Journal of Food Biochemistry最新文献

{"title":"Hepatoprotective Effects of Fermented Laminaria japonica in Oleic Acid–Induced HepG2 Cells and in a High-Fat Diet–Induced NAFLD Mice Model via Activating the SIRT1 Signaling Pathway","authors":"Qiulin Yue,&nbsp;Xianwei Wang,&nbsp;Yongxuan Liu,&nbsp;Mengrui Cai,&nbsp;Shousen Guo,&nbsp;Lin Zhao,&nbsp;Le Su,&nbsp;Song Zhang,&nbsp;Baojun Li,&nbsp;Chen Zhao,&nbsp;Kunlun Li","doi":"10.1155/jfbc/1706266","DOIUrl":"https://doi.org/10.1155/jfbc/1706266","url":null,"abstract":"<div>\u0000 <p><i>Laminaria japonica</i> is a kind of brown algal with good nutritional and medicinal value. Our previous studies demonstrated that the phytochemical components and bioactivities of <i>Laminaria japonica</i> were markedly enhanced by fermentation. However, the specific activity and underlying mechanism of fermented <i>Laminaria japonica</i> (FLJ) against NAFLD remain poorly understood. For this study, <i>Laminaria japonica</i> was fermented using <i>S. cerevisiae</i> and <i>Lactiplantibacillus</i>. <i>In vitro</i> assays were employed to evaluate the efficacy of FLJ in regulating cholesterol reduction and fat binding. In addition, the hepatoprotective effects and underlying mechanisms of FLJ in the treatment of NAFLD were evaluated using oleic acid (OA)–induced HepG2 cells and NAFLD mice. Our data revealed that FLJ significantly promoted fat-binding and cholesterol-reducing activity <i>in vitro</i>. Moreover, FLJ alleviated hepatic lipid accumulation, oxidative stress, and the inflammatory response in high-fat diet (HFD)–induced NAFLD mice and in OA–induced HepG2 cells. The underlying protective mechanisms of FLJ against NAFLD may be attributed to the activation of the SIRT1 signaling pathway. These observations suggested that FLJ could be developed as a functional food supplement for the prevention or improvement of NAFLD.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/1706266","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Applications of Hill Lemon (Citrus pseudolimon Tanaka) in Sustainable Bioprocessing: Bioactive Extraction, Nanoparticle Synthesis, and Functional Food Products","authors":"Ankita Thakur,&nbsp;Rajat Suhag,&nbsp;Yogesh Kumar,&nbsp;Anshu Sharma","doi":"10.1155/jfbc/5560966","DOIUrl":"https://doi.org/10.1155/jfbc/5560966","url":null,"abstract":"<div>\u0000 <p>Hill lemon (<i>Citrus pseudolimon</i> Tanaka) is an underutilized citrus fruit native to India, with significant potential in the food, pharmaceutical, and cosmetic industries due to its rich nutritional and bioactive profile. This review consolidates existing research on Hill lemon, highlighting its various components and their associated health benefits. Studies have documented its diverse health benefits, including antioxidant, antibacterial, antiviral, anti-inflammatory, and anticancer properties. The leaves, peel, and seeds of Hill lemon are rich sources of bioactive compounds like limonene, citronellol, pectin, essential oils, and vitamin C, contributing to its beneficial properties. Despite its promising potential, the short shelf life of the processed Hill lemon juice presents a challenge for commercialization. This review underscores the need for further research to fully explore the potential of Hill lemon and its bioactive compounds, particularly in developing value-added products with enhanced stability and extended shelf life.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5560966","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Deep Eutectic Solvent and Ethanol for the Extraction of Oil and Astaxanthin From Black Tiger Shrimp (Penaeus monodon) Shells","authors":"Chi Hai Tran,&nbsp;Van Man Phan,&nbsp;Thi Hong Anh Le","doi":"10.1155/jfbc/4288724","DOIUrl":"https://doi.org/10.1155/jfbc/4288724","url":null,"abstract":"<div>\u0000 <p>The black tiger shrimp (<i>Penaeus monodon</i>) shell, a by-product of shrimp processing, is a valuable natural source of oil and astaxanthin (AXT). However, extracting these from the shell is difficult due to its tough cell walls. This