Journal of Food Biochemistry最新文献

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Nuciferine Promotes Longevity and Fitness in Caenorhabditis elegans through the Regulation of the Insulin/IGF-1 Signaling Pathway 核iferine 通过调节胰岛素/IGF-1 信号通路促进秀丽隐杆线虫的寿命和体能
IF 4 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-05-16 DOI: 10.1155/2024/2779989
Yan Xu, Yuanxin Miao, Rong Li
{"title":"Nuciferine Promotes Longevity and Fitness in Caenorhabditis elegans through the Regulation of the Insulin/IGF-1 Signaling Pathway","authors":"Yan Xu,&nbsp;Yuanxin Miao,&nbsp;Rong Li","doi":"10.1155/2024/2779989","DOIUrl":"10.1155/2024/2779989","url":null,"abstract":"<p>Nuciferine, as one of the most abundant plant-derived alkaloids, has multiple bioactivities including anti-inflammatory, antitumor, and lipid-lowering effects. Nevertheless, the antiaging effects and related mechanisms of nuciferine are rarely reported. In this study, we found that nuciferine significantly prolonged the mean lifespan of <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) by 14.86% at a dose of 100 <i>μ</i>M. Moreover, nuciferine promoted the health of <i>C. elegans</i> by increasing the body bending and pharyngeal pumping rates and reducing the lipofuscin accumulation level. Meanwhile, nuciferine enhanced stress tolerance by inducing the expression of stress-related genes or proteins. The molecular mechanism behind the antiaging effect of nuciferine occurred by downregulating the insulin/IGF-1 signaling (IIS) pathway. Our findings shed new light on the application of nuciferine for longevity promotion and human health.</p>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid and Visual Favor Analysis Using Gas Chromatography-Ion Mobility Spectrometry (GC-IMS) in Meat Products: Research Progress and Future Trends 利用气相色谱-离子迁移谱法 (GC-IMS) 对肉类产品中的青睐成分进行快速、直观的分析:研究进展与未来趋势
IF 4 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-05-16 DOI: 10.1155/2024/6711621
Shiliang Jia, Zhifang Jia, Jun An, Yicheng Ding, Jie Chang, Yanbo Wang, Xuxia Zhou
{"title":"Rapid and Visual Favor Analysis Using Gas Chromatography-Ion Mobility Spectrometry (GC-IMS) in Meat Products: Research Progress and Future Trends","authors":"Shiliang Jia,&nbsp;Zhifang Jia,&nbsp;Jun An,&nbsp;Yicheng Ding,&nbsp;Jie Chang,&nbsp;Yanbo Wang,&nbsp;Xuxia Zhou","doi":"10.1155/2024/6711621","DOIUrl":"10.1155/2024/6711621","url":null,"abstract":"<p>The flavor profile of meat and its processed products is highly volatile and subject to significant changes during storage, processing, and transportation. It is therefore crucial to monitor the flavor of meat to evaluate sensory quality and protect consumer health and safety. Gas chromatography-ion mobility spectrometry (GC-IMS) has become increasingly popular due to its advantages of being nondestructive, rapid, and capable of trace detection. The analysis of volatile organic compounds (VOCs) using this technique is continuously applied in the assessment of food freshness, origin traceability, and adulteration detection. GC-IMS has emerged as a promising tool for accurate monitoring and characterization of VOCs in food, particularly in the field of meat flavor analysis. Its applications include meat product authentication, adulteration detection, processing and storage-related flavor changes, and freshness monitoring. This paper provides a comprehensive overview of the working principle of GC-IMS and its applications in meat flavor analysis, while exploring future trends and potential limitations associated with the technique.</p>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140968902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vivo and In Vitro Study on the Mechanism of Anticervical Cancer Effects of Corilagin in Mice 小鼠体内和体外科里拉金抗宫颈癌作用机制研究
IF 4 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-05-13 DOI: 10.1155/2024/4822900
Li-Mei Wang, Yu-Han Jiang, Xing-Yu Li, Min-Rui Wu, Zi-Yang Xu, Long-Jie Li, Yang Yi, Hong-Xun Wang
