Journal of biomedical materials research. Part B, Applied biomaterials最新文献

{"title":"Piezoelectric Biomaterials for Use in Bone Tissue Engineering—A Narrative Review","authors":"Sandeep Choudhury,&nbsp;Debolina Das,&nbsp;Sandipan Roy,&nbsp;Amit Roy Chowdhury","doi":"10.1002/jbm.b.35564","DOIUrl":"https://doi.org/10.1002/jbm.b.35564","url":null,"abstract":"<div>\u0000 \u0000 <p>To examine natural bone's bioelectrical traits, notably its piezoelectricity, and to look into how these characteristics influence bone growth and repair. In the context of exploring the potential of piezoelectric biomaterials, such as biopolymers and bio-ceramics, towards orthopedic and bone regeneration applications, the research seeks to evaluate the significance of piezoelectricity-driven osteogenesis. The paper reviews recent research on bone's electrical and dielectric properties, surface polarization/electrical stimulation effects interacting with cell activity and the effectiveness of piezoelectric biomaterials to support tissues' regenerative process. The study includes a number of materials, such as collagen, polyvinylidene fluoride (PVDF) and barium titanate. The applications of piezoelectric bio-ceramics, piezoelectric organic polymers, and piezoelectric natural polymers are particularly highlighted. Piezoelectric biomaterials are being shown in recent studies to enhance cellular metabolism in vitro as well as promote the regeneration of tissues in vivo, especially when paired with electric field stimulation or interface polarization. Piezoelectric bio-ceramics like magnesium silicate and barium titanate, as well as biopolymers like collagen and PVDF, have shown possibilities for orthopedic applications. However, there are several challenges regarding the manufacturing of bio-ceramics of specific compositions having the desired properties. This review highlighted the potential of piezoelectric biomaterials in orthopedic applications with special emphasis on biopolymers and bioceramics. Therefore, these types of materials have huge potential for bone regeneration because they can mimic the piezoelectric properties of bone and allow better advances in tissue engineering or regenerative medicine. To date, little is known about their mechanism of action, and modifications are needed to improve efficacy for clinical uptake.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Restorative Viability of Zinc Oxide Nanoparticle-Reinforced Zirconia and Baghdadite Ceramic Composites","authors":"James Martin M. Jimenez,&nbsp;Ricky Kristan M. Raguindin,&nbsp;Eduardo R. Magdaluyo Jr.","doi":"10.1002/jbm.b.35562","DOIUrl":"https://doi.org/10.1002/jbm.b.35562","url":null,"abstract":"<div>\u0000 \u0000 <p>This study explores the enhancement of properties in zirconia-based ceramic dental restorative materials through the incorporation of baghdadite (Ca₃ZrSi₂O₉) and zinc oxide (ZnO) nanoparticles. Baghdadite was synthesized via a solid-state sintering method and integrated into zirconia to form baghdadite/zirconia ceramic composites. These composites were sintered with varying concentrations of baghdadite (0%, 5%, and 10%) to enhance bioactivity and support bone tissue repair, and incorporated with 0.6% ZnO nanoparticles to improve antimicrobial properties. The crystallographic structure, surface morphology, apparent density, antibacterial properties, and cell viability were characterized using x-ray diffraction (XRD), scanning electron microscopy (SEM), Archimedes principle, agar plate method, and trypan blue exclusion assay, respectively. Protein adsorption was evaluated using bovine serum albumin (BSA). Results showed that higher concentrations of baghdadite increased protein adhesion on the surface. The agar plate method revealed that ZnO nanoparticle-reinforced zirconia/baghdadite composites exhibited significant antimicrobial activity, particularly against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. In addition, the composites demonstrated a significant high cell viability of 83.71%, promoting cell growth. These findings suggest that the incorporation of baghdadite and ZnO nanoparticles enhances the bioactivity, antimicrobial effectiveness, and biocompatibility of zirconia, making it a viable candidate for dental restorative applications.