Journal of Food Biochemistry最新文献

{"title":"A Green and Rapid High-Performance Liquid Chromatography–Ultraviolet Method for Determination of Four Organic Acids in Different Parts of Dandelion With Blue Applicability Grade Index Assessment","authors":"Jing Chen,&nbsp;Qinggui Lei,&nbsp;Weiqi Yang,&nbsp;Wenhao Wang,&nbsp;Guang’ e Tan,&nbsp;Zhengming Qian","doi":"10.1155/jfbc/4077536","DOIUrl":"https://doi.org/10.1155/jfbc/4077536","url":null,"abstract":"<div>\u0000 <p>Dandelion is a functional food that serves both medicinal and dietary purposes, which requires quality control to ensure its safety and efficacy. This study established a rapid high-performance liquid chromatography-ultraviolet (HPLC-UV) method for analyzing four organic acids in different parts of dandelion. After ultrasonic extraction with 40% methanol, samples were analyzed using an Agilent InfinityLab Poroshell 120 EC-C₁₈ column with a mobile phase of 0.1% formic acid aqueous-methanol and detection wavelength at 325 nm. The method completed the analysis in 5 min (2 min for extraction and 3 min for chromatographic analysis). The 4 organic acid standards (caftaric acid, chlorogenic acid, caffeic acid, and chicoric acid) showed excellent linearity (<i>r</i> &gt; 0.9995), and the average spiked recoveries were 101.38%, 96.85%, 103.94%, and 100.15% (relative standard deviations were 1.00%, 1.00%, 0.97%, and 0.55%), respectively. The total content of 4 organic acids is highest in dandelion flowers (1.355 mg/g dry weight [DW]), followed by stems/leaves (1.182 mg/g DW), and lowest in roots (0.026 mg/g DW). Additionally, to evaluate the environmental impact of both new and reported methods, this study performed an analysis using the blue applicability grade index. The developed methodology obtained the highest score of 80.0, which indicated that the developed HPLC method was most effective and eco-friendly. In conclusion, this method is rapid, accurate, and eco-friendly, which is help to the product development and quality evaluation of dandelion.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/4077536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apoptotic and Cytotoxic Potential of Carnosic Acid- and Carnosol-Rich Fractions From Salvia dorystaechas on Human Hepatoma (HepG2) Cells","authors":"İlker Çinbilgel,&nbsp;Naciye Erkan,&nbsp;Serap Kocaoğlu Cenkci,&nbsp;Timur Tongur,&nbsp;Taner Erkaymaz,&nbsp;Kudret Akpınar","doi":"10.1155/jfbc/4440039","DOIUrl":"https://doi.org/10.1155/jfbc/4440039","url":null,"abstract":"<div>\u0000 <p>Plant isolates from <i>Salvia dorystaechas</i> (Lamiaceae) were investigated for their apoptotic and cytotoxic effects on human hepatocellular carcinoma (HepG2) cells under various treatment conditions. Chromatographic isolation yielded fractions (Fr C, D, F, and H) rich in carnosic acid (CA) and carnosol (CL), with significantly higher concentrations (26.3–93.5 g/kg) compared to the crude extract (10.0 g/kg). Other phenolic compounds, including caftaric acid, epicatechin, quercetin, and rutin, were also detected in notable amounts via ultra-high-performance liquid chromatography-mass spectrometry/mass spectrometry (UHPLC-MS/MS). CA-/CL-rich fractions effectively induced caspase-9 and caspase-3 activities, decreased cell viability, and increased lactate dehydrogenase (LDH) release. These effects were significant compared to those induced by 0.1 mM hydrogen peroxide (H₂O₂). Notably, Fr D and Fr H, which contained the highest CA/CL concentrations, showed caspase-9/caspase-3 activities of 1.60/1.83 and 1.63/1.94, respectively, at 25 μg/mL after 24 h of treatment, whereas the crude plant extract showed corresponding activity values of 1.33/1.36 under the same conditions. In contrast, the crude extract exhibited its strongest apoptotic and cytotoxic effects under harsher conditions (50 μg/mL and 48 h), with caspase-9/caspase-3 activities of 1.70/2.59, 12.0% cell viability, and 65.4% LDH release. Apoptosis was further supported by superoxide (O₂•⁻) production mediated by NADPH oxidases (NOXs), as the NOX inhibitor diphenyleneiodonium (DPI) reduced O₂•⁻ levels by 28.6%–48.6%. Additionally, nuclei-stained cells revealed morphological changes, including nuclear fragmentation, apoptotic body formation, and loss of adhesion. In conclusion, CA-/CL-rich <i>S. dorystaechas</i> isolates demonstrated strong apoptotic and cytotoxic effects on HepG2 cells, with contributions from other phenolic compounds. These findings highlight the potential therapeutic value of <i>S. dorystaechas</i> isolates in liver cancer treatment.