Journal of Food Biochemistry最新文献

{"title":"Pharmacological Appraisal of Phyllanthus emblica in Letrozole-Induced Polycystic Ovarian Syndrome Female Rats Model","authors":"Jiangyu Han,&nbsp;Majid Manzoor,&nbsp;Rida Siddique,&nbsp;Hina Manzoor,&nbsp;Subhan Moazzam,&nbsp;Rizwan Rashid Bazmi,&nbsp;Liaqat Hussain","doi":"10.1155/jfbc/8015756","DOIUrl":"https://doi.org/10.1155/jfbc/8015756","url":null,"abstract":"<div>\u0000 <p>Polycystic ovarian syndrome (PCOS) is a complex endocrinological condition affecting women of reproductive age. It may lead to insulin resistance, hyperandrogenism, obesity, cardiovascular issues, and menstrual irregularities. This study aimed to evaluate the ethanolic extract of <i>Phyllanthus emblica</i> (EEPE) against letrozole-induced PCOS in adult female rats. Phytochemical analysis revealed the presence of kaempferol, caffeic acid, quercetin, and ferulic acid. Thirty female rats were first divided into two groups: Group I (normal control, <i>n</i> = 5) and a disease control or PCOS group (<i>n</i> = 25). PCOS was induced using letrozole (1 mg/kg, p.o.), the diseased animals were further divided into four groups: Group II (PCOS control, <i>n</i> = 5) and Groups III–VI (treatment groups, <i>n</i> = 5). The induction of the disease was confirmed through weight gain and vaginal smear cytology. After study completion, female rats were euthanized and blood samples were collected for hormonal evaluation and biochemical analysis. Ovaries were dissected and preserved for histopathological study. Study findings revealed that PCOS significantly elevated the insulin, testosterone, and LH levels. Meanwhile, it significantly reduced the FSH level. Similarly, it also aggravated oxidative stress with reduced levels of SOD, CAT, GSH, and higher levels of lipid peroxidation marker (MDA). Treatment with EEPE elevated FSH levels and reduced the elevated levels of insulin and testosterone. PCOS induction increased the number of cystic follicles in the ovary. It reduced the no. of Graafian and mature follicles, while treatment with EEPE reduced cystic follicles and made it possible to mature these cystic follicles into secondary and Graafian follicles. It also improved the oxidation status of ovaries, which resulted in a good impact on ovulation. In conclusion, this study provided pharmacological validation for the efficacy of EEPE in managing PCOS. Its novelty lies in being the first to scientifically authenticate the traditional use of <i>Phyllanthus emblica</i> for PCOS, offering evidence-based support for its folkloric uses.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8015756","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant Activity of Pressafonin-A Isolated From Sicilian Ferulago nodosa (L.) Boiss. Roots and Its Proapoptotic Effect Through ROS-Dependent p53/p21Waf1/Cip1 Pathway in Human Melanoma A-375 Cells","authors":"Ignazio Restivo,&nbsp;Natale Badalamenti,&nbsp;Maurizio Bruno,&nbsp;Ilenia Concetta Giardina,&nbsp;Alessandro Massaro,&nbsp;Mario Allegra,&nbsp;Luisa Tesoriere,&nbsp;Alessandro Attanzio","doi":"10.1155/jfbc/8353971","DOIUrl":"https://doi.org/10.1155/jfbc/8353971","url":null,"abstract":"<div>\u0000 <p><i>Ferulago nodosa</i> (L.) Boiss. is a species belonging to the Apiaceae family which grows spontaneously in the Balkan and southern Tyrrhenian areas of the Mediterranean Sea. Plants of the <i>Ferulago</i> genus are widely used in the ethnopharmacological field, mainly in the form of infusions, as remedies against panic attacks, to solve problems related to the gastrointestinal tract, and for ulcer complications. In this study, we assessed antioxidant and antiproliferative activities of the pressafonin-A (PA), extracted from <i>F. nodosa</i> roots, following its spectroscopical characterization. Among the assays conducted, reducing capacity tests and free radical scavenging assays showed that PA can act as an antioxidant. PA also exhibited time- and concentration-dependent antiproliferative activity against human cancer cell lines, including A-375 (melanoma), HCT-116 (colorectal carcinoma), and MCF-7 (breast adenocarcinoma). Selectivity index (SI) was calculated using normal 16-HBE cells. Among the cell lines tested, PA demonstrated an SI &gt; 10 in A-375 cells. Treatment with PA 6.2 μM (IC₂₅) and 12.4 μM (IC₅₀) for 24-h induced apoptosis, as cytofluorimetrically evidenced by phosphatidylserine exposure, loss of mitochondrial membrane potential, and intracellular ROS production. Moreover, PA caused an arrest of cell cycle at the G1/S phase transition. Western blot analysis showed that PA caused an increase in protein levels of p53, p21^Waf1/Cip1, cytochrome c, and BAX, along with a decrease in Bcl-2 protein. In conclusion, natural PA demonstrated antioxidant and antiproliferative properties on A-375 by inducing apoptosis via ROS-dependent intrinsic mitochondrial pathway and cell cycle arrest. These results suggest that PA may have potential as a chemopreventive agent for skin diseases.