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soft Flexible Skin Conformable Nanocomposites as a Platform for Electroceutical and Orthopedic Applications","authors":"Dhruv R. Seshadri,&nbsp;Aziz N. Radwan,&nbsp;Nicholas D. Bianco,&nbsp;Joseph A. Lerchbacker,&nbsp;Audrey M. Zorman,&nbsp;Christian A. Zorman,&nbsp;Kath M. Bogie","doi":"10.1002/jbm.b.35559","DOIUrl":"https://doi.org/10.1002/jbm.b.35559","url":null,"abstract":"<p>Designing biomimetic substrates and electrodes for bioelectronic devices with the necessary mechanical, electrical, and biological properties is critical considering the potential mismatch between soft tissue and rigid electronics, where incompatibility leads to decreased device performance, delamination, inflammation, and discomfort. There is an unmet engineering and clinical need for epidermal bioelectronics that are bioinert, can emulate host tissue mechanical properties, demonstrate low bulk resistivity, and are flexible and scalable. To address this shortcoming, this work describes innovations pertaining to the development of a hydrophilic, biocompatible nanocomposite comprised of carbon black (CB), polyvinyl alcohol (PVA), and glycerol for neuro-muscular and rehabilitative applications. We find that this materials platform (herein referred to as CB-<i>AFTI</i>Derm), comprised of 3 wt% PVA and 5 wt% glycerol, demonstrated superior biocompatibility (cytotoxic grade of 0), high flexibility (maximum of 140% stretchability and as low as 1% ∆R/R_o at 3.5-cm bending diameter), low electrical resistivity (as low as 0.6 Ω.cm), and electrical stability over a long-term duration (at 235 Ω in the lateral direction and between 300 Ω and 400 Ω in the transverse direction for a 24 h period). We find that the optimal CB concentration for our material platform is at 50% CB. We present examples for use in electroceutical therapy of chronic wounds and in orthopedic rehabilitation for monitoring joint angles. Achieving such results from a material, mechanics, biological, and electrical perspective facilitates the translational potential of this materials platform for the digital health and wearable technologies community to improve patient outcomes.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35559","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Applied Pressure and Thickness Variation on the Bond Strength Between 3Y-TZP Zirconia and Self-Adhesive Resin Cement","authors":"Paulo Pinto,&nbsp;Óscar Carvalho,&nbsp;Rita Ferreira,&nbsp;Sara Madeira,&nbsp;Filipe S. Silva","doi":"10.1002/jbm.b.35563","DOIUrl":"https://doi.org/10.1002/jbm.b.35563","url":null,"abstract":"<div>\u0000 \u0000 <p>This study evaluated the influence of applied pressure on the shear bond strength (SBS) between commercial 3Y-TZP zirconia and self-adhesive resin cement. Five test groups were created, each subjected to different applied pressures: 195.15, 97.47, 48.74, 9.75, and 0.20 kPa. A piston-type shear device was used to assess the effect of these pressures on cement layer thickness and SBS. The results demonstrated that the highest applied pressure (195.15 kPa) produced the thinnest cement layers (36.60 ± 1.67 μm) and the highest SBS values (58.8 ± 1.6 MPa), whereas the lower applied pressure (0.20 kPa) resulted in the thickest cement layers (73.20 ± 1.64 μm) and significantly lower SBS (30.8 ± 2.0 MPa). Regression analysis confirmed a strong correlation (<i>R</i>² = 0.82, <i>p</i> &lt; 0.05) between cement thickness and SBS, indicating that cement thickness is a critical factor influencing adhesion. These findings highlight the importance of controlling applied pressure during cementation to optimize bonding performance. Standardizing pressure application through calibrated pressure devices may improve the durability of zirconia-based restorations and minimize variability during the cementation process.