Journal of Food Biochemistry最新文献

{"title":"Therapeutic Potential and Bioactive Compounds of Prunus mume: A Comprehensive Review of Pharmacological Benefits and Future Directions","authors":"Haochen Ying,&nbsp;Yuying Shuai","doi":"10.1155/jfbc/5057210","DOIUrl":"https://doi.org/10.1155/jfbc/5057210","url":null,"abstract":"<div>\u0000 <p><i>Prunus mume</i>, a nutritious fruit and traditional Chinese medicine, has been widely used in clinical applications and health foods for centuries. Recent studies have highlighted its diverse pharmacological properties, prompting a systematic review of its bioactive components and therapeutic potential. This review synthesizes evidence from PubMed, Web of Science, and ScienceDirect (1999–2024) to characterize the bioactive matrix of <i>Prunus mume</i>, including phenolic compounds, organic acids, triterpenoids, and the thermally derived compound mumefural. Key findings reveal that <i>Prunus mume</i> exhibits anti-inflammatory, antitumor, antioxidant, metabolic regulatory, cardiovascular protective, hepatoprotective, gastrointestinal protective, and cognitive-enhancing effects, with mechanisms elucidated through in vivo and in vitro studies. Notably, mumefural demonstrates significant anti-inflammatory and neurocognitive benefits, while triterpenoids show promising anticancer activity. Unlike previous reviews, this study emphasizes the underexplored potential of mumefural and identifies critical research gaps, such as its low oral bioavailability and the need for clinical validation. These insights underscore the potential of <i>Prunus mume</i>–derived compounds, particularly mumefural, for developing innovative pharmaceuticals and functional health products.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5057210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papaya Leaf Extract Ameliorates Hepatic Steatosis in High-Fat Diet–Induced Obese Mice and Oleic Acid–Stimulated HepG2 Cells","authors":"Divina C. Cominguez,&nbsp;Hye-Min Kim,&nbsp;Tae-Young Gil,&nbsp;Hee-Young Kim,&nbsp;Yea-Jin Park,&nbsp;Yun-Mi Kang,&nbsp;Agung Nugroho,&nbsp;Yun-Yeop Cha,&nbsp;Hyo-Jin An","doi":"10.1155/jfbc/1906540","DOIUrl":"https://doi.org/10.1155/jfbc/1906540","url":null,"abstract":"<div>\u0000 <p>Hepatic steatosis, characterized by the accumulation of lipids in hepatocytes, is a chronic stage of nonalcoholic fatty liver disease (NAFLD). Papaya (<i>Carica papaya</i> L.), belonging to the Caricaceae family, possesses therapeutic and nutritional properties. Notably, papaya leaves have medicinal properties; however, their effect on hepatic steatosis remains to be elucidated. Therefore, in this study, we investigated the ameliorative effect of papaya leaf extract (PLE) on hepatic steatosis using a high-fat diet (HFD)–induced obese mice and oleic acid (OA)–treated HepG2 cells. Administration of PLE ameliorated body weight gain and hepatic lipid accumulation in HFD-induced obese mice. Furthermore, PLE decreased the expression of critical adipogenic markers, including CCAAT/enhancer-binding protein <i>α</i> (C/EBP<i>α</i>), sterol regulatory element-binding protein 1 (SREBP-1), and peroxisome proliferator-activated <i>γ</i> (PPAR<i>γ</i>), in the liver. The expression of phospho-adenosine monophosphate-activated protein kinase (p-AMPK) increased in the liver of PLE-administered mice. Consistent with the in vivo study, PLE reduced lipid accumulation and the protein expression of adipogenic factors and increased p-AMPK expression in OA-treated HepG2 cells. Collectively, these results indicate the potential of PLE as a therapeutic agent for obesity-induced hepatic steatosis.