study examined the use of deep eutectic systems (DESs) to extract oil and AXT from black tiger shrimp shells. Three DESs (choline chloride/glycerol, choline chloride/citric acid, and choline chloride/lactic acid) were tested, and their extraction efficiencies were compared with those of traditional solvents (hexane, ethanol, and acetone). Results indicated that the extraction efficiency of oil and AXT from DESs was lower than that of traditional solvents, but when ethanol was added to the DES as a co-solvent, it significantly improved the yield. Specifically, combining choline chloride/lactic acid with 45% ethanol resulted in the highest concentrations of oil (6.42/100 g) and AXT (39.10 μg/g), surpassing ethanol (5.12/100 g and 31.56 μg/g) or hexane (5.62/100 g and 33.47 μg/g), and acetone (4.46/100 g and 28.59 μg/g). The shrimp extracts were rich in polyunsaturated fatty acids (i.e., linoleic acid, α-linolenic acid, EPA, and DHA) and AXT with potent antioxidant properties.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/4288724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review of the Health Benefits, Nutritional Composition, and Agricultural Aspects of Sesame Seeds","authors":"Hafiza Madiha Jaffar,&nbsp;Irfana Akhtar,&nbsp;Mah Zaib Saleem,&nbsp;Tabarak Malik,&nbsp;Arusha Ayub","doi":"10.1155/jfbc/8713698","DOIUrl":"https://doi.org/10.1155/jfbc/8713698","url":null,"abstract":"<div>\u0000 <p>Sesame seeds (<i>Sesamum indicum</i>) are considered valuable for their nutritional qualities and wide range of uses in several sectors of the global economy. Bioactive substances such as lignans, phytosterols, γ-tocopherol, phenolic acids, flavonoids, and tryptophan which have strong anti-inflammatory, lipid-lowering, and antioxidant properties are present in them. In addition, sesame seeds contribute to human health by offering vital elements like protein, unsaturated fatty acids, vitamins, and minerals. The bioavailability of these nutrients has been enhanced by recent developments in processing technologies and agricultural methods. Apart from the food industry, sesame seeds are also being used extensively in the pharmaceutical, cosmetic, and industrial sectors, such as in the manufacturing of biodiesel and animal feed. This review highlights the potential contribution of sesame seeds to sustainable food systems by compiling the most recent research on their nutritional makeup, health advantages, and variety of uses.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8713698","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of Inhibitory and Anti-Inflammatory Effects of Aloe-Emodin Against Multidrug-Resistant Escherichia coli: A Network Pharmacology and Molecular Dynamics Approach","authors":"Xuanpan Ding,&nbsp;Yuan Zhao,&nbsp;Junfeng Li,&nbsp;Shuai Zhang,&nbsp;Dan Yao,&nbsp;Haotian Yang,&nbsp;Yong Zhang,&nbsp;Honggang Fan","doi":"10.1155/jfbc/5709147","DOIUrl":"https://doi.org/10.1155/jfbc/5709147","url":null,"abstract":"<div>\u0000 <p><i>Aloe vera</i> is an important raw material for medicine and food, and aloe-emodin (AE) is one of the main extracts of <i>Aloe vera</i>. The aim of this study was to investigate the inhibitory effect of AE on multidrug-resistant <i>Escherichia coli</i> (MDR<i>-E. coli</i>) and the anti-inflammatory mechanism of this pathogenic bacterial infection. The minimum inhibitory concentration of AE against MDR<i>-E. coli</i> was determined in vitro. The potential therapeutic targets and signaling pathways of AE on inflammation were predicted by network pharmacology, and a mouse infection model was constructed by intraperitoneal injection of pathogenic bacteria and treated with AE. The results showed that AE had a better bacteriostatic effect and modulated the inflammatory response by affecting the expression of multiple inflammatory factors, and AE treatment significantly reduced symptoms such as inflammation, organ swelling, and bacterial load in the mouse model. The results suggest that AE may be an important active ingredient for <i>Aloe vera</i> to exert therapeutic health effects.