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8353971","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Bovine Serum Albumin on the Antioxidant and Anti-Inflammatory Activities of Arbutus unedo L. Extract","authors":"Idir Moualek,&nbsp;Hamdi Bendif,&nbsp;Karima Benarab,&nbsp;Fehmi Boufahja,&nbsp;Natale Badalamenti,&nbsp;Maurizio Bruno,&nbsp;Stefania Garzoli,&nbsp;Karim Houali","doi":"10.1155/jfbc/9947897","DOIUrl":"https://doi.org/10.1155/jfbc/9947897","url":null,"abstract":"<div>\u0000 <p>This study explored the impact of bovine serum albumin (BSA) on the antioxidant and anti-inflammatory activities of <i>Arbutus unedo</i> leaf extract and its polyphenolic compounds. HPLC-MS analysis identified compounds like quinic acid, arbutin, and flavonoids. Antioxidant activity was evaluated using ferric reducing power, phosphomolybdenum, and DPPH assays, while anti-inflammatory effects were assessed via red blood cell membrane stability. BSA enhanced hydroxyl radical scavenging but reduced ferric reducing power and total antioxidant capacity, with no significant anti-inflammatory improvement. The findings reveal assay-dependent effects of BSA due to protein–polyphenol interactions, emphasizing the need for further research to optimize therapeutic potential.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9947897","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Metabolic Function of Three Types of High-Temperature Daqu During Baijiu Fermentation","authors":"Shanqimuge,&nbsp;Ping Tang,&nbsp;Minsha Qiao,&nbsp;Fan Wang,&nbsp;Ying Guo,&nbsp;Li Wang,&nbsp;Rongyu Bi,&nbsp;Shuyue Hao,&nbsp;Xinyue Kang,&nbsp;Liqin Qin,&nbsp;Changwen Li,&nbsp;Jun Lu","doi":"10.1155/jfbc/6762405","DOIUrl":"https://doi.org/10.1155/jfbc/6762405","url":null,"abstract":"<div>\u0000 <p>White, yellow, and black Daqu are three typical types of Jiangxiangxing high-temperature Daqu, which result from differences in the microenvironment during Daqu culture. However, there is still limited research on the metabolic characteristics of three types of Daqu and their impact on the final products. In this work, headspace solid-phase microextraction coupled with gas chromatography–mass spectrometry (HS-SPME-GC-MS) and high-throughput sequencing were utilized to reveal volatile compounds and microbial genera in different types of Daqu. Furthermore, simulated fermentation of different types of Daqu was employed to verify their fermentation performance. The results revealed 64 representative volatile compounds and 21 differential microbial genera among three types of Daqu. The correlation analysis and prediction of microbial functional potential indicated that white Daqu was characterized by significant decomposition and utilization of bio-macromolecules, while yellow Daqu had more pronounced formation of aroma compounds. The content of relevant metabolites related to fatty acid and phenylalanine metabolism was significantly higher in yellow Daqu than in the other types. The results of the simulated fermentation of three types of Daqu demonstrated that all types of Daqu stably maintained their functional diversity during fermentation. Specifically, yellow Daqu promoted the production of alcohols and aldehydes, while white and yellow Daqu tended to generate esters and nitrogen-containing compounds such as pyrazines, whereas black and yellow Daqu produced more acids and ketones during fermentation. This study provides a theoretical basis for the rational use of different types of Daqu in Baijiu production.