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/1906540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AMPK Activation and Lipid Homeostasis Regulation in MASLD: Investigating the Hepatoprotective and Anti-Inflammatory Effects of Meta-Capridin Medium-Chain Triglycerides","authors":"Alireza Doagoo,&nbsp;Sajad Ehtiati,&nbsp;Reza Ataei kachouei,&nbsp;Seyyed Hossein Khatami,&nbsp;Shima Rajaei,&nbsp;Maral Jalilzadeh,&nbsp;Nastaran Hamed,&nbsp;Fatemeh Namvarjah,&nbsp;Reyhane Ahmadzade,&nbsp;Marjan Ajami,&nbsp;Farzaneh Salmani,&nbsp;Somayeh Mahmoodi Baram,&nbsp;Mitra Rezaei,&nbsp;Majid Sirati-Sabet,&nbsp;Hojjat Allah Abbaszadeh,&nbsp;Ali Riazi,&nbsp;Behzad Hatami,&nbsp;Saeed Karima","doi":"10.1155/jfbc/9463646","DOIUrl":"https://doi.org/10.1155/jfbc/9463646","url":null,"abstract":"<div>\u0000 <p>Metabolic dysfunction–associated steatotic liver disease (MASLD) is characterized by hepatic lipid accumulation, mitochondrial dysfunction, and chronic inflammation. Disruptions in fatty acid oxidation and ketogenesis contribute to disease progression, highlighting the potential of dietary interventions that enhance hepatic metabolic adaptation. This study investigates the effects of a medium-chain triglyceride supplement, meta-Capridin (m-CAP), on hepatic ketogenesis, mitochondrial function, and inflammatory responses in a MASLD rat model. Male Wistar rats were assigned to preventive and therapeutic groups and fed a normal diet, a high-fat diet (HFD), or a HFD supplemented with m-CAP. Key metabolic markers, including β-hydroxybutyrate, mitochondrial enzyme activity, peroxisome proliferator-activated receptor alpha (PPAR-α), AMP-activated protein kinase (AMPK), and LXR, were assessed alongside inflammatory cytokines and NLRP3 inflammasome activation. Results showed that m-CAP enhanced hepatic ketogenesis, increased AMPK phosphorylation, and upregulated PPAR-α, improving mitochondrial function. Additionally, it suppressed NLRP3 activation and proinflammatory cytokines, particularly in the therapeutic phase. These findings suggest that m-CAP promotes hepatic ketogenesis and modulates inflammation, supporting its potential as a functional food-based strategy for MASLD prevention and treatment.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/9463646","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Weight–Dependent Pyroptosis Induction by Yeast Mannans Through Dectin-2/Syk/NLRP3 Axis Enhances Cisplatin Efficacy in Melanoma Therapy","authors":"Dandan Zhang,&nbsp;Xiaoting Ren,&nbsp;Kai Zhang,&nbsp;Yingbing Hu,&nbsp;Chunyu Wang,&nbsp;Guoqun Zhao,&nbsp;Jinlong Liu,&nbsp;Xu Sun","doi":"10.1155/jfbc/7630023","DOIUrl":"https://doi.org/10.1155/jfbc/7630023","url":null,"abstract":"<div>\u0000 <p>Mannans from various sources have shown to possess antitumor activities. However, the antitumor properties of yeast mannans (YMs) are not yet fully explored, and the mechanisms underlying the antitumor effects of mannans remain unclear. In this study, we prepared three YMs with average molecular weights (Mws) of 21.3 kDa, 41.5 kDa, and 123.2 kDa, designated as YM-L, YM-M, and YM-H, respectively. Cell viability and LDH assays demonstrated that all three YMs exhibited cytotoxic effects on A357 cells in a dose-dependent manner. Morphological observations, flow cytometry analysis, and western blotting revealed that YMs induced membrane rupture and activation of Caspase 1 and GSDMD, which are hallmark characteristics of pyroptosis. Real-time PCR, western blotting, reactive oxygen species (ROS) assays, immunofluorescence assays, and RNA interference assays indicated that YMs induced cell pyroptosis by binding to C-type lectin pathogen receptors Dectin-2, leading to Syk phosphorylation, ROS production, and NLRP3 inflammasome activation. The Mw of YMs was found to significantly affect pyroptosis in A357 cells, with the high Mw YM (YM-H) displaying the highest activity. Moreover, YM-H significantly potentiated cisplatin cytotoxicity both in vitro and in vivo, while demonstrating no observable systemic toxicity, highlighting its promise as an effective adjuvant for combination chemotherapy regimens in melanoma treatment.