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5709147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143581927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhamnetin-3-O-α-L-Rhamnoside Attenuates Alcoholic Liver Injury in Mice via Regulation of the Autophagy/Ferroptosis Pathway","authors":"Jiangtao Zhou,&nbsp;Borong Zhao,&nbsp;Fan Yang,&nbsp;Dandan Deng,&nbsp;Jiayu Chang,&nbsp;Lihan Yan,&nbsp;Hong Yang,&nbsp;Fei Yang,&nbsp;Liwen Han,&nbsp;Guan’e Yang","doi":"10.1155/jfbc/2599489","DOIUrl":"https://doi.org/10.1155/jfbc/2599489","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Rhamnetin-3-α-L-rhamnoside (ARR) is the principal monomer isolated from <i>Loranthus tanakae Franch</i>. and Sav, with the effect of prevention and treatment of inflammatory diseases. This study was to investigate the effects of ARR on acute alcoholic liver injury (ALI) in a mouse model and elucidate the mechanisms.</p>\u0000 <p><b>Methods:</b> Balb/c mice were divided into six groups: naive control (NC), model control (MC), positive control (PC), ARR low-dose group (ARR-L), medium-dose group (ARR-M), and high-dose group (ARR-H). The treatment lasted for 11 days, with alcohol administration on the 9th and 11th day. Blood samples were taken 24 h postadministration for glutamic pyruvic transaminase (ALT) and glutamic oxaloacetic transaminase (AST) detection. Liver tissue samples underwent hematoxylin–eosin (H&amp;E) staining, immunohistochemical analysis, and biochemical assays for glutathione (GSH), glutathione (MDA), superoxide dismutase (SOD), and tissue iron. Western blotting analysis was conducted for ferroptosis-related proteins including glutathione peroxidase 4 (GPX4), solute carrier family 7 member 11 (SLC7A11), and ferritin light chain (FTL) as well as autophagy-related proteins comprising benzyl chloride 1 (Beclin-1), autophagy-associated Gene 5 (ATG5), sequestosome 1 (P62), and microtubule associated protein 1 light chain 3 (LC3).</p>\u0000 <p><b>Results:</b> H&amp;E staining and analysis showed that alcohol caused liver cell damage, which was improved in the positive and ARR groups. The immunohistochemical analysis indicated decreased levels of heme oxygenase 1 (HO-1) and nuclear factor erythroid 2–related factor 2 (Nrf2) in the MC mice, whereas enhanced in the administration groups. Liver index, serum ALT, and AST significantly elevated in the MC group, which confirm successful modeling. Both positive drug and ARR ameliorated liver index, aminotransferase levels, oxidative stress, and tissue iron. Furthermore, western blotting revealed abnormal expression of ferroptosis- and autophagy-related proteins due to alcohol. In comparison with MC mice, administration groups showed significantly increased expressions of GPX4, SLC7A11, Beclin-1, ATG5, and LC3II/I and decreased expressions of FTL and P62.</p>\u0000 <p><b>Conclusion:</b> ARR prevents acute ALI by inhibiting ferroptosis and inducing autophagy. These findings suggested that ARR may represent a natural therapeutic approach for this disease.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/2599489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combatting BPA-Induced Neurotoxicity With Purple Carrot Extract (Daucus carota): Modulation of Key Neurotransmitters and Cellular Pathways in Albino Rats","authors":"Amira M. El-Moslemany,&nbsp;Mai Hussein Abd-Elfatah,&nbsp;Wesam Mohammed Abd Elrahman,&nbsp;Manal Salah Abbas Elgendy,&nbsp;Heba I. Ghamry,&nbsp;Mohamed El-Sherbiny,&nbsp;Moaz Abdullah Mojaddidi,&nbsp;Lamya Ahmed Alkeridis,&nbsp;Nora Hamdy Mouhamed El-Wakeil,&nbsp;Mustafa Shukry","doi":"10.1155/jfbc/9071056","DOIUrl":"https://doi.org/10.1155/jfbc/9071056","url":null,"abstract":"<div>\u0000 <p><b>Ethnopharmacological Relevance:</b> Bisphenol A (BPA) is a widely used chemical, particularly in producing epoxy resins and polycarbonate plastics, which can contaminate food and water sources. Even low levels of BPA exposure have been associated with negative impacts on neural development, leading to neurotoxicity. Purple carrots, known for their health-promoting properties, are rich in bioactive compounds such as polyphenols.