Journal of Food Biochemistry最新文献

{"title":"Calamintha incana Methanolic Extract: Investigation of Phytochemical Composition and Antioxidant and Antibacterial Activities","authors":"Arwa R. Althaher,&nbsp;Reham F. Shehabi,&nbsp;Hanan H. Ameen,&nbsp;Mirna W. Awadallah,&nbsp;Andrea Mastinu","doi":"10.1155/2024/6634969","DOIUrl":"https://doi.org/10.1155/2024/6634969","url":null,"abstract":"<div>\u0000 <p><i>Calamintha</i><i>incana</i>, a medicinal plant traditionally used for its therapeutic properties, has been investigated for its phytochemical constituents and biological activities. Through a specific LC-MS/MS analysis method, the phytochemical constituents of <i>Calamintha incana</i> methanolic extract have been identified and quantified. The 2,2-diphenyl-1-picrylhydrazyl method was used to measure the antioxidant properties. The antibacterial properties of this extract have been tested against four harmful bacteria using disc diffusion and the minimum inhibitory concentration methods. A colorimetric assay has evaluated the total phenolic and flavonoid content. The extract contained 34 compounds, with linolenic acid (11.2%) and myristic acid (10.3%) being the most abundant. Despite the low phenolic and flavonoid content, the extract exhibited antioxidant activity with an IC₅₀ of 96.8 ± 0.3 <i>μ</i>g/mL. Moreover, the extract demonstrated potent antimicrobial properties against <i>B. cereus</i> and <i>S. aureus</i>, with minimum inhibitory concentrations of 11.8 and 21.5 <i>μ</i>g/mL, respectively. These robust results underscore the potential of <i>C. incana</i> methanolic extract in the development of effective antibacterial agents.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6634969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142123141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Voluntary Exercise on Liver and Adipose Tissue Dysfunction in Both Young and Middle-Aged Mice Fed a High-Fat Diet Combined with Dietary Advanced Glycation End Products","authors":"Ruitong Liu,&nbsp;Tongtong Ma,&nbsp;Zhilong He,&nbsp;Guochong Chen,&nbsp;Huiwen Gu,&nbsp;Zhongxiao Wan","doi":"10.1155/2024/5226432","DOIUrl":"https://doi.org/10.1155/2024/5226432","url":null,"abstract":"<div>\u0000 <p>To determine whether voluntary exercise is capable of improving liver and adipose tissue dysfunction caused by the high-fat diet (HFD) combined with dietary advanced glycation end products (AGEs). Young and middle-aged male C57BL/6J mice were divided into the control group, HFD group, HFD combined AGE group (HFD + AGE), and combined diet with exercise group (HFD + AGE + EX). For young mice, in the liver tissue, compared to the YCON group, RAGE from the YHFD + AGE group and SREBP1 from the YHFD + AGE and YHFD + AGE + EX groups were increased, while LXR<i>α</i> from the YHFD YHFD + AGE, and YHFD + AGE + EX groups was decreased. In epididymal fat, CLOCK from the YHFD group; RAGE, OST48, BMAL1, and Rev-Erb<i>α</i> from the YHFD + AGE group; RAGE, OST48, CLOCK, BMAL1, and Rev-Erb<i>α</i> from the YHFD + AGE + EX group; SIRT1 from the YHFD + AGE group; adiponectin from the YHFD group; and ATGL from the YHFD and YHFD + AGE groups were significantly lower, while p-HSLser660 from the YHFD + AGE group and p-Aktser473 from the YHFD + AGE + EX group were significantly higher than in the YCON group. Additionally, IL-10 and IL-1Ra mRNA expressions from the YHFD and YHFD + AGE group were significantly decreased, while IL-10 and IL-1Ra from the YHFD + AGE + EX group and TNF-<i>α</i> from the YHFD, YHFD + AGE, and YHFD + AGE + EX groups were significantly increased. For middle-aged mice, in the liver tissue, compared to the MACON group, CLOCK and Rev-Erb<i>α</i> from three intervention groups were increased, while p-Aktser473 from the MAHFD and MAHFD + AGE groups was decreased and PPAR<i>α</i> from the MAHFD and MAHFD + AGE groups was decreased. In epididymal fat, compared to the MACON group, RAGE from the MAHFD + AGE group; p-Aktser473 from the MAHFD + AGE + EX group; and TNF-<i>α</i> gene expressions from three intervention groups were increased, while BMAL1 from the MAHFD + AGE and MAEX groups; PPAR<i>γ</i> and IL-1Ra from the MAHFD + AGE group; SIRT1 from the MAHFD, MAHFD + AGE, and MAHFD + AGE + EX groups; adiponectin from the MAHFD group; and p-HSLser660, ATGL, and IL-10 from the MAHFD and MAHFD + AGE groups were decreased. In conclusion, HFD combined with AGE diet caused dysfunction in the liver and adipose glucolipid metabolism, especially in middle-aged mice, and voluntary exercise reversed metabolic abnormalities to some extent with different mechanisms involved for young and middle-aged mice.