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/4440039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Bitter Melon (Mormordica charantia) on Weight Loss and Body Composition: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials","authors":"Mohammad Reza Amini,&nbsp;Sanaz Pourreza,&nbsp;Camellia Akhgarjand,&nbsp;Fatemeh Sheikhhossein,&nbsp;Gholamreza Askari,&nbsp;Azita Hekmatdoost","doi":"10.1155/jfbc/2921435","DOIUrl":"https://doi.org/10.1155/jfbc/2921435","url":null,"abstract":"<div>\u0000 <p>Results from the clinical research about <i>Momordica charantia</i> (MC) benefits on weight loss have been contradictory. This study, which included the most available randomized placebo-controlled trials (RCTs), was the first to investigate the impact of MC supplementation on body weight and composition. The effects of the given MC on weight, body mass index (BMI), waist circumference (WC), and percentage of body fat (PBF) were examined in RCTs up to February 2023 (without limitation on release date). Online databases (PubMed/Medline, Google Scholar, Scopus, and Web of Science) were searched for these studies. The inclusion and exclusion criteria were followed in the screening and evaluation of the literature. The Cochrane tool was used to assess bias risk. There were a total of ten RCTs, including 448 participants. The meta-analysis revealed that MC supplementation had no effect on weight (weighted mean difference (WMD): 0.04 kg; 95% confidence interval ([CI]: −0.16 to 0.25; <i>p</i> = 0.66), BMI (WMD: −0.18 kg/m²; 95% CI: −0.43 to 0.25; <i>p</i> = 0.16), WC (WMD: −0.94 cm; 95% CI: −3.04 to 1.16; <i>p</i> = 0.37), and BFP (WMD: −0.99; 95% CI: −2.33 to 0.35; <i>p</i> = 0.14). According to the subgroup analysis, MC could lower the BMI at a dosage of ≤ 2000 mg/d when compared to a placebo group (<i>p</i>&lt;0.001). The dose-response analysis represented a significant nonlinear connection between the MC dosage and weight reduction (<i>P</i>_{non−linearity} = 0.011); the effect on weight loss was observed the most at doses of 2000 and 4500 mg. Moreover, MC consumption decreased the BMI by the sixth week and then increased the BMI up to the 17th week (<i>P</i>_nonlinearity = 0.03). Our results indicate that MC consumption can reduce the BMI in some dosages and duration of supplementation.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/2921435","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Bacterial Community Changes and Volatile Flavor Correlation During Fermentation of Low-Salt Dry-Cured Ham","authors":"Yijia Sun,&nbsp;Xin Liu,&nbsp;Jingqi Cao,&nbsp;Yingdao Nan,&nbsp;Baide Mu,&nbsp;Guanhao Li,&nbsp;Tingyu Li,&nbsp;Chunxiang Piao","doi":"10.1155/jfbc/9709367","DOIUrl":"https://doi.org/10.1155/jfbc/9709367","url":null,"abstract":"<div>\u0000 <p>The aim of this work is to elucidate the effects of reduced salt content on the microbial ecology and flavor profile of dry-cured ham. To develop the low-salt (LS) treatment group, a curing mixture consisting of 18% potassium lactate, 12% lysine, and 70% sodium chloride was utilized instead of traditional curing salts. On the other hand, the standard protocol for curing the control group (CK) involved the use of 100% sodium chloride. The results demonstrate that the ham in the LS group had a noteworthy 9.01% increase in protein content when compared to the ham in the CK group. Through SPME-GC-MS analysis, 40 distinct types of volatile compounds were identified. The LS group had a much higher nonanal content, which improved the ham’s flavor and rose aroma. Illumina