Journal of Food Biochemistry最新文献

{"title":"Tanshinone IIA Combined With Rutin and Squalene Improves Hyperlipidemia to Alleviate Atherosclerosis in New Zealand Rabbits Through Upregulation of the SREBP2/LDLR Pathway","authors":"Yuanjie Wu,&nbsp;Yuntian Zhang,&nbsp;Xike Wu,&nbsp;Ziyan Zhang,&nbsp;Junhui Shen,&nbsp;Nan Tian,&nbsp;Chunlei Fan","doi":"10.1155/jfbc/8349248","DOIUrl":"https://doi.org/10.1155/jfbc/8349248","url":null,"abstract":"<div>\u0000 <p>This study investigated the effects of tanshinone IIA combined with rutin and squalene (RTS) on atherosclerosis (AS) associated with hyperlipidemia and the underlying mechanisms. Female New Zealand rabbits were subjected to a hyperlipidemia and AS model. Treatment with RTS for 4 weeks reduced the weight, and some serum lipid levels include serum TC, serum TG, serum LDL-C. RTS also improved lesions of the liver and aorta. In vitro analyses showed that RTS significantly activated LDLR-mediated hepatic lipid endocytosis, but blocking LDLR activation with si-SREBP2 attenuated the therapeutic effect, which demonstrated that RTS can activate the SREBP2/LDLR pathway mediating liver clearance of blood lipids. This study highlights the therapeutic potential of RTS in hyperlipidemia and AS. As a convenient form of a combination drug, RTS has shown considerable potential in the improvement of hyperlipidemia combined with AS.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8349248","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ellagic Acid Protects Against Acute Stress-Induced Kidney Damage in Rats by Regulating the SIRT1/Nrf2 Signaling Pathway","authors":"Yongping Chen,&nbsp;Yunxuan Jiang,&nbsp;Yuhong Kou,&nbsp;Cailin Xu,&nbsp;Zhenjun Sun,&nbsp;Honggang Fan,&nbsp;Huanqi Liu","doi":"10.1155/jfbc/3463133","DOIUrl":"https://doi.org/10.1155/jfbc/3463133","url":null,"abstract":"<div>\u0000 <p>Ellagic acid displays multiple biological and pharmacological effects. Here, we explore its protective role against acute stress (AS)–induced kidney damage. We established the AS model through excessive swimming (15 min) and restraint stress (3 h), which decreased movement and exploratory behaviors in the open field test. Pretreatment with ellagic acid (10 mg/kg, orally for 14 days) reversed these changes and improved histopathological lesion and renal dysfunction. Moreover, ellagic acid alleviated AS-induced renal oxidative stress and apoptosis. This was evidenced by increased superoxide dismutase, glutathione, total antioxidant capacity, and catalase, alongside decreased levels of reactive oxygen species, malondialdehyde, apoptotic cells, caspase-3, and the Bax/Bcl-2 protein ratio. Additionally, ellagic acid mitigated AS-induced renal inflammation by lowering the nuclear factor kappa B (NF-κB) level, granulocyte percentage, myeloperoxidase activity, and tumor necrosis factor–α content. Notably, molecular docking suggested a stable interaction between ellagic acid and sirtuin 1 (SIRT1). Ellagic acid significantly enhanced the expression levels of SIRT1, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1, and NAD(P)H oxidoreductase 1 proteins. Importantly, the afore-mentioned effects of ellagic acid were substantially diminished by the SIRT1 inhibitor EX527. Correlation analysis showed that the SIRT1/Nrf2 signaling pathway was inversely related to oxidative stress, apoptosis, inflammation, and kidney damage. Collectively, these findings indicate that ellagic acid mitigates AS-induced renal damage by stimulating the SIRT1/Nrf2 signaling pathway, suppressing oxidative stress, inhibiting apoptosis, and attenuating NF-κB-mediated inflammation.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/3463133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valorization of Mushroom By-Products for Sustainability: Exploring Antioxidant and Prebiotic Properties","authors":"Pablo Navarro-Simarro,&nbsp;Lourdes Gómez-Gómez,&nbsp;Ángela Rubio-Moraga,&nbsp;Elena Moreno-Gimenez,&nbsp;Alberto López-Jimenez,&nbsp;Alicia Prieto,&nbsp;Oussama Ahrazem","doi":"10.1155/jfbc/3527311","DOIUrl":"https://doi.org/10.1155/jfbc/3527311","url":null,"abstract":"<div>\u0000 <p><i>Agaricus bisporus</i> (white button mushroom), <i>Pleurotus ostreatus</i> (oyster mushroom), and <i>Lentinula edodes</i> (shiitake mushroom) are the most cultivated mushrooms in the Spanish region of Castilla-La Mancha. The increasing production of these mushrooms has created opportunities for sustainable utilization of their by-products such as undersized mushrooms, stalks, and stems. This study evaluated the antioxidant, prebiotic, and antimicrobial properties of aqueous, ethanolic, and alkaline extracts derived from these by-products. Aqueous extracts from oyster mushroom, rich in glucose-polysaccharides (59.4 ± 