Journal of biomedical materials research. Part B, Applied biomaterials最新文献

{"title":"β-TCP/Collagen Composite Scaffolds Facilitate Bone Remodeling in Vertebral Plate Fusion","authors":"Jichen Liu,&nbsp;Shaowei Xu,&nbsp;Haishan Xu,&nbsp;Wei He,&nbsp;Xuegang Liang,&nbsp;Zhen Wang","doi":"10.1002/jbm.b.70140","DOIUrl":"https://doi.org/10.1002/jbm.b.70140","url":null,"abstract":"<div>\u0000 \u0000 <p>β-tricalcium phosphate (β-TCP) is widely used as a bone substitute because of its biocompatibility, osteoconductivity, and biodegradability; however, its brittleness and limited adaptability to irregular bone surfaces may restrict its performance in spinal fusion. This study aimed to evaluate whether a β-TCP/collagen composite scaffold could enhance osteogenesis and promote sustained bone remodeling in a sheep lumbar interlaminar fusion model. β-TCP/collagen composite scaffolds and β-TCP scaffolds were compared in vitro using MC3T3-E1 osteogenic precursor cells. Cell adhesion, proliferation, apoptosis, extracellular matrix mineralization, and osteogenic differentiation were assessed by scanning electron microscopy, CCK-8 assay, flow cytometry, alizarin red staining, alkaline phosphatase staining, RT-qPCR, and western blotting. In vivo, β-TCP and β-TCP/collagen scaffolds were implanted into the L3–L4 and L4–L5 interlaminar spaces, respectively, in a self-controlled sheep model. Bone formation and remodeling were evaluated by X-ray, micro-CT, and Van Gieson staining at 3, 5, and 8 months after surgery. The β-TCP/collagen scaffold showed a porous collagen-containing structure that supported greater MC3T3-E1 cell spreading and pseudopod extension than β-TCP alone. Cell proliferation on the β-TCP/collagen scaffold was significantly increased from day 3, whereas apoptosis remained low in all groups, with apoptotic cells accounting for less than 5%. Alizarin red and alkaline phosphatase staining showed more pronounced extracellular matrix mineralization in the β-TCP/collagen group. RT-qPCR and western blotting further demonstrated enhanced expression of osteogenic markers in the β-TCP/collagen group compared with β-TCP alone. In the sheep lumbar interlaminar fusion model, radiological, and histological analyses showed more sustained new bone formation and more organized trabecular remodeling in the β-TCP/collagen group. The β-TCP/collagen composite scaffold enhanced osteogenic activity in vitro and promoted more sustained bone remodeling in a sheep lumbar interlaminar fusion model compared with β-TCP alone. These findings suggest that β-TCP/collagen scaffolds may provide a clinically relevant biomaterial strategy for posterior spinal fusion, although further studies are needed to clarify the mechanisms underlying scaffold-mediated vascularized bone remodeling.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148695772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Response to Electrocompacted Tendon-Derived Thread Scaffolds During Tendon Repair","authors":"Joohee Choi,&nbsp;Phillip McClellan,&nbsp;Maximilian Zernic,&nbsp;Kamal Gautam,&nbsp;James M. Anderson,&nbsp;Ozan Akkus","doi":"10.1002/jbm.b.70135","DOIUrl":"10.1002/jbm.b.70135","url":null,"abstract":"<p>Tendon injuries remain a major clinical challenge due to the tissue's limited regenerative capacity and poor remodeling of current allograft-based therapies. To address these limitations, we developed a tendon-derived thread (TDT) scaffold by electrocompacting decellularized tendon powder into aligned threads, which were subsequently woven into a porous overlay patch. Biochemical analyses of TDT confirmed efficient decellularization (DNA &lt; 50 ng/mg) and the preservation of collagen and proteoglycans. Compared to en bloc human tendon graft (HTG), the TDT scaffold exhibited significantly higher swelling ratios and greater weight loss over 8 weeks in vitro, indicating greater porosity and faster degradation. In a rabbit infraspinatus partial-thickness fenestration injury model, the TDT scaffold and HTG were sutured over the injury and evaluated at 2 and 8 weeks to observe tissue infiltration and in vivo response to biomaterial degradation during early phases of healing. Biomechanical testing of shoulders showed no significant differences in load relaxation, ultimate tensile strength, and stiffness among intact, HTG, and TDT scaffold groups in this injury model, suggesting comparable mechanical restoration. Histological and gross observations indicated progressive resorption of TDT scaffolds, which were infiltrated by cells at 2 weeks, and neotissue formation was evident by 8 weeks. In contrast, cell infiltration into the allograft was limited at both time points, and there was no evidence of degradation in vivo. These findings support the potential of the TDT scaffold as a degradable scaffold to support tendon healing during injury.