Journal of Food Biochemistry最新文献

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Hepatoprotective Effects of Medicinal Honey: Introducing a New Classification Based on Phenolic Content and Antioxidant Capacity 药用蜂蜜的肝脏保护作用:根据酚类物质含量和抗氧化能力进行新的分类
IF 3.5 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-11-17 DOI: 10.1155/2024/4475104
Bardia Zamani Ranjbar Garmroodi, Mahdieh Rajabi Moghadam, Asghar Zarban, Milad Bideh
{"title":"Hepatoprotective Effects of Medicinal Honey: Introducing a New Classification Based on Phenolic Content and Antioxidant Capacity","authors":"Bardia Zamani Ranjbar Garmroodi,&nbsp;Mahdieh Rajabi Moghadam,&nbsp;Asghar Zarban,&nbsp;Milad Bideh","doi":"10.1155/2024/4475104","DOIUrl":"https://doi.org/10.1155/2024/4475104","url":null,"abstract":"<div>\u0000 <p>Honey contains vital compounds capable of ameliorating oxidative stress damage. Two markers of total phenolic content (TPC) and antioxidant capacity (TAC) have been selected for the classification of honey samples for investigating the protective effects of different honey samples on hepatotoxicity induced by CCl<sub>4</sub>. Hence, 56 male Wistar rats in 8 groups were selected and were given a daily single dose (20%) of honey samples classified as weak, medium, and strong based on TPC and TAC. After four weeks of pretreatment, acute liver damage (ALD) was induced in treated groups using CCl4 mixed with corn oil in a 1:1 ratio. Following ALD induction, the animals were sacrificed. Various samples were then collected for analysis, including serum samples for biochemistry tests (ALT, AST, ALP, and FBS) and antioxidant status assessment (DPPH, FRAP, THIOL, and MDA); urine samples for antioxidant status evaluation (DPPH, FRAP, and MDA); liver tissue homogenate for oxidative stress marker analysis (SOD, CAT, GPx, and MDA); and tissue samples for histopathological examination. Biochemical results showed a significant decrease (<i>p</i> ≤ 0.05) in ALT, AST, ALP, and FBS values in ALD groups treated with honey; antioxidant and oxidative stress evaluations also exactly approved the same results by an insignificant decrease (<i>p</i> ≥ 0.05) in serum MDA and a significant increase (<i>p</i> ≤ 0.05) in THIOL and DPPH and also a reduction in urinary MDA and increase of urinary DPPH all compared to positive control (<i>p</i> ≤ 0.05). SOD, CAT, and GPx activities and MDA values in liver homogenate also ameliorated in honey-treated group (<i>p</i> ≤ 0.05). Histopathological evaluations confirmed less damage in treated groups, especially in stronger honey. Potent honey samples based on TPC and TAC have more protective effects in hepatotoxicity.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/4475104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Broad-Spectrum Nutritional and Pharmacological Significance of the Wild Hyphaene thebaica Palm Fruit 野生棕榈果的广谱营养和药理作用
IF 3.5 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-11-16 DOI: 10.1155/2024/8380215
Abiola Fatimah Adenowo, Olufemi Mulkah Ajagun-Ogunleye, Titilola Fausat Salisu, Olubunmi Sarat Olaleye-Haroun, Hameed Adeniran Omotayo, Mushafau Adewale Akinsanya
{"title":"Broad-Spectrum Nutritional and Pharmacological Significance of the Wild Hyphaene thebaica Palm Fruit","authors":"Abiola Fatimah Adenowo,&nbsp;Olufemi Mulkah Ajagun-Ogunleye,&nbsp;Titilola Fausat Salisu,&nbsp;Olubunmi Sarat Olaleye-Haroun,&nbsp;Hameed Adeniran Omotayo,&nbsp;Mushafau Adewale Akinsanya","doi":"10.1155/2024/8380215","DOIUrl":"https://doi.org/10.1155/2024/8380215","url":null,"abstract":"<div>\u0000 <p>Despite the number of nutritional and medicinal plant-based products that have been studied for decades, there are still many rare and underutilized plants of biological importance, whose nutritional and biochemical properties are unmatched, especially the wild doum palm, <i>Hyphaene thebaica</i>. Therefore, it is necessary to unveil the potential advantages of the wild fruit <i>Hyphaene thebaica.