Journal of Food Biochemistry最新文献

{"title":"Rosemary: A Promising Therapeutic Agent in Alleviating Nephrotoxicity","authors":"Jalileh Jalali,&nbsp;Mahboobeh Ghasemzadeh Rahbardar","doi":"10.1155/jfbc/5519628","DOIUrl":"https://doi.org/10.1155/jfbc/5519628","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Nephrotoxicity, kidney damage caused by a variety of chemicals, presents a significant challenge in the medical field. To address nephrotoxicity, innovative therapeutic techniques must be investigated. Rosemary (<i>Rosmarinus officinalis</i> L.) has been studied for its antioxidant, anti-inflammatory, and cytoprotective effects; however, existing literature lacks a comprehensive analysis of its mechanistic role in nephrotoxicity. This narrative review evaluates current findings, highlighting gaps in previous studies and presenting an updated perspective on the molecular pathways of rosemary in renal protection.</p>\u0000 <p><b>Methods:</b> This narrative review analyzed the nephroprotective effects of rosemary and its main components (rosmarinic acid, carnosic acid, carnosol, and ursolic acid) based on studies retrieved from Google Scholar, PubMed, Web of Science, and Scopus (2010–2025). Selection criteria focused on peer-reviewed research investigating the impact of rosemary on nephrotoxicity, including experimental and mechanistic studies. Studies unrelated to renal toxicity or lacking mechanistic insights were excluded. While no formal systematic review methodology was applied, a qualitative assessment of study relevance and methodological rigor was considered. Preclinical and mechanistic studies were prioritized to provide a comprehensive understanding of the nephroprotective properties of rosemary.</p>\u0000 <p><b>Results:</b> This review consolidates evidence demonstrating the nephroprotective potential of rosemary and its main components. Unlike prior reviews, our analysis provides a comprehensive mechanistic overview of the effects of rosemary on nephrotoxicity, emphasizing its ability to modulate pyroptosis and pivotal molecular pathways, including NF-κB/NLRP3 inflammasome and TGF-β1/Smad/collagen IV signaling. These findings are primarily based on preclinical studies with limited direct evidence from clinical trials.</p>\u0000 <p><b>Conclusion:</b> By addressing key mechanistic gaps, this review positions rosemary as a potential therapeutic agent for nephrotoxicity, based on promising findings from preclinical models. Our findings underscore its underexplored role in pyroptosis modulation and its ability to regulate key nephrotoxicity-related molecular pathways. Future research should focus on further elucidating these mechanisms to optimize rosemary’s potential as a nephroprotective agent.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5519628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Anti-Vasculogenic Mimicry Effect of Duchesnea indica (Andr.) Focke Acidic Polysaccharide in Colon Cancer","authors":"Qiuying Shi,&nbsp;Hanqing Li,&nbsp;Xindan Li,&nbsp;Jianyu Deng,&nbsp;Xiaoyu Wang,&nbsp;Jiaye Jiang,&nbsp;Yan Ke","doi":"10.1155/jfbc/8148622","DOIUrl":"https://doi.org/10.1155/jfbc/8148622","url":null,"abstract":"<div>\u0000 <p>Vasculogenic mimicry (VM) is an endothelium-independent tumor microcirculation that provides adequate blood supply for tumor growth, which is closely associated with the poor prognosis of colon cancer. As a traditional medicinal plant, <i>Duchesnea indica</i> has shown a new potential in preventing the progress of colon cancer. This research aims to investigate whether the polysaccharide of <i>Duchesnea indica</i> (DIP2) has an effective ability to inhibit VM in colon cancer and to further study its mechanism of action. In in vitro experiments, three-dimensional tubule and invasion experiments proved that DIP2 could inhibit CoCl₂-induced VM and invasion. Western blot and RT-PCR results revealed a dose-dependent inhibition by DIP2 on the expression of VM-related proteins and genes. In vivo experiments have shown that DIP2 has a dose-dependent inhibitory effect on colon cancer tumor growth and can reduce the sudden weight loss of transplanted tumors in nude mice. H&amp;E staining showed that DIP2 could alleviate the deterioration of cell morphology caused by tumor. The results of CD31/PAS double staining showed that DIP2 could inhibit the occurrence of VM in colon cancer. Meanwhile, DIP2 also suppressed the expression of proteins and genes related to the VEGF/PI3K/AKT and Wnt3a/β-catenin signaling pathways. The inhibition of VM process in tumor cells by DIP2 is believed to contribute to its potential as an antitumor agent. As a useful and untapped pharmaceutical/food resource, <i>Duchesnea indica</i> has great prospects for application.