{"title":"In Vivo and In Vitro Study on the Mechanism of Anticervical Cancer Effects of Corilagin in Mice","authors":"Li-Mei Wang,&nbsp;Yu-Han Jiang,&nbsp;Xing-Yu Li,&nbsp;Min-Rui Wu,&nbsp;Zi-Yang Xu,&nbsp;Long-Jie Li,&nbsp;Yang Yi,&nbsp;Hong-Xun Wang","doi":"10.1155/2024/4822900","DOIUrl":"10.1155/2024/4822900","url":null,"abstract":"<p><i>Background</i>. Corilagin has several pharmacological effects such as antitumor, anti-inflammatory, and cardiovascular disease treatment. Our previous studies have shown that the Corilagin can significantly inhibit proliferation of HeLa cells. However, there are no scientific data on the anticervical cancer effect of Corilagin <i>in vivo</i>. <i>Methods</i>. Network pharmacology was used to predict the mechanism, followed by <i>in vitro</i> experiments to detect cell proliferation, cycle, and apoptosis, and <i>in vivo</i> experiments to verify the mechanism. <i>Results</i>. It was speculated that the mechanism of action for the anticervical cancer of Corilagin could be related to PI3K/AKT and MAPK signaling pathways through network pharmacology. Results of cell assays in the present study showed that the Corilagin has significant effect on the proliferation, cell cycle, and apoptosis of murine cervical cancer U14 cells <i>in vitro</i>. In addition, Corilagin can significantly inhibit the growth of U14 tumor-bearing mice with insignificant toxic effect on the liver and kidney of the transplanted mice. The current study found that Corilagin can delay development of cervical cancer by boosting antitumor immune responses of the body. RT-PCR and Western blotting were applied in the current study to evident that Corilagin can achieve anticervical cancer property by inducing apoptosis of tumor tissues through both PI3K/AKT and MAPK signaling pathways. <i>Conclusion</i>. Therefore, this study provided theoretical reference for research of Corilagin as a bioresource for development of an anticervical cancer drug and functional food.</p>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140985684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis and Validation of the Network Pharmacology of the Mechanism of Glycyrrhetinic Acid for the Treatment of High-Altitude Pulmonary Hypertension 甘草酸治疗高海拔肺动脉高压机制的网络药理学分析与验证
IF 4 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-05-10 DOI: 10.1155/2024/1552878
Zulipiye Ainaisi, Yang Tao, Dilinuer Maimaitiyiming, Fang Lei, Yiliyaer Nijiati, Liao Xijiang, Ainiwaer Aikemu
{"title":"Analysis and Validation of the Network Pharmacology of the Mechanism of Glycyrrhetinic Acid for the Treatment of High-Altitude Pulmonary Hypertension","authors":"Zulipiye Ainaisi,&nbsp;Yang Tao,&nbsp;Dilinuer Maimaitiyiming,&nbsp;Fang Lei,&nbsp;Yiliyaer Nijiati,&nbsp;Liao Xijiang,&nbsp;Ainiwaer Aikemu","doi":"10.1155/2024/1552878","DOIUrl":"10.1155/2024/1552878","url":null,"abstract":"<p>Glycyrrhetinic acid (GA) is a pentacyclic triterpene component in <i>Glycyrrhize glabra</i> L, it has demonstrated an inhibitive effect on high-altitude pulmonary hypertension (HAPH), but the molecular action is still not known. We aimed to explore the mechanism of GA for the treatment of HAPH based on network pharmacology and molecular docking method. Cell experiment validation was also conducted. The targets for GA were screened using the Swiss Target Prediction and Batman databases. The HAPH-related targets were obtained using the GeneCards and OMIM databases. The common targets for diseases and drugs were obtained using a Venn diagram. The core targets were screened using the String database. Then, a component-target-disease diagram and protein–protein interaction (PPI) network mutual assistance diagram were developed using Cytoscape3.9.1 software. GO functional and KEGG pathway enrichment analyses were conducted using the Metascape database. Finally, molecular docking of the target and its corresponding active components were performed using Autodock software. A total of 68 common targets for glycyrrhetinic acid high-altitude pulmonary hypertension were screened out. The core targets include PTGS1, MMP1, SERPINA6, and nitric oxide synthase (NOS2), involving PPAR signal pathway, human cytomegalovirus infection, IL-17 signal pathway, proteoglycans in cancer, and other pathways. The molecular docking affinity was −8.4 kcal·mol<sup>−1</sup> in average, indicating that GA has a good binding stability with key target proteins. In the PDGF-BB-induced PASMC proliferation model, PASMC proliferation and the p-p38, p38, p-ERK1/2, and ERK1/2 protein expression were inhibited. The pharmacological mechanism of GA for the treatment of HAPH was characterized by multi-target and multi pathway. GA may serve as a promising therapeutic candidate for HAPH but still needs further <i>in vivo/in vitro</i> experiment.