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/7630023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Enzyme-Assisted Extraction on Structural and Functional Properties of Palm Kernel Protein","authors":"Shi Cheng Tong,&nbsp;Lee Fong Siow,&nbsp;Teck Kim Tang,&nbsp;Yee Ying Lee","doi":"10.1155/jfbc/8869943","DOIUrl":"https://doi.org/10.1155/jfbc/8869943","url":null,"abstract":"<div>\u0000 <p>Palm kernel seed is massively produced in Malaysia and conferred a complete amino acid profile, sufficient for an average adult. To harvest this protein, enzyme extraction was introduced. The extraction was performed in an aqueous environment using protease and carbohydrase in alkaline and acidic conditions, and their effect on structural and functional properties of the protein was evaluated. Increasing the extraction time and enzyme concentration leads to increased protein extraction until a plateau was reached. Specifically, 5% Viscozyme L extraction for 1 h was found to be the most effective condition increasing the extracted protein content from 0.19% to 0.50%. Enzyme hydrolysis was found to significantly affect the protein structural property where cellulase caused the loss of hydrophobic amino acids, while Viscozyme L and papain caused protein aggregation. Due to the change in structural property, a decrease in the emulsifying activity index and an increase in the emulsifying stability of the protein extracted with the aid of enzymes were observed. This suggests the possibility of the extracted protein being used as an emulsifier or stabilizer of a food hydrocolloid system.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8869943","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of Soybean Bioactive Compounds on Liver Disorders: A Bibliometric Analysis and Review","authors":"Xiwei Liu,&nbsp;Yichao Ma,&nbsp;Ziyi Xu,&nbsp;Jun Wang","doi":"10.1155/jfbc/7436788","DOIUrl":"https://doi.org/10.1155/jfbc/7436788","url":null,"abstract":"<div>\u0000 <p>Diet intervention and nutritional support have been accepted as a cornerstone of therapy for various disorders of the liver, a central organ of metabolism and digestion. Epidemiological data have shown the beneficial effects of soy-containing diets on patients with liver disorders represented by nonalcoholic fatty liver disease (NAFLD), the latter of which has now been officially replaced by metabolic dysfunction–associated steatotic liver disease (MASLD). This study focused on the specific bioactive compounds derived from soybean, and aimed to provide a systematic overview of their potential application in control of liver disorders. We employed a bibliometric analysis and review of relevant research papers published in the past 15 years gathered from the PubMed and Web of Science databases. A total of 93 eligible studies were retrieved. Temporal analysis of publications revealed an ongoing interest in investigating soybean bioactive compounds with hepatoprotective activity, published in 61 different academic journals, from 2009 to 2023. Papers mainly came from China, the United States, and Japan. “Genistein (<i>n</i> = 26),” “NAFLD (<i>n</i> = 21),” and “soy protein (<i>n</i> = 20)” were the top three most frequently occurring keywords. More than 19 specific compounds from soybean have been explored for their potential hepatoprotective effect, among which flavonoids were most frequently studied in 53 (57.0%) articles, followed by soy proteins (30.1%). Genistein that was studied by 33 (35.5%) articles appeared as the most focused soy flavonoids. Only two recent clinical trials from Japan supported hepatoprotective activities of equol, a novel ingredient derived from soy. MASLD/metabolic dysfunction–associated steatohepatitis (MASH) was the overwhelmingly attractive indication for soy-based hepatoprotection studied by 61.3% of the included articles, followed by liver cancer (14.0%), toxicant-induced nonmalignant liver lesions (14.0%), alcohol-related liver disease (9.7%), and autoimmune hepatitis (1.0%). Findings suggested that the development of soybean bioactive compounds to control liver disorders, in particular, soybean genistein used for MASLD/MASH, has garnered considerable attention, and there is a need for future studies to investigate the potential effect of novel bioactive compounds from soybean on other liver disorders.