Journal of Food Biochemistry最新文献

{"title":"Mulberry Leaf Extract and Deoxynojirimycin Modulates Glucose and Lipid Levels via the IRS1/PI3K/AKT Signaling Pathway in Cells","authors":"Yin-Di Zhang,&nbsp;Jun-Xi Liu,&nbsp;Fei-Fei Wang,&nbsp;Li-Ping Qu","doi":"10.1155/jfbc/7345044","DOIUrl":"https://doi.org/10.1155/jfbc/7345044","url":null,"abstract":"<div>\u0000 <p>Various diseases caused by disorders of glucose and lipid metabolism are increasing day by day. Although many drugs have certain therapeutic effects, they still produce some side effects. Therefore, this article chooses the natural medicinal plant mulberry leaves to reveal its mechanism of regulating glucose and lipid metabolism. By establishing an insulin resistance model and a 3T3-L1 adipocyte model, it was found that mulberry leaf extract (MLE) and deoxynojirimycin (DNJ) significantly increased glucose consumption and glycogen consumption, while reducing total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) levels. Network pharmacology, molecular docking, and protein level showed that MLE and DNJ could improve glucose and lipid metabolism disorders through IRS1/PI3K/AKT signaling pathway. These results suggest that MLE and DNJ may have broad application prospects in regulating glycolipid metabolism in functional foods and healthcare products.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/7345044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Royal Jelly Effect on Chronic Unpredictable Stress-Induced Pancreatic Oxidative and Endoplasmic Reticulum Stress and Insulin Secretion Impairment in Adult Male Rats","authors":"Payam Shahsavar,&nbsp;Fateme Binayi,&nbsp;Mina Sadat Izadi,&nbsp;Mina Salimi,&nbsp;Mehdi Hedayati,&nbsp;Rasoul Ghasemi,&nbsp;Homeira Zardooz","doi":"10.1155/jfbc/8812441","DOIUrl":"https://doi.org/10.1155/jfbc/8812441","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Royal jelly (RJ), secreted by nurse honeybees, possesses antioxidant properties. Studies have demonstrated that chronic stress can impair glucose metabolism, a process intricately linked to oxidative stress and endoplasmic reticulum (ER) stress induction. Consequently, this study investigated the effects of RJ on oxidative stress, apoptosis and ER stress markers, and insulin secretion from isolated pancreatic islets in rats subjected to chronic unpredictable stress (CUS).</p>\u0000 <p><b>Method:</b> Four groups were established, comprising adult male rats: None-STR-Water, STR-Water, None-STR-RJ, and STR-RJ. Over 4 weeks, CUS was applied, and RJ was administered via oral gavage. A glucose tolerance test was conducted, and fasting blood samples were collected to analyze corticosterone, leptin, antioxidants, and malondialdehyde (MDA) plasma levels. Additionally, pancreatic oxidative stress and ER stress markers, apoptosis indicators, and insulin secretion from isolated pancreatic islets were evaluated.</p>\u0000 <p><b>Results:</b> Exposure to CUS increased plasma corticosterone and leptin levels, catalase activity and glutathione (GSH) levels in both plasma and pancreatic tissue and reduced plasma MDA levels. RJ administration in the STR-RJ group restored the mentioned parameters. Furthermore, CUS elevated pancreatic BIP, CHOP, and cleaved CASPASE-3 protein levels; however, these levels were diminished following RJ treatment. The CALNEXIN protein level remained unchanged between the study groups. In the STR-Water group, glucose-stimulated insulin secretion was diminished, whereas in the RJ-treated groups, insulin secretion from islets in response to the high glucose concentration was significantly enhanced.</p>\u0000 <p><b>Conclusion:</b> The administration of RJ, in conjunction with CUS exposure, may protect the normal insulin response to glucose by mitigating oxidative stress, as evidenced by the restoration of catalase activity and GSH levels, and ER stress, as supported by the decrease in BIP and CHOP protein levels.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8812441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the Molecular Pathways: How Polygonatum sibiricum Alleviates Myocardial Ischemia","authors":"Zhenzhong Zhu,&nbsp;Junzhi Pan,&nbsp;Bin Jiang,&nbsp;Yuanlong Zhang,&nbsp;Yanxia Lv,&nbsp;Yifan Pan,&nbsp;Yunxiang Wang,&nbsp;Weijun Lv","doi":"10.1155/jfbc/8543663","DOIUrl":"https://doi.org/10.1155/jfbc/8543663","url":null,"abstract":"<div>\u0000 <p>Herbal medicine, like <i>Polygonatum sibiricum</i>, is gaining attention for its potential in treating myocardial ischemia. Comprehensive research on its molecular interplay is essential for its development as a therapeutic agent. The aim is to investigate the molecular mechanisms by which <i>Polygonatum sibiricum</i> ameliorates myocardial ischemia. The study involves a thorough database exploration, molecular docking, and the use of both in vivo and in vitro models for detailed assessment. The role of the HIF-1α pathway is particularly emphasized. Identification of 11 principal components and 23 core proteins, with a dominant role of HIF-1α, was achieved. A notable improvement in myocardial conditions, attributable to <i>Polygonatum sibiricum</i>, was observed. <i>Polygonatum sibiricum</i> improves myocardial ischemic injury by augmenting mitochondrial activity and enhancing the HIF-1α pathway.