Exploring the Role of Nutraceuticals in the Management and Prevention of Experimental-Induced Abdominal Aortic Aneurysms: Mechanisms and Therapeutic Potential

Abstract

A potentially fatal ailment, abdominal aortic aneurysms (AAAs) frequently result in death by dissection or rupture. AAA is caused by a histopathologic anomaly that includes smooth muscle cell loss, media degeneration, inflammatory cell infiltration, and elastic fiber damage in the aorta wall. Nevertheless, it is still unknown how AAAs form. Improved knowledge of how AAA develops and progresses might lead to the development of innovative, less intrusive treatment approaches for those suffering from this debilitating illness. Functional foods have a range of protective impacts, such as antioxidant, anti-inflammatory, antifibrotic, anticarcinogenic, and cardiovascular protective impacts, as shown by numerous human and animal research. Pretreatment with nutraceuticals can suppress the growth of AAA and pro-inflammatory markers. The use of nutraceuticals to treat ischemic-reperfusion cardiac cells has been shown to protect against ischemia–reperfusion damage through a diversity of mechanisms. This information was most recently reported. Thus, by inhibiting apoptosis, oxidative damage, c-Jun N-terminal kinase pathway, and inflammation, we investigated the impact of nutraceuticals on experimental-induced AAA in the current review.