</i> The edible wild palm fruit is a rich source of novel nutraceutical and pharmaceutical constituents. It is a rare, underutilized but highly nutritious fruit found in the tropics, and it is rich in a variety of time-proven healthy macro- and micronutrients. In addition to its domestic uses, it has a variety of significant healing potentials such as antioxidant properties, antihypertensive properties, hypolipidemic properties, antidiabetic properties, antimicrobial properties, cytotoxic/anticancer properties, hypolipidemic and neuroprotective properties, anti-inflammatory properties, and hepatoprotective properties, among others. We hereby present a review of this multifunctional palm fruit, a rare and highly potent edible palm fruit with a broad spectrum of biochemical, domestic, nutraceutical, and pharmacological properties, which makes it a rare gem in the class of plant-based functional food products. Much research and more clinical trials are necessary to further ascertain the veracity of the reported bioactivities through isolation, purification, and identification of the bioactive compounds. The multipurpose nature of the plant necessitates more research on its utilization in the fulfilment of various aspects of the United Nation’s Sustainable Development Goals.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/8380215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing the Effects of Korean and Brazilian Propolis on Anti-Atopic Dermatitis and the Related Mechanisms Through In Silico and In Vitro Analyses 通过硅学和体外分析比较韩国和巴西蜂胶抗特异性皮炎的作用及相关机制
IF 3.5 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-11-16 DOI: 10.1155/2024/1845999
Kyeong Ah Jo, Soo-Yeon Park, Kwanyong Choi, Doo-Hee Lee, Ji Yeon Kim
{"title":"Comparing the Effects of Korean and Brazilian Propolis on Anti-Atopic Dermatitis and the Related Mechanisms Through In Silico and In Vitro Analyses","authors":"Kyeong Ah Jo,&nbsp;Soo-Yeon Park,&nbsp;Kwanyong Choi,&nbsp;Doo-Hee Lee,&nbsp;Ji Yeon Kim","doi":"10.1155/2024/1845999","DOIUrl":"https://doi.org/10.1155/2024/1845999","url":null,"abstract":"<div>\u0000 <p>Atopic dermatitis (AD) is a chronic inflammatory skin disorder requiring continuous care and treatment. Therefore, exploring the therapeutic potential of natural ingredients for AD is essential. This study conducted a network analysis to investigate the anti-AD effects of propolis and its underlying mechanism, with a focus on the compositional differences between Korean and Brazilian propolis. To identify the bioactive components and related mechanisms, differentially expressed genes (DEGs) in AD-induced HaCaT cells with and without propolis treatment were identified. NCBI, SwissTargetPrediction, STITCH, and the Comparative Toxicogenomics Database (CTD) were used to identify target genes of the propolis compounds, and these genes were compared with the DEGs to identify the shared target genes. Notably, CXCL10 and CCL2 were highly associated with target genes shared between Korean and Brazilian propolis, with Korean propolis affecting TLR4, RIPK2, and PYCARD and Brazilian propolis influencing CEBPB, PTGS2, and DAB2IP. Korean propolis was found to predominantly impact the regulation of mast cell activation and the cytosolic DNA-sensing pathway, whereas Brazilian propolis primarily affects Type I interferon–mediated regulation and the TNF signaling pathway. Additionally, both the TNF and IL-17 signaling pathways were implicated in the mechanisms of both Brazilian propolis and Korean propolis. Furthermore, our study validated the therapeutic potential of propolis in AD treatment, as evidenced by significant reductions in TNF-<i>α</i>, IFN-<i>γ</i>, IL-4, IL-13, CXCL10, CCL2, and histamine release in an AD-induced model. This study confirms the efficacy of Korean and Brazilian propolis in treating AD and reveals molecular mechanism differences due to variations in major components and target genes.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/1845999","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment With Kiwi Peel Extract Delays Browning in Ready-to-Eat Lettuce 用猕猴桃果皮提取物处理可延缓即食生菜的褐变
IF 3.5 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-11-15 DOI: 10.1155/2024/4610926