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.70135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148678739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Therapeutic Potential of H2S-Releasing Platforms in Cardiovascular Applications","authors":"Tia N. Shorter,&nbsp;Elizabeth J. Brisbois","doi":"10.1002/jbm.b.70133","DOIUrl":"10.1002/jbm.b.70133","url":null,"abstract":"<p>Once known as a toxic gas, hydrogen sulfide (H₂S) is now making its way into many therapeutic applications. Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H₂S is a small gas with a short half-life, making it extremely capable of penetrating through cell membranes quite easily and fast via gas exchange. This fundamental small molecule possesses many physiological and pathological functions and is found in almost every mammalian system, such as the cardiovascular system, the integumentary/skin system, the neural system, the gastrointestinal tract system, and the skeletal system. As a therapeutic, the gas can modulate biological pathways, maintain homeostasis under physiological conditions, and mediate several pathological processes, thereby supporting cardioprotective applications. Due to the ever-increasing cardiovascular complications, especially concerning myocardial infarction and atherosclerosis, more and more patients are suffering from heart failure, and in some cases, this results in death. To remedy the progression of cardiovascular complications and cardiovascular disease burden as a whole, H₂S has emerged as a potential candidate to mediate this problem. This review will specifically focus on the therapeutic potential of H₂S-releasing platforms tailored to aid in cardiovascular applications.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.70133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Autologous and Allogeneic Platelet-Rich Fibrin in the Repair of Chronic Wounds","authors":"Jiali Miao,&nbsp;Naziat Begum,&nbsp;Tariq Aziz,&nbsp;Lijun Zhang,&nbsp;Shangsheng Yao,&nbsp;Yifan Zhang,&nbsp;Yating Wei,&nbsp;Yongkang Zhu,&nbsp;Xin Liu,&nbsp;Jinhui Chen,&nbsp;Guangtao Huang,&nbsp;Jun Wu","doi":"10.1002/jbm.b.70119","DOIUrl":"10.1002/jbm.b.70119","url":null,"abstract":"<div>\u0000 \u0000 <p>Chronic wounds remain a significant clinical challenge, primarily because of persistent obstacles including prolonged healing duration, high recurrence rates, and limited responsiveness to standard therapies. These limitations impose a considerable burden, which severely affects patients' quality of life. Autologous platelet-rich fibrin has emerged as a promising regenerative strategy to overcome these challenges; however, its clinical utility is restricted in patients with underlying conditions such as diabetic foot ulcers or impaired platelet function. In this context, allogeneic platelet-rich fibrin has been proposed as a promising therapeutic alternative, offering distinct advantages in selected patient populations. This study provides a comparative evaluation of autologous versus allogeneic platelet-rich fibrin in the management of persistent wounds, specifically assessing wound area reduction, granulation tissue score quality, and time of healing. Seventeen patients with prolonged, chronic non-healing wounds were assigned to two groups: autologous platelet-rich fibrin (<i>n</i> = 6) and allogeneic platelet-rich fibrin (<i>n</i> = 11). Despite a significant difference in pre-treatment wound duration (6 vs. 13 weeks, <i>p</i> &lt; 0.05), both groups showed a remarkable reduction in wound area, from a median of 7.50 to 1.25 cm² within 2 weeks, with no statistical difference in healing rates (<i>p</i> &gt; 0.05). Granulation tissue scores improved markedly post-treatment, with 64.71% of patients achieving a score of 4/5, regardless of the source. Autologous platelet-rich fibrin demonstrated a faster complete healing time (30.67 vs. 48.27 days, <i>p</i> &lt; 0.05). Treatment with allogeneic platelet-rich fibrin on a diabetic foot ulcer resulted in an 85.7% reduction in affected area, reaching complete closure within a five-week period. The findings show that while both groups are equally proficient in stimulating wound closure and tissue regeneration, the autologous method may accelerate the final stage of the healing process. This research encourages the broader use of allogeneic alternatives, particularly for patients with insufficient autologous blood, without compromising healing quality.