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8148622","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical Characteristics and Functionality of Burdekin Plum During Fruit Maturation","authors":"Gengning Chen,&nbsp;Michael E. Netzel,&nbsp;Daniel Cozzolino,&nbsp;Yasmina Sultanbawa","doi":"10.1155/jfbc/8811862","DOIUrl":"https://doi.org/10.1155/jfbc/8811862","url":null,"abstract":"<div>\u0000 <p>Burdekin plum (<i>Pleiogynium timoriense</i>) is a rich source of phytochemicals with many health benefits, but the effect of maturation on its physicochemical properties and functionality is unknown. To fill this knowledge gap, Burdekin plums harvested at three different maturity stages (mature green, turning and dark maroon) were analysed, including basic physicochemical parameters, bioactive compounds, antimicrobial activity and antioxidant capacity. Results showed that the dietary fibre content decreased from around 50% to 30% during maturation. Three different solvents (water, 80% ethanol and 80% methanol) were used for extraction and tested for bioactive compounds and functionality. Bioactive compounds were identified and quantified using Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry. Water extracts contained higher content of gallic acid and galloylquinic acid content. However, ethanol and methanol extracts contained higher content of ellagic acid, anthocyanins and catechins. During maturation, most bioactive compounds decreased, except for anthocyanins, quercetin 3-glucoside and epicatechin, which increased. Similarly, the antioxidant capacity reduced during maturation. Regarding the antimicrobial activity, extracts from turning and dark maroon stages demonstrated a stronger inhibition against <i>Staphylococcus aureus</i> (inhibition zone &gt; 8 mm) compared to mature green stage (inhibition zone &lt; 6 mm), while no inhibition against the <i>Escherichia coli</i> and <i>Candida albicans</i> was observed. In conclusion, the physicochemical characteristics and functionality of Burdekin plums changed significantly during maturation, which should be considered when utilising the fruits as a functional food source.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8811862","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Profile and Evaluation of the Antioxidant, Anticancer, and Antimicrobial Potential of Artocarpus lacucha Bark Extracts: In Vitro and In Silico Studies","authors":"Md. Junaid Haruni,&nbsp;Mst. Shahnaj Parvin,&nbsp;Sirajum Munira,&nbsp;Md. Ekramul Islam","doi":"10.1155/jfbc/8016598","DOIUrl":"https://doi.org/10.1155/jfbc/8016598","url":null,"abstract":"<div>\u0000 <p><i>Artocarpus lacucha</i> Roxb., traditionally used in ethnomedicine, was investigated for its pharmacological potential through a multimethodological approach. The ethyl acetate fraction (EAF) and chloroform fraction (CHF) of bark extracts were analyzed for antioxidant, anticancer, and antimicrobial properties. HPLC identified key polyphenols (e.g., catechin hydrate, myricetin), while bioassays revealed EAF as the most active fraction, exhibiting the highest phenolic content (116.16 ± 1.98 mg GAE/g), potent DPPH scavenging (IC₅₀ = 6.85 μg/mL), and significant cytotoxicity against A549 lung cancer cells (58.87% viability at 300 μg/mL). CHF, EAF, and aqueous fraction (AQF) exhibited selective antibacterial activity against resistant strain, with the CHF fraction showing the highest activity against <i>Staphylococcus aureus</i> (inhibition zone: 14 ± 0.6 mm). Molecular docking highlighted strong SRBD1 binding for myricetin (−6.8 kcal/mol) and catechin hydrate (−6.6 kcal/mol), supported by stable interactions in MD simulations. The findings highlight the therapeutic potential of <i>Artocarpus lacucha</i> bark extracts as promising sources of natural antioxidants, cytotoxic agents, and antimicrobial compounds.