Miseq sequencing indicates that the genus <i>Staphylococcus</i> is the most common microbial genus at the late ripening stage of dry-cured ham. Spearman correlation analysis revealed that <i>Staphylococcus</i> had a significant relationship with the C18:0 concentration and was substantially linked with most metabolites. Finally, instead of utilizing the standard 30% sodium chloride, it is recommended to process dry-cured ham using a formulation that comprises 18% potassium lactate, 12% lysine, and 70% sodium chloride. It is anticipated that this substitution will result in a higher production of volatile compounds and <i>Staphylococcus</i>, which will enhance the overall quality and flavor profile of the finished product.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9709367","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Phenolic Profiling of Moroccan Ferula communis L. Fruits: A Combination of In Silico and In Vivo Protective Effect Against Methotrexate-Induced Hepato-Renal Dysfunction","authors":"Ghizlane Nouioura,&nbsp;Mohamed El Fadili,&nbsp;Mohamed Bouhrim,&nbsp;El Hassania Loukili,&nbsp;Hazem K. Ghneim,&nbsp;Mourad A. M. Aboul-Soud,&nbsp;John P. Giesy,&nbsp;Badiaa Lyoussi,&nbsp;Elhoussine Derwich","doi":"10.1155/jfbc/1106215","DOIUrl":"https://doi.org/10.1155/jfbc/1106215","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Methotrexate (MTX) is associated with several side effects, including hepatic and renal toxicities, which limit its effectiveness as an anticancer medication. These toxicities can lead to hepatotoxicity, nephrotoxicity, and potential liver and kidney failure. On the other hand, the fruit of the giant fennel plant (<i>Ferula communis</i>) contains bioactive compounds with proven antioxidant and anti-inflammatory properties, as demonstrated in previous studies. These compounds have protective effects against various diseases.</p>\u0000 <p><b>Aim of the Study:</b> The current study combines <i>in silico</i> ADMET prediction and <i>in vivo</i> evaluation of hepatorenal toxicity of MTX in rats to predict potential effects in humans.</p>\u0000 <p><b>Materials:</b> Chemical constituents of FC were identified using HPLC-DAD analysis. <i>In silico</i> pharmacokinetics, ADMET predictions, and Egan’s boiled egg model were employed. For the <i>in vivo</i> experiments, 32 rats were divided into four groups to investigate the impact of FC extract (FC-Ext) on MTX-induced hepatorenal toxicity. The rats were pretreated with FC-Ext (250 mg/kg, body mass, dissolved in distilled water) from days 1 to 21 and administered MTX (25 mg/kg) on day 7. Various parameters, including body and organ masses, serum toxicity biomarkers (such as albumin, ALT, AST, BUN, creatinine, uric acid, and total protein), hematological parameters, and tissue histopathology, were evaluated to assess MTX-induced hepato-renal damage.</p>\u0000 <p><b>Results:</b> The analysis of FC revealed the presence of various phenolic acids, with 15 compounds identified using HPLC-DAD. ADMET prediction provided assurance regarding the safety of the phytochemical compounds from FC concerning liver injury. Experimental validation <i>in vivo</i> confirmed that MTX-induced hepato-renal damage led to increased levels of AST, ALT, BUN, and creatinine in blood serum. Hemoglobin, total protein, albumin, and uric acid levels decreased following exposure to MTX. However, co-treatment with a hydro-ethanolic extract of FC significantly mitigated these changes, restored kidney and liver functions, and preserved tissue architecture.</p>\u0000 <p><b>Conclusion:</b> FC-Ext shows promise in managing liver and renal diseases and mitigating the hematological toxicity induced by MTX. These findings suggest potential applications for humans in preventing MTX-induced renal, hepatic, and hematological toxicity.