</p>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140990728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variations in Bioactive Compounds and Sensory Properties of Flower-Flavored Chardonnay Wine during Floral Maceration and Bottle Aging 花香霞多丽葡萄酒在浸花和瓶中陈酿过程中生物活性化合物和感官特性的变化
IF 4 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-05-09 DOI: 10.1155/2024/8712690
Zijian Liang, Shuge Yang, Jingning Xiao, Ying Chia, Yipeng Chen, Zhongxiang Fang, Pangzhen Zhang
{"title":"Variations in Bioactive Compounds and Sensory Properties of Flower-Flavored Chardonnay Wine during Floral Maceration and Bottle Aging","authors":"Zijian Liang,&nbsp;Shuge Yang,&nbsp;Jingning Xiao,&nbsp;Ying Chia,&nbsp;Yipeng Chen,&nbsp;Zhongxiang Fang,&nbsp;Pangzhen Zhang","doi":"10.1155/2024/8712690","DOIUrl":"10.1155/2024/8712690","url":null,"abstract":"<p>An innovative flavored wine was developed by macerating six different edible flowers into Chardonnay wine, where the physicochemical characteristics (titratable acidity, pH), antioxidant activity (DPPH, FRAP) and volatile profile were modulated. Bottle aging of the flower-flavored wines were performed for 9 months where a significant (<i>p</i> &lt; 0.05) increases of total phenolic content and an opposite trend in antioxidant power (assessed by DPPH and FRAP assays) were observed. A total of 37 volatile substances were characterized in the aged flower-flavored wines. The aging process led to a decline in fruity and floral odors. Among the 12 month-aged wines, 1% (w/v) <i>O. fragrans</i>-flavored Chardonnay wine aged for 12 months was perceived as the most-liked product in human sensory analysis. This study manifested a bright future of edible flowers as a novel additive in the development of flavored wine with desirable sensory attributes.</p>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140996935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Composition and In Vitro and In Silico Biological Activities of Myrciaria tenella (DC.) O.Berg (Myrtaceae) Essential Oil from Brazil 巴西 Myrciaria tenella (DC.) O.Berg(桃金娘科)精油的化学成分及体外和硅学生物活性
IF 4 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-05-08 DOI: 10.1155/2024/2848736
Oberdan Oliveira Ferreira, Vanessa Guimarães Costa, Jorddy Nevez Cruz, Maria Sueli da Silva Kataoka, João de Jesus Viana Pinheiro, Lidiane Diniz do Nascimento, Everton Luiz Pompeu Varela, Márcia Moraes Cascaes, Sandro Percário, Suraj N. Mali, Tatiany Oliveira de Alencar Menezes, Mozaniel Santana de Oliveira, Eloisa Helena de Aguiar Andrade
{"title":"Chemical Composition and In Vitro and In Silico Biological Activities of Myrciaria tenella (DC.) O.Berg (Myrtaceae) Essential Oil from Brazil","authors":"Oberdan Oliveira Ferreira,&nbsp;Vanessa Guimarães Costa,&nbsp;Jorddy Nevez Cruz,&nbsp;Maria Sueli da Silva Kataoka,&nbsp;João de Jesus Viana Pinheiro,&nbsp;Lidiane Diniz do Nascimento,&nbsp;Everton Luiz Pompeu Varela,&nbsp;Márcia Moraes Cascaes,&nbsp;Sandro Percário,&nbsp;Suraj N. Mali,&nbsp;Tatiany Oliveira de Alencar Menezes,&nbsp;Mozaniel Santana de Oliveira,&nbsp;Eloisa Helena de Aguiar Andrade","doi":"10.1155/2024/2848736","DOIUrl":"10.1155/2024/2848736","url":null,"abstract":"<p><i>Myrciaria</i><i>tenella</i> O.Berg, a native plant species of Brazil, exhibits pharmacological applications, including antitumor activity. In this study, we isolated the essential oil (EO) of <i>M. tenella</i> and identified its phytochemical profile. In addition, we determined the in vitro and in silico cytotoxic activities of EO in nontumor and tumor cell lines (gingival fibroblasts and oral squamous cell carcinoma, respectively) and