI models. Knockdown of PTGS2 attenuated pyroptosis in BV2 microglial cells exposed to oxygen-glucose deprivation/reoxygenation (OGD/R). Using network pharmacology and molecular docking, we identified berberine (BBR) as a specific PTGS2 inhibitor, capable of suppressing its expression. To overcome BBR’s poor aqueous solubility and low bioavailability, we developed a novel nanoliposomal formulation of BBR (BBR-LNPs). In a murine middle cerebral artery occlusion/reperfusion (MCAO/R) model, BBR-LNPs markedly alleviated neurological dysfunction and reduced CIRI by regulating PTGS2-mediated pyroptosis. Collectively, our findings demonstrate that BBR-LNPs mitigate CIRI by inhibiting PTGS2-dependent pyroptosis, highlighting their potential as a therapeutic strategy for ischemic stroke.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8896885","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gardenia Fruit and Its Active Compound Crocin Protect Against Dexamethasone-Induced Muscle Atrophy via Nrf2 Activation","authors":"Jung-In Kim,&nbsp;Hang Yeon Jeong,&nbsp;Young In Kim,&nbsp;Ahyoung Yoo,&nbsp;Hyunjung Lee,&nbsp;Chang Hwa Jung,&nbsp;Jiyun Ahn","doi":"10.1155/jfbc/2952670","DOIUrl":"https://doi.org/10.1155/jfbc/2952670","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Muscle mass gradually declines with age and the development of an effective strategy to prevent this is important. Gardenia fruit (<i>Gardenia jasminoides</i>; GJ), commonly used as a natural food colorant and in traditional herbal medicines, possesses antiinflammatory, antidiabetic, and antiangiogenic properties. However, its effects on muscle atrophy remain unexplored.</p>\u0000 <p><b>Purpose:</b> In this study, we investigated the potential of GJ extract to mitigate dexamethasone (DEX)-induced muscle atrophy.</p>\u0000 <p><b>Methods:</b> Cell experiments used C2C12 cells and myotube atrophy was induced with 50 μM DEX. Animal experiments used 7 week-old C57BL/6 mice and fed GJ at 0.05% or 0.1% in the diet for 8 weeks. DEX was injected intraperitoneally at 15 mg/kg per day for 18 days before dissection to induce muscle atrophy and the effects were evaluated.</p>\u0000 <p><b>Results:</b> GJ enhanced myogenic differentiation by upregulating myogenic regulatory factors like <i>Myf5</i> and <i>MyoD</i> and inhibited DEX-induced myotube atrophy. Additionally, GJ reduced DEX-induced ROS production and mitochondrial dysfunction via Nrf2 activation. In mice, GJ protected the loss of muscle mass and decrease in muscle function by DEX. DEX-induced oxidative stress was reduced by GJ via the activation of Nrf2, followed by the transcription of antioxidant genes. HPLC analysis identified geniposide (GP) and crocin (CC) as the main constituents of GJ. However, only CC was found to exert antioxidant effects and effectively reduce DEX-induced oxidative stress and muscle atrophy via Nrf2 activation.</p>\u0000 <p><b>Conclusion:</b> These findings suggest that GJ, particularly its bioactive component CC, may serve as a potential therapeutic agent for muscle atrophy.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/2952670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardioprotective Effects of Aerial or Underground Parts of Angelica gigas Nakai in a Rat Transient Acute Myocardial Infarction (AMI) Model","authors":"Hee Jeong Eo,&nbsp;Woori Jo,&nbsp;Nami Joo","doi":"10.1155/jfbc/4262732","DOIUrl":"https://doi.org/10.1155/jfbc/4262732","url":null,"abstract":"<div>\u0000 <p><i>Angelica gigas</i>Nakai (AGN) is a medicinal herb traditionally used for vascular and inflammatory disorders due to its bioactive compounds, including decursin (DC) and decursinol angelate (DA). While the underground (UG) parts of AGN have been extensively studied, the aerial parts remain underutilized. This study evaluates the cardioprotective effects of AGN aerial and UG parts in a rat model of transient acute myocardial infarction (AMI) by assessing cardiac biomarkers, echocardiography, and infarct size. Sprague–Dawley rats underwent left anterior descending (LAD) artery ligation to induce AMI and were orally administered AGN extracts (200 mg/kg) for 7 days. Serum