Journal of biomedical materials research. Part B, Applied biomaterials最新文献

{"title":"Biosafety and Efficacy Studies of Colchicine-Encapsulated Liposomes for Ocular Inflammatory Diseases","authors":"Lu Yuan,&nbsp;Daohuan Kang,&nbsp;Liping Teng,&nbsp;Nan Chen,&nbsp;Jiao Zhan,&nbsp;Rui Yu,&nbsp;Yong Wang,&nbsp;Bin Lu","doi":"10.1002/jbm.b.35540","DOIUrl":"10.1002/jbm.b.35540","url":null,"abstract":"<div>\u0000 \u0000 <p>Inflammation is a critical component in the progression of various ocular diseases, such as age-related macular degeneration, diabetic retinopathy, and uveitis, leading to significant vision loss. Colchicine has been used for treating gout with its anti-inflammatory effect. However, free colchicine demonstrated cytotoxicity to ocular cells and cannot directly be used for eye disease. Thus, this study introduces, for the first time, the development and use of colchicine-encapsulated liposomes as a novel therapeutic approach for managing inflammation-driven ocular conditions. The encapsulation of colchicine within liposomes represents a significant innovation, aimed at enhancing biocompatibility and therapeutic efficacy while minimizing cytotoxic effects associated with free colchicine. Our research synthesized colchicine-loaded liposomes and assessed their therapeutic impact on human monocytes, macrophages, and retinal pigment epithelium (RPE) cells in an inflammatory environment. The findings reveal a groundbreaking improvement in treatment strategies, with a substantial reduction in TNF-alpha-induced reactive oxygen species (ROS) and nitric oxide (NO) production in RPE cells. Moreover, the colchicine-loaded liposomes significantly inhibited the proliferation and ROS production in activated monocytes and macrophages and effectively decreased interleukin (IL)-1β and IL-6 secretion, highlighting their strong anti-inflammatory properties and showed slightly better suppression of these two cytokines than dexamethasone-liposomes.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cutting-Edge Multilayer Nanofiber Wound Dressing: Design, Synthesis, and Investigation for Enhanced Wound Healing In Vitro and In Vivo","authors":"Irem Mukaddes Bilgiseven,&nbsp;Ilyas Deveci,&nbsp;Kemal Kismet,&nbsp;Serdar Karakurt","doi":"10.1002/jbm.b.35544","DOIUrl":"10.1002/jbm.b.35544","url":null,"abstract":"<div>\u0000 \u0000 <p>Wounds, disruptions in normal anatomy, are classified as acute or chronic. The choice of wound treatment relies significantly on dressing materials. Electrospun nanofibrous materials offer promising applications in wound healing, featuring a substantial surface area, close mimicry of the natural extracellular matrix, and adjustable water resistance, air permeability, and drug release. This research endeavors to formulate an innovative three-layered nanofibrous wound dressing using the electrospinning technique with the primary objectives of enhancing patient well-being, exhibiting antimicrobial characteristics, and expediting wound healing. The designed dressing comprises nanofibers of polyurethane (PU), quercetin (Q)-loaded polyethylene glycol (PEG), polyvinyl alcohol (PVA), and gelatin. Characterization of individual layers and the integrated wound dressing was conducted through SEM and FT-IR analyses. The efficacy of the nanofibrous wound dressing was assessed through in vitro human cell culture and in vivo rat wound models. The anti-toxic effects of nanofiber wound dressing on human epithelial and keratin cells have been proven. In vitro wound models in 24-well plates were utilized to assess the impact on wound healing rates. Photographic documentation of wound closure was performed at the different treatment hours, revealing complete closure of the wounds by the end of the 48th hour. Rats with 2 × 1 cm wounds were treated with the nanofibrous dressings, and wound healing progress was observed over a 14-day period. qRT-PCR was employed to analyze MMP-9, TIMP1, COL1A1, PDGFA, and VEGFC mRNA expressions. With its contemporary design surpassing existing treatments, the nanofiber wound dressing stands out for its wound-healing acceleration and antibacterial properties.