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8543663","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Phenolic compounds present in fruit extracts of Malus spp. show antioxidative and pro-apoptotic effects on human gastric cancer cell lines”","authors":"","doi":"10.1155/jfbc/9803181","DOIUrl":"https://doi.org/10.1155/jfbc/9803181","url":null,"abstract":"<p>M. Han, A. Li, T. Shen, et al., “Phenolic compounds present in fruit extracts of <i>Malus</i> spp. show antioxidative and pro-apoptotic effects on human gastric cancer cell lines.” Journal of Food Biochemistry. 2019; 43: e13028. https://doi.org/10.1111/jfbc.13028.</p><p>In the published version of the above article, the authors reported experiments conducted using the gastric cancer cell line BGC-803, which has been reported as a nonverifiable/unknown cell line. After reassessing the cell line authentication documentation, it was concluded that the cell line used in the study corresponds to the cell line MGC-803 (RRID: CVCL_5334).</p><p>This corrigendum has been issued to state that all references to “BGC-803” in the article should now be recognized as “MGC-803.”</p><p>While the authors were not responsible for the misidentification, they apologize for any confusion this may have caused.</p>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9803181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Techno-Functional Biochemical Analysis and Food Applications of Edible Mushroom Powder","authors":"Subhra De,&nbsp;Prince Chawla,&nbsp;Sanju Bala Dhull,&nbsp;Gulden Goksen,&nbsp;Anarase Dattatray Arjun,&nbsp;Aarti Bains","doi":"10.1155/jfbc/2888689","DOIUrl":"https://doi.org/10.1155/jfbc/2888689","url":null,"abstract":"<div>\u0000 <p>The edible mushroom powder has an essential role in sustainable food technology and innovation, and therefore, it is considered a multifaceted functional food ingredient. Edible mushrooms are rich in proteins, fibers, vitamins, and bioactive compounds like polysaccharides and antioxidants, making them valuable for food product innovation. Mushroom powder enhances food texture, stability, and nutritional value, aligning with consumer preferences for nutritious and eco-friendly alternatives. The present review highlights the role of mushroom powder in improving the health attributes and sensory qualities of food products, providing a comprehensive overview of its nutritional benefits, processing methods, and applications in the food industry. By incorporating mushroom powder, food technologists can develop health-oriented products that meet the demands of modern consumers seeking dietary diversity and sustainability. This manuscript emphasizes mushroom powder’s utility in food technology and product development, promising significant advancements in functional and sustainable food solutions.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/2888689","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network Pharmacology Prediction and Molecular Docking Analysis Reveal the Mechanism of XueFu ZhuYu Decoction on Malignant Pleural Effusion","authors":"Zhe Chen,&nbsp;Yixing Li,&nbsp;Yilong Zhao,&nbsp;Heng Zhao,&nbsp;Bin He,&nbsp;Chi Wang,&nbsp;Haotian Bai,&nbsp;Rui Zhao,&nbsp;Jinteng Feng,&nbsp;Guangjian Zhang","doi":"10.1155/jfbc/9949812","DOIUrl":"https://doi.org/10.1155/jfbc/9949812","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> XueFu ZhuYu Decoction (XFZYD) is a classic herbal formula that shows promise in the treatment of malignant pleural effusion (MPE). However, its primary components and the underlying mechanisms of action remain unclear. Therefore, the objective of this study is to preliminarily elucidate the potential mechanisms by which XFZYD may treat MPE through network pharmacology and molecular docking.</p>\u0000 <p><b>Methods:</b> The effective components and their corresponding targets of XFZYD were identified using the traditional chinese medicine (TCM) systems Pharmacology database, and a related network was constructed utilizing Cytoscape. Subsequently, the targets associated with MPE were retrieved from the Online Mendelian Inheritance in Man (OMIM) and GeneCards databases. We then determined the intersection between compound targets and disease targets, constructing a protein–protein interaction (PPI) network by importing these into the STRING database. