Journal of Food Biochemistry最新文献

{"title":"Characteristic Flavor Analysis of Inner Mongolia Air-Dried Meat and the Impact of Vacuum Tumbling Curing on Flavor","authors":"Hao Shiqi,&nbsp;Du Jialu,&nbsp;Sun Xueyin,&nbsp;Hu Guanhua,&nbsp;Sun Erke,&nbsp;Li Xiaotong,&nbsp;Jin Ye,&nbsp;Zhao Lihua","doi":"10.1155/2024/4077505","DOIUrl":"https://doi.org/10.1155/2024/4077505","url":null,"abstract":"<div>\u0000 <p>Air-dried beef is a traditional specialty dried meat product that has a rich history in Inner Mongolia. In-depth understanding of the characteristic flavor substances of air-dried meat in different regions can help branding of traditional air-dried meat products and sustainable development of the air-dried meat industry in Inner Mongolia. This study aims to investigate the characteristic flavors of air-dried beef from various regions of Inner Mongolia (Ordos, Xinlingol, and Chifeng) by using electronic nose and GC-MS combined with ROAV value and explore the impact of the vacuum tumbling curing process on the flavor of air-dried meat. The samples from each region were found to contain characteristic flavor substances such as alcohols, aldehydes, hydrocarbons, and oxygenates. There are five characteristic flavor substances unique to the Ordos region: 3-dodecanol (5.938), 4-methyl-5-decanol (32.686), 2,4-dimethyl-2-pentanol (4.139), methylheptenone (67.445), and 3-ethyl-2,5-dimethylpyrazine (4.256); three characteristic flavor substances unique to the Xilingol region: isovaleraldehyde (68.917), ethyl phenylacetate (3.746), and thymol (2.091); and two characteristic flavor substances unique to the Chifeng region: 2-heptanol (3.984) and 6-methyl-2-heptanone (6.191). Vacuum tumbling curing not only improved the pH (6.35) and <i>L</i>^∗ value (33.74) of air-dried meat but also increased the variety of flavor substances characteristic of air-dried meat, including trans-2-decenol (2.989), isopentanol (0.585), trans-2-nonenal (2.937), methyl decyl ketone (4.836), phenylacetic acid (4.262), and benzoic acid (0.554). In conclusion, the addition of vacuum tumbling curing process in the industrial production of air-dried beef products can increase the curing efficiency and improve the flavor of air-dried beef products.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/4077505","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulforaphane Alleviates Bisphenol A-Induced Glucose Intolerance via Improving Inflammation and Oxidative Stress","authors":"Lixia Hong,&nbsp;Yide Xu,&nbsp;Dongdong Wang,&nbsp;Qi Zhang,&nbsp;Xiaoting Li,&nbsp;Chunfeng Xie,&nbsp;Jieshu Wu,&nbsp;Caiyun Zhong,&nbsp;Gu Gao,&nbsp;Ye Ding,&nbsp;Shanshan Geng","doi":"10.1155/2024/5538651","DOIUrl":"https://doi.org/10.1155/2024/5538651","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Bisphenol A (BPA) disrupts glucose homeostasis via inflammatory pathways in liver cells, affecting insulin sensitivity. This study examines sulforaphane (SFN), known for its anti-inflammatory and antioxidative properties, for counteracting BPA’s effects. <i>Methods</i>. We evaluated SFN’s impact on BPA-exposed C57/BL6J mice and HepG2 cells, focusing on metabolic parameters, insulin signaling, and inflammatory markers. Mice were treated with SFN (10 mg/kg) for six weeks, with assessments including body weight, serum glucose, insulin levels, and glucose tolerance. Molecular analyses in both models included gene expressions related to glucose metabolism, insulin and MAPK signaling pathways, and markers of inflammation and oxidative stress. <i>Results</i>. SFN reduced blood glucose and improved glucose tolerance of BPA-treated mice. In BPA-treated HepG2 cells, SFN significantly boosted glucose consumption in vitro. Moreover, SFN treatment enhanced the protein expression of phosphorylated-insulin receptor and phosphorylated-AKT and reversed glycolytic and gluconeogenic gene expression in HepG2 cells and mice liver. SFN also decreased phosphorylation levels of p38 and JNK and reduced inflammation and oxidative stress markers in vitro and in vivo. <i>Conclusion</i>. Our findings underscore SFN’s capacity to ameliorate BPA-induced glucose intolerance and insulin resistance by enhancing hepatic insulin signaling and metabolic functions. This action is likely mediated through SFN’s inhibitory effects on inflammatory and oxidative pathways. Consequently, SFN holds promise as an intervention for mitigating BPA-related metabolic disorders.