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Bioceramic Systems for Wound Regeneration: Design, Mechanisms and Therapeutic Applications","authors":"Behnaz Niroomand,&nbsp;Mahdi Farokhi,&nbsp;Ibrahim Mohammadzadeh,&nbsp;Ehsaneh Azaryan","doi":"10.1002/jbm.b.70127","DOIUrl":"10.1002/jbm.b.70127","url":null,"abstract":"<div>\u0000 \u0000 <p>Chronic wounds constitute a global crisis that has a substantial financial and social impact on healthcare systems. Many attempts have been made in recent decades to create bioceramic-based wound dressing materials to aid in the healing process. Bioceramics are frequently used as materials or alternatives for bone repair because of their strong mechanical qualities. Both soft and hard tissues can be repaired thanks to the release of various metallic ions from bioceramics. Cell motility, proliferation, differentiation, adhesion, angiogenesis, and antibiosis may all benefit from these ions. These substances can be added to sophisticated composite systems like hydrogels, porous scaffolds, films, and membrane-based dressings, or they can be used on their own as powders or suspensions of nanoparticles. Bioceramic-based wound dressings have a lot of potential, but their clinical application is still constrained by a number of issues, such as their inherent brittleness, low mechanical flexibility, poor degradation control, and occasionally inadequate interaction with the dynamic wound environment. However, incorporating bioceramics into scaffold-based platforms may help get around many of these restrictions. Furthermore, the scaffold architecture can improve the overall therapeutic performance of bioceramic systems by better simulating the extracellular matrix and enabling controlled delivery of bioactive components. This review focuses on advanced ceramic-based wound dressings and their role in enhancing structural support, promoting cell attachment and proliferation, and creating a favorable environment for skin regeneration.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148603435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot Histomorphometric Study of Combined Use of Poly-L-Lactic Acid and Calcium Hydroxyapatite to Improve Dermis Remodeling","authors":"Pedro Ivo Romani de Oliveira Gonçalves,&nbsp;Flavia Pedrini,&nbsp;Isabela Rodrigues de Souza Barros,&nbsp;Rogério de Oliveira Ruiz,&nbsp;Eliana A. Rezende Duek,&nbsp;Moema de Alencar Hausen","doi":"10.1002/jbm.b.70124","DOIUrl":"10.1002/jbm.b.70124","url":null,"abstract":"<p>Injectable collagen biostimulators such as Calcium Hydroxyapatite and Poly-L-Lactic Acid are well-established in regenerative dermatology for their ability to induce neocollagenesis and improve skin quality. Despite their proven individual efficacy, the combined use of these biomaterials remains underexplored. This study aimed to evaluate the histological and stereological effects of Calcium Hydroxyapatite, Poly-L-Lactic Acid, and their combination on dermal remodeling and connective tissue deposition. A pilot histomorphometric study was conducted in patients undergoing abdominoplasty, allowing access to treated and untreated tissue. Injections of Calcium Hydroxyapatite, Poly-L-Lactic Acid, their combination (Composite), or saline were administered in infraumbilical areas, using intradermal and deep dermal planes according to the material. Tissue samples were collected at D-30 (before intervention), and at 60 and 120 days for analysis. Histological assessment included fiber density, organization, and inflammatory infiltrates. Stereological analysis was performed using the point-counting method to quantify extracellular matrix (ECM) content. Results showed that all active treatments induced significant dermal remodeling compared with controls. Calcium Hydroxyapatite and Poly-L-Lactic Acid individually led to increased fiber bundle thickness and reduced interstitial spaces. The Composite group demonstrated the most pronounced effects, with fiber compaction and enhanced ECM remodeling. The ECM content increased up to 1000% by 60 days, with slower gains between 60 and 120 days, suggesting early peak stimulation followed by stabilization. In conclusion, the combination of Calcium Hydroxyapatite and Poly-L-Lactic Acid resulted in superior histological outcomes compared with isolated applications. These findings support the potential of a dual-modality dermis biostimulation as a promising strategy for treating skin laxity.