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8016598","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Berberine Liposome Nanoparticles as a Potential Therapeutic Strategy for Managing Ischemic Stroke Through PTGS2 Inhibition","authors":"Peng Xie,&nbsp;Mingyan Xia,&nbsp;Wenpeng Cao,&nbsp;Dongfen Guo,&nbsp;Zhenkui Ren,&nbsp;Wenfeng Yu","doi":"10.1155/jfbc/8896885","DOIUrl":"https://doi.org/10.1155/jfbc/8896885","url":null,"abstract":"<div>\u0000 <p>Pyroptosis following cerebral ischemia–reperfusion injury (CIRI) is a key driver of long-term neuronal damage and poor functional recovery. Microglia, the primary immune cells of the central nervous system (CNS), play a pivotal role in regulating pyroptosis and orchestrating neuroinflammation. In this study, we observed significant upregulation of prostaglandin endoperoxide synthase-2/cyclooxygenase-2 (PTGS2/COX-2) in ischemic stroke patients, as well as in both in vivo and in vitro CIRI models. Knockdown of PTGS2 attenuated pyroptosis in BV2 microglial cells exposed to oxygen-glucose deprivation/reoxygenation (OGD/R). Using network pharmacology and molecular docking, we identified berberine (BBR) as a specific PTGS2 inhibitor, capable of suppressing its expression. To overcome BBR’s poor aqueous solubility and low bioavailability, we developed a novel nanoliposomal formulation of BBR (BBR-LNPs). In a murine middle cerebral artery occlusion/reperfusion (MCAO/R) model, BBR-LNPs markedly alleviated neurological dysfunction and reduced CIRI by regulating PTGS2-mediated pyroptosis. Collectively, our findings demonstrate that BBR-LNPs mitigate CIRI by inhibiting PTGS2-dependent pyroptosis, highlighting their potential as a therapeutic strategy for ischemic stroke.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8896885","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gardenia Fruit and Its Active Compound Crocin Protect Against Dexamethasone-Induced Muscle Atrophy via Nrf2 Activation","authors":"Jung-In Kim,&nbsp;Hang Yeon Jeong,&nbsp;Young In Kim,&nbsp;Ahyoung Yoo,&nbsp;Hyunjung Lee,&nbsp;Chang Hwa Jung,&nbsp;Jiyun Ahn","doi":"10.1155/jfbc/2952670","DOIUrl":"https://doi.org/10.1155/jfbc/2952670","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Muscle mass gradually declines with age and the development of an effective strategy to prevent this is important. Gardenia fruit (<i>Gardenia jasminoides</i>; GJ), commonly used as a natural food colorant and in traditional herbal medicines, possesses antiinflammatory, antidiabetic, and antiangiogenic properties. However, its effects on muscle atrophy remain unexplored.</p>\u0000 <p><b>Purpose:</b> In this study, we investigated the potential of GJ extract to mitigate dexamethasone (DEX)-induced muscle atrophy.</p>\u0000 <p><b>Methods:</b> Cell experiments used C2C12 cells and myotube atrophy was induced with 50 μM DEX. Animal experiments used 7 week-old C57BL/6 mice and fed GJ at 0.05% or 0.1% in the diet for 8 weeks. DEX was injected intraperitoneally at 15 mg/kg per day for 18 days before dissection to induce muscle atrophy and the effects were evaluated.</p>\u0000 <p><b>Results:</b> GJ enhanced myogenic differentiation by upregulating myogenic regulatory factors like <i>Myf5</i> and <i>MyoD</i> and inhibited DEX-induced myotube atrophy. Additionally, GJ reduced DEX-induced ROS production and mitochondrial dysfunction via Nrf2 activation. In mice, GJ protected the loss of muscle mass and decrease in muscle function by DEX. DEX-induced oxidative stress was reduced by GJ via the activation of Nrf2, followed by the transcription of antioxidant genes. HPLC analysis identified geniposide (GP) and crocin (CC) as the main constituents of GJ. However, only CC was found to exert antioxidant effects and effectively reduce DEX-induced oxidative stress and muscle atrophy via Nrf2 activation.</p>\u0000 <p><b>Conclusion:</b> These findings suggest that GJ, particularly its bioactive component CC, may serve as a potential therapeutic agent for muscle atrophy.