its free radical scavenging activity (i.e., antioxidant activity) using ABTS and DPPH assays. The EO of <i>M. tenella</i> primarily constitutes hydrocarbons and oxygenated sesquiterpenes, with (<i>E</i>)-caryophyllene (33.95%), <i>δ</i>-cadinene (7.4%), caryophyllene oxide (4.74%), and viridiflorene (4.49%) as its four major components. EO effectively suppressed the cell viability of CAL-27 tumor cells to below 70% at concentrations of 125 and 250 <i>μ</i>g/mL and exhibited a free radical inhibition potential of 75.63 ± 0.41% and 28.46 ± 0.36%, respectively, in the DPPH and ABTS assays. This chemical and biological potential may be attributed to the major compounds present in EO, as well as the molecular coupling simulations conducted, which revealed the anticancer mechanism of EO in the sesquiterpenes (<i>E</i>)-caryophyllene, <i>δ</i>-cadinene, caryophyllene oxide, and viridiflorene.</p>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macroalgae as Alkalizing Marine Drugs with a Low Potential Renal Acid Load 大型藻类作为潜在肾酸负荷低的碱性海洋药物
IF 4 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-05-08 DOI: 10.1155/2024/9683391
Maximilian Andreas Storz
{"title":"Macroalgae as Alkalizing Marine Drugs with a Low Potential Renal Acid Load","authors":"Maximilian Andreas Storz","doi":"10.1155/2024/9683391","DOIUrl":"10.1155/2024/9683391","url":null,"abstract":"<p>A growing interest in more sustainable and alternative food sources has brought seaweed and macroalgae to the spotlight for the general worldwide cuisine. Algae are often praised for their high nutritional value and are rich in potassium, calcium, and magnesium. Abundant in base precursors, algae are particularly interesting from an acid-base perspective. Their unique biochemical composition suggests a low potential renal acid load (PRAL), which is a commonly used estimate for the amount of acid or base a certain food produces in humans. Here, we analyzed the PRAL value of <i>n</i> = 106 macroalgae. Results suggested a strong alkalizing potential, with a mean PRAL value of −86.76 mEq/100 g. The lowest PRAL values were found for <i>Laminaria ochroleuca</i> (−286.78 mEq/100 g), <i>Gelidium micropterum</i> (−268.46 mEq/100 g), and <i>Palmaria palmata</i> (−259.16 mEq/100 g). We observed a strong inverse relationship of PRAL with algae’s potassium content (Spearman’s rho = −0.79, <i>p</i> &lt; 0.001) and a moderate relationship with algae’s calcium content (Spearmen’s rho: −0.34, <i>p</i> &lt; 0.001). Our data point at a potential role for several macroalgae as potent alkalizing marine drugs and suggest that a 10 g edible portion of some algae alone could contribute to a substantial PRAL reduction of up to −28.68 mEq. This might be of particular importance for individuals who benefit from a more alkaline diet and warrants further investigation in future studies.</p>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141001363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune-Enhancing Activity of Vitis coignetiae Extract via Increasing Cytokine and Natural Killer Cell Activity in Splenocytes and Cyclophosphamide-Induced Immunosuppressed Rats 通过提高细胞因子和自然杀伤细胞在脾细胞和环磷酰胺诱导的免疫抑制大鼠中的活性,增强葡萄籽提取物的免疫活性
IF 4 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-05-06 DOI: 10.1155/2024/5010095
Young Mi Park, Hak Yong Lee, Dong Yeop Shin, Han Na Jeong, Hai Min Hwang, Hyo Yeon Park, Suk Hun Kim, Min Ji Kim, Hee Joo Kang, Jin Hee Kim, Myung-sunny Kim, Hye Jeong Yang, Min Jung Kim, Jae Gon Kim
{"title":"Immune-Enhancing Activity of Vitis coignetiae Extract via Increasing Cytokine and Natural Killer Cell Activity in Splenocytes and Cyclophosphamide-Induced Immunosuppressed Rats","authors":"Young Mi Park,&nbsp;Hak Yong Lee,&nbsp;Dong Yeop Shin,&nbsp;Han Na Jeong,&nbsp;Hai Min Hwang,&nbsp;Hyo Yeon Park,&nbsp;Suk Hun Kim,&nbsp;Min Ji Kim,&nbsp;Hee Joo Kang,&nbsp;Jin Hee Kim,&nbsp;Myung-sunny Kim,&nbsp;Hye Jeong Yang,&nbsp;Min Jung Kim,&nbsp;Jae Gon Kim","doi":"10.1155/2024/5010095","DOIUrl":"10.1155/2024/5010095","url":null,"abstract":"<p>Plant and fruit extracts exhibit fewer side effects than pharmaceuticals and can