biochemistry results showed that CK-MB and LDH levels in AGN aerial part administration were significantly decreased compared to the negative (MI + Veh) group. Echocardiographic analysis on days 3 and 7 post-AMI demonstrated improved cardiac function in the AGN-treated groups. Both groups exhibited increased ejection fraction (EF) and fractional shortening (FS), indicating enhanced systolic function. TTC staining confirmed a significant reduction in infarct size in both AGN treatment groups. These findings highlight the cardioprotective potential of AGN aerial parts, suggesting their potential application in therapeutic and functional food development. This study underscores the relevance of AGN as a candidate for nutraceuticals and sustainable plant-based interventions for cardiovascular health.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/4262732","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro, In Silico, and In Vivo Antineoplastic Activity of Maslinic Acid From Olive Leaves on Diethylnitrosamine-Induced Hepatocellular Carcinoma: Impact on ATP Citrate Lyase/Wnt/Beta-Catenin Signaling","authors":"Gehad M. Elnagar,&nbsp;Mohamed M. Elseweidy,&nbsp;Ayat M. Emad,&nbsp;Dalia M. Rasheed,&nbsp;Rana G. Eissa,&nbsp;Ghada M. Ragab,&nbsp;Amira A. El-Gazar,&nbsp;Sawsan A. Zaitone,&nbsp;Gehan I. EL-Salamony,&nbsp;Shaimaa A. Fattah,&nbsp;Mohammed S. Sobh,&nbsp;Asmaa K. K. Abdelmaogood,&nbsp;Hanaa M. Elzahed,&nbsp;Nesreen M. I. M. Elkomy","doi":"10.1155/jfbc/1380085","DOIUrl":"https://doi.org/10.1155/jfbc/1380085","url":null,"abstract":"<div>\u0000 <p><b>Background/Objectives:</b> Increasing incidences of hepatocellular carcinoma (HCC) and its complicated treatment protocols promote novel drug discovery programs. Maslinic acid (MA) is a naturally occurring oleane-type triterpenoid derived mainly from <i>Olea europaea</i> L., with evident antineoplastic potential.</p>\u0000 <p><b>Aims:</b> This study aimed to investigate in vitro, in silico, and in vivo antineoplastic activity of MA from olive leaves.</p>\u0000 <p><b>Methods:</b> The in vitro antiproliferative activity of MA on HCC cell line (HepG-2) was investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The study comprised an in silico exploration of the putative targets of MA predicted via open-access databases in order to reach a refined list of genes/proteins that would be later investigated to explore the predisposed pathways guiding the experiment forward. The novel antineoplastic molecular mechanisms of MA were further evaluated in vivo against diethylnitrosamine (DEN)-induced HCC probably mediated by targeting hepatic ATP citrate lyase (ACLY)/Wnt/β-catenin pathway for the first time in rats, when administered on the 12^th week of the experiment model (50 mg or 100 mg/kg/day orally).</p>\u0000 <p><b>Results:</b> MA showed significant anticancer activity against HepG-2 cancer cell line with the concentration required for 50% growth inhibition (IC₅₀) value of 18.6 μg/mL, compared to the reference drug doxorubicin, which had an IC₅₀ value of 3.181 μg/mL. The in silico prediction results illustrated that most of the acknowledged genes/proteins were implicated and enriched in cancer pathways, regulation of inflammatory response and cellular response to stress. Wnt–catenin pathway and apoptosis-related markers were furthermore investigated experimentally. MA downregulated ACLY expression, switching off both Wnt arms and stabilizing cell death machinery. Furthermore, MA modulated hepatocellular oxidative and inflammatory responses. Additionally, this overall state was reflected positively, displaying conservation of the liver histopathological architecture.</p>\u0000 <p><b>Conclusions:</b> The study showed new evidence for the potential of MA to ameliorate DEN-induced HCC; therefore, MA is a promising antitumor agent for attenuating HCC.