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Perspectives on Additive Manufacturing and Titanium Surface Nanotopography in Bone Formation","authors":"Mariana Lima da Costa Valente,&nbsp;Lívia Maiumi Uehara,&nbsp;Rodolfo Lisboa Batalha,&nbsp;Claudemiro Bolfarini,&nbsp;Rayana Longo Bighetti Trevisan,&nbsp;Roger Rodrigo Fernandes,&nbsp;Marcio Mateus Beloti,&nbsp;Andréa Cândido dos Reis","doi":"10.1002/jbm.b.35554","DOIUrl":"https://doi.org/10.1002/jbm.b.35554","url":null,"abstract":"<div>\u0000 \u0000 <p>This study aimed to assess the impact of manufacturing methods (conventional and additive manufacturing) and surface treatments (polished and nanotopographic) on the physicochemical properties of Ti6Al4V alloy and their correlation with osteoblast cellular behavior. The evaluated groups were Machined Discs (MD), Machined Discs with Treatment (MD-WT), Additive-manufactured Discs (AD), and Additive-manufactured Discs with Treatment (AD-WT). Surface analyses included SEM, AFM, surface roughness, EDS, XRD, surface free energy, and zeta potential. MC3T3-E1 cells were cultured for biological assessments, including cell morphology, viability, gene expression, alkaline phosphatase activity, and mineralization. ANOVA and Holm-Sidak tests were applied (<i>p</i> &lt; 0.05). MD exhibited grooved topography, AD had partially fused spherical particles, while MD-WT and AD-WT showed patterns from chemical treatment (H₃PO₄ + NaOH). EDS identified additional ions in MD-WT and AD-WT. XRD patterns indicated crystal lattice orientation differences. MD-WT and AD-WT displayed higher surface free energy than MD and AD (<i>p</i> &lt; 0.05). AD had greater roughness (Sa 6.98 μm, <i>p</i> &lt; 0.05). Biological analyses revealed higher cell viability for MD and AD (<i>p</i> &lt; 0.001), higher ALP activity in MD, and lower in AD-WT. Gene expression varied, with MD showing higher <i>Alpl</i>, <i>Ibsp</i>, and <i>Bglap</i> (<i>p</i> &lt; 0.001), and AD-WT showing higher <i>Runx2</i> (<i>p</i> &lt; 0.001). Mineralized matrix behavior was similar for MD, AD, and MD-WT (<i>p</i> &gt; 0.05). MD and AD surfaces demonstrated superior osteogenic differentiation potential, while AD exhibited greater roughness, lower surface free energy, higher cell viability, and osteoblastic differentiation potential.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143581804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Mechanical Strength, Translucency, and Microstructure in Graded Zirconia Layers Before and After Hydrothermal Aging","authors":"Pablo Machado Soares,&nbsp;Luiza Freitas Brum Souza,&nbsp;Lucas Saldanha da Rosa,&nbsp;Luiz Felipe Valandro,&nbsp;Lucio Strazzabosco Dorneles,&nbsp;Alice Penteado Holkem,&nbsp;Paola de Azevedo Mello,&nbsp;Edson Irineu Müller,&nbsp;Atais Bacchi,&nbsp;Gabriel Kalil Rocha Pereira","doi":"10.1002/jbm.b.35550","DOIUrl":"https://doi.org/10.1002/jbm.b.35550","url":null,"abstract":"<div>\u0000 \u0000 <p>This study aimed to evaluate the monotonic and fatigue strength, translucency, topography, and grain size of different layers in two types of graded zirconia, both before and after hydrothermal aging. A total of 180 bar-shaped specimens (<i>n</i> = 15 per group) were prepared from each layer (cervical, transitional, and incisal) of two graded zirconias (IPS e.max ZirCAD MT Multi—4 mol% yttrium stabilized at the cervical region and 5 mol% at the incisal region; IPS e.max ZirCAD Prime, Ivoclar AG—3 mol% yttrium stabilized at the cervical region and 5 mol% at the incisal region) with dimensions of 14.0 × 4.0 × 3.0 mm, following ISO 6872 standards for a three-point-bending test. These specimens were divided into two groups: baseline and hydrothermal aging (134°C under 2 bars of pressure for 20 h). Monotonic and fatigue three-point bending tests (initial stress: 250 MPa/5000 cycles at 20 Hz; increments: 50 MPa/step) were performed until fracture. The translucency parameter (TP00) was calculated using the CIEDE2000 formula, and <i>L</i>*, <i>a</i>*, <i>b</i>* color coordinates were measured on disc-shaped specimens (<i>n</i> = 6 per layer; Ø = 10 mm, 1 mm thickness) before and after aging. Additional analyses included topography, fractography, and grain size. Data were analyzed using three-way ANOVA, Kaplan–Meier, and Mantel-Cox post hoc tests (log-rank). Hydrothermal aging decreased fatigue flexural strength across all layers and types of graded zirconia. After aging, the fatigue flexural strength of Prime zirconia was higher than that of MT Multi in the cervical layer. The cervical layers exhibited the highest flexural strength and smallest grain size, while incisal layers showed higher translucency compared to other layers. The induced aging protocol impacted the mechanical properties of the graded zirconia layers. Each layer within the multilayer zirconia systems displayed distinct mechanical, microstructural, and optical properties, with variations depending on the specific zirconia material. Overall, all layers demonstrated satisfactory performance, supporting the use of multilayer zirconia systems.