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/1106215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatoprotective Effects of Fermented Laminaria japonica in Oleic Acid–Induced HepG2 Cells and in a High-Fat Diet–Induced NAFLD Mice Model via Activating the SIRT1 Signaling Pathway","authors":"Qiulin Yue,&nbsp;Xianwei Wang,&nbsp;Yongxuan Liu,&nbsp;Mengrui Cai,&nbsp;Shousen Guo,&nbsp;Lin Zhao,&nbsp;Le Su,&nbsp;Song Zhang,&nbsp;Baojun Li,&nbsp;Chen Zhao,&nbsp;Kunlun Li","doi":"10.1155/jfbc/1706266","DOIUrl":"https://doi.org/10.1155/jfbc/1706266","url":null,"abstract":"<div>\u0000 <p><i>Laminaria japonica</i> is a kind of brown algal with good nutritional and medicinal value. Our previous studies demonstrated that the phytochemical components and bioactivities of <i>Laminaria japonica</i> were markedly enhanced by fermentation. However, the specific activity and underlying mechanism of fermented <i>Laminaria japonica</i> (FLJ) against NAFLD remain poorly understood. For this study, <i>Laminaria japonica</i> was fermented using <i>S. cerevisiae</i> and <i>Lactiplantibacillus</i>. <i>In vitro</i> assays were employed to evaluate the efficacy of FLJ in regulating cholesterol reduction and fat binding. In addition, the hepatoprotective effects and underlying mechanisms of FLJ in the treatment of NAFLD were evaluated using oleic acid (OA)–induced HepG2 cells and NAFLD mice. Our data revealed that FLJ significantly promoted fat-binding and cholesterol-reducing activity <i>in vitro</i>. Moreover, FLJ alleviated hepatic lipid accumulation, oxidative stress, and the inflammatory response in high-fat diet (HFD)–induced NAFLD mice and in OA–induced HepG2 cells. The underlying protective mechanisms of FLJ against NAFLD may be attributed to the activation of the SIRT1 signaling pathway. These observations suggested that FLJ could be developed as a functional food supplement for the prevention or improvement of NAFLD.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/1706266","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Applications of Hill Lemon (Citrus pseudolimon Tanaka) in Sustainable Bioprocessing: Bioactive Extraction, Nanoparticle Synthesis, and Functional Food Products","authors":"Ankita Thakur,&nbsp;Rajat Suhag,&nbsp;Yogesh Kumar,&nbsp;Anshu Sharma","doi":"10.1155/jfbc/5560966","DOIUrl":"https://doi.org/10.1155/jfbc/5560966","url":null,"abstract":"<div>\u0000 <p>Hill lemon (<i>Citrus pseudolimon</i> Tanaka) is an underutilized citrus fruit native to India, with significant potential in the food, pharmaceutical, and cosmetic industries due to its rich nutritional and bioactive profile. This review consolidates existing research on Hill lemon, highlighting its various components and their associated health benefits. Studies have documented its diverse health benefits, including antioxidant, antibacterial, antiviral, anti-inflammatory, and anticancer properties. The leaves, peel, and seeds of Hill lemon are rich sources of bioactive compounds like limonene, citronellol, pectin, essential oils, and vitamin C, contributing to its beneficial properties. Despite its promising potential, the short shelf life of the processed Hill lemon juice presents a challenge for commercialization. This review underscores the need for further research to fully explore the potential of Hill lemon and its bioactive compounds, particularly in developing value-added products with enhanced stability and extended shelf life.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5560966","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Deep Eutectic Solvent and Ethanol for the Extraction of Oil and Astaxanthin From Black Tiger Shrimp (Penaeus monodon) Shells","authors":"Chi Hai Tran,&nbsp;Van Man Phan,&nbsp;Thi Hong Anh Le","doi":"10.1155/jfbc/4288724","DOIUrl":"https://doi.org/10.1155/jfbc/4288724","url":null,"abstract":"<div>\u0000 <p>The black tiger shrimp (<i>Penaeus monodon</i>) shell, a by-product of shrimp processing, is a valuable natural source of oil and astaxanthin (AXT). However, extracting these from the shell is difficult due to its tough cell walls. This study examined the use of deep eutectic systems (DESs) to extract oil and AXT from black tiger shrimp shells. Three DESs (choline chloride/glycerol, choline chloride/citric acid, and choline