Journal of Food Biochemistry最新文献

{"title":"Shenbing Decoction III and Apigenin Improve Peritoneal Fibrosis Mediated by Epithelial–Mesenchymal Transition Through TAK1/p38MAPK/NF-κB Pathways","authors":"Yang Tang,&nbsp;Ying Wang,&nbsp;Xiaomin Sun,&nbsp;Jie Zheng,&nbsp;Jingying Fang,&nbsp;Shufeng Liu,&nbsp;Juan Luo,&nbsp;Yunqiang Liao,&nbsp;Yalin Cheng,&nbsp;Jiawei Lu,&nbsp;Shuyuan Zhou,&nbsp;Xiaosheng Li","doi":"10.1155/jfbc/7841565","DOIUrl":"https://doi.org/10.1155/jfbc/7841565","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> This study aimed to evaluate the effect of Shenbing Decoction III (SBD III) and its key Apigenin on peritoneal dialysis (PD)–induced peritoneal fibrosis and explore the underlying mechanisms.</p>\u0000 <p><b>Methods:</b> Liquid chromatography–mass spectrometry confirmed the presence of Apigenin in SBD III. Human peritoneal mesothelial cells (HMrSV5) were stimulated with PD solution (PDS) to induce fibrosis, and treatment with SBD III and Apigenin was administered.</p>\u0000 <p><b>Results:</b> PDS decreased cell viability and increased the migration and invasion capabilities of HMrSV5 cells. It also reduced E-cadherin expression, while increasing the expression of α-SMA, fibronectin, collagen I, and TGF-β1. SBD III and Apigenin effectively counteracted these effects. Additionally, SBD III and Apigenin inhibited the PDS-induced upregulation and phosphorylation of transforming growth factor-β-activated kinase 1 (TAK1), p38, and nuclear factor-κB (NF-κB), similar to the effects of 5z-7-oxozeaenol. Chronic kidney disease (CKD) was induced in mice by 5/6 nephrectomy, followed by PDS treatment. The therapeutic effects of SBD III and Apigenin were evaluated. CKD mice exhibited reduced body weight and kidney weight indices, along with elevated blood urea nitrogen, urinary creatinine, and urinary protein levels. Fibrosis was observed in the kidneys and peritoneum. PDS treatment also significantly alleviated these effects. Notably, therapeutic effects were further augmented when SBD III and Apigenin were administered.</p>\u0000 <p><b>Conclusion:</b> SBD III and Apigenin ameliorated PDS-induced peritoneal fibrosis by inhibiting epithelial–mesenchymal transition via the TAK1/p38MAPK/NF-κB pathway, indicating promising pharmaceutical candidates for CKD.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/7841565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Commercial Preparations of Pectinases on the Chemical Composition and Stability of Phenolic Compounds in Grape Juices","authors":"Maria da Conceição Prudêncio Dutra,&nbsp;Ana Júlia de Brito Araújo Carvalho,&nbsp;Newton Carlos Santos,&nbsp;Sérgio Tonetto de Freitas,&nbsp;Ederlan de Souza Ferreira,&nbsp;Aline Telles Biasoto Marques,&nbsp;Marcos dos Santos Lima","doi":"10.1155/jfbc/2856691","DOIUrl":"https://doi.org/10.1155/jfbc/2856691","url":null,"abstract":"<div>\u0000 <p>Enzymatic preparations in juice processing come in different formulations, but their enzymatic activities on the stability of this beverage must be studied. This study evaluated five commercial yield and color extraction preparations concerning the chemical composition of grape juice, color, and phytochemicals quantified in HPLC. The activity of the enzymes was evaluated, and a study of the stability of the juices over 360 days was carried out. The color extraction enzymes Everzym Thermo and Endozym Rouge (hemicellulases) increased the content of flavonoids, especially malvidin-3-glucoside. The Endozym Pectofruit PR preparation (pectin lyase) stood out for its yield and extraction of organic acids such as tartaric. When assessing the stability of the juice using the half-life parameter, it became clear that all the juices showed similar evolutionary behavior, with more accelerated degradation of the components related to color in the first 100 days. Even though the Everzym Thermo preparation showed greater color extraction, it had higher degradation rates for these parameters and anthocyanins than the other preparations evaluated. At the end of the storage period, the differences in color and anthocyanins were small between the preparations, practically equal to the control. This shows that in the juice obtained without enzymes, the nondegradation of polysaccharides may be associated with a protective effect on color and anthocyanins.