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simvastatin-Loaded Chitosan Microspheres as a Biomaterial for Dentin Tissue Engineering","authors":"Erika Soares Bronze-Uhle,&nbsp;Camila Correa da Silva Braga de Melo,&nbsp;Isabela Sanches Pompeo da Silva,&nbsp;Vitor de Toledo Stuani,&nbsp;Victor Hugo Bueno,&nbsp;Daniel Rinaldo,&nbsp;Carlos Alberto de Souza Costa,&nbsp;Paulo Noronha Lisboa Filho,&nbsp;Diana Gabriela Soares","doi":"10.1002/jbm.b.35536","DOIUrl":"10.1002/jbm.b.35536","url":null,"abstract":"<div>\u0000 \u0000 <p>In the present study, chitosan microspheres (MSCH) loaded with different concentrations of simvastatin (2%, 5%, and 10%) were synthesized as a biomaterial for dentin tissue engineering. The microspheres were prepared by emulsion crosslinking method, and simvastatin was incorporated during the process. The microspheres were then physicochemically and morphologically characterized. Scanning electron microscopy and infrared spectroscopy confirmed the spherical morphology of synthesized microspheres and the chemical incorporation of simvastatin into MSCH, respectively. UV–visible absorption confirmed the controlled and continuous release pattern of the drug. To mimic the clinical application in vitro, the microspheres were applied onto three-dimensional (3D) cultures of human dental pulp cells (HDPCs). Cell viability, proliferation, and in situ-mineralized matrix deposition were evaluated. The results indicated no cytotoxic effects for all 3D cultures for all tested biomaterials, with cells being able to proliferate significantly over time. HDPCs showed a significant increase in the deposition of mineralization nodules when 3D cultures were in direct contact with chitosan microspheres in comparison to control; nevertheless, the highest expression was observed for MSCH encapsulated with 5% and 10% simvastatin, which was significantly higher than plain MSCH. Therefore, chitosan microsphere systems loaded with 5%–10% simvastatin provided the development of a controlled release system in bioactive dosages for dentin tissue engineering.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Silk Fibroin Based Bilayer Scaffolds for Bioabsorbable Internal Biliary Stenting","authors":"Benedetta Isella,&nbsp;Nourhan Hassan,&nbsp;Aleksander Drinic,&nbsp;Roman M. Eickhoff,&nbsp;Nadja Kröger,&nbsp;Ted J. Vaughan,&nbsp;Alexander Kopp","doi":"10.1002/jbm.b.35499","DOIUrl":"10.1002/jbm.b.35499","url":null,"abstract":"<p>Biliary duct reconstruction is one of the most challenging parts of liver transplantation and accounts for 40%–60% of complications. While current stent-based devices on the market show promising results in reducing complications, they are manufactured from permanent synthetic materials and require a second reintervention for their removal. This exposes the patients to other potential complications and increases healthcare costs. This study develops a fabrication technique to produce a bioabsorbable biliary stent based on silk fibroin. The process used a dip-coating procedure for silk fibroin that produced highly smooth monolayer tubular specimens without the use of any additional surfactants during removal. This process was combined with an electrospinning step to produce bilayer structures through the deposition of electrospun silk fibroin on the outer surface. The structures proved to have promising mechanical, morphological, and cytocompatibility properties for use in the field of biliary stenting. Furthermore, the technique investigated proved to be reproducible, achieving an important requirement for large-scale use even in the presence of a biomaterial derived from a natural source. These results show the possibility of obtaining a completely bioabsorbable internal biliary stent that does not require any second reintervention. This study can be the starting point for further investigations both in vitro and in vivo to assess the suitability of silk fibroin biliary stents for clinical applications.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35499","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological, Biomechanical, and Histopathological Evaluation of Polyetherketoneketone Bioactive Composite as Implant Material","authors":"Manar E. Al-Samaray,&nbsp;Abdalbseet A. Fatalla","doi":"10.1002/jbm.b.35535","DOIUrl":"10.1002/jbm.b.35535","url":null,"abstract":"<div>\u0000 \u0000 <p>While polyetherketoneketone is a high-performance thermoplastic polymer, its hydrophobicity and inertness limit bone adhesion. This study aimed to evaluate a novel PEKK/CaSiO₃/TeO₂ nanocomposite, comparing it to PEKK/15 wt.