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5226432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astragaloside IV Protects against Diabetic Nephropathy by Inhibiting FUNDC1-Dependent Mitochondria-Associated Endoplasmic Reticulum Membranes","authors":"Zeng Zhang,&nbsp;Yanyan Wang,&nbsp;Fengzhu Zhou,&nbsp;Siyu Xu,&nbsp;Xinyi Zhang,&nbsp;Yueying Ma,&nbsp;Yifei Liu,&nbsp;Yanming He","doi":"10.1155/2024/2602406","DOIUrl":"https://doi.org/10.1155/2024/2602406","url":null,"abstract":"<div>\u0000 <p>Studies have demonstrated the potential therapeutic effects of Astragaloside IV (AS-IV) in various diseases. However, its effect on diabetic nephropathy (DN) and the underlying mechanisms are not clear. The expression of FUNDC1 in DN patients and high glucose-induced human renal tubular epithelial cell line (HK-2) with or without AS-IV was analyzed using quantitative real-time polymerase chain reaction and Western blot. Cell Counting Kit-8 (CCK-8) assay was used to quantify cell viability. The intracellular oxygen consumption rate was measured by using the seahorse energy analyzer, and the mitochondrial reactive oxygen species and mitochondrial Ca²⁺ levels were determined by flow cytometry. A mice model of diabetes was constructed and treated with different doses of AS-IV. Hematoxylin-eosin and Masson staining were used to examine the pathological changes in renal tissue. Creatinine, blood urea nitrogen, and urinary protein were detected by the biochemical method. The results demonstrated increased FUNDC1 expression in patients with DN and high glucose-cultured HK-2 cells. FUNDC1 silencing inhibited high glucose-induced mitochondria-associated endoplasmic reticulum (ER) membrane formation and mitochondrial dysfunction in HK-2 cells. Importantly, AS-IV treatment inhibited FUNDC1-induced mitochondria-associated ER membrane formation and mitochondrial dysfunction in HK-2 cells. AS-IV treatment also protected against renal injury and improved renal function in mice. AS-IV alleviates the progression of DN by inhibiting FUNDC1-dependent mitochondria-associated ER membrane.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/2602406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioaccessibility and Speciation of Iron from Aqueous Extracts of Moringa oleifera Leaves","authors":"Saliou Mawouma,&nbsp;Souaibou Hamidou Yaya,&nbsp;Jude Mbyeya,&nbsp;Florence Doudou Walko,&nbsp;Emmanuel Awoudamkine,&nbsp;Carl Moses Mbofung Funtong","doi":"10.1155/2024/9312118","DOIUrl":"https://doi.org/10.1155/2024/9312118","url":null,"abstract":"<div>\u0000 <p>Investigating the different chemical species of soluble iron in food digests provides more relevant information on the nutritional potential of an iron-rich food. The objective of this study was to assess the bioaccessibility and speciation of iron from various aqueous extracts of Moringa <i>(Moringa oleifera)</i> leaves. Aqueous extracts were prepared from fresh and dried Moringa leaves using infusion and decoction methods. Spectrophotometric assays were performed to quantify inhibitors and enhancers of iron absorption in the extracts, bioaccessible iron, and its different chemical species. The highest contents of inhibitors (239.43 mg/L for polyphenols and 2.92 mg/L for phytates) and enhancers of iron absorption (1.58 mmol/L for carotenoids and 488.00 mg/L for ascorbic acid) were found in the 5-minute decoction extract of fresh leaves, and the lowest in all infusion extracts (27.34 mg/L for polyphenols, 0.50 mg/L for phytates, 0.15 mmol/L for carotenoids, and 86.00 mg/L for ascorbic acid). The percentages of bioaccessible iron were higher for decoction extracts (42.57–52.70%) compared to infusion extracts (33.89–36.44%). Ferrous iron was the dominant inorganic species of bioaccessible iron and was more concentrated in the digests of decoction extracts (1.32–4.85 mg/L). The highest content of organic iron (5.33 mg/L) was found in the digest of the 8-minute decoction extract of dried leaves. Drinking decoction extracts of fresh and dried Moringa leaves could be recommended to alleviate iron deficiency in vulnerable groups of the population living in areas where this plant can grow.