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/2856691","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amelioratory Role of Lactobacillus paracasei N1115 on Blood Glucose, Inflammation, Cognitive Function, and Gut Microbiota Composition in Type 2 Diabetes Mellitus Rats","authors":"Qing Li,&nbsp;Feng Feng,&nbsp;Yanqing Bian,&nbsp;Hanyi Zhao,&nbsp;Sijia Cao,&nbsp;Dongzhe Sun,&nbsp;Tianyue Jiao,&nbsp;Baohua Zhao,&nbsp;Liping Peng","doi":"10.1155/jfbc/6891209","DOIUrl":"https://doi.org/10.1155/jfbc/6891209","url":null,"abstract":"<div>\u0000 <p>This study aims to investigate the effect of probiotic <i>Lactobacillus paracasei</i> N1115 on Type 2 diabetes mellitus (T2DM) rats. SD rats were randomly divided into 5 groups, including control group (ND), diabetes mellitus (DM) group, and high (10⁹ CFU/mL), medium (10⁸ CFU/mL), or low (10⁷ CFU/mL) doses of probiotics intervention groups. The ND rats were fed a normal diet, and the others were fed a high-fat diet and injected with streptozotocin (STZ) to build a T2DM model. In the three probiotic intervention groups, rats were given high, medium, or low doses of <i>L. paracasei</i> N1115 by gavage for 12 weeks. Results indicated that probiotics could prevent weight loss and decrease the blood glucose levels of T2DM rats, in a dose-dependent manner. A high dose of <i>L. paracasei</i> N1115 also led to a significant decline in the inflammatory response by regulating the TLR4/NF-κB inflammatory pathway and reducing proinflammatory cytokines, such as tumor necrosis factor-<i>α</i> (TNF-α), interleukin-1β (IL-1β), and lipopolysaccharide (LPS) (<i>p</i> &lt; 0.05). Besides, the memory factor cAMP and the cognitive regulatory pathway BDNF/TrkB were increased by high dose of <i>L. paracasei</i> N1115 treatment (<i>p</i> &lt; 0.05), revealing an enhanced cognitive memory competence. In addition, analysis of the gut microbiome showed that a high dose of <i>L.paracasei</i> N1115 decreased Firmicutes/Bacteroidota ratio and increased the relative abundance of beneficial bacteria, such as unclassified_Lachnospiraceae, Ligilactobacillus, and Lachnospiraceae_NK4A136_group. The microbial gene contents associated with metabolic pathways, nicotinate and nicotinamide metabolism, glycine, serine, and threonine metabolism and the citrate cycle were upregulated under <i>L. paracasei</i> N1115 treatment. In summary, this study elucidated the regulatory effects of <i>L. paracasei</i> N1115 on T2DM in rats and revealed a promising dietary supplement for the treatment of T2DM.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/6891209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Antiobesity Mechanisms of Polygonatum cyrtonema Hua Based on Network Analysis and Experimental Validation In Vivo and In Vitro","authors":"Lihua Xing,&nbsp;Chenchen Zhao,&nbsp;Jun Xu,&nbsp;He Cheng,&nbsp;Jiayi Hu,&nbsp;Heng Liu,&nbsp;Mengjin Wang,&nbsp;An Zhou,&nbsp;Rongchun Han,&nbsp;Nianjun Yu","doi":"10.1155/jfbc/3379148","DOIUrl":"https://doi.org/10.1155/jfbc/3379148","url":null,"abstract":"<div>\u0000 <p>Obesity is a chronic and complex disease that serves as a precursor to numerous chronic conditions. Its development is linked to gut microbiota and often accompanies inflammation and insulin resistance. The rhizome of <i>Polygonatum cyrtonema</i> Hua is commonly employed in the treatment of metabolic disorders. The mechanisms of <i>P</i>. <i>cyrtonema</i> Hua in treating obesity have not been deeply investigated. This study aimed to explore the protective effect and the possible mechanism of the water extract of <i>P</i>. <i>cyrtonema</i> Hua (PHWE) in high-fat diet–induced obesity in mice. We employed a combination of network pharmacology and molecular docking methods to predict the mechanisms of traditional Chinese medicine in treating obesity, followed by <i>in vivo</i> and <i>in vitro</i> validations. After a series of biological information analyses, 10 potential core targets were identified: AKT1, PPARG, ESR1, STAT3, SIRT1, PPARA, MMP9, FASN, mTOR, and IGF1R. The key pathways mainly include the AMPK signaling pathway, insulin signaling pathway, insulin resistance, and mTOR signaling pathway. In experiments conducted on live mice with obesity, PHWE was found to significantly reduce body weight, IL-6, and