0.4% mushroom dw), promoted the growth and lactic acid production of the probiotic bacteria <i>Lactocaseibacillus casei</i> and <i>Lactoplantibacillus plantarum</i>. Shiitake extracts demonstrated antimicrobial activity against <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli,</i> and <i>Salmonella enterica</i> (minimal inhibitory concentrations: 15, 7.5, and 7.5 mg/mL, respectively) and stimulated the growth of lactic acid bacteria at low concentrations (1.875 mg/mL) but inhibiting them at higher concentrations. Extracts from white button mushrooms exhibited the strongest antioxidant activity, particularly ethanolic extracts rich in phenolic compounds (0.015 mg gallic acid/mg extract). These results highlight the potential of extracts of mushroom by-products as organic sources of antioxidants, antimicrobials, and prebiotics, creating new avenues for food product development. Reusing these by-products could encourage sustainability and assist the mushroom sector in implementing zero-waste and circular economy methods.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/3527311","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional and Metabolic Profiles of Three Traditional Functional Dishes Based on Maize Flour and Wild Fruit Pulp of “Tomi” (Tamarindus indica), “Baobab” (Adansonia digitata), and “Néré” (Parkia biglobosa) Consumed in Côte d’Ivoire","authors":"Kouakou Nestor Kouassi,&nbsp;Kouame Aristide Kouakou,&nbsp;Yapo Hypolithe Kouadio,&nbsp;Kouadio Benal Kouassi,&nbsp;Gbè Aya Jacqueline Konan,&nbsp;Yao Denis N’dri,&nbsp;N’Guessan Georges Amani","doi":"10.1155/jfbc/8812417","DOIUrl":"https://doi.org/10.1155/jfbc/8812417","url":null,"abstract":"<div>\u0000 <p>Badégué-baca with tomi, Badégué-baca with baobab, and Wasséra are dishes made from maize flour, and “baobab” (<i>Adansonia digitata</i>), “tomi” (<i>Tamarindus indica</i>), and “néré” (<i>Parkia biglobosa</i>) pulp were consumed by the populations of northern Côte d’Ivoire to cover their dietary and nutritional needs. This study was initiated to determine the nutritional and physiological profiles of dishes made from maize and “baobab”, “tomi”, and “néré” pulp. To this end, these foods were prepared using traditional technologies to determine the nutrient density score (SAIN) and the score of nutrients to limit (LIM), followed by the determination of glycemic indexes (GIs) and glycemic loads (GLs). The results showed that Badégué-baca with baobab (4.70), Badégué-baca with tomi (5.17), and Wasséra (0.34) had LIM values below 7.5. However, Badégué-baca with baobab (7.51) and Wasséra (8.49) have SAIN values above 5, while Badégué-baca with tomi (3.56) has a SAIN score below 5. Moreover, Wasséra has a moderate GI (GI = 57.22 ± 0.2) and a high GL (CG = 23.21 ± 0.21). Badégué-baca with tomi has a high GI (GI = 76.30 ± 0.3) with a moderate GL (CG = 16.45 ± 0.09). As for Badégué-baca with baobab, the associated GL is moderate (14.11 ± 0.1) with a moderate GI (GI = 67.89 ± 1.00). Moderate consumption of Badégué-baca with baobab and Wasséra is safe for the body, they are recommended health foods (LIM below 7.5 and SAIN above 5), and could be used therapeutically to combat nutritional deficiencies. However, the consumption of Wasséra must take into account its high GL. As for Badégué-baca with tomi, a neutral food (LIM below 7.5; SAIN below 5), it would expose the diabetic patient to complications due to its high GI.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8812417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mulberry Leaf Extract and Deoxynojirimycin Modulates Glucose and Lipid Levels via the IRS1/PI3K/AKT Signaling Pathway in Cells","authors":"Yin-Di Zhang,&nbsp;Jun-Xi Liu,&nbsp;Fei-Fei Wang,&nbsp;Li-Ping Qu","doi":"10.1155/jfbc/7345044","DOIUrl":"https://doi.org/10.1155/jfbc/7345044","url":null,"abstract":"<div>\u0000 <p>Various diseases caused by disorders of glucose and lipid metabolism are increasing day by day. Although many drugs have certain therapeutic effects, they still produce some side effects. Therefore, this article chooses the natural medicinal plant mulberry leaves to reveal its mechanism of regulating glucose and lipid metabolism. By establishing an insulin resistance model and a 3T3-L1 adipocyte model, it was found that mulberry leaf extract (MLE) and deoxynojirimycin (DNJ) significantly increased glucose consumption and glycogen consumption, while reducing total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) levels. Network pharmacology, molecular docking, and protein level showed that MLE and DNJ could improve glucose and lipid metabolism disorders through IRS1/PI3K/AKT signaling pathway. These results suggest that MLE and DNJ may have broad application prospects in regulating glycolipid metabolism in functional foods and healthcare products.