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/9312118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quercetin Attenuates Cancer-Associated Fibroblast Activation via Tumor-Stromal Interactions and Demonstrates Its Clinical Value in Pancreatic Cancer","authors":"Defeng Lei,&nbsp;Yicui Piao,&nbsp;Tongning Zhong,&nbsp;Citing Zhang,&nbsp;Weipeng Ai,&nbsp;Yixing Kang,&nbsp;Haijun Ye,&nbsp;Biao Zheng,&nbsp;Jianhua Qu,&nbsp;Zilong Yan,&nbsp;Zhengquan Lai,&nbsp;Jikui Liu","doi":"10.1155/2024/2177516","DOIUrl":"https://doi.org/10.1155/2024/2177516","url":null,"abstract":"<div>\u0000 <p>Pancreatic ductal adenocarcinoma (PDAC) is a rapidly progressing malignancy with a poor prognosis. Quercetin is a flavonoid compound with various biological benefits that can be extracted from Chinese herbs or daily foods. Quercetin has anticancer properties in various types of cancers. However, its therapeutic effects and potential mechanisms in PDAC have not been investigated extensively. Here, we confirmed the therapeutic effect of quercetin in PDAC using a mouse model. Based on high-throughput RNA sequencing (RNA-seq) and bioinformatic analysis, we propose that quercetin is involved in stromal infiltration of PDAC. Quercetin attenuates the activation of cancer-associated fibroblasts (CAFs) via tumor-stromal interaction. Meanwhile, we have identified two quercetin-related prognostic models for patients with PDAC. Finally, we proposed a downstream target of quercetin, the ITGB4 gene, which could be a potential therapeutic target for PDAC.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/2177516","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Analysis of Nonvolatile Substances in Yingde Black Tea (Camellia sinensis) from Different Regions at Various Processing Stages","authors":"Yiqin Chen,&nbsp;Jiayan Song,&nbsp;Na Li,&nbsp;Jiaxing He,&nbsp;Hongyu Sun,&nbsp;Yi Xiang,&nbsp;Lizheng Xiao","doi":"10.1155/2024/6642166","DOIUrl":"https://doi.org/10.1155/2024/6642166","url":null,"abstract":"<div>\u0000 <p>The influence of origin on tea quality has been understudied. Little research has compared metabolites during tea processing from different origins. This study aims to address this gap by using nontargeted metabolomics to examine the differential metabolites present in Yingde black tea from various origins at different processing stages. Nontargeted metabolomics was employed to compare the differential metabolites present in fresh tea leaves, withered leaves, rolled leaves, fermented leaves, and processed tea from various origins. The study revealed significant differences in the metabolites present at each processing stage. Despite using identical processing techniques, the quality of finished teas from different regions was found to vary through sensory evaluation. The study found that taste differences between regions were primarily influenced by flavonoids and amino acids. The relative taste activity value (RTAV) approach was used to identify key contributors to taste differences and regulation. The quality of fresh tea leaves was found to be the main determinant of the taste of black tea from various regions. To reduce these differences, the same processing techniques were employed. These findings enhance our understanding of quality variations in dried tea from different origins and contribute to the theoretical foundation of tea processing.