IL-1β levels in adipose tissue and improve insulin resistance. Based on the characteristics of obesity, the modulation of inflammation and insulin resistance by PHWE in obese mice may be related to gut microbiota. PHWE modulated the mTOR signaling pathway by decreasing the expression of mTOR, Raptor-mTORC1, and pS6K1 proteins while increasing the expression of pIRS1 and pAKT. PHWE could also regulate the protein expression of PPARγ and the key target FASN. These findings were further validated in <i>in vitro</i> experiments. Combining network pharmacology with <i>in vivo</i> and <i>in vitro</i> experiments, we investigated the potential mechanisms of PHWE in treating obesity. These findings provide an experimental foundation for the clinical utilization of <i>P</i>. <i>cyrtonema</i> Hua.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/3379148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation, Identification, and Cellular Antioxidant Activity Evaluation of Antioxidant Peptides From the Antler Tips of Sika Deer (Cervus nippon)","authors":"Xingyu Xiao,&nbsp;Jilun Meng,&nbsp;Xi Chen,&nbsp;Yi Li,&nbsp;Shuo Zheng,&nbsp;Xunming Zhang,&nbsp;Libo Zhang,&nbsp;Jiayuan Fang,&nbsp;Tong Su,&nbsp;Ze Ma,&nbsp;Hong Zhang,&nbsp;Linlin Hao","doi":"10.1155/jfbc/9974213","DOIUrl":"https://doi.org/10.1155/jfbc/9974213","url":null,"abstract":"<div>\u0000 <p>A process for extracting the antler tip peptides (ATPs) from Sika deer (<i>Cervus nippon</i>) antler tips was optimized using a method that combines single-factor experiment and response surface methodology. The optimal conditions involved papain as the hydrolase, an enzyme concentration of 5000 U/g, a hydrolysis time of 3.0 h, a temperature of 52.0°C, a pH of 7.10, and a substrate concentration of 14%. Under these conditions, the clearance rate of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical was 73.05 ± 1.49%, and the degree of hydrolysis (DH) was 19.43 ± 1.06%. The antioxidant compound ATPs-2 exhibited strong free radical and anion scavenging activity. In a model of Ultraviolet B (UVB)-induced oxidative damage, ATP-2 reduced reactive oxygen species (ROS) and malondialdehyde (MDA) levels, increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities, and alleviated UVB-induced cellular oxidative damage. A total of 6279 unique peptide sequences were identified in ATP-2, with 2496 potential bioactive peptides predicted using PeptideRanker. Of these, 12 peptides with PeptideRanker scores above 0.95 were analyzed using BIOPEP-UWM, identifying three antioxidant peptides: GPWPPGAP, GPAGPPGGPGL, and PGSPGPPGMPGP. Among them, GPWPPGAP displayed the highest antioxidant activity, with an IC₅₀ value on DPPH radical of 1.1 mg/mL and a strong binding energy of −9.8 kcal/mol to MMP-1.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9974213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structurally Diverse Quinoline Alkaloids With Antileukaemia Activities From Taraxacum mongolicum","authors":"Xiaodong Zhang,&nbsp;Qinge Ma,&nbsp;Weiwei Yan,&nbsp;Meng Li,&nbsp;Haixia Liu,&nbsp;Bo Yuan,&nbsp;Xiaoxue Wang","doi":"10.1155/jfbc/5545155","DOIUrl":"https://doi.org/10.1155/jfbc/5545155","url":null,"abstract":"<div>\u0000 <p><i>Taraxacum mongolicum</i>, a medicinal and food homologous traditional Chinese medicine, has important research value in clinical practice. Eight new quinoline alkaloids (<b>1</b>–<b>8</b>), including 1N-geranyl quinoline alkaloids (<b>1</b>–<b>3</b>), 3,4-phenylquinoline alkaloids (<b>4</b>–<b>6</b>) and 10-carbonyl-11-pyrrolyl quinoline alkaloids (<b>7</b>–<b>8)</b>, and twelve known quinoline alkaloid derivatives (<b>9</b>–<b>20</b>) were isolated from <i>T. mongolicum</i> for the first time. These compounds were elucidated according to analysing NMR, MS, UV and IR spectra and compared with references. Among them, compounds (<b>7</b>, <b>8</b>, <b>14</b> and <b>16</b>) showed certain antileukaemia activities, which exhibited important cell growth inhibitory activities against HL-60 and K562 cells than adriamycin, which could be potential antileukaemia agents. The plausible biogenetic pathway and preliminary structure–activity relationship of the selected compounds were scientifically summarised and discussed in this work.