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/1380085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Municipal Green Waste to Agriculture: Biostimulant Production by Solid-State Fermentation and Its Role in Improving Germination and Seedling Growth of Lettuce (Lactuca sativa)","authors":"Roberto Carlos Solano Porras,&nbsp;Adriana Artola,&nbsp;Raquel Barrena,&nbsp;Cindy Ballardo,&nbsp;Antoni Sanchez","doi":"10.1155/jfbc/5555098","DOIUrl":"https://doi.org/10.1155/jfbc/5555098","url":null,"abstract":"<div>\u0000 <p>Circular economy aims to transform waste into resources by closing organic cycles and reducing dependence on nonrenewable inputs. In this study, the use of a solid organic amendment containing indole-3-acetic acid (IAA) produced by solid-state fermentation (SSF) of municipal green waste composed of grass clippings and wood chips from parks and gardens and inoculated with <i>Trichoderma harzianum</i> was evaluated as a biostimulant for the improvement of germination and growth of lettuce seedlings (<i>Lactuca sativa</i>). Two organic amendments from different SSF processes were tested: the first one was obtained using tryptophan as a precursor for IAA production by <i>Trichoderma harzianum</i> and contained 119.02 μg IAA g⁻¹ dw (FS-H), whereas the second one did not include tryptophan in the SSF process and resulted in a concentration of 11.80 μg IAA g⁻¹ dw (FS-L). A control experiment without the addition of fermented solid was also performed. At 7, 14, 21, and 35 days after sowing (DAS), the application of FS-H, FS-L significantly improved germination indicators and biomass accumulation (shoot and root weights) compared to control. Furthermore, the content of photosynthetic pigments, including Chlorophyll a, Chlorophyll b, and carotenoids, was significantly higher in the treatments with high IAA content, with increases of 214%, 200%, and 175%, respectively, compared to those of control. Therefore, the use of these organic amendments acting as biostimulants favors seed germination, phenotypic changes, and chlorophyll content, while enhancing the yield of lettuce seedlings. This demonstrates the potential of the application of these organic amendments produced by SSF from organic waste inoculated with biostimulant producer strains, and it offers a sustainable and circular approach to improve agricultural yields.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5555098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction of Polyphenols and Anthocyanins From Apple Pomace With Natural Deep Eutectic Solvents: Evaluation of Their Antioxidant and Antibacterial Activities","authors":"Lauriane Bruna,&nbsp;Micheline Draye,&nbsp;Emilie Lyautey,&nbsp;Cléa Fourreaux,&nbsp;Giorgio Grillo,&nbsp;Giancarlo Cravotto,&nbsp;Gregory Chatel","doi":"10.1155/jfbc/8483951","DOIUrl":"https://doi.org/10.1155/jfbc/8483951","url":null,"abstract":"<div>\u0000 <p>The aim of this study was to evaluate the antioxidant and antibacterial properties of apple pomace (AP) extracts using natural deep eutectic solvents (NADES). Six NADES, based on choline chloride (ChCl), were used as environmentally friendly solvents. Four of these were combined with organic acids, while the other two were combined with urea; they were then used to extract bioactive compounds from AP. ChCl:urea mixture proved to be the solvent with the highest total polyphenol content (TPC), with 13.15 ± 4.70 mg gallic acid equivalent/mL. Antioxidant activity and total anthocyanidin content (TAC) were also assessed. ChCl:oxalic acid recorded the highest values with 35.59 ± 9.53 mg extract/mL and 64.81 ± 4.65 malvidin-3-glucose equivalent μg/mL, respectively. Solvent pH plays a crucial role in selective extraction; an acidic pH facilitates selective anthocyanidin extraction, while a basic pH does not. Anthocyanidin extraction correlated with extract antioxidant activity and solvent viscosity. In addition, the antibacterial activity of the extracts against <i>Bacillus cereus</i>, <i>Listeria innocua</i>, and <i>Escherichia coli</i> strains was studied. All extracts showed antibacterial properties against the strains tested. The ChCl:oxalic acid extracts showed particularly low minimum inhibitory concentrations (e.g., 25 mg_extract/mL for <i>B. cereus</i>) and EC₅₀ values (e.g., 6.0 ± 0.3 mg_extract/mL for <i>B. cereus</i>).