</p>\u0000 <p><b>Materials and Methods:</b> This study aimed to evaluate the neuroprotective effects of purple carrot extract in mitigating BPA-induced neurotoxicity in albino rats. Forty albino rats were divided into four groups: Group I (control) received water and a standard diet. Group II (BPA group) was orally administered 50 mg/kg body weight of BPA dissolved in 1 mL of olive oil daily for 30 days. Group III received 400 mg/kg of purple carrot extract along with 50 mg/kg of BPA daily. Group IV received 800 mg/kg of purple carrot extract along with 50 mg/kg of BPA daily, following the same 30-day oral administration protocol.</p>\u0000 <p><b>Results:</b> The results showed that treatment with purple carrot extract increased serum levels of critical neurotransmitters, including serotonin, dopamine, acetylcholine, acetylcholineesterase, and gamma-aminobutyric acid (GABA). Additionally, brain tissue analysis revealed elevated activity of antioxidant enzymes, such as catalase (CAT) and superoxide dismutase (SOD), in response to extract administration. Conversely, the extract significantly reduced levels of malondialdehyde (MDA), α-tumor necrosis factor (α-TNF), and interleukin-6 (IL-6) in brain tissues compared to the BPA-only group. These results indicate that purple carrot extract regulates genes related to oxidative stress, inflammation, and apoptosis in a dose-dependent manner during BPA-induced neurotoxicity. At a dose of 400 mg/kg, the extract increased the expression of antioxidant genes like Nrf2 and HO-1 while reducing the pro-apoptotic marker Bax. At the higher dose of 800 mg/kg, these protective effects were even more pronounced, leading to enhanced neuroprotection through increased antioxidant and antiapoptotic gene expression and reduced inflammation, mainly through the MAPK pathway.</p>\u0000 <p><b>Conclusion:</b> The study demonstrates that purple carrot extract reduces BPA-induced neurotoxicity in rats by enhancing antioxidants, neurotransmitters, and anti-inflammatory responses, suggesting natural protection against BPA-related neural damage.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9071056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginger (Zingiber officinale Roscoe) Bioactive Components: Potential Resources for Kidney Health","authors":"Yichuan Wang,&nbsp;Yuehua Jiang,&nbsp;Cong Han,&nbsp;Le Zhou,&nbsp;Hongzhen Hu,&nbsp;Huihui Song,&nbsp;Wei Li","doi":"10.1155/jfbc/2625586","DOIUrl":"https://doi.org/10.1155/jfbc/2625586","url":null,"abstract":"<div>\u0000 <p>Ginger (<i>Zingiber officinale</i> Roscoe), being a customary dietary component across various regions globally, possesses numerous biological functionalities, such as antioxidative, anti-inflammatory, immune-regulatory, and anti-apoptotic properties. Ginger plays a crucial role in the management of kidney health due to its bioactive constituents, which are extensively implicated in various processes, including antioxidant activity, anti-inflammatory activity, amelioration of endothelial dysfunction, inhibition of cell apoptosis and necrosis, mitigation of renal fibrosis, and promotion of autophagy. In clinical trials, it was also found that the effect of ginger on blood sugar, blood lipid, and inflammatory factors could improve kidney function. These studies summarize the ginger active ingredients and their potential functions in the protection of kidney health, and provide an overview of the application and targeted delivery of ginger bioactive in functional food. In the future, more health-related information of bioactive compounds in ginger is needed, and their health effects for kidney should be further investigated.