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5545155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Chuanxiong Rhizoma and Wine-Processed Chuanxiong Rhizoma Based on HS-GC–MS and Intelligent Sensory Technology","authors":"Ling-Fang Wu,&nbsp;Yi-Fei Ren,&nbsp;Jia-Qi Zhan,&nbsp;Yong-Ben Ma,&nbsp;Qi Qian,&nbsp;Han-Yu Ma,&nbsp;Li-Ying Niu,&nbsp;Xin-Guo Wang,&nbsp;Sheng Lin","doi":"10.1155/jfbc/9943931","DOIUrl":"https://doi.org/10.1155/jfbc/9943931","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> To investigate the differences in odor characteristics and volatile components between raw and wine-processed Chuanxiong Rhizoma and to establish a rapid differentiation method based on taste, smell, color, and volatile chemical components.</p>\u0000 <p><b>Methods:</b> Electronic tongue, electronic nose, and ultraviolet spectrophotometer were used to analyze 23 batches of raw and wine-processed Chuanxiong Rhizoma. Principal component analysis, one-way ANOVA, and orthogonal partial least-squares discriminant analysis were employed to differentiate between Chuanxiong Rhizoma and alcoholic Chuanxiong Rhizoma. Headspace gas chromatography–mass spectrometry (HS-GC–MS) and multivariate statistical analysis were used to identify potential differential components between raw and wine-processed Chuanxiong Rhizoma. Correlation analysis of these differential components with odor and color was performed to identify the main compounds responsible for the differences in odor and color.</p>\u0000 <p><b>Results:</b> The electronic tongue analysis showed that after alcohol processing, Chuanxiong Rhizoma exhibited a significant decrease in aftertaste and umami, a notable reduction in saltiness, and a significant increase in sweetness, enabling rapid differentiation between raw and wine-processed Chuanxiong Rhizoma. The electronic nose analysis indicated that odor differences were primarily detected by sensors W1W and W2W, which can be used to quickly distinguish between raw and wine-processed Chuanxiong Rhizoma. The ultraviolet spectrophotometer results showed no significant color differences between raw and wine-processed Chuanxiong Rhizoma, making it difficult to distinguish between the two. HS-GC–MS identified 18 differential components between raw and wine-processed Chuanxiong Rhizoma. Pearson correlation analysis of volatile components and odor revealed that the main differential compounds include monoterpenes, alcohols, and aliphatic aldehydes. Notably, isoterpinolene, isoamyl alcohol, 2-ethyl-2-hexenal, and hexenal were found to significantly contribute to odor differences, indicating a relationship between these differential components and the efficacy changes in Chuanxiong Rhizoma before and after wine processing.</p>\u0000 <p><b>Conclusion:</b> The combined use of the electronic tongue, electronic nose, and HS-GC–MS enables rapid and accurate differentiation between raw and wine-processed Chuanxiong Rhizoma. This method is valuable for the processing and quality control of traditional Chinese medicines.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9943931","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIRT3 Regulates H3K9Ac Modification to Affect DDIT4 Involved in Abnormal Hepatic Lipid Metabolism in Male Offspring of Paternal High-Fat Diet","authors":"Yan Zhao,&nbsp;Dan Zhu,&nbsp;Yajun Shi,&nbsp;Xi Yu,&nbsp;Bin Wei,&nbsp;Qinqin Gao,&nbsp;Lingjun Li,&nbsp;Dongyi Yu,&nbsp;Pengjie Zhang,&nbsp;Miao Sun","doi":"10.1155/jfbc/8272754","DOIUrl":"https://doi.org/10.1155/jfbc/8272754","url":null,"abstract":"<div>\u0000 <p>Studies indicate that the male environment and feeding patterns may impact the offspring. In this study, a paternal high-fat diet (HFD) model was established to investigate the lipid metabolism of male offspring. We found that HFD-F1 male mice exhibited abnormal hepatic gluconeogenesis in intraperitoneal pyruvate tolerance test (IPPTT) and increased lipid deposition in the liver. Additionally, the contents of triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) in plasma and liver tissues were significantly elevated in HFD-F1 male mice. Transcriptome analysis revealed upregulation of genes involved in adipogenesis, such as <i>Ddit4</i>, and downregulation of oxidative phosphorylation-related genes like <i>Nmrk1</i>. Western blotting confirmed decreased SIRT3 expression, increased