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/6762405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abutilon indicum (L.) Sweet Extracts Inhibit Key Glucose Metabolic Enzymes While Enhancing Glucose Transport in L6 Myotubes and 3T3L1 Adipocytes","authors":"Subhadip Banerjee,&nbsp;Pravaree Phuneerub,&nbsp;Wuttichai Jaidee,&nbsp;Narawadee Rujanapun,&nbsp;Thidarat Duangyod,&nbsp;Kulwadee Malee,&nbsp;Wisanu Maneerat,&nbsp;Virayu Suthiphasilp,&nbsp;Surat Laphookhieo,&nbsp;Salfarina Ramli,&nbsp;Siau Hui Mah,&nbsp;Kitthisak Khlaeo Chansukh,&nbsp;Poonsit Hiransai,&nbsp;Panupong Puttarak,&nbsp;Satyajit D. Sarker,&nbsp;Lutfun Nahar,&nbsp;Rawiwan Charoensup","doi":"10.1155/jfbc/8252812","DOIUrl":"https://doi.org/10.1155/jfbc/8252812","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> <i>Abutilon indicum</i> (L.) Sweet (Malvaceae) is a traditional medicinal plant known for its antidiabetic properties in Ayurveda and other health systems.</p>\u0000 <p><b>Aims:</b> This study aims to profile metabolites in <i>Abutilon indicum</i> (L.) Sweet extracts (AI) and elucidate their antidiabetic mechanisms through bioinformatics and experimental methods.</p>\u0000 <p><b>Study Design:</b> The ethanolic (AIE) and aqueous (AIA) extracts were evaluated for their inhibitory effects on <i>α</i>-glucosidase and <i>α</i>-amylase, as well as their impact on glucose metabolism in 3T3-L1 adipocytes and L6 skeletal muscle cells. AIE was characterized via HPLC-DAD-QTOF-MS, with network pharmacology and molecular docking analyses used to explore molecular targets.</p>\u0000 <p><b>Methods:</b> In vitro assays were performed to assess enzyme inhibition, and cell line studies HPLC-DAD-QTOF-MS were utilized for compound characterization. Network pharmacology and molecular docking were conducted to reveal underlying antidiabetic mechanisms.</p>\u0000 <p><b>Results:</b> LC-MS-QTOF analysis identified gallic acid, stigmasterol, and riboflavin as abundant compounds. The AIE exhibited significant <i>α</i>-glucosidase (IC₅₀ = 74.15 ± 1.61 μg/mL) and <i>α</i>-amylase inhibition (IC₅₀ = 13.41 ± 0.71 μg/mL). Moreover, it enhanced glucose consumption in 3T3-L1 cells (IC₅₀ = 6.25 μg/mL) and promoted glucose uptake in L6 myotubes. Network pharmacology analyses highlighted the PI3K–Akt signaling pathway’s role in facilitating glucose transport.</p>\u0000 <p><b>Conclusion:</b> The phytochemicals in AIE may contribute significantly to its antidiabetic effects, particularly through the modulation of glucose transport via the PI3K–Akt pathway. Future studies should focus on the preclinical development of safe herbal formulations utilizing these mechanisms for effective diabetes management.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8252812","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Material Basis and Mechanism of Action of Different Parts of Honey Bran Cimicifuga Rhizoma in the Treatment of IBS-D","authors":"Yigeng Wu,&nbsp;Xiaoxia Deng,&nbsp;Xiao Xue,&nbsp;En Yuan,&nbsp;Yuxuan Zou,&nbsp;Yiming Huang,&nbsp;Li Yan,&nbsp;Songhong Yang,&nbsp;Hao Chen,&nbsp;Lingyun Zhong,&nbsp;Jing Zhu","doi":"10.1155/jfbc/5014978","DOIUrl":"https://doi.org/10.1155/jfbc/5014978","url":null,"abstract":"&lt;div&gt;\u0000 &lt;p&gt;&lt;b&gt;Background of the study:&lt;/b&gt; Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common disease of the brain–gut axis with clinical manifestations such as abdominal pain and abdominal leakage. It is usually accompanied by anxiety and depression, which severely affects the activities of daily living of patients. After Cimicifuga Rhizoma (CR) is processed through the honey bran, the effect of replenishing qi to increase yang is enhanced, and it is often used to treat abdominal pain, diarrhea, and other gastrointestinal discomforts. Honey Bran CR (HBCR) is clinically available for the treatment of IBS-D, but there is a lack of research on its material basis and mechanism of action, among other aspects.&lt;/p&gt;\u0000 &lt;p&gt;&lt;b&gt;Aim of the study:&lt;/b&gt; This study aimed to investigate the material basis of HBCR for replenishing qi to increase yang and predict its mechanism of action in treating IBS-D. Materials and Methods: First, the chemical constituents of different fractionated extracts of HBCR were identified by UPLC-Q-TOF-MS/MS, and the ingredient library was established. Second, the therapeutic effects of different parts on IBS-D model rats were compared. Third, the spectrum–effect relationship between the chemical components and pharmacodynamic indexes of HBCR was established by gray correlation analysis. Network pharmacology and molecular docking techniques were utilized to validate the effectiveness of the effector components. Finally, the action mechanism of HBCR for IBS-D was further analyzed by serum metabolomics.