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6642166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dried Zingiber officinale Alleviates Dehydroepiandrosterone-Induced Ovarian Granulosa Cell Apoptosis via the Reactive Oxygen Species-Mediated Pathway","authors":"Yuan Liu,&nbsp;Xin Luo,&nbsp;Keran Jia,&nbsp;Shuang Liu,&nbsp;Yongqiu Zeng,&nbsp;Xiyuan Lin,&nbsp;Xinyue Lin,&nbsp;Ying Wan,&nbsp;Lishang Liao,&nbsp;Hongwei Su,&nbsp;Jingyan Yi,&nbsp;Jinshan Xing","doi":"10.1155/2024/1883974","DOIUrl":"https://doi.org/10.1155/2024/1883974","url":null,"abstract":"<div>\u0000 <p>Polycystic ovary syndrome (PCOS), a prevalent reproductive endocrine disorder, frequently coincides with insulin resistance, lipid dysregulation, and cellular apoptosis. In this study, we aimed to evaluate the therapeutic potential of Dried <i>Zingiber officinale</i> (DZO), renowned for its antibacterial, antiviral, anti-inflammatory, and antioxidant properties, in the context of PCOS. To this end, we induced a PCOS mouse model through the administration of dehydroepiandrosterone (DHEA) and a high-fat diet (HFD), followed by DZO treatment to assess its effects on ovarian pathology, insulin resistance, and hormonal imbalances. The anti-apoptotic effect of DZO on PCOS ovarian granulosa cells was confirmed through network pharmacological analysis, TUNEL staining, FITC-PI staining, and protein blotting. Notably, DZO treatment significantly alleviated ovarian pathological changes in PCOS mice and normalized hormone levels, including testosterone, estradiol, and progesterone/follicle-stimulating hormone ratios. Furthermore, our findings confirmed the anti-apoptotic effect of DZO on PCOS ovarian granulosa cells. Mechanistically, DZO primarily exerted its therapeutic effects in PCOS by inhibiting apoptosis induced by the accumulation of reactive oxygen species (ROS). In conclusion, our study demonstrates the promising therapeutic role of DZO in the management of obese PCOS patients, particularly in reversing ROS-mediated apoptosis in ovarian granulosa cells.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/1883974","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Potential of Organic Phenolic Compounds from Wild Mushroom Extracts: Impact on Proliferation and Kinetic Growth of Multidrug-Resistant Neisseria gonorrhoeae Strains","authors":"Sinethemba Yakobi,&nbsp;Lindiwe Zuma,&nbsp;Nothando Gasa,&nbsp;Ofentse Pooe","doi":"10.1155/2024/2336255","DOIUrl":"https://doi.org/10.1155/2024/2336255","url":null,"abstract":"<div>\u0000 <p>Extracts derived from various mushroom species have been documented to possess notable antimicrobial properties. However, the current corpus of knowledge pertaining to the precise evaluation of their structural characteristics is currently inadequate. In this study, a comprehensive analysis was undertaken to ascertain the antimicrobial attributes and effectiveness of phenolic compounds, such as ferulic acid, <i>o-</i>coumaric acid, <i>p</i>-coumaric acid, rutin, quercetin, gallic <i>p-</i>hydroxybenzoic acid, and protocatechuic acid, identified from <i>P. ostreatus</i>. These compounds were examined for potential antiproliferative properties against multidrug-resistant gonococcal clinical isolates. The results of this study revealed that <i>p-</i>hydroxybenzoic acid, <i>o-</i>coumaric acid, and chysin exhibited no antibacterial activity (MIC &gt; 50 <i>µ</i>g/ml) against any of the target <i>N. gonorrhoeae</i> isolates in the range of tested concentrations (0.1–50 <i>µ</i>g/ml). A notable reduction in the growth activity of the target organisms was observed when subjected to cultivation in the presence of flavonoid compounds. The statistical significance of the parameter estimate for quercetin was observed at intercept (ISID 59), with a <i>p</i> value less than 0.0001 and a Chi-square value of 44.84. The combination of ferulic acid with either protocatechuic acid or <i>p-</i>coumaric acid showed a trend towards reduced antimicrobial efficacy against most target isolates. However, our findings highlight its remarkable promise, as quercetin exhibited both independent and cooperative effectiveness.