display therapeutic qualities. Consequently, they have attracted increased attention among health-conscious individuals, and many studies related to their health-promoting effects are being actively conducted. <i>Vitis coignetiae</i> is well-known for its antioxidant, anti-inflammatory, and anticancer properties. However, the immune-enhancing effects of <i>Vitis coignetiae</i> have not yet been studied. In this study, <i>Vitis coignetiae</i> extract (VCE) increased immune-related activity in Wistar rat splenocytes and cyclophosphamide (Cy)-induced immunosuppressed rats. In splenocytes, VCE was nontoxic up to 300 <i>μ</i>g/mL and increased cell viability in the presence of Cy. VCE also recovered Cy-induced decreases in cytokine (tumor necrosis factor alpha (TNF-<i>α</i>), interferon gamma (IFN-<i>γ</i>), interleukin-2 (IL-2), and IL-12) levels and natural killer (NK) cell activity in splenocytes. In Cy-induced immunosuppressed rats, VCE protected against Cy-induced spleen tissue damage and decreases in body and spleen weight, cytokine (TNF-<i>α</i>, IFN-<i>γ</i>, IL-2, and IL-12) levels, and NK cell activity. We also observed recovery of immunoglobulin G (IgG) and IgM levels following VCE treatment. In conclusion, the ability of VCE to restore immune activity from an immunosuppressive state to normal levels suggests its immune-enhancing efficacy. Therefore, VCE may have the potential for application in the development of immune-enhancing functional foods and medicines.</p>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141007329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network Pharmacology Prediction and Metabolomics Validation of the Novel Targets of Morus alba L. against High-Fat Diet-Induced Diabetes Mellitus in C57/6J Mice 桑叶抗高脂肪饮食诱导的 C57/6J 小鼠糖尿病新靶点的网络药理学预测和代谢组学验证
IF 4 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-05-02 DOI: 10.1155/2024/7652471
Fan Qiu, Yu-Ping Chen, Hong-Yan Wu, Ji-Hu Sun
{"title":"Network Pharmacology Prediction and Metabolomics Validation of the Novel Targets of Morus alba L. against High-Fat Diet-Induced Diabetes Mellitus in C57/6J Mice","authors":"Fan Qiu,&nbsp;Yu-Ping Chen,&nbsp;Hong-Yan Wu,&nbsp;Ji-Hu Sun","doi":"10.1155/2024/7652471","DOIUrl":"10.1155/2024/7652471","url":null,"abstract":"<p>Diabetes mellitus (DM) is an endocrine-metabolic disorder that has limited approaches to treat effectively. <i>Morus alba</i> L., also known as mulberry, is a well-known medicinal plant, and its branch bark has shown hypoglycemic activity. It is rich in antioxidant and anti-inflammatory ingredients. In this study, we used metabolomics combined with network pharmacology to investigate the molecular mechanism and potential key targets of mulberry branch bark powder (MBBP) for treating DM. Serum metabolomics was performed to analyze the differences in metabolites and enrich metabolic pathways. Network pharmacology, based on systems biology tools, was applied to generate the pathway-target-compound network. Integrated analyses were then used to screen for key targets. To verify the obtained key targets, we used a molecular docking method and experimental validation. Our findings revealed that thirty-five endogenous metabolites contributed to the therapeutic impact of MBBP against DM. The analysis of 10 hub genes in the compound-target network partially supported the enrichment of metabolic pathways. Further analysis focused on two compounds (eugenol and mulberrofuran A) and three key targets (NOS2, MAOA, and CYP1A1). This study explores the active compounds of MBBP against DM and provides a novel perspective for improving DM treatment based on key targets.</p>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141020616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of the Freshness of Grass Carp during Storage with Electric Nose Based on Signal Sequence Merging and Wavelet Transform 基于信号序列合并和小波变换的 "电鼻 "预测草鱼储存期间的新鲜度
IF 4 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-04-23 DOI: 10.1155/2024/6327916
Guoqiang Zhao, Yuanyuan Chen, Mei Xie, Yihong Tan, Yong Jiang, Li Zhao
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