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Compromised Maxillofacial Wound Healing Model for Characterization of Particulate Bone Grafting: An In Vivo Study in Rabbits","authors":"Nourhan Hussein,&nbsp;Vasudev Vivekanand Nayak,&nbsp;Neeraja Dharmaraj,&nbsp;Nicholas A. Mirsky,&nbsp;William Norton,&nbsp;Lori Ramagli,&nbsp;Ramesh Tailor,&nbsp;F. Kurtis Kasper,&nbsp;Paulo G. Coelho,&nbsp;Lukasz Witek,&nbsp;Simon Young","doi":"10.1002/jbm.b.35556","DOIUrl":"https://doi.org/10.1002/jbm.b.35556","url":null,"abstract":"<div>\u0000 \u0000 <p>Preclinical testing of tissue engineering modalities are commonly performed in a healthy wound bed. These conditions do not represent clinically relevant compromised oral wound environments due to radiation treatments seen clinically. This study aimed to characterize the bone regeneration outcomes in critical-sized mandibular defects using particulate grafting in an irradiated preclinical model of compromised wound healing. Sixteen New Zealand white rabbits were divided into two groups (<i>n</i> = 8/group), namely (i) irradiated (experimental) and (ii) non-irradiated (control). The rabbits in the experimental group received a total of 36 Gy radiation, followed by surgical intervention to create critical-sized (10 mm), full-thickness mandibular defects. The control group was subjected to the same surgical intervention. All defects were filled with bovine bone grafting material (Bio-Oss, Geistlich, Princeton, NJ, USA) and allowed to heal for 8 weeks. At the study endpoint, rabbits were euthanized, and their mandibles were harvested for micro-computed tomographic, histological, and histomorphometric processing and analysis. Qualitative histological analysis revealed increased levels of bone formation and bridging in the control group relative to the experimental group. This was accompanied by increased levels of soft tissue presence in the experimental group. Volumetric reconstruction showed a significantly higher degree of bone in the control group (27.59% ± 2.71), relative to the experimental group (22.02% ± 2.71) (<i>p</i> = 0.001). The irradiated rabbit model exhibited decreased bone regeneration capacity relative to the healthy subjects, highlighting its suitability as a robust compromised wound healing environment for further preclinical testing involving growth factors or customized, high-fidelity 3D printed tissue engineering scaffolds.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesoporous Bioactive Glass-Based Composite Cryogel for Noncompressible Hemorrhage","authors":"Jie Zhou,&nbsp;Yang Liu,&nbsp;Changren Mo,&nbsp;Kun Yang,&nbsp;Guangyu Zhang","doi":"10.1002/jbm.b.35552","DOIUrl":"https://doi.org/10.1002/jbm.b.35552","url":null,"abstract":"<p>Uncontrollable bleeding is one of the important causes of death in war, road traffic injuries, surgical accidents, and other accidents. Using hemostatic materials to control bleeding quickly and effectively can improve the survival rate of patients, especially for incompressible visceral bleeding. Traditional inorganic materials and natural polymers alone still have limitations, such as non-degradability and ineffective control of bleeding through wounds. In this work, we designed a cryogel sponge combined Mesoporous bioactive glass (MBG) with Gelatin Methacryloyl (GelMA), which has enhanced mechanical strength and improved in vitro coagulation properties. And MBG@GelMA cryogel could absorb water more than 5 times in 5 min, while it also demonstrates significant improvement in mechanical strength from 4 kap to 12 kpa. Additionally, MBG@GelMA cryogel showed excellent biocompatibility and hemostatic performance. The multi-stage pore structure and hydrophilicity of frozen gel and MBG help to concentrate blood quickly and activate endogenous coagulation pathway through the release of calcium ions to promote coagulation. The findings of this study demonstrate that the MBG@GelMA composite cryogel possesses outstanding properties in terms of hemostasis, portability, and ease of use, suggesting its remarkable potential as a promptly applicable hemostatic material in both civil and military settings.