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/2625586","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvegetables and Their Potential Health Relevance: A Systematic Review of In Vitro and In Vivo Evidence","authors":"Cealan O. Henry,&nbsp;Joanna L. Bowtell,&nbsp;Mary F. O’Leary","doi":"10.1155/jfbc/9953644","DOIUrl":"https://doi.org/10.1155/jfbc/9953644","url":null,"abstract":"<div>\u0000 <p>A rise in noncommunicable disease (NCD) prevalence has been partly attributed to the low intake of food groups rich in phytochemicals, particularly fruits and vegetables. For this reason, microvegetables (MV) are an emerging functional food group. Nutrient-dense with bioactive compounds, MV exhibit bioactive properties that may be relevant for NCD and malnutrition risk modulation. No chronic MV supplementation human clinical trials have been conducted. However, experimental in vitro and in vivo studies have shown that MV can exert a range of beneficial effects. In this systematic review, we analysed the effects of MV in such investigations and discussed the potential mechanisms involved. A bibliographical search was performed in PubMed and Scopus, and based on the inclusion criteria, 28 articles were summarised and critically discussed. Twelve studies demonstrated direct antioxidant capabilities of MVs via <i>in vitro</i> assays. Few studies investigated the more physiologically relevant impact of MV on endogenous cellular antioxidant systems. MV demonstrated proapoptotic activity in immortalised cell lines, with limited in vivo evidence indicating potential anti-inflammatory, lipid and gut microbiota-modifying effects. These properties warrant further investigation in human trials to evaluate their translational potential, and our summary of the literature offers a rationale and basis for such clinical trials.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9953644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shenbing Decoction III and Apigenin Improve Peritoneal Fibrosis Mediated by Epithelial–Mesenchymal Transition Through TAK1/p38MAPK/NF-κB Pathways","authors":"Yang Tang,&nbsp;Ying Wang,&nbsp;Xiaomin Sun,&nbsp;Jie Zheng,&nbsp;Jingying Fang,&nbsp;Shufeng Liu,&nbsp;Juan Luo,&nbsp;Yunqiang Liao,&nbsp;Yalin Cheng,&nbsp;Jiawei Lu,&nbsp;Shuyuan Zhou,&nbsp;Xiaosheng Li","doi":"10.1155/jfbc/7841565","DOIUrl":"https://doi.org/10.1155/jfbc/7841565","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> This study aimed to evaluate the effect of Shenbing Decoction III (SBD III) and its key Apigenin on peritoneal dialysis (PD)–induced peritoneal fibrosis and explore the underlying mechanisms.</p>\u0000 <p><b>Methods:</b> Liquid chromatography–mass spectrometry confirmed the presence of Apigenin in SBD III. Human peritoneal mesothelial cells (HMrSV5) were stimulated with PD solution (PDS) to induce fibrosis, and treatment with SBD III and Apigenin was administered.</p>\u0000 <p><b>Results:</b> PDS decreased cell viability and increased the migration and invasion capabilities of HMrSV5 cells. It also reduced E-cadherin expression, while increasing the expression of α-SMA, fibronectin, collagen I, and TGF-β1. SBD III and Apigenin effectively counteracted these effects. Additionally, SBD III and Apigenin inhibited the PDS-induced upregulation and phosphorylation of transforming growth factor-β-activated kinase 1 (TAK1), p38, and nuclear factor-κB (NF-κB), similar to the effects of 5z-7-oxozeaenol. Chronic kidney disease (CKD) was induced in mice by 5/6 nephrectomy, followed by PDS treatment. The therapeutic effects of SBD III and Apigenin were evaluated. CKD mice exhibited reduced body weight and kidney weight indices, along with elevated blood urea nitrogen, urinary creatinine, and urinary protein levels. Fibrosis was observed in the kidneys and peritoneum. PDS treatment also significantly alleviated these effects. Notably, therapeutic effects were further augmented when SBD III and Apigenin were administered.</p>\u0000 <p><b>Conclusion:</b> SBD III and Apigenin ameliorated PDS-induced peritoneal fibrosis by inhibiting epithelial–mesenchymal transition via the TAK1/p38MAPK/NF-κB pathway, indicating promising pharmaceutical candidates for CKD.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/7841565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}