DDIT4 expression, and reduced AKT phosphorylation in the liver of HFD-F1 male mice. In AML12 cells, knockdown of <i>Sirt3</i> led to increased DDIT4 expression and decreased AKT phosphorylation, while overexpression of <i>Sirt3</i> had the opposite effect in vitro. Notably, H3K9Ac was significantly elevated in the liver of HFD-F1 male mice. Furthermore, changes in SIRT3 expression influenced the levels of H3K9Ac. ChIP-qPCR assays demonstrated a significant increase in the binding of H3K9Ac to the <i>Ddit4</i> promoter in HFD-F1 male mice. In conclusion, our findings highlight the role of the SIRT3-H3K9Ac-DDIT4-AKT pathway in mediating abnormal hepatic lipid metabolism in male offspring of paternal HFD. These results provide new mechanistic insights into the epigenetic regulation and the molecular basis of lipid metabolism dysregulation and suggest potential targets for therapeutic intervention.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8272754","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Protection of Alpha-Glucosyl Hesperidin and Procyanidin Against Testicular Ischemia-Reperfusion Injury","authors":"Ehsan Zeynali,&nbsp;Ali Soleimanzadeh,&nbsp;Saeed Azizi","doi":"10.1155/jfbc/5634210","DOIUrl":"https://doi.org/10.1155/jfbc/5634210","url":null,"abstract":"<div>\u0000 <p>The present study was designed to examine the protective effects of alpha-glucosyl hesperidin (AGH) and procyanidin (PC) against testicular ischemia/reperfusion (I/R) injury, which is a severe medical condition. Seven groups of male rats were divided into control, torsion/detorsion (T/D), T/D+50 mg/kg PC, T/D+25 mg/kg AGH, T/D+50 mg/kg AGH, T/D+50 mg/kg PC+25 mg/kg AGH, and T/D+50 mg/kg PC+50 mg/kg AGH. The evaluation of testicular tissue, sperm quality, oxidative status, gene activity, and fertility levels after T/D was conducted using various tests. The results showed that sperm motility, viability, and plasma membrane functionality, as well as total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and <i>Bcl-2</i> gene expression levels, all increased after treatment with AGH or PC and coadministration. Additionally, the levels of glutathione (GSH), malondialdehyde (MDA), <i>Bax,</i> and <i>caspase-3</i> gene expression and abnormal morphology and DNA damage decreased compared to the T/D group. The study found that AGH and PC had a more substantial synergistic effect when used together to improve reproductive health following T/D damage.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5634210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on the Extraction Methods, Bioactivities, and Application in Foods of Silk Sericin","authors":"Yijin Wang,&nbsp;Jingxuan Gao,&nbsp;Yemei Yang,&nbsp;Lizhou Zhu,&nbsp;Wei Yang,&nbsp;Pingping Li,&nbsp;Weike Yang,&nbsp;Wen Yang","doi":"10.1155/jfbc/2155701","DOIUrl":"https://doi.org/10.1155/jfbc/2155701","url":null,"abstract":"<div>\u0000 <p>Silk sericin, a byproduct of the silk industry, is typically discarded during degumming in the textile industry. However, recent studies have revealed that sericin possesses various biological activities, including antibacterial, anti-inflammatory, and antioxidative activities; lowers blood sugar; and promotes intestinal health. These activities can be attributed to the rich content of polar amino acids with hydroxyl groups, such as serine and threonine, in the secondary structure of sericin. Additionally, sericin contains eight essential amino acids necessary for the human body that humans cannot synthesize by their own, most get them through food. Thus, sericin is a potential food resource. The ability to utilize sericin as a source of bioactive peptides and amino acids from silk byproducts is very important for fully utilizing silk products, increasing the value of byproducts, and addressing the current low utilization rate of sericin in the food industry. This review provides a summary and analysis of the extraction methods, research activities, and current applications of sericin in the food industry. In addition, the study provides reference information for the effective utilization of surplus resources from silkworm cocoons and the full utilization of sericin.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/2155701","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}