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/7436788","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rosemary: A Promising Therapeutic Agent in Alleviating Nephrotoxicity","authors":"Jalileh Jalali,&nbsp;Mahboobeh Ghasemzadeh Rahbardar","doi":"10.1155/jfbc/5519628","DOIUrl":"https://doi.org/10.1155/jfbc/5519628","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Nephrotoxicity, kidney damage caused by a variety of chemicals, presents a significant challenge in the medical field. To address nephrotoxicity, innovative therapeutic techniques must be investigated. Rosemary (<i>Rosmarinus officinalis</i> L.) has been studied for its antioxidant, anti-inflammatory, and cytoprotective effects; however, existing literature lacks a comprehensive analysis of its mechanistic role in nephrotoxicity. This narrative review evaluates current findings, highlighting gaps in previous studies and presenting an updated perspective on the molecular pathways of rosemary in renal protection.</p>\u0000 <p><b>Methods:</b> This narrative review analyzed the nephroprotective effects of rosemary and its main components (rosmarinic acid, carnosic acid, carnosol, and ursolic acid) based on studies retrieved from Google Scholar, PubMed, Web of Science, and Scopus (2010–2025). Selection criteria focused on peer-reviewed research investigating the impact of rosemary on nephrotoxicity, including experimental and mechanistic studies. Studies unrelated to renal toxicity or lacking mechanistic insights were excluded. While no formal systematic review methodology was applied, a qualitative assessment of study relevance and methodological rigor was considered. Preclinical and mechanistic studies were prioritized to provide a comprehensive understanding of the nephroprotective properties of rosemary.</p>\u0000 <p><b>Results:</b> This review consolidates evidence demonstrating the nephroprotective potential of rosemary and its main components. Unlike prior reviews, our analysis provides a comprehensive mechanistic overview of the effects of rosemary on nephrotoxicity, emphasizing its ability to modulate pyroptosis and pivotal molecular pathways, including NF-κB/NLRP3 inflammasome and TGF-β1/Smad/collagen IV signaling. These findings are primarily based on preclinical studies with limited direct evidence from clinical trials.</p>\u0000 <p><b>Conclusion:</b> By addressing key mechanistic gaps, this review positions rosemary as a potential therapeutic agent for nephrotoxicity, based on promising findings from preclinical models. Our findings underscore its underexplored role in pyroptosis modulation and its ability to regulate key nephrotoxicity-related molecular pathways. Future research should focus on further elucidating these mechanisms to optimize rosemary’s potential as a nephroprotective agent.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/5519628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Anti-Vasculogenic Mimicry Effect of Duchesnea indica (Andr.) Focke Acidic Polysaccharide in Colon Cancer","authors":"Qiuying Shi,&nbsp;Hanqing Li,&nbsp;Xindan Li,&nbsp;Jianyu Deng,&nbsp;Xiaoyu Wang,&nbsp;Jiaye Jiang,&nbsp;Yan Ke","doi":"10.1155/jfbc/8148622","DOIUrl":"https://doi.org/10.1155/jfbc/8148622","url":null,"abstract":"<div>\u0000 <p>Vasculogenic mimicry (VM) is an endothelium-independent tumor microcirculation that provides adequate blood supply for tumor growth, which is closely associated with the poor prognosis of colon cancer. As a traditional medicinal plant, <i>Duchesnea indica</i> has shown a new potential in preventing the progress of colon cancer. This research aims to investigate whether the polysaccharide of <i>Duchesnea indica</i> (DIP2) has an effective ability to inhibit VM in colon cancer and to further study its mechanism of action. In in vitro experiments, three-dimensional tubule and invasion experiments proved that DIP2 could inhibit CoCl₂-induced VM and invasion. Western blot and RT-PCR results revealed a dose-dependent inhibition by DIP2 on the expression of VM-related proteins and genes. In vivo experiments have shown that DIP2 has a dose-dependent inhibitory effect on colon cancer tumor growth and can reduce the sudden weight loss of transplanted tumors in nude mice. H&amp;E staining showed that DIP2 could alleviate the deterioration of cell morphology caused by tumor. The results of CD31/PAS double staining showed that DIP2 could inhibit the occurrence of VM in colon cancer. Meanwhile, DIP2 also suppressed the expression of proteins and genes related to the VEGF/PI3K/AKT and Wnt3a/β-catenin signaling pathways. The inhibition of VM process in tumor cells by DIP2 is believed to contribute to its potential as an antitumor agent. As a useful and untapped pharmaceutical/food resource, <i>Duchesnea indica</i> has great prospects for application.