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Reliability and Stress Distribution of Wide Diameter Extra-Short Implants as Support for Single Crowns and Fixed Partial Dentures","authors":"Vanessa Felipe Vargas-Moreno,&nbsp;Michele Costa de Oliveira Ribeiro,&nbsp;Rafael Soares Gomes,&nbsp;Edmara Tatiely Pedroso Bergamo,&nbsp;Estevam Augusto Bonfante,&nbsp;Altair Antoninha Del Bel Cury,&nbsp;Raissa Micaella Marcello-Machado","doi":"10.1002/jbm.b.35560","DOIUrl":"https://doi.org/10.1002/jbm.b.35560","url":null,"abstract":"<div>\u0000 \u0000 <p>This study evaluated the reliability, failure mode, and stress distribution of wide-diameter extra-short dental implants (ESDI) as support for single crowns (SC) and fixed partial dentures (FPD) (3:1 crown-to-implant ratio [<i>C</i>:<i>I</i>]) for rehabilitation in the posterior atrophic mandible. For that, 126 ESDI (of 5 mm length) were allocated in four groups based on diameter (Ø4 and Ø6 mm) and prostheses (SC and FPD): SC4, SC6, FPD4, and FPD6. The fatigue test was performed by step-stress accelerated life testing (<i>n</i> = 21/group), failure mode by fractographic analysis, and stress distribution by finite element analysis: von Mises stress (<i>σ</i>_vM), maximum shear stress (<i>τ</i>_max), and minimum principal stress (<i>σ</i>_min). Reliability at 200 N was higher than 84% in both SC4 and SC6, with SC6 showing significantly higher reliability at 300 N. Failure mode involved the abutment (SC4 and SC6). The missions were suspended for the FPD groups due to 100% survival at the maximum load. The <i>σ</i>_vM showed a stress reduction of about 40% at the SC6 implant when compared to SC4 and FPD6 compared to FPD4. For the abutment, a minor decrease of at least 6.72% was observed comparing SC6 to SC4 and 2.78% for the FPD6 compared to FPD4. The <i>τ</i>_max and <i>σ</i>_min in the cortical bone demonstrated a stress reduction of at least 38.85% for the SC6 compared to SC4 and at least 3.78% in FPD6 compared to FPD4. The <i>σ</i>_min in the cancellous bone showed an overall reduction of at least 8.46% for SC6 compared to SC4 and for FPD6 compared to FPD4. But, for <i>τ</i>_max, in the cancellous bone, a 19.42% higher stress was found in SC6 compared to SC4 and 27.21% in FPD6 compared to FPD4. Finally, when splinting was used, a general stress reduction was found, about 50% in both diameters in the implant and abutment. According to the limitations of this in vitro study, it is possible to conclude that both groups (SC4 and SC6) showed high reliability in clinically relevant loads for the posterior atrophic mandible, SC6 having the lowest probability of failure at 300 N, with failure restricted to the abutment. Meanwhile, FPD6 has better stress distribution.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Coatings: Advanced Strategies Driving Multifunctionality and Clinical Potential in Dermal Substitutes","authors":"Yixin Wu,&nbsp;Chao Ji,&nbsp;Zhenzhen Yan,&nbsp;Xiaowan Fang,&nbsp;Yuxiang Wang,&nbsp;Yicheng Ma,&nbsp;Jingzhu Li,&nbsp;Shunxin Jin,&nbsp;Hao Chen,&nbsp;Shizhao Ji,&nbsp;Yongjun Zheng,&nbsp;Shichu Xiao","doi":"10.1002/jbm.b.35545","DOIUrl":"https://doi.org/10.1002/jbm.b.35545","url":null,"abstract":"<div>\u0000 \u0000 <p>Skin tissue defects caused by various acute and chronic etiologies frequently occur in clinical medicine. Traditional surgical repair methods have certain limitations, while dermal substitutes combined with skin grafting have become an alternative to conventional surgery. Biological coatings, by loading bioactive substances such as polysaccharides and proteins, or by using bioactive substances as carriers, can promote cell adhesion, proliferation, and differentiation. This optimizes the mechanical properties and biocompatibility of the substitutes, enhances their antibacterial properties, and improves their feasibility for clinical application. This paper explores various common biological coating materials and the construction methods used in the field of dermal substitutes. It highlights the importance and necessity of biological coatings in the development of multifunctional designs for dermal substitutes. By summarizing the current research, this paper aims to offer new insights and references for the multifunctional design and clinical application of dermal substitutes.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}