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5538651","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difference Analysis of White, Red, and Grey Sufu: Crosstalk between Metabolomics, Proteomics, and Microbiomics","authors":"Chenning Zhang,&nbsp;Ying Li,&nbsp;Tao He,&nbsp;Mo Sun,&nbsp;Yuanyang Shao","doi":"10.1155/2024/3104640","DOIUrl":"https://doi.org/10.1155/2024/3104640","url":null,"abstract":"<div>\u0000 <p>The present study aimed to systematically analyse the differences in metabolites, proteins, and the microbiota among white sufu (WS), red sufu (RS), and grey sufu (GS) by integrating multi-omics detection techniques. First, the various metabolites in sufu were identified through widely targeted metabolomics. Then, differential proteins in sufu were screened, and the principal functions of differential proteins were further mined using proteomic techniques. Finally, the microbiota in the sufu were analysed via 16S rRNA sequencing technology to observe differences in the microbial composition. The results showed that approximately 306 metabolites were present in the three kinds of sufu. Among them, there are 448 differential metabolites in RS and WS, 412 differential metabolites in WS and GS, and 517 differential metabolites in RS and GS. A total of 4663 proteins were identified. Among them, 448 differential proteins were found in RS and WS, 412 differential proteins were identified in WS and GS, and 517 differential proteins were detected in RS and GS. Approximately 77 types of microbes were distributed among three kinds of sufu. The population of WS is mainly distributed with 55.3% of protobacteria and 42.5% of Firmicutes. <i>Proteobacteria</i> and <i>Firmicutes</i> were the dominant microbial phyla common to the three kinds of sufu: the dominant bacteria in WS, RS, and GS were <i>Enterobacter</i>, <i>Pantoea</i>, and <i>Kluyveromyces</i>. The integrative crosstalk of multi-omics analysis illustrated that the metabolites, proteins, and microorganisms in sufu are closely interrelated and together produce unique amino acids in different kinds of sufu.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/3104640","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142137745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Regulative Effect and Mechanism in a MetS Mice Model of Functional Components in Freeze-Dried Powder from Phyllanthus emblica L. Fruit","authors":"Yvping Wei,&nbsp;Yongping Huang,&nbsp;Yisheng Huang,&nbsp;Lei Hu,&nbsp;Xianghui Zou,&nbsp;Yaqun Liu,&nbsp;Qiulan Luo,&nbsp;Yuzhong Zheng,&nbsp;Fang Fang,&nbsp;Ying Nie","doi":"10.1155/2024/2199647","DOIUrl":"https://doi.org/10.1155/2024/2199647","url":null,"abstract":"<div>\u0000 <p>The medicinal plant <i>Phyllanthus emblica</i> Linn. has been recognized for its health-beneficial properties and has a long history of cultivation in ancient China and India. However, its effects and main mechanism in high-fat diet (HFD)-induced metabolic syndrome (MetS) have not been revealed yet. According to our findings, emblica fruit powder (EFP) through the freeze-drying process was able to modulate the composition of the intestinal microbiota, with a significant increase in the beneficial bacteria genera Lactobacillus and Turicibacter. In addition, fecal metabolite profiling revealed that 20 metabolites were deferentially expressed, which were mainly organic acids, amino acids, and their derivatives. They are primarily enriched in the biological process of lipid metabolism, including the metabolism process of cholic acid, glycerophospholipid, and <i>α</i>-linoleic acid. Subsequent qPCR testing of the liver tissue suggested that the regulatory effects of EFP in HFD mice may stem from its influence on the expression levels of over 20 key genes involved in host metabolic processes. In conclusion, EFP is able to alleviate the MetS caused by HFD, and this positive impact may be partially through the regulation of the “gut-liver axis.” Consequently, EFP holds potential as a functional food ingredient for the prevention and management of MetS.