Ilaria Fraudentali, Chiara Pedalino, Adriana Furlani, Andrea Secchiero, Hilary J. Rogers, Valentina Gallo, Giovanni Antonini, Riccardo Angelini, Alessandra Cona
{"title":"Treatment With Kiwi Peel Extract Delays Browning in Ready-to-Eat Lettuce","authors":"Ilaria Fraudentali,&nbsp;Chiara Pedalino,&nbsp;Adriana Furlani,&nbsp;Andrea Secchiero,&nbsp;Hilary J. Rogers,&nbsp;Valentina Gallo,&nbsp;Giovanni Antonini,&nbsp;Riccardo Angelini,&nbsp;Alessandra Cona","doi":"10.1155/2024/4610926","DOIUrl":"https://doi.org/10.1155/2024/4610926","url":null,"abstract":"<div>\u0000 <p>Browning reactions caused by oxidative stress occurring during postharvest procedures significantly compromise the quality of ready-to-eat (RTE) vegetables, negatively affecting their market value. Polyphenol oxidase (PPO) and peroxidase (POD) are two major enzymes involved in this phenomenon, as they oxidize phenolic compounds to quinones, which in turn polymerize to brown pigments. Recently, there has been an increasing interest in developing antibrowning treatments using food by-products. Herein, the efficiency of a kiwi peel extract in reducing enzymatic browning of minimally processed lettuce (<i>Lactuca sativa</i>) has been investigated. PPO and POD activities showed an opposite spatial distribution within the leaf, with a higher POD activity in the midvein (MV) and in the inner lamina tissues, and a prevalence of PPO activity in the mesophyll. Considering that MV lignified tissues are those mainly affected by browning, the temporal trend of POD activity over a 20-day storage period at 4°C was investigated. Data showed that treatment with a kiwi peel extract hinders both the increasing trend of POD activity and browning development compared to control leaves. These results could be potentially useful for the industry as they confirm that natural extracts, such as kiwi peel extract, can be valuable for extending the shelf-life of RTE products.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/4610926","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticancer Activities of Peanut (Arachis hypogaea L.) Testa Extract in Combination With Cisplatin and 5-Fluorouracil Against Cholangiocarcinoma Cells In Vitro and in Mouse Xenograft Models 花生(Arachis hypogaea L.)Testa 提取物与顺铂和 5-氟尿嘧啶联用在体外和小鼠异种移植模型中对胆管癌细胞的抗癌活性
IF 3.5 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-11-14 DOI: 10.1155/2024/9058244
Jarckrit Jeeunngoi, Gulsiri Senawong, Sanun Jogloy, Somprasong Saenglee, Banchob Sripa, Thanaset Senawong
{"title":"Anticancer Activities of Peanut (Arachis hypogaea L.) Testa Extract in Combination With Cisplatin and 5-Fluorouracil Against Cholangiocarcinoma Cells In Vitro and in Mouse Xenograft Models","authors":"Jarckrit Jeeunngoi,&nbsp;Gulsiri Senawong,&nbsp;Sanun Jogloy,&nbsp;Somprasong Saenglee,&nbsp;Banchob Sripa,&nbsp;Thanaset Senawong","doi":"10.1155/2024/9058244","DOIUrl":"https://doi.org/10.1155/2024/9058244","url":null,"abstract":"<div>\u0000 <p>Cholangiocarcinoma (CCA) is a very aggressive cancer and CCA treatments with cisplatin and 5-fluorouracil (5-FU) often cause side effects and drug resistance. This study aimed to investigate the combined effects of Valencia KK4-type peanut’s (<i>Arachis hypogaea</i> L.) skin ethanolic extract (KK4-PSE) and cisplatin or 5-FU on CCA cells <i>in vitro</i> and in nude mouse xenografts. Antiproliferative activity was evaluated using MTT assay. The <i>in vitro</i> drug interaction was studied by the Chou–Talalay method. Apoptosis induction and cell cycle arrest were analyzed by flow cytometry. The levels of proteins involved in apoptosis were evaluated by western blot analysis. Mouse xenograft models were used to evaluate the anticancer activity of KK4-PSE in animals (<i>in vivo</i>). KK4-PSE inhibited the proliferation of CCA cell line (IC<sub>50</sub> = 37.22 ± 4.31, 26.27 ± 0.78, and 17.72 ± 0.50 μg/mL at 24 h, 48 h, and 72 h exposures, respectively) more effectively than that of the noncancer H69 cholangiocyte cell line (IC<sub>50</sub> = 193.35 ± 6.55, 75.35 ± 1.00, and 57.41 ± 0.96 μg/mL at 24 h, 48 h, and 72 h exposures, respectively). In