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO) enrichment analyses were performed through the Metascape database. Finally, molecular docking studies between core targets and effective compound molecules were conducted.</p>\u0000 <p><b>Result:</b> Quercetin, kaempferol, and luteolin were identified as the compounds with the highest values. The primary common targets of XFZYD in relation to MPE included STAT3, MAPK1, and MAPK3. Furthermore, GO and KEGG analyses indicated that XFZYD treatment for MPE was associated with responses to lipopolysaccharide, vesicle lumen dynamics, and protein kinase activity overall. The signaling pathways predominantly involved were the AGE-RAGE pathway, IL-17 signaling pathway, and P13K-Akt signaling pathway. Molecular docking demonstrated high affinities between the lead compounds and their target proteins.</p>\u0000 <p><b>Conclusions:</b> The active ingredients Quercetin, kaempferol, and luteolin in XFZYD exert therapeutic effects against MPE via the PI3K-Akt signaling pathway, with key targets involving STAT3, MAPK1, and MAPK3.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9949812","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Polyphenols in Mallotus peltatus (Geiseler) Mull. Arg. Based on UPLC-MS/MS and Their Protective Effects on H2O2-Induced Liver Injury","authors":"Ying-Jing Zhang,&nbsp;Jin-Xin Li,&nbsp;Ke-Xin Hao,&nbsp;Rui-Fang Zhong,&nbsp;Yi-Meng Li,&nbsp;Jian-Guo Jiang,&nbsp;Wei Zhu","doi":"10.1155/jfbc/9941885","DOIUrl":"https://doi.org/10.1155/jfbc/9941885","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Liver cells are particularly susceptible to mitochondrial dysfunction due to external stimuli, leading to excess reactive oxygen species (ROS) and redox imbalance. The aim of this study was to extract and purify the polyphenolic fractions of <i>Mallotus peltatus</i> (Geiseler) Mull. Arg. and evaluate their potential protective effect against H₂O₂-induced oxidative stress injury in hepatocytes.</p>\u0000 <p><b>Methods:</b> The extraction process of polyphenols in MPMA was optimized by the response surface method. Then, we purified the crude extracts with macroporous resin HPD600 to obtain MPMAP-I, MPMAP-II, and MPMAP-III. The physical properties and component composition of the samples were analyzed by FT-IR and UPLC-MS/MS. An in vitro H₂O₂-induced oxidative stress injury model in hepatocytes was established to investigate the protective effect of MPMAP-I on L02 cells. The effect was assessed by measuring cell survival rate, enzyme activities, intracellular ROS levels, cell apoptosis rate, mitochondrial membrane potential, and the mRNA expression of related signaling pathways.</p>\u0000 <p><b>Results:</b> The results showed that the optimized extraction conditions of MPMA were 60% ethanol, 140 min, 85°C, and liquid-to-solid ratio of 30 mL/g. All three purified fractions contained different polyphenols (such as kaempferol 3-O-sophoroside, corilagin, and cirsiliol) and had great antioxidant activities. MPMAP-I treatment could increase the activities of SOD, CAT, and GPx in H₂O₂-induced L02 cells, reduce the content of MDA, the activities of transaminases, the production of intracellular ROS, and the rate of cell apoptosis, and restore mitochondrial function. Furthermore, these effects might be related to the inactivation of the Bcl2/Bax/caspase-3 apoptotic pathway and the activation of the Nrf2/γ-GCL antioxidant pathway.</p>\u0000 <p><b>Conclusion:</b> Our study provided a theoretical basis for the protective effect of MPMA polyphenols on liver injury, which is helpful to improve the development and application of MPMA in medicine and healthcare products.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9941885","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Inhibitory Effect of Bioactive Substances on Immunoreactivity of Gluten and Crustacean Protein by ELISA Method","authors":"Lenka Havlová,&nbsp;Matej Pospiech,&nbsp;Zdeňka Javůrková,&nbsp;Martina Pečová,&nbsp;Marie Bartlová,&nbsp;Bohuslava Tremlová","doi":"10.1155/jfbc/4461077","DOIUrl":"https://doi.org/10.1155/jfbc/4461077","url":null,"abstract":"<div>\u0000 <p>This study deals with the possibility of using bioactive substances to reduce the allergenic potential of food. In the first phase of the research, the work aimed to verify the inhibitory effect of bioactive substances on crustacean protein (tropomyosin) and gluten (gliadin) in model samples. In the next phase of the research, the inhibitory effect of selected antioxidants was demonstrated on samples from the market network. The ELISA method showed a decrease in the immunoreactivity of the kits (Veratox, Biocheck) by