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/2952670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardioprotective Effects of Aerial or Underground Parts of Angelica gigas Nakai in a Rat Transient Acute Myocardial Infarction (AMI) Model","authors":"Hee Jeong Eo,&nbsp;Woori Jo,&nbsp;Nami Joo","doi":"10.1155/jfbc/4262732","DOIUrl":"https://doi.org/10.1155/jfbc/4262732","url":null,"abstract":"<div>\u0000 <p><i>Angelica gigas</i>Nakai (AGN) is a medicinal herb traditionally used for vascular and inflammatory disorders due to its bioactive compounds, including decursin (DC) and decursinol angelate (DA). While the underground (UG) parts of AGN have been extensively studied, the aerial parts remain underutilized. This study evaluates the cardioprotective effects of AGN aerial and UG parts in a rat model of transient acute myocardial infarction (AMI) by assessing cardiac biomarkers, echocardiography, and infarct size. Sprague–Dawley rats underwent left anterior descending (LAD) artery ligation to induce AMI and were orally administered AGN extracts (200 mg/kg) for 7 days. Serum biochemistry results showed that CK-MB and LDH levels in AGN aerial part administration were significantly decreased compared to the negative (MI + Veh) group. Echocardiographic analysis on days 3 and 7 post-AMI demonstrated improved cardiac function in the AGN-treated groups. Both groups exhibited increased ejection fraction (EF) and fractional shortening (FS), indicating enhanced systolic function. TTC staining confirmed a significant reduction in infarct size in both AGN treatment groups. These findings highlight the cardioprotective potential of AGN aerial parts, suggesting their potential application in therapeutic and functional food development. This study underscores the relevance of AGN as a candidate for nutraceuticals and sustainable plant-based interventions for cardiovascular health.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/4262732","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro, In Silico, and In Vivo Antineoplastic Activity of Maslinic Acid From Olive Leaves on Diethylnitrosamine-Induced Hepatocellular Carcinoma: Impact on ATP Citrate Lyase/Wnt/Beta-Catenin Signaling","authors":"Gehad M. Elnagar,&nbsp;Mohamed M. Elseweidy,&nbsp;Ayat M. Emad,&nbsp;Dalia M. Rasheed,&nbsp;Rana G. Eissa,&nbsp;Ghada M. Ragab,&nbsp;Amira A. El-Gazar,&nbsp;Sawsan A. Zaitone,&nbsp;Gehan I. EL-Salamony,&nbsp;Shaimaa A. Fattah,&nbsp;Mohammed S. Sobh,&nbsp;Asmaa K. K. Abdelmaogood,&nbsp;Hanaa M. Elzahed,&nbsp;Nesreen M. I. M. Elkomy","doi":"10.1155/jfbc/1380085","DOIUrl":"https://doi.org/10.1155/jfbc/1380085","url":null,"abstract":"<div>\u0000 <p><b>Background/Objectives:</b> Increasing incidences of hepatocellular carcinoma (HCC) and its complicated treatment protocols promote novel drug discovery programs. Maslinic acid (MA) is a naturally occurring oleane-type triterpenoid derived mainly from <i>Olea europaea</i> L., with evident antineoplastic potential.</p>\u0000 <p><b>Aims:</b> This study aimed to investigate in vitro, in silico, and in vivo antineoplastic activity of MA from olive leaves.</p>\u0000 <p><b>Methods:</b> The in vitro antiproliferative activity of MA on HCC cell line (HepG-2) was investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The study comprised an in silico exploration of the putative targets of MA predicted via open-access databases in order to reach a refined list of genes/proteins that would be later investigated to explore the predisposed pathways guiding the experiment forward. The novel antineoplastic molecular mechanisms of MA were further evaluated in vivo against diethylnitrosamine (DEN)-induced HCC probably mediated by targeting hepatic ATP citrate lyase (ACLY)/Wnt/β-catenin pathway for the first time in rats, when administered on the 12^th week of the experiment model (50 mg or 100 mg/kg/day orally).</p>\u0000 <p><b>Results:</b> MA showed significant anticancer activity against HepG-2 cancer cell line with the concentration required for 50% growth inhibition (IC₅₀) value of 18.6 μg/mL, compared to the reference drug doxorubicin, which had an IC₅₀ value of 3.181 μg/mL. The in silico prediction results illustrated that most of the acknowledged genes/proteins were implicated and enriched in cancer pathways, regulation of inflammatory response and cellular response to stress. Wnt–catenin pathway and apoptosis-related markers were furthermore investigated experimentally. MA downregulated ACLY expression, switching off both Wnt arms and stabilizing cell death machinery. Furthermore, MA modulated hepatocellular oxidative and inflammatory responses. Additionally, this overall state was reflected positively, displaying conservation of the liver histopathological architecture.</p>\u0000 <p><b>Conclusions:</b> The study showed new evidence for the potential of MA to ameliorate DEN-induced HCC; therefore, MA is a promising antitumor agent for attenuating HCC.