&lt;/p&gt;\u0000 &lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; A total of 61 chemical constituents were identified by UPLC-Q-TOF-MS/MS. They included 40 for the petroleum ether group, 48 for the dichloromethane group, 26 for the ethyl acetate group, 37 for the N-butanol group, and 19 for the water group. The results of AWR experiments showed that the IBS-D rat model was successfully constructed. The NGF and TRPV1 immunohistochemical sections; TNF-α, VIP, and 5-HT expressions in the colon; and SP, BDNF, and 5-HT expressions in the hypothalamus showed that different extracted parts of HBCR had curative effects on IBS-D model rats, and the treatment effect of the ethyl acetate group was the best. So the different extracted parts of HBCR could inhibit the release of TRPV1 and SP mediators by downregulating the expressions of BDNF and NGF. It could also affect the production of 5-HT to alleviate the development of visceral hypersensitivity and inhibit the production of inflammatory factors such as TNF-α and the downregulation of gastrointestinal motility by VIP to treat IBS-D. Six potential effective components were screened using the spectrum–effect relationship: fukiic acid (Peak 1), cimicifugic acid C (Peak 26), piscidic acid (Peak 3), cimicifugic acid B (Peak 30), cimicifugic acid A (Peak 29), and cimicifugic acid D (Peak 25). The results of network pharmacology and molecular docking showed that the effective components played a rol","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5014978","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking Microbial Communities and Organic Matter Dynamics in Longjing and Fuding Tea Ecosystems","authors":"Rui Cao,&nbsp;Juncheng Yang,&nbsp;Zhentuo Meng,&nbsp;Hao Zhou,&nbsp;Xuan Dong,&nbsp;Lei Peng,&nbsp;Shuangshuang Hou","doi":"10.1155/jfbc/9981444","DOIUrl":"https://doi.org/10.1155/jfbc/9981444","url":null,"abstract":"<div>\u0000 <p>Tea (<i>Camellia sinensis</i>) is widely cultivated worldwide. This study explores the effects of different tea varieties on soil organic matter (SOM) content and microbial communities in tea plantations, providing insights for the green development of the tea industry. We conducted a comparative analysis using metagenomic sequencing to evaluate disparities in SOM content and microbial community composition among a 12-year mature Fuding tea (FD) plantation, Longjing 43 tea (LJ) plantation, and virgin land (VL). Compared with VL, the soil respiration rate, temperature, moisture, and organic matter in LJ and FD plantations increased significantly, with LJ showing the highest SOM content. Bacterial diversity and richness were highest in LJ while fungal diversity and richness decreased. Tea plantation construction alters the SOM content and microbial diversity, with LJ showing the greatest increase in SOM. This study provides new insights for tea plantation management and bacterial fertilizer development.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9981444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Complete Genome Analysis of Toxic Compound Gene Families in the Genus Cordyceps","authors":"Yingling Lu,&nbsp;Songyu Li,&nbsp;Zuoheng Liu,&nbsp;Yue Chen,&nbsp;Yufan Yin,&nbsp;Quanying Dong,&nbsp;Guodong Niu,&nbsp;Baomin Fan,&nbsp;Hong Yu","doi":"10.1155/jfbc/9371774","DOIUrl":"https://doi.org/10.1155/jfbc/9371774","url":null,"abstract":"<div>\u0000 <p>To evaluate the safety of drug and food homologous properties of <i>Cordyceps</i> species at the genomic level, the complete genomes of 18 <i>Cordyceps</i> strains were sequenced and annotated. Subsequently, their genomic features were compared with those of an additional six <i>Cordyceps</i> strains, and their major secondary metabolites were analyzed using antiSMASH and local BLAST. The results demonstrated significant variations in genome size and GC content among different <i>Cordyceps</i> species, while closely related species exhibited minor differences in these parameters. As wild-type strains, the 24 strains of <i>Cordyceps</i> are likely to lack toxin-encoding genes. <i>C. cateniobliqua</i> YFCC 8434, <i>C. javanica</i> YFCC 8439, and <i>C. javanica</i> IJ1G are expected to serve as novel resources for food ingredients. The genomes of the remaining 21 strains may harbor gene clusters responsible for one or more potentially toxic compounds that could cause morbidity or mortality in the host. This study provides a comprehensive assessment of the safety of potential toxins from <i>Cordyceps</i> fungi at the genomic level, offering a theoretical basis for the development and utilization of novel drug homologous strains.