KKU-M213B cells, KK4-PSE treatments in combination with cisplatin caused cell cycle arrest at G2/M, whereas combined KK4-PSE and 5-FU caused a significant increase of Sub G1 population for 24 h exposure. Furthermore, a significant increase in the percentage of apoptotic cells was also observed in combination treatments. The combination treatments of KK4-PSE with cisplatin and 5-FU caused downregulation of pERK1/2 and Bcl2 and caused a decrease in the Bcl2/Bax ratio, resulting in enhanced apoptosis. In addition, KK4-PSE treatments in combination with 5-FU suppressed tumor growth in BALB/cAJcl-Nu/Nu xenograft models more effectively than the combinations with cisplatin. Taken together, KK4-PSE may be an effective synergistic agent with 5-FU and cisplatin for CCA chemotherapy, warranting further clinical examination.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/9058244","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Ethanol, SO2, and Transition Metals on Browning Kinetics in Low- and No-Alcohol Model Wine 乙醇、二氧化硫和过渡金属对低醇和无醇模型葡萄酒褐变动力学的影响
IF 3.5 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-11-14 DOI: 10.1155/2024/2318470
Yogesh Kumar, Arianna Ricci, Guanghao Wang, Giuseppina Paola Parpinello, Andrea Versari
{"title":"The Effect of Ethanol, SO2, and Transition Metals on Browning Kinetics in Low- and No-Alcohol Model Wine","authors":"Yogesh Kumar,&nbsp;Arianna Ricci,&nbsp;Guanghao Wang,&nbsp;Giuseppina Paola Parpinello,&nbsp;Andrea Versari","doi":"10.1155/2024/2318470","DOIUrl":"https://doi.org/10.1155/2024/2318470","url":null,"abstract":"<div>\u0000 <p>The study delved into the rate of browning (A<sub>420</sub> nm) within a model wine solution, aiming to elucidate mechanisms impacting real product scenarios, including low- and no-alcohol wines. The model wine solutions were prepared by adding tartaric acid, caffeic acid, and catechin into an aqueous ethanol solution containing transition metals (iron [Fe] and copper [Cu]) along with sulfur dioxide (SO<sub>2</sub>). The results indicated that the model wines without ethanol exhibited the highest browning rates both in the presence (<i>k</i> = 0.0022 day<sup>−1</sup>) and absence (<i>k</i> = 0.0035 day<sup>−1</sup>) of SO<sub>2</sub>. Notably, ethanol concentration showed a negative correlation with kinetic rates in both scenarios: with SO<sub>2</sub> (<i>r</i> = −0.9317) and without SO<sub>2</sub> (<i>r</i> = −0.9667). The addition of Fe and Cu separately led to a slight elevation in browning, particularly evident with Fe, while adding only Cu exhibited nonsignificant impact. However, their combined addition revealed a marked synergistic effect, rendering the rate notably sensitive to Cu concentration.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/2318470","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Protease Combined With Heat Treatment on the Stability of Proteins in Liqueur Wine 蛋白酶与热处理相结合对利口酒中蛋白质稳定性的影响
IF 3.5 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-11-13 DOI: 10.1155/jfbc/7630049
Yuanyuan Zhao, Zhen Zhang, Wen Li, Wei Li, Qi Shang, Jianming Du, Li Wang
{"title":"Effect of Protease Combined With Heat Treatment on the Stability of Proteins in Liqueur Wine","authors":"Yuanyuan Zhao,&nbsp;Zhen Zhang,&nbsp;Wen Li,&nbsp;Wei Li,&nbsp;Qi Shang,&nbsp;Jianming Du,&nbsp;Li Wang","doi":"10.1155/jfbc/7630049","DOIUrl":"https://doi.org/10.1155/jfbc/7630049","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Protein instability has been reported to be an important cause of haze in white wines; to investigate the feasibility of protease as a substitute for bentonite in the protein stability of white grape liqueurs, the effect of protease combined with heat treatment on the composition and protein stability of liqueur wines was investigated by chemical analysis, sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE), and amino acid analysis.