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/1380085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Municipal Green Waste to Agriculture: Biostimulant Production by Solid-State Fermentation and Its Role in Improving Germination and Seedling Growth of Lettuce (Lactuca sativa)","authors":"Roberto Carlos Solano Porras,&nbsp;Adriana Artola,&nbsp;Raquel Barrena,&nbsp;Cindy Ballardo,&nbsp;Antoni Sanchez","doi":"10.1155/jfbc/5555098","DOIUrl":"https://doi.org/10.1155/jfbc/5555098","url":null,"abstract":"<div>\u0000 <p>Circular economy aims to transform waste into resources by closing organic cycles and reducing dependence on nonrenewable inputs. In this study, the use of a solid organic amendment containing indole-3-acetic acid (IAA) produced by solid-state fermentation (SSF) of municipal green waste composed of grass clippings and wood chips from parks and gardens and inoculated with <i>Trichoderma harzianum</i> was evaluated as a biostimulant for the improvement of germination and growth of lettuce seedlings (<i>Lactuca sativa</i>). Two organic amendments from different SSF processes were tested: the first one was obtained using tryptophan as a precursor for IAA production by <i>Trichoderma harzianum</i> and contained 119.02 μg IAA g⁻¹ dw (FS-H), whereas the second one did not include tryptophan in the SSF process and resulted in a concentration of 11.80 μg IAA g⁻¹ dw (FS-L). A control experiment without the addition of fermented solid was also performed. At 7, 14, 21, and 35 days after sowing (DAS), the application of FS-H, FS-L significantly improved germination indicators and biomass accumulation (shoot and root weights) compared to control. Furthermore, the content of photosynthetic pigments, including Chlorophyll a, Chlorophyll b, and carotenoids, was significantly higher in the treatments with high IAA content, with increases of 214%, 200%, and 175%, respectively, compared to those of control. Therefore, the use of these organic amendments acting as biostimulants favors seed germination, phenotypic changes, and chlorophyll content, while enhancing the yield of lettuce seedlings. This demonstrates the potential of the application of these organic amendments produced by SSF from organic waste inoculated with biostimulant producer strains, and it offers a sustainable and circular approach to improve agricultural yields.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5555098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction of Polyphenols and Anthocyanins From Apple Pomace With Natural Deep Eutectic Solvents: Evaluation of Their Antioxidant and Antibacterial Activities","authors":"Lauriane Bruna,&nbsp;Micheline Draye,&nbsp;Emilie Lyautey,&nbsp;Cléa Fourreaux,&nbsp;Giorgio Grillo,&nbsp;Giancarlo Cravotto,&nbsp;Gregory Chatel","doi":"10.1155/jfbc/8483951","DOIUrl":"https://doi.org/10.1155/jfbc/8483951","url":null,"abstract":"<div>\u0000 <p>The aim of this study was to evaluate the antioxidant and antibacterial properties of apple pomace (AP) extracts using natural deep eutectic solvents (NADES). Six NADES, based on choline chloride (ChCl), were used as environmentally friendly solvents. Four of these were combined with organic acids, while the other two were combined with urea; they were then used to extract bioactive compounds from AP. ChCl:urea mixture proved to be the solvent with the highest total polyphenol content (TPC), with 13.15 ± 4.70 mg gallic acid equivalent/mL. Antioxidant activity and total anthocyanidin content (TAC) were also assessed. ChCl:oxalic acid recorded the highest values with 35.59 ± 9.53 mg extract/mL and 64.81 ± 4.65 malvidin-3-glucose equivalent μg/mL, respectively. Solvent pH plays a crucial role in selective extraction; an acidic pH facilitates selective anthocyanidin extraction, while a basic pH does not. Anthocyanidin extraction correlated with extract antioxidant activity and solvent viscosity. In addition, the antibacterial activity of the extracts against <i>Bacillus cereus</i>, <i>Listeria innocua</i>, and <i>Escherichia coli</i> strains was studied. All extracts showed antibacterial properties against the strains tested. The ChCl:oxalic acid extracts showed particularly low minimum inhibitory concentrations (e.g., 25 mg_extract/mL for <i>B. cereus</i>) and EC₅₀ values (e.g., 6.0 ± 0.3 mg_extract/mL for <i>B. cereus</i>).</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8483951","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}