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/2199647","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142137825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calamintha incana Methanolic Extract: Investigation of Phytochemical Composition and Antioxidant and Antibacterial Activities","authors":"Arwa R. Althaher,&nbsp;Reham F. Shehabi,&nbsp;Hanan H. Ameen,&nbsp;Mirna W. Awadallah,&nbsp;Andrea Mastinu","doi":"10.1155/2024/6634969","DOIUrl":"https://doi.org/10.1155/2024/6634969","url":null,"abstract":"<div>\u0000 <p><i>Calamintha</i><i>incana</i>, a medicinal plant traditionally used for its therapeutic properties, has been investigated for its phytochemical constituents and biological activities. Through a specific LC-MS/MS analysis method, the phytochemical constituents of <i>Calamintha incana</i> methanolic extract have been identified and quantified. The 2,2-diphenyl-1-picrylhydrazyl method was used to measure the antioxidant properties. The antibacterial properties of this extract have been tested against four harmful bacteria using disc diffusion and the minimum inhibitory concentration methods. A colorimetric assay has evaluated the total phenolic and flavonoid content. The extract contained 34 compounds, with linolenic acid (11.2%) and myristic acid (10.3%) being the most abundant. Despite the low phenolic and flavonoid content, the extract exhibited antioxidant activity with an IC₅₀ of 96.8 ± 0.3 <i>μ</i>g/mL. Moreover, the extract demonstrated potent antimicrobial properties against <i>B. cereus</i> and <i>S. aureus</i>, with minimum inhibitory concentrations of 11.8 and 21.5 <i>μ</i>g/mL, respectively. These robust results underscore the potential of <i>C. incana</i> methanolic extract in the development of effective antibacterial agents.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6634969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142123141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Voluntary Exercise on Liver and Adipose Tissue Dysfunction in Both Young and Middle-Aged Mice Fed a High-Fat Diet Combined with Dietary Advanced Glycation End Products","authors":"Ruitong Liu,&nbsp;Tongtong Ma,&nbsp;Zhilong He,&nbsp;Guochong Chen,&nbsp;Huiwen Gu,&nbsp;Zhongxiao Wan","doi":"10.1155/2024/5226432","DOIUrl":"https://doi.org/10.1155/2024/5226432","url":null,"abstract":"<div>\u0000 <p>To determine whether voluntary exercise is capable of improving liver and adipose tissue dysfunction caused by the high-fat diet (HFD) combined with dietary advanced glycation end products (AGEs). Young and middle-aged male C57BL/6J mice were divided into the control group, HFD group, HFD combined AGE group (HFD + AGE), and combined diet with exercise group (HFD + AGE + EX). For young mice, in the liver tissue, compared to the YCON group, RAGE from the YHFD + AGE group and SREBP1 from the YHFD + AGE and YHFD + AGE + EX groups were increased, while LXR<i>α</i> from the YHFD YHFD + AGE, and YHFD + AGE + EX groups was decreased. In epididymal fat, CLOCK from the YHFD group; RAGE, OST48, BMAL1, and Rev-Erb<i>α</i> from the YHFD + AGE group; RAGE, OST48, CLOCK, BMAL1, and Rev-Erb<i>α</i> from the YHFD + AGE + EX group; SIRT1 from the YHFD + AGE group; adiponectin from the YHFD group; and ATGL from the YHFD and YHFD + AGE groups were significantly lower, while p-HSLser660 from the YHFD + AGE group and p-Aktser473 from the YHFD + AGE + EX group were significantly higher than in the YCON group. Additionally, IL-10 and IL-1Ra mRNA expressions from the YHFD and YHFD + AGE group were significantly decreased, while IL-10 and IL-1Ra from the YHFD + AGE + EX group and TNF-<i>α</i> from the YHFD, YHFD + AGE, and YHFD + AGE + EX groups were significantly increased. For middle-aged mice, in the liver tissue, compared to the MACON group, CLOCK and Rev-Erb<i>α</i> from three intervention groups were increased, while p-Aktser473 from the MAHFD and MAHFD + AGE groups was decreased and PPAR<i>α</i> from the MAHFD and MAHFD + AGE groups was decreased. In epididymal fat, compared to the MACON group, RAGE from the