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.70124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148591360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Characterization of Thiol-Ene Microparticles for Doxycycline Delivery","authors":"Chipo Chapusha,&nbsp;Nicholas McGowan,&nbsp;Paige Smith,&nbsp;Mary Carr,&nbsp;Mary E. Marquart,&nbsp;Jared Cobb,&nbsp;Amol V. Janorkar","doi":"10.1002/jbm.b.70132","DOIUrl":"10.1002/jbm.b.70132","url":null,"abstract":"<div>\u0000 \u0000 <p>Osteomyelitis is a significant clinical challenge that leads to bone destruction and loss. Systemic antibiotic treatments do not reach infected sites at therapeutic levels, necessitating high dosages, which in turn can lead to toxicity and promote the emergence of antibiotic-resistant bacteria. To overcome these challenges, our objective was to synthesize a biocompatible drug-delivery system that has the potential to achieve localized antibiotic delivery to completely eradicate bacteria. We synthesized four formulations of microparticles using thiol-ene click chemistry by varying the thiol monomer-to-crosslinker (2-thiol:4-thiol) ratio and the ene monomer-to-surfactant (2-ene:Hitenol) ratio. The microparticles were loaded with doxycycline by soaking them in 20 or 50 mg/mL doxycycline (D20 or D50) over 24 h. The microparticles exhibited a payload-dependent release, with the D20 groups releasing approximately 11%–22% of their total doxycycline content, while the D50 groups released less than 10% of the total doxycycline content by 96 h. All doxycycline-loaded microparticle formulations showed antibacterial activity against Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) over a 7-day period, with the formulation with a 2-thiol:4-thiol ratio of 0.1:0.9 and a 2-ene:Hitenol ratio of 0.8:0.2 showing complete eradication of bacteria by Day 7. The MTT and Live/Dead assays showed that doses of 12 mg or less of this formulation were not cytotoxic to mouse pre-osteoblast cells. Taken together, we successfully synthesized a biocompatible microparticle-based drug delivery system that can be loaded with doxycycline and that exhibits drug release under physiological conditions.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current-Generation Crosslinked Polyethylenes for Total Hip Arthroplasty: Mechanistic Insights Into Oxidative Stability and Antioxidant Efficiency","authors":"Yasuhito Takahashi,&nbsp;Toshiyuki Tateiwa,&nbsp;Kengo Yamamoto","doi":"10.1002/jbm.b.70134","DOIUrl":"10.1002/jbm.b.70134","url":null,"abstract":"<p>Highly crosslinked polyethylene (XLPE) has revolutionized total hip arthroplasty (THA), but increased radiation doses and complex crosslink structures may increase oxidation susceptibility. The long-term oxidative stability of XLPE depends on manufacturing factors, including crosslink density, antioxidant (vitamin E) concentration, incorporation method, and radiation parameters. This study examined their interplay in current-generation XLPE acetabular liners produced by sequential irradiation and annealing, vitamin E diffusion, or grafting under extended accelerated aging. XLPE liners were thermally aged at 70°C in 5 atm oxygen for up to 18 weeks. Raman and Fourier-transform infrared spectroscopy were used to assess oxidative degradation via oxidation index (OI), <i>trans</i>-vinylene index (TVI), vitamin E index (VEI), and phase composition. Sequentially irradiated and annealed XLPE showed a sigmoidal OI increase with post-aging crystallization, indicating structural reorganization and potential embrittlement. In contrast, all vitamin E-stabilized XLPEs (0.1–0.7 wt%) maintained negligible OI values. Although an inverse correlation between VEI and OI was not strictly observed, OI increased with TVI, suggesting that higher crosslink density may increase oxidation susceptibility despite overall negligible oxidation. Vitamin E-diffused XLPEs exhibited greater antioxidant depletion than grafted variants but demonstrated comparable oxidation resistance. These findings highlight the inherent limitations of sequentially irradiated and annealed XLPE in resisting oxidation due to persistent residual free radicals, whereas vitamin E stabilization, either by diffusion or grafting, effectively suppressed oxidation and preserved XLPE integrity. Although formulations differed in vitamin E concentration, incorporation route, and radiation source, these factors exerted only secondary influence once approximately 0.1 wt% vitamin E was incorporated.