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8148622","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical Characteristics and Functionality of Burdekin Plum During Fruit Maturation","authors":"Gengning Chen,&nbsp;Michael E. Netzel,&nbsp;Daniel Cozzolino,&nbsp;Yasmina Sultanbawa","doi":"10.1155/jfbc/8811862","DOIUrl":"https://doi.org/10.1155/jfbc/8811862","url":null,"abstract":"<div>\u0000 <p>Burdekin plum (<i>Pleiogynium timoriense</i>) is a rich source of phytochemicals with many health benefits, but the effect of maturation on its physicochemical properties and functionality is unknown. To fill this knowledge gap, Burdekin plums harvested at three different maturity stages (mature green, turning and dark maroon) were analysed, including basic physicochemical parameters, bioactive compounds, antimicrobial activity and antioxidant capacity. Results showed that the dietary fibre content decreased from around 50% to 30% during maturation. Three different solvents (water, 80% ethanol and 80% methanol) were used for extraction and tested for bioactive compounds and functionality. Bioactive compounds were identified and quantified using Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry. Water extracts contained higher content of gallic acid and galloylquinic acid content. However, ethanol and methanol extracts contained higher content of ellagic acid, anthocyanins and catechins. During maturation, most bioactive compounds decreased, except for anthocyanins, quercetin 3-glucoside and epicatechin, which increased. Similarly, the antioxidant capacity reduced during maturation. Regarding the antimicrobial activity, extracts from turning and dark maroon stages demonstrated a stronger inhibition against <i>Staphylococcus aureus</i> (inhibition zone &gt; 8 mm) compared to mature green stage (inhibition zone &lt; 6 mm), while no inhibition against the <i>Escherichia coli</i> and <i>Candida albicans</i> was observed. In conclusion, the physicochemical characteristics and functionality of Burdekin plums changed significantly during maturation, which should be considered when utilising the fruits as a functional food source.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8811862","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Profile and Evaluation of the Antioxidant, Anticancer, and Antimicrobial Potential of Artocarpus lacucha Bark Extracts: In Vitro and In Silico Studies","authors":"Md. Junaid Haruni,&nbsp;Mst. Shahnaj Parvin,&nbsp;Sirajum Munira,&nbsp;Md. Ekramul Islam","doi":"10.1155/jfbc/8016598","DOIUrl":"https://doi.org/10.1155/jfbc/8016598","url":null,"abstract":"<div>\u0000 <p><i>Artocarpus lacucha</i> Roxb., traditionally used in ethnomedicine, was investigated for its pharmacological potential through a multimethodological approach. The ethyl acetate fraction (EAF) and chloroform fraction (CHF) of bark extracts were analyzed for antioxidant, anticancer, and antimicrobial properties. HPLC identified key polyphenols (e.g., catechin hydrate, myricetin), while bioassays revealed EAF as the most active fraction, exhibiting the highest phenolic content (116.16 ± 1.98 mg GAE/g), potent DPPH scavenging (IC₅₀ = 6.85 μg/mL), and significant cytotoxicity against A549 lung cancer cells (58.87% viability at 300 μg/mL). CHF, EAF, and aqueous fraction (AQF) exhibited selective antibacterial activity against resistant strain, with the CHF fraction showing the highest activity against <i>Staphylococcus aureus</i> (inhibition zone: 14 ± 0.6 mm). Molecular docking highlighted strong SRBD1 binding for myricetin (−6.8 kcal/mol) and catechin hydrate (−6.6 kcal/mol), supported by stable interactions in MD simulations. The findings highlight the therapeutic potential of <i>Artocarpus lacucha</i> bark extracts as promising sources of natural antioxidants, cytotoxic agents, and antimicrobial compounds.</p>\u0000 </div>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2025 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/jfbc/8016598","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}