MAHFD + AGE group; p-Aktser473 from the MAHFD + AGE + EX group; and TNF-<i>α</i> gene expressions from three intervention groups were increased, while BMAL1 from the MAHFD + AGE and MAEX groups; PPAR<i>γ</i> and IL-1Ra from the MAHFD + AGE group; SIRT1 from the MAHFD, MAHFD + AGE, and MAHFD + AGE + EX groups; adiponectin from the MAHFD group; and p-HSLser660, ATGL, and IL-10 from the MAHFD and MAHFD + AGE groups were decreased. In conclusion, HFD combined with AGE diet caused dysfunction in the liver and adipose glucolipid metabolism, especially in middle-aged mice, and voluntary exercise reversed metabolic abnormalities to some extent with different mechanisms involved for young and middle-aged mice.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5226432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astragaloside IV Protects against Diabetic Nephropathy by Inhibiting FUNDC1-Dependent Mitochondria-Associated Endoplasmic Reticulum Membranes","authors":"Zeng Zhang,&nbsp;Yanyan Wang,&nbsp;Fengzhu Zhou,&nbsp;Siyu Xu,&nbsp;Xinyi Zhang,&nbsp;Yueying Ma,&nbsp;Yifei Liu,&nbsp;Yanming He","doi":"10.1155/2024/2602406","DOIUrl":"https://doi.org/10.1155/2024/2602406","url":null,"abstract":"<div>\u0000 <p>Studies have demonstrated the potential therapeutic effects of Astragaloside IV (AS-IV) in various diseases. However, its effect on diabetic nephropathy (DN) and the underlying mechanisms are not clear. The expression of FUNDC1 in DN patients and high glucose-induced human renal tubular epithelial cell line (HK-2) with or without AS-IV was analyzed using quantitative real-time polymerase chain reaction and Western blot. Cell Counting Kit-8 (CCK-8) assay was used to quantify cell viability. The intracellular oxygen consumption rate was measured by using the seahorse energy analyzer, and the mitochondrial reactive oxygen species and mitochondrial Ca²⁺ levels were determined by flow cytometry. A mice model of diabetes was constructed and treated with different doses of AS-IV. Hematoxylin-eosin and Masson staining were used to examine the pathological changes in renal tissue. Creatinine, blood urea nitrogen, and urinary protein were detected by the biochemical method. The results demonstrated increased FUNDC1 expression in patients with DN and high glucose-cultured HK-2 cells. FUNDC1 silencing inhibited high glucose-induced mitochondria-associated endoplasmic reticulum (ER) membrane formation and mitochondrial dysfunction in HK-2 cells. Importantly, AS-IV treatment inhibited FUNDC1-induced mitochondria-associated ER membrane formation and mitochondrial dysfunction in HK-2 cells. AS-IV treatment also protected against renal injury and improved renal function in mice. AS-IV alleviates the progression of DN by inhibiting FUNDC1-dependent mitochondria-associated ER membrane.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/2602406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioaccessibility and Speciation of Iron from Aqueous Extracts of Moringa oleifera Leaves","authors":"Saliou Mawouma,&nbsp;Souaibou Hamidou Yaya,&nbsp;Jude Mbyeya,&nbsp;Florence Doudou Walko,&nbsp;Emmanuel Awoudamkine,&nbsp;Carl Moses Mbofung Funtong","doi":"10.1155/2024/9312118","DOIUrl":"https://doi.org/10.1155/2024/9312118","url":null,"abstract":"<div>\u0000 <p>Investigating the different chemical species of soluble iron in food digests provides more relevant information on the nutritional potential of an iron-rich food. The objective of this study was to assess the bioaccessibility and speciation of iron from various aqueous extracts of Moringa <i>(Moringa oleifera)</i> leaves. Aqueous extracts were prepared from fresh and dried Moringa leaves using infusion and decoction methods. Spectrophotometric assays were performed to quantify inhibitors and enhancers of iron absorption in the extracts, bioaccessible iron, and its different chemical species. The highest contents of inhibitors (239.43 mg/L for polyphenols and 2.92 mg/L for phytates) and enhancers of iron absorption (1.58 mmol/L for carotenoids and 488.00 mg/L for ascorbic acid) were found in the 5-minute decoction extract of fresh leaves, and the lowest in all infusion extracts (27.34 mg/L for polyphenols, 