an average of 36% in the model samples. Model samples containing gluten and shellfish showed lower immunoreactivity due to the addition of p-coumaric acid (33.2%), <i>β</i>-carotene (26.5%), caffeic acid (33.3%), quercetin (26.4%), gallic acid (46.2%), lycopene (32.4%), epicatechin (43.5%), chlorogenic acid (32.7%), and rutin (46.8%). This study further demonstrated an inhibitory effect in samples from the market network with gluten content (breadcrumbs, tarragon) by an average of 61.1% and in samples with crustacean content (shrimp and surimi sticks) by 15.7% after the addition of lycopene, epicatechin, and caffeic acid. The results confirmed the impact of bioactive substances on the immunoreactivity of ELISA tests and provide a foundation for developing hypoallergenic foods and enhancing allergen detection accuracy in food safety applications.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/4461077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin-Loaded Mesenchymal Stem Cell-Derived Exosomes: A Potential Effective Strategy for NAFLD","authors":"Ruixi Luo,&nbsp;Jing Zhang,&nbsp;Peng Chen,&nbsp;La Wang,&nbsp;Wenjia Wang,&nbsp;Ping Wang,&nbsp;Xing Zhao,&nbsp;Weiyi Tian","doi":"10.1155/jfbc/6134296","DOIUrl":"https://doi.org/10.1155/jfbc/6134296","url":null,"abstract":"<div>\u0000 <p>The aim of this study was to construct curcumin-loaded mesenchymal stem cell-derived exosomes (Cur-exos) and explore their effects on nonalcoholic fatty liver disease (NAFLD) models both in vitro and in vivo. Cur-exos were prepared using three common drug-loading techniques—incubation, sonication, and freeze–thaw cycles. Among these, Cur-exos prepared via repeated freeze–thawing demonstrated higher encapsulation efficiency and drug-loading rates than those produced by other methods. In vitro, Cur-exos exhibited enhanced stability, were efficiently taken up by hepatocytes, and mitigated palmitic acid (PA)–induced lipotoxicity in HepG2 cells. Moreover, Cur-exos significantly ameliorated liver damage in NAFLD model mice, reduced inflammation, decreased reactive oxygen species (ROS) levels, and mitigated endoplasmic reticulum (ER) stress. Additionally, Cur-exos effectively regulated lipid metabolism disorders and improved impaired glucose tolerance. Overall, we demonstrate that, compared with free curcumin, Cur-exos significantly improve curcumin stability and offer superior therapeutic effects in NAFLD mouse models. This study provides a novel approach for developing treatments for NAFLD.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/6134296","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracts of Nauclea latifolia (African Peach) Roots Attenuate Oxidative Stress, Inflammation, and Hepatic and Renal Damage in Wistar Rats Induced by Arsenic and High-Fat Diet","authors":"Wusa Makena,&nbsp;Barka Ishaku,&nbsp;Abel Yashim Solomon,&nbsp;Ekom Monday Etukudo,&nbsp;Aisha Aminu,&nbsp;Onyinoyi Bethel Onimisi,&nbsp;Gidok Kogi Abednego,&nbsp;Victor Kayode Jerome,&nbsp;Augustine Oviosun","doi":"10.1155/jfbc/5783346","DOIUrl":"https://doi.org/10.1155/jfbc/5783346","url":null,"abstract":"<div>\u0000 <p>Arsenic is an internationally recognized groundwater pollutant. Arsenic exposure causes a number of negative consequences on the human body, including the upsurge of oxidant. Nutrition is a significant susceptibility factor for arsenic toxicity through various conceivable pathways. The rise of high-fat diets in numerous countries leads to an increase in chronic, noncommunicable diseases. This research examined how <i>Nauclea latifolia</i> could reduce oxidative stress, inflammation, and distortion to the liver and kidneys in Wistar rats exposed to high-fat diets and arsenic. Five groups of five rats each were treated daily for 6 weeks. Rats fed only with high-fat diet with arsenic exhibited considerable elevations in proinflammatory markers, urea, creatinine, and liver enzymes, alongside significant decreases in SOD, CAT, and GSH levels. Treatment with silymarin and <i>N. latifolia</i> root extract prevented oxidative stress and elevated liver enzyme activity and kidney function biomarkers. The rats subjected to a high-fat diet and arsenic suffered significant damage to the histology of the liver and kidney. However, treatment with extracts and silymarin protected the kidney and the liver damage. <i>N. latifolia</i> roots may attenuate the toxic consequences of diets high in fat and arsenic on the renal system and the liver by lowering reactive oxygen molecules and improving renal and liver function. Thus, <i>N. latifolia</i> roots could serve as a natural agent to prevent hepatorenal toxicity.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5783346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}