</p>\u0000 <p><b>Results:</b> The results showed that the contents of total acid, volatile acid, pH, and glycerol were not significantly different from the blank control; the effect on total protein content and thermal stability were similar to the bentonite treatment; the L<sup>∗</sup>, b<sup>∗</sup>, and <span></span><math></math> values of liqueur wines increased by 5.59%, 4.33%, and 4.33% after protease combined with heat treatment (<i>p</i> &lt; 0.05); SDS-PAGE results confirmed that protease combined with heat treatment had good hydrolysis for thaumatin-like proteins (TLPs) and chitinases (CHIs) in liqueur wines. Amino acid analysis revealed that the levels of threonine, serine, tyrosine, arginine, and proline had increased, respectively, and isoleucine (1.26 mg/L) and leucine (1.16 mg/L) were newly detected after protease combined with heat treatment. Particle size analysis showed that the protease combined with heat treatment had less effect on the particle size distribution of the wines.</p>\u0000 <p><b>Conclusion:</b> Protease combined with heat treatment had a certain protein stabilizing effect and had no significant negative impact on other nutrients of liqueur wines. Thus, it can be used as an alternative to bentonite for the protein stabilization of liqueur wines.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/7630049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142641881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating Network Pharmacology and Metabolomics to Explore the Potential Mechanism of β-Sitosterol Against Hyperuricemia Nephropathy 整合网络药理学和代谢组学探索β-谷甾醇防治高尿酸血症肾病的潜在机制
IF 3.5 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-11-13 DOI: 10.1155/2024/7645677
Fan Yang, Lu Sun, Yingjie Gao, Jingzhen Liang, Wenqian Ye, Wenjing Yang, Siyi Xie, Jiangtao Zhou, Rongshan Li
{"title":"Integrating Network Pharmacology and Metabolomics to Explore the Potential Mechanism of β-Sitosterol Against Hyperuricemia Nephropathy","authors":"Fan Yang,&nbsp;Lu Sun,&nbsp;Yingjie Gao,&nbsp;Jingzhen Liang,&nbsp;Wenqian Ye,&nbsp;Wenjing Yang,&nbsp;Siyi Xie,&nbsp;Jiangtao Zhou,&nbsp;Rongshan Li","doi":"10.1155/2024/7645677","DOIUrl":"https://doi.org/10.1155/2024/7645677","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Renal involvement resulting from hyperuricemia, known as hyperuricemia nephropathy (HN), is characterized by chronic tubulointerstitial inflammation caused by extensive urate crystal deposition. Managing this condition requires straightforward preventive or therapeutic interventions, primarily through dietary measures.</p>\u0000 <p><b>Methods:</b> In this study, the mouse model of HN was established using yeast extract combined with potassium oxonate. The effect and potential mechanism of β-sitosterol in treating HN were investigated through biochemical indexes, pathological changes, untargeted metabolomics, and network pharmacology.</p>\u0000 <p><b>Results:</b> β-Sitosterol reduced the levels of four biomarkers of HN: uric acid (UA), creatinine (CRE), blood urea nitrogen (BUN), and xanthine oxidase (XOD). It also mitigated inflammatory injury in renal tissues and reversed the abnormal expression of four key urate transporter proteins: glucose transporter protein 9 (GLUT9), organic anion transporter 1 (OAT1), ATP-binding cassette transporter G2 (ABCG2), and urate transporter 1 (URAT1). To explore the mechanism of β-sitosterol in treating HN, this study employed network pharmacology and metabolomics to analyze 27 intersecting gene targets and 14 differential metabolites. The findings indicated that glutathione (GSH) metabolism might be a crucial pathway. Treatment with β-sitosterol increased the levels of reduced GSH as well as the activity and expression of 6-phosphogluconate dehydrogenase (G6PDH) in mice, thereby effectively modulating GSH metabolism. This study proposes a novel strategy using β-sitosterol for treating HN, providing a promising approach for addressing this condition.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7645677","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142641880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Slice Thickness and Pretreatments on the Quality of Dried Apple Slices (Golden Delicious) 切片厚度和预处理对金味苹果干片质量的影响