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/2336255","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142050526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorating Effects of Aloe Emodin in an Aluminum-Induced Alzheimer’s Disease Rat Model","authors":"Xitong Zhao,&nbsp;Ni Yao,&nbsp;Wenqian Fan,&nbsp;Baojian Du,&nbsp;Yang Chen,&nbsp;Chuyin Wang,&nbsp;Lingling Song,&nbsp;Jianing Yin,&nbsp;Fang Fang,&nbsp;Jun Guan","doi":"10.1155/2024/7306081","DOIUrl":"https://doi.org/10.1155/2024/7306081","url":null,"abstract":"<div>\u0000 <p>Alzheimer’s disease (AD) is a neurodegenerative disease and threatens the health of the aged population worldwide. In the present study, we investigated cognitive improvement by aloe emodin in aluminum-induced AD rats. We orally administered aluminum chloride (150 mg/kg) to Sprague–Dawley rats for 8 weeks to induce AD. In the 5th to the 8th week, the rats were injected intraperitoneally with AE (5, 10, and 15 mg/kg). Behavioral, histopathological, and biochemical assessments were performed. The results showed that AE alleviated cognitive impairment in aluminum-induced AD rats and inhibited aluminum-induced hippocampal neuronal damage. Furthermore, aloe emodin relieved the aluminum burden in the brain of aluminum-induced AD rats, attenuated the aluminum-induced increase in A<i>β</i>₄₂ level and acetylcholinesterase activity, and reduced the levels of tumor necrosis factor-<i>α</i>, interleukin-6, interleukin-1<i>α</i>, and interleukin-1<i>β</i>. These effects suggest that the mechanism by which AE alleviates AD-related cognitive impairment is by removal of excess aluminum, decreasing A<i>β</i>₄₂ deposition, regulating the cholinergic system, and reducing neuroinflammation.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7306081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Hepatoprotective Possessions of Specific Iranian Medicinal Plants","authors":"Salome Dini,&nbsp;Shubhra Singh,&nbsp;Faezeh Fatemi","doi":"10.1155/2024/8783113","DOIUrl":"https://doi.org/10.1155/2024/8783113","url":null,"abstract":"<div>\u0000 <p>With its historical roots, Iranian traditional medicine has played a significant role in addressing liver-related disorders and providing alternative approaches to synthetic drugs. Liver-related disorders, such as hepatitis, liver cirrhosis, and nonalcoholic fatty liver disease, pose significant health challenges worldwide. From traditional practices and indigenous knowledge, Iranian traditional medicine offers a holistic approach to liver health. It emphasizes the importance of lifestyle modifications, including dietary adjustment, physical activity, and stress reduction, to support liver function and restore balance within the body. This review collects from different databases, mainly Google Scholar, ScienceDirect, and SID. It focused on medicinal plants that are recommended in Iranian traditional medicine and scientifically proved to have liver protection properties as well as summarized our 10 years of experience in this field. This comprehensive article is an effort to study the integration of traditional knowledge with modern evidence-based practices that can contribute to a comprehensive understanding of Iranian medicine’s potential in managing liver-related disorders. Iranian traditional medicine incorporates many natural remedies derived from medicinal plants, minerals, and animal products. These remedies are often used in the form of herbal preparations, decoctions, and dietary supplements. Specific plants include <i>Zataria multiflora, Satureja</i> spp., <i>Heracleum persicum</i>, <i>Carum carvi</i>, <i>Ferula</i> spp., <i>Hypericum scabrum</i>, and <i>Archillae</i> spp. They are known for their hepatoprotective properties and are commonly employed in the management of liver disorders in Iranian traditional medicine. This traditional treatment provides a unique perspective by offering natural approaches to liver health. Traditional remedies aim to minimize potential side effects associated with synthetic drugs while addressing the root causes of liver disorders.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/8783113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141991737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}