</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8483951","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of Phenolic Compounds Release and Functional Property Enhancement Through Autochthonous Probiotic Fermentation of Qingjinju Puree","authors":"Shuaiguang Liu,&nbsp;Zewei Ma,&nbsp;Huan Huang,&nbsp;Jinlian Li,&nbsp;Jiale He,&nbsp;Yunyang Xu,&nbsp;Xin Qin,&nbsp;Lianhe Zheng,&nbsp;Hongjian Zhang","doi":"10.1155/jfbc/8660445","DOIUrl":"https://doi.org/10.1155/jfbc/8660445","url":null,"abstract":"<div>\u0000 <p>This study examined the fermentation of whole qingjinju puree using the autochthonous probiotic <i>Pichia terricola</i> QJJY1. The results indicated that <i>Pichia terricola</i> QJJY1 could dynamically regulate the ratio of organic acids to sugars in fermented whole qingjinju puree (FWQP) at various fermentation stages, leading to a reduction of 26.59% and 53.65%, respectively. Additionally, fermentation significantly enhanced the release of free and bound phenolics in FWQP, with total phenolic content and total flavonoid content increasing by 50.51% and 106.59%, respectively, compared to the unfermented samples. This positive correlation resulted in a 15.20%, 56.94%, and 148.19% increase in DPPH, ABTS free radical scavenging abilities, and CUPRAC, respectively, while the ability to inhibit α-amylase, α-glucosidase, and pancreatic lipase activities were increased by 38.60%, 27.34%, and 18.14%, respectively. The increase in the activities of five enzymes produced by <i>Pichia terricola</i> QJJY1 and its metabolites altered the microstructure of FWQP, manifesting as increased porosity and structural loosening. This subsequently facilitated the release and conversion of phenolic compounds, and ultimately influenced the composition and content of these compounds. This study effectively enhanced the release of phenolic compounds and functional activity in whole qingjinju puree, offering a valuable bioprocessing strategy and reference for qingjinju.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8660445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freshness Assessment of Sweetpotatoes Based on Physicochemical Properties and VOCs Using HS-GC-IMS Combined With HS-SPME-GC-MS Analyses","authors":"Xiaowei Wu,&nbsp;Wen Zhang,&nbsp;Zhixin Guo,&nbsp;Jian Zheng,&nbsp;Ping Xu,&nbsp;Xinru Zhang,&nbsp;Mingyi Yang,&nbsp;Yuge Guan,&nbsp;Jiyu Cheng,&nbsp;Guoquan Lu,&nbsp;Linjiang Pang,&nbsp;Xinghua Lu","doi":"10.1155/jfbc/6855678","DOIUrl":"https://doi.org/10.1155/jfbc/6855678","url":null,"abstract":"<div>\u0000 <p>This study investigates the dynamic changes of volatile organic compounds (VOCs) during the storage of sweetpotatoes and their correlation with freshness, providing guidance for quality evaluation. The physicochemical indicators of sweetpotatoes stored at 15°C and 90% relative humidity were analyzed, followed by cluster analysis based on these indicators. VOCs during storage were measured using headspace–gas chromatography–ion mobility spectroscopy (HS-GC-IMS) and headspace–solid-phase microextraction–gas chromatography–mass spectrometry (HS-SPME-GC-MS) techniques. The results showed that the physicochemical properties of sweetpotatoes changed regularly with storage time, allowing for the classification of freshness into three stages. Both HS-GC-IMS and HS-SPME-GC-MS results indicated significant changes in VOCs during storage, with orthogonal partial least squares discriminant analysis (OPLS-DA) effectively distinguishing between different freshness stages. Further multivariate statistical analysis of the HS-SPME-GC-MS data identified benzaldehyde, β-cyclocitral, β-cyclohomocitral, methyl phenylacetate, ethyl phenylacetate, eugenol, and β-ionone as indicators of freshness changes. A prediction model for the freshness variation of sweetpotatoes was constructed based on these VOCs, providing an important reference for analyzing freshness changes by measuring the VOCs released during storage.