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9371774","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potency of Antioxidant Peptides Encrypted in Commercially Important Marine Invertebrates: A Bioinformatics Approach","authors":"Andreas Vratsistas,&nbsp;Dimitris Vafidis","doi":"10.1155/jfbc/5692584","DOIUrl":"https://doi.org/10.1155/jfbc/5692584","url":null,"abstract":"<div>\u0000 <p>Efficient and beneficial food utilization calls for sustainable and innovative practices that add value at every stage of production. In this study, we conducted a computational analysis of protein sequences from the bivalve <i>Mytilus galloprovincialis</i>, the crustacean <i>Penaeus vannamei</i> (whiteleg shrimp), the purple sea urchin <i>Paracentrotus lividus</i>, and the echinoderm <i>Holothuria leucospilota</i>, utilizing bioinformatic tools to estimate their antioxidant bioactive potential. This potential is indicated by the presence of small bioactive peptides encrypted within their sequences, which can be released by proteolytic enzymes. The peptides of interest from a total of 47 proteins were matched with known antioxidant peptides (APs) from the BIOPEP database. We studied the properties of 236 different peptides out of a total of 995 peptides encrypted in the proteins. To evaluate the bioactivity of peptides, we sorted them based on the predicted free radical scavenging (FRS) and ion-chelating (CHEL) scores. Furthermore, to investigate protein–peptide interactions, molecular docking of selected peptides was performed with two protein models. <i>Penaeus vannamei</i> and <i>Paracentrotus lividus</i> exhibited the highest average antioxidant FRS potency. The most potent FRS peptides for each organism are encrypted in the kinesin-like Boursin protein of <i>Paracentrotus lividus</i>, the Chitinase protein of <i>Penaeus vannamei</i>, the Myosin-16 protein of <i>Holothuria leucospilota</i>, and the Perlucin-like protein of <i>Mytilus galloprovincialis</i>. We demonstrate a correlation between the potency of APs, based on the FRS score, and their calculated binding affinity to serine/threonine protein kinase D1 and glutathione peroxidase. Our results highlight an effective approach to utilizing by-products of primary production for mining high-value ingredients.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5692584","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Role of Nutraceuticals in the Management and Prevention of Experimental-Induced Abdominal Aortic Aneurysms: Mechanisms and Therapeutic Potential","authors":"Yi Yang,&nbsp;Kun Chen,&nbsp;Jun Chen,&nbsp;Sima-Sadat Sabihi","doi":"10.1155/jfbc/3780766","DOIUrl":"https://doi.org/10.1155/jfbc/3780766","url":null,"abstract":"<div>\u0000 <p>A potentially fatal ailment, abdominal aortic aneurysms (AAAs) frequently result in death by dissection or rupture. AAA is caused by a histopathologic anomaly that includes smooth muscle cell loss, media degeneration, inflammatory cell infiltration, and elastic fiber damage in the aorta wall. Nevertheless, it is still unknown how AAAs form. Improved knowledge of how AAA develops and progresses might lead to the development of innovative, less intrusive treatment approaches for those suffering from this debilitating illness. Functional foods have a range of protective impacts, such as antioxidant, anti-inflammatory, antifibrotic, anticarcinogenic, and cardiovascular protective impacts, as shown by numerous human and animal research. Pretreatment with nutraceuticals can suppress the growth of AAA and pro-inflammatory markers. The use of nutraceuticals to treat ischemic-reperfusion cardiac cells has been shown to protect against ischemia–reperfusion damage through a diversity of mechanisms. This information was most recently reported. Thus, by inhibiting apoptosis, oxidative damage, c-Jun N-terminal kinase pathway, and inflammation, we investigated the impact of nutraceuticals on experimental-induced AAA in the current review.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/3780766","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}