chloride/lactic acid) were tested, and their extraction efficiencies were compared with those of traditional solvents (hexane, ethanol, and acetone). Results indicated that the extraction efficiency of oil and AXT from DESs was lower than that of traditional solvents, but when ethanol was added to the DES as a co-solvent, it significantly improved the yield. Specifically, combining choline chloride/lactic acid with 45% ethanol resulted in the highest concentrations of oil (6.42/100 g) and AXT (39.10 μg/g), surpassing ethanol (5.12/100 g and 31.56 μg/g) or hexane (5.62/100 g and 33.47 μg/g), and acetone (4.46/100 g and 28.59 μg/g). The shrimp extracts were rich in polyunsaturated fatty acids (i.e., linoleic acid, α-linolenic acid, EPA, and DHA) and AXT with potent antioxidant properties.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/4288724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review of the Health Benefits, Nutritional Composition, and Agricultural Aspects of Sesame Seeds","authors":"Hafiza Madiha Jaffar,&nbsp;Irfana Akhtar,&nbsp;Mah Zaib Saleem,&nbsp;Tabarak Malik,&nbsp;Arusha Ayub","doi":"10.1155/jfbc/8713698","DOIUrl":"https://doi.org/10.1155/jfbc/8713698","url":null,"abstract":"<div>\u0000 <p>Sesame seeds (<i>Sesamum indicum</i>) are considered valuable for their nutritional qualities and wide range of uses in several sectors of the global economy. Bioactive substances such as lignans, phytosterols, γ-tocopherol, phenolic acids, flavonoids, and tryptophan which have strong anti-inflammatory, lipid-lowering, and antioxidant properties are present in them. In addition, sesame seeds contribute to human health by offering vital elements like protein, unsaturated fatty acids, vitamins, and minerals. The bioavailability of these nutrients has been enhanced by recent developments in processing technologies and agricultural methods. Apart from the food industry, sesame seeds are also being used extensively in the pharmaceutical, cosmetic, and industrial sectors, such as in the manufacturing of biodiesel and animal feed. This review highlights the potential contribution of sesame seeds to sustainable food systems by compiling the most recent research on their nutritional makeup, health advantages, and variety of uses.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8713698","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of Inhibitory and Anti-Inflammatory Effects of Aloe-Emodin Against Multidrug-Resistant Escherichia coli: A Network Pharmacology and Molecular Dynamics Approach","authors":"Xuanpan Ding,&nbsp;Yuan Zhao,&nbsp;Junfeng Li,&nbsp;Shuai Zhang,&nbsp;Dan Yao,&nbsp;Haotian Yang,&nbsp;Yong Zhang,&nbsp;Honggang Fan","doi":"10.1155/jfbc/5709147","DOIUrl":"https://doi.org/10.1155/jfbc/5709147","url":null,"abstract":"<div>\u0000 <p><i>Aloe vera</i> is an important raw material for medicine and food, and aloe-emodin (AE) is one of the main extracts of <i>Aloe vera</i>. The aim of this study was to investigate the inhibitory effect of AE on multidrug-resistant <i>Escherichia coli</i> (MDR<i>-E. coli</i>) and the anti-inflammatory mechanism of this pathogenic bacterial infection. The minimum inhibitory concentration of AE against MDR<i>-E. coli</i> was determined in vitro. The potential therapeutic targets and signaling pathways of AE on inflammation were predicted by network pharmacology, and a mouse infection model was constructed by intraperitoneal injection of pathogenic bacteria and treated with AE. The results showed that AE had a better bacteriostatic effect and modulated the inflammatory response by affecting the expression of multiple inflammatory factors, and AE treatment significantly reduced symptoms such as inflammation, organ swelling, and bacterial load in the mouse model. The results suggest that AE may be an important active ingredient for <i>Aloe vera</i> to exert therapeutic health effects.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5709147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143581927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}