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/7345044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Royal Jelly Effect on Chronic Unpredictable Stress-Induced Pancreatic Oxidative and Endoplasmic Reticulum Stress and Insulin Secretion Impairment in Adult Male Rats","authors":"Payam Shahsavar,&nbsp;Fateme Binayi,&nbsp;Mina Sadat Izadi,&nbsp;Mina Salimi,&nbsp;Mehdi Hedayati,&nbsp;Rasoul Ghasemi,&nbsp;Homeira Zardooz","doi":"10.1155/jfbc/8812441","DOIUrl":"https://doi.org/10.1155/jfbc/8812441","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Royal jelly (RJ), secreted by nurse honeybees, possesses antioxidant properties. Studies have demonstrated that chronic stress can impair glucose metabolism, a process intricately linked to oxidative stress and endoplasmic reticulum (ER) stress induction. Consequently, this study investigated the effects of RJ on oxidative stress, apoptosis and ER stress markers, and insulin secretion from isolated pancreatic islets in rats subjected to chronic unpredictable stress (CUS).</p>\u0000 <p><b>Method:</b> Four groups were established, comprising adult male rats: None-STR-Water, STR-Water, None-STR-RJ, and STR-RJ. Over 4 weeks, CUS was applied, and RJ was administered via oral gavage. A glucose tolerance test was conducted, and fasting blood samples were collected to analyze corticosterone, leptin, antioxidants, and malondialdehyde (MDA) plasma levels. Additionally, pancreatic oxidative stress and ER stress markers, apoptosis indicators, and insulin secretion from isolated pancreatic islets were evaluated.</p>\u0000 <p><b>Results:</b> Exposure to CUS increased plasma corticosterone and leptin levels, catalase activity and glutathione (GSH) levels in both plasma and pancreatic tissue and reduced plasma MDA levels. RJ administration in the STR-RJ group restored the mentioned parameters. Furthermore, CUS elevated pancreatic BIP, CHOP, and cleaved CASPASE-3 protein levels; however, these levels were diminished following RJ treatment. The CALNEXIN protein level remained unchanged between the study groups. In the STR-Water group, glucose-stimulated insulin secretion was diminished, whereas in the RJ-treated groups, insulin secretion from islets in response to the high glucose concentration was significantly enhanced.</p>\u0000 <p><b>Conclusion:</b> The administration of RJ, in conjunction with CUS exposure, may protect the normal insulin response to glucose by mitigating oxidative stress, as evidenced by the restoration of catalase activity and GSH levels, and ER stress, as supported by the decrease in BIP and CHOP protein levels.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8812441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the Molecular Pathways: How Polygonatum sibiricum Alleviates Myocardial Ischemia","authors":"Zhenzhong Zhu,&nbsp;Junzhi Pan,&nbsp;Bin Jiang,&nbsp;Yuanlong Zhang,&nbsp;Yanxia Lv,&nbsp;Yifan Pan,&nbsp;Yunxiang Wang,&nbsp;Weijun Lv","doi":"10.1155/jfbc/8543663","DOIUrl":"https://doi.org/10.1155/jfbc/8543663","url":null,"abstract":"<div>\u0000 <p>Herbal medicine, like <i>Polygonatum sibiricum</i>, is gaining attention for its potential in treating myocardial ischemia. Comprehensive research on its molecular interplay is essential for its development as a therapeutic agent. The aim is to investigate the molecular mechanisms by which <i>Polygonatum sibiricum</i> ameliorates myocardial ischemia. The study involves a thorough database exploration, molecular docking, and the use of both in vivo and in vitro models for detailed assessment. The role of the HIF-1α pathway is particularly emphasized. Identification of 11 principal components and 23 core proteins, with a dominant role of HIF-1α, was achieved. A notable improvement in myocardial conditions, attributable to <i>Polygonatum sibiricum</i>, was observed. <i>Polygonatum sibiricum</i> improves myocardial ischemic injury by augmenting mitochondrial activity and enhancing the HIF-1α pathway.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8543663","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Phenolic compounds present in fruit extracts of Malus spp. show antioxidative and pro-apoptotic effects on human gastric cancer cell lines”","authors":"","doi":"10.1155/jfbc/9803181","DOIUrl":"https://doi.org/10.1155/jfbc/9803181","url":null,"abstract":"<p>M. Han, A. Li, T. Shen, et al., “Phenolic compounds present in fruit extracts of <i>Malus</i> spp. show antioxidative and pro-apoptotic effects on human gastric cancer cell lines.” Journal of Food Biochemistry. 2019; 43: e13028. https://doi.org/10.1111/jfbc.13028.