IF 3.5 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-11-12 DOI: 10.1155/2024/1711150
Abhishek Thakur, Ritika Sharma, Devina Vaidya, Nilakshi Sharma, Dhruv Thakur, Rajat Suhag
{"title":"Effect of Slice Thickness and Pretreatments on the Quality of Dried Apple Slices (Golden Delicious)","authors":"Abhishek Thakur,&nbsp;Ritika Sharma,&nbsp;Devina Vaidya,&nbsp;Nilakshi Sharma,&nbsp;Dhruv Thakur,&nbsp;Rajat Suhag","doi":"10.1155/2024/1711150","DOIUrl":"https://doi.org/10.1155/2024/1711150","url":null,"abstract":"<div>\u0000 <p>Apple is a perishable fruit due to its higher moisture content, which leads to spoilage and also reduces its shelf life. To improve the storage stability of apples, drying is the most effective and oldest method as it leads to the reduction of water activity. In the present study, dried apple slices were developed from “<i>Golden Delicious</i>” apples. The suggested methodology involves the use of dried apple slices with skin and a thickness of 4.5 mm, pretreated with 1% salt solution for 15 min. The drying process takes place at a temperature of 50°C for 3 h, followed by a temperature of 90°C for 2 h. The water activity of salt- and KMS-pretreated dried apple slices was 0.422 ± 0.00 and 0.438 ± 0.01, respectively, whereas a higher value 0.473 ± 0.01 of water activity was observed in untreated dried apple slices, demonstrating better stability. Also, compared to the control sample, the pretreated slices showed 13% lesser shrinkage due to drying, thereby retaining its shape. The total phenolic content was the lowest in the control sample (101.52 ± 0.37 mg GAE/100 g), while a significant increase was observed in KMS-pretreated (115.44 ± 4.08 mg/100 g) and salt-pretreated (131.55 ± 0.58 mg/100 g) dried apple slices. Moreover, antioxidant activity also was higher in salt-pretreated dried apple slices. Texture profile analysis revealed that the developed apple slices had better crispiness than nonpretreated ones. Thus, pretreatment before drying is of great significance to improve the appearance and quality of products.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/1711150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142641909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Acclimation Length on the Metabolic Profile of Tea Plants 适应期对茶树代谢特征的影响
IF 3.5 2区 农林科学
Journal of Food Biochemistry Pub Date : 2024-11-12 DOI: 10.1155/2024/1323945
Zhao Shilei, Lv Han, Zhao Mengjie, Hua Xuewen, Sun Litao, Shen Jiazhi, Wang Yu, Ma Qingping, Ding Zhaotang
{"title":"The Effect of Acclimation Length on the Metabolic Profile of Tea Plants","authors":"Zhao Shilei,&nbsp;Lv Han,&nbsp;Zhao Mengjie,&nbsp;Hua Xuewen,&nbsp;Sun Litao,&nbsp;Shen Jiazhi,&nbsp;Wang Yu,&nbsp;Ma Qingping,&nbsp;Ding Zhaotang","doi":"10.1155/2024/1323945","DOIUrl":"https://doi.org/10.1155/2024/1323945","url":null,"abstract":"<div>\u0000 <p>Acclimation refers to the process by which plants adapt to the environment. This study was to illustrate the effect of acclimation length on the metabolic profile of tea leaves. In this study, 32 long-acclimated tea varieties in Shandong Province and 61 ST varieties were used as materials, and the metabolites of tea plants were detected by using UPLC-MS/MS method. The results showed that the accumulation of flavonoids, organic acids, and alkaloids in long-acclimated tea plants was higher than that in ST plants. In contrast, the accumulation of phenolic acids, lipids, and amino acids showed an opposite trend. In long-acclimated tea varieties, <i>Camellia sinensis</i> cv. <i>Lucha11</i> (LC11), LC24, and LC30 showed high flavonoids, phenolic acids, organic acids, and alkaloids, which were important metabolites and related to tea quality. This study provides a theoretical basis for understanding the effect of environment on metabolism of tea plants and guides the breeding of new tea varieties with high quality or special flavor.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/1323945","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142641908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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