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/6855678","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Intermittent Fasting on Physical Performance and Exercise Outcomes: A Systematic Review and Meta-Analysis of Clinical Trials","authors":"Erfan Mortezapour,&nbsp;Mahsa Ranjbar,&nbsp;Elaheh Dehghani,&nbsp;Zahra Noushzadeh,&nbsp;Sakineh Shab-Bidar,&nbsp;Nagham Jouni,&nbsp;Kurosh Djafarian","doi":"10.1155/jfbc/2856753","DOIUrl":"https://doi.org/10.1155/jfbc/2856753","url":null,"abstract":"<div>\u0000 <p>Intermittent fasting (IF) practices are common eating patterns among physically active population. Therefore, the possible effect of IF on physical activity should be vigorously explored. The objective was to perform a systematic review along with a meta-analysis to determine the possible impacts of IF on physical performance. From the earliest feasible date to January 2024, all of three electronic databases of PubMed, Scopus, and Web of Science were searched thoroughly. Two authors identified studies that evaluated the effect of IF on physical performance. The combined effects were expressed as weighted mean differences (WMDs) and 95% confidence intervals (CIs) implementing a random effect model. The risk of bias in the selected studies was evaluated with the Cochrane Collaboration’s tool. A total of 29 studies met the inclusion criteria. Results elucidated that IF did not exert any significant effect on some physical performance parameters including Wingate peak power output, vertical jump height, maximal heart rate, bench press 1RM, rating of perceived exertion, blood lactate concentration, and handgrip strength. Overall, our findings indicate that IF does not exert a significant impact on key physical performance indicators, including strength, anaerobic capacity, perceived exertion, or cardiovascular response to exercise. However, more studies need to be done in this area incorporating athletes from a wider range of physical fitness and diverse exercise routines.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/2856753","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colla Corii Asini Prevents H2O2-Induced Cellular Aging and Skin Barrier Damage in HaCaT Keratinocytes","authors":"Xinyu Gao,&nbsp;Shuhua Ma,&nbsp;Yanan Sun,&nbsp;Lishuang Li,&nbsp;Yucui Jin,&nbsp;Jianjun Gu,&nbsp;Haibin Liu,&nbsp;Huiyuan Gao,&nbsp;Yi Wang","doi":"10.1155/jfbc/2885165","DOIUrl":"https://doi.org/10.1155/jfbc/2885165","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Aging weakens the skin barrier, causing dryness and inflammation. <i>Colla Corii Asini</i> (CCA) shows antioxidant and antiaging potential, possibly protecting against aging-related skin damage.</p>\u0000 <p><b>Objective:</b> This study aims to evaluate the effects of CCA on H₂O₂-induced aging and skin barrier damage in human keratinocytes (HaCaT) cells and to explore its underlying mechanisms.</p>\u0000 <p><b>Method:</b> We performed proteomics on CCA, simulated its digestion to obtain CCA intestinal absorption solution (CCA IAS), and tested its therapeutic effects on H₂O₂-induced skin aging and barrier damage in HaCaT cells.</p>\u0000 <p><b>Results:</b> Proteomic analysis of CCA reveals its potential to prevent aging and repair skin barrier damage by regulating key protein domains and biological processes. CCA enhances intestinal absorption of amino acids, hydroxyproline, and proteins, with significant antioxidant capabilities in the absorption fluid. CCA intestinal absorption solution (CCA IAS) enhances the proliferation and migration of H₂O₂-induced HaCaT cells and reduces oxidative stress by regulating reactive oxygen species (ROS) levels and antioxidant enzyme activity. Additionally, CCA reduces gene expression of aging markers p21, p53, and senescence-associated secretory phenotype (SASP). CCA IAS modulates gene expression of differentiation markers FLG, IVL, K10, tight junction proteins CLD-1, ZO-1, E-cadherin, and AMPs, while inhibiting phosphorylation in the mitogen-activated protein kinase (MAPK) pathway.</p>\u0000 <p><b>Conclusion:</b> This study demonstrates that CCA alleviates oxidative stress-induced aging and repairs H₂O₂-induced barrier damage in HaCaT cells, potentially through reducing phosphorylation levels in the MAPK pathway. These findings provide a foundation for further mechanistic and application-focused research on CCA.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/2885165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}