</p><p>In the published version of the above article, the authors reported experiments conducted using the gastric cancer cell line BGC-803, which has been reported as a nonverifiable/unknown cell line. After reassessing the cell line authentication documentation, it was concluded that the cell line used in the study corresponds to the cell line MGC-803 (RRID: CVCL_5334).</p><p>This corrigendum has been issued to state that all references to “BGC-803” in the article should now be recognized as “MGC-803.”</p><p>While the authors were not responsible for the misidentification, they apologize for any confusion this may have caused.</p>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9803181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Techno-Functional Biochemical Analysis and Food Applications of Edible Mushroom Powder","authors":"Subhra De,&nbsp;Prince Chawla,&nbsp;Sanju Bala Dhull,&nbsp;Gulden Goksen,&nbsp;Anarase Dattatray Arjun,&nbsp;Aarti Bains","doi":"10.1155/jfbc/2888689","DOIUrl":"https://doi.org/10.1155/jfbc/2888689","url":null,"abstract":"<div>\u0000 <p>The edible mushroom powder has an essential role in sustainable food technology and innovation, and therefore, it is considered a multifaceted functional food ingredient. Edible mushrooms are rich in proteins, fibers, vitamins, and bioactive compounds like polysaccharides and antioxidants, making them valuable for food product innovation. Mushroom powder enhances food texture, stability, and nutritional value, aligning with consumer preferences for nutritious and eco-friendly alternatives. The present review highlights the role of mushroom powder in improving the health attributes and sensory qualities of food products, providing a comprehensive overview of its nutritional benefits, processing methods, and applications in the food industry. By incorporating mushroom powder, food technologists can develop health-oriented products that meet the demands of modern consumers seeking dietary diversity and sustainability. This manuscript emphasizes mushroom powder’s utility in food technology and product development, promising significant advancements in functional and sustainable food solutions.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/2888689","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network Pharmacology Prediction and Molecular Docking Analysis Reveal the Mechanism of XueFu ZhuYu Decoction on Malignant Pleural Effusion","authors":"Zhe Chen,&nbsp;Yixing Li,&nbsp;Yilong Zhao,&nbsp;Heng Zhao,&nbsp;Bin He,&nbsp;Chi Wang,&nbsp;Haotian Bai,&nbsp;Rui Zhao,&nbsp;Jinteng Feng,&nbsp;Guangjian Zhang","doi":"10.1155/jfbc/9949812","DOIUrl":"https://doi.org/10.1155/jfbc/9949812","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> XueFu ZhuYu Decoction (XFZYD) is a classic herbal formula that shows promise in the treatment of malignant pleural effusion (MPE). However, its primary components and the underlying mechanisms of action remain unclear. Therefore, the objective of this study is to preliminarily elucidate the potential mechanisms by which XFZYD may treat MPE through network pharmacology and molecular docking.</p>\u0000 <p><b>Methods:</b> The effective components and their corresponding targets of XFZYD were identified using the traditional chinese medicine (TCM) systems Pharmacology database, and a related network was constructed utilizing Cytoscape. Subsequently, the targets associated with MPE were retrieved from the Online Mendelian Inheritance in Man (OMIM) and GeneCards databases. We then determined the intersection between compound targets and disease targets, constructing a protein–protein interaction (PPI) network by importing these into the STRING database. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO) enrichment analyses were performed through the Metascape database. Finally, molecular docking studies between core targets and effective compound molecules were conducted.</p>\u0000 <p><b>Result:</b> Quercetin, kaempferol, and luteolin were identified as the compounds with the highest values. The primary common targets of XFZYD in relation to MPE included STAT3, MAPK1, and MAPK3. Furthermore, GO and KEGG analyses indicated that XFZYD treatment for MPE was associated with responses to lipopolysaccharide, vesicle lumen dynamics, and protein kinase activity overall. The signaling pathways predominantly involved were the AGE-RAGE pathway, IL-17 signaling pathway, and P13K-Akt signaling pathway. Molecular docking demonstrated high affinities between the lead compounds and their target proteins.</p>\u0000 <p><b>Conclusions:</b> The active ingredients Quercetin, kaempferol, and luteolin in XFZYD exert therapeutic effects against MPE via the PI3K-Akt signaling pathway, with key targets involving STAT3, MAPK1, and MAPK3.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9949812","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}