0.50 mg/L for phytates, 0.15 mmol/L for carotenoids, and 86.00 mg/L for ascorbic acid). The percentages of bioaccessible iron were higher for decoction extracts (42.57–52.70%) compared to infusion extracts (33.89–36.44%). Ferrous iron was the dominant inorganic species of bioaccessible iron and was more concentrated in the digests of decoction extracts (1.32–4.85 mg/L). The highest content of organic iron (5.33 mg/L) was found in the digest of the 8-minute decoction extract of dried leaves. Drinking decoction extracts of fresh and dried Moringa leaves could be recommended to alleviate iron deficiency in vulnerable groups of the population living in areas where this plant can grow.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/9312118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quercetin Attenuates Cancer-Associated Fibroblast Activation via Tumor-Stromal Interactions and Demonstrates Its Clinical Value in Pancreatic Cancer","authors":"Defeng Lei,&nbsp;Yicui Piao,&nbsp;Tongning Zhong,&nbsp;Citing Zhang,&nbsp;Weipeng Ai,&nbsp;Yixing Kang,&nbsp;Haijun Ye,&nbsp;Biao Zheng,&nbsp;Jianhua Qu,&nbsp;Zilong Yan,&nbsp;Zhengquan Lai,&nbsp;Jikui Liu","doi":"10.1155/2024/2177516","DOIUrl":"https://doi.org/10.1155/2024/2177516","url":null,"abstract":"<div>\u0000 <p>Pancreatic ductal adenocarcinoma (PDAC) is a rapidly progressing malignancy with a poor prognosis. Quercetin is a flavonoid compound with various biological benefits that can be extracted from Chinese herbs or daily foods. Quercetin has anticancer properties in various types of cancers. However, its therapeutic effects and potential mechanisms in PDAC have not been investigated extensively. Here, we confirmed the therapeutic effect of quercetin in PDAC using a mouse model. Based on high-throughput RNA sequencing (RNA-seq) and bioinformatic analysis, we propose that quercetin is involved in stromal infiltration of PDAC. Quercetin attenuates the activation of cancer-associated fibroblasts (CAFs) via tumor-stromal interaction. Meanwhile, we have identified two quercetin-related prognostic models for patients with PDAC. Finally, we proposed a downstream target of quercetin, the ITGB4 gene, which could be a potential therapeutic target for PDAC.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/2177516","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Analysis of Nonvolatile Substances in Yingde Black Tea (Camellia sinensis) from Different Regions at Various Processing Stages","authors":"Yiqin Chen,&nbsp;Jiayan Song,&nbsp;Na Li,&nbsp;Jiaxing He,&nbsp;Hongyu Sun,&nbsp;Yi Xiang,&nbsp;Lizheng Xiao","doi":"10.1155/2024/6642166","DOIUrl":"https://doi.org/10.1155/2024/6642166","url":null,"abstract":"<div>\u0000 <p>The influence of origin on tea quality has been understudied. Little research has compared metabolites during tea processing from different origins. This study aims to address this gap by using nontargeted metabolomics to examine the differential metabolites present in Yingde black tea from various origins at different processing stages. Nontargeted metabolomics was employed to compare the differential metabolites present in fresh tea leaves, withered leaves, rolled leaves, fermented leaves, and processed tea from various origins. The study revealed significant differences in the metabolites present at each processing stage. Despite using identical processing techniques, the quality of finished teas from different regions was found to vary through sensory evaluation. The study found that taste differences between regions were primarily influenced by flavonoids and amino acids. The relative taste activity value (RTAV) approach was used to identify key contributors to taste differences and regulation. The quality of fresh tea leaves was found to be the main determinant of the taste of black tea from various regions. To reduce these differences, the same processing techniques were employed. These findings enhance our understanding of quality variations in dried tea from different origins and contribute to the theoretical foundation of tea processing.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6642166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}