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.70134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148455923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Model Explaining the Competition Between Calcium Phosphate Resorption and Bone Formation in Sheep Model","authors":"Bikramjit Basu,&nbsp;Susantika Paik,&nbsp;Abhay Nagaraj,&nbsp;Marc Bohner","doi":"10.1002/jbm.b.70115","DOIUrl":"10.1002/jbm.b.70115","url":null,"abstract":"<div>\u0000 \u0000 <p>The biocompatibility of bioresorbable ceramics is critically influenced by the interplay between ceramic resorption and bone formation. This study presents a mathematical framework to quantitatively model the competition between these processes using beta-tricalcium phosphate (<i>β</i>-TCP) as a model system. Such a framework incorporates the paracrine and autocrine signaling interactions among osteoblasts and osteoclasts. While analysing in vivo data (sheep model), the temporal dynamics of bone formation and ceramic resorption are evaluated. The model predictions align closely with the experimental results, capturing key biophysical mechanisms. Apart from fitting with empirical models, the bone growth kinetics data of the published studies follow Hill's model closely, which is regarded as the foundation of quantitative pharmacology. While analysing its physiological relevance, the parametric sensitivity analysis reveals the dominant influence of osteoclast removal rates and specific signaling pathways (osteoblast-to-osteoblast and osteoblast-to-osteoclast) on bone growth. The competition between bone growth and <i>β</i>-TCP resorption leads to a cross-over at 6 weeks, which correlates well with the time period to produce the half-of-the-maximum bone growth as per Hill's model. These findings provide insights into optimising the design of bioresorbable ceramics for clinical applications, emphasising the tailoring of resorption rates to support bone growth, in vivo.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148446681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shape-Dependent Self-Assembled Targeting Peptide Electrosensitizer for Enhanced Radiofrequency Ablation of Lipid-Rich Atherosclerotic Plaques","authors":"Ruizhe Hou,&nbsp;Yu Yi,&nbsp;Quanshu Han,&nbsp;Jincheng Zou,&nbsp;Shiqing Zhao,&nbsp;Hao Wang,&nbsp;Aili Zhang","doi":"10.1002/jbm.b.70118","DOIUrl":"10.1002/jbm.b.70118","url":null,"abstract":"<div>\u0000 \u0000 <p>Radiofrequency ablation (RFA) is an effective strategy in realizing targeted lesions. However, its application for highly heterogeneous tissues like lipid-rich atherosclerotic plaques remains challenging due to its strong dependence on Joule heating. Current electrosensitizers used to enhance radiofrequency (RF) energy deposition are limited by their reliance on passive diffusion and random distribution. In this study, inspired by Geobacter OmcZ nanowire networks, electrosensitive atherosclerosis-targeting self-assembled peptides (EASPs) are designed as RF sensitizers to improve the heat deposition in lipid-rich plaques. Based on a targeting motif and a self-assembling module, EASPs accumulate in inflammatory regions of the aorta via recognition-induced self-assembly, resulting in in situ network aggregation. Taking advantage of the rapid amplification of nanofiber networks triggered by vascular cell adhesion molecule-1 and the unique shape-dependent electrical properties of the design, the local conductivity exhibits a rapid and sustained increase following systemic delivery, exceeding 2.39-fold the initial level within 2 h. EASP-assisted RFA demonstrates a significant enhancement in heat deposition, characterized by increased temperatures and expanded ablation zones in the diseased arteries. Notably, the 4 h accumulation group exhibited a 59.85% higher temperature increase and a 94.48% greater ablation area than the 2 h group. Through the integration of nanotechnology, this study provides a new approach to improving both the targeting precision and therapeutic efficiency of RFA-based atherosclerosis treatment.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}