% CaSiO₃ and PEKK groups. The in vitro study, involving 90 discs (<i>n</i> = 30), assessed the cytotoxicity of all groups after 24, 72, and 168 h. The in vivo animal study, using cylinder-type implants (<i>n</i> = 30), evaluated osseointegration through biomechanical push-out tests, descriptive histopathological examinations of decalcified sections stained with hematoxylin and eosin, and histomorphometric analysis of new bone formation area after 2- and 6-week healing intervals. The cytocompatibility of PEKK/15 wt.% CaSiO₃/1 wt.% TeO₂ composite confirmed its acceptance as a biomedical material. Additionally, in vivo study results showed that the PEKK/15 wt.% CaSiO₃/1 wt.% TeO₂ had the highest shear strength value and the highest new bone formation area compared to other experimental groups. The multimodal concept of adding CaSiO₃ micro fillers and TeO₂ nanofillers to PEKK produces a cytocompatible composite that enhances osseointegration and new bone formation in a rabbit's femur after 2- and 6-week healing intervals.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosynthesis of Zinc Oxide Nanoparticles by Origanum majorana Aqueous Leaves Extracts, Characterization and Evaluated Against to Schistosoma haematobium","authors":"Samah S. Eldera,&nbsp;Lila A. Alkhtaby,&nbsp;Reem Al-Wafi,&nbsp;Mohamed Abou El-Nour","doi":"10.1002/jbm.b.35538","DOIUrl":"10.1002/jbm.b.35538","url":null,"abstract":"<div>\u0000 \u0000 <p>Schistosomiasis, caused by <i>Schistosoma</i> worms, is a major neglected tropical disease in Africa, this disease is ranked as second after malaria. Nanotechnology is important for treating schistosomiasis while minimizing chemotherapy side effects. The current investigate aimed to assess the effectiveness of biosynthesized zinc oxide nanoparticles (ZnO NPs), which were used for the first time in an attempt to find alternative treatment for schistosomiasis and synthesized by <i>Origanum majorana</i>, and to compare them with praziquantel (PZQ), the only chemical treatment approved by the World Health Organization. The study included evaluations both in the laboratory and in vivo. In the laboratory experiment, adult worms exposed to ZnO nanoparticles at concentrations of 100, 50, 25, 12.5, 6.25, and 3.125 μg/mL showed the highest complete mortality rates at concentrations of 100 and 50 μg/mL after 6 and 12 h, respectively. Combinations of ZnO nanoparticles at concentrations of 12.5 + 0.4, 25 + 0.3, 50 + 0.2, and 75 + 0.1 μg/mL with PZQ were also tested. In vivo, four groups of hamsters infected with <i>Schistosoma haematobium</i> were treated. In hamsters, the number of eggs present in the tissues as well as the size and number of granulomas significantly decreased when ZnO nanoparticles combined with PZQ were administered. The properties of ZnO particles synthesized by <i>Origanum majorana</i> were consistent and confirmed by all previous studies. These results indicate that green ZnO nanoparticles with PZQ showed high activity against <i>S</i>. <i>haematobium</i> in laboratory experiments.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Biological Properties of Co-Doped Monetite Are Influenced by Thermal Treatment","authors":"Gerson Santos de Almeida,&nbsp;Luisa Camilo Suter,&nbsp;Thais Silva Pinto,&nbsp;Maria Gabriela Jacheto Carra,&nbsp;Géorgia da Silva Feltran,&nbsp;Julia Ferreira de Moraes,&nbsp;Diego Rafael Nespeque Corrêa,&nbsp;Margarida Juri Saeki,&nbsp;Paulo Noronha Lisboa-Filho,&nbsp;Willian Fernando Zambuzzi","doi":"10.1002/jbm.b.35531","DOIUrl":"10.1002/jbm.b.35531","url":null,"abstract":"<div>\u0000 \u0000 <p>Calcium phosphates, notably monetite, are valued biomaterials for bone applications owing to their osteogenic properties and rapid uptake by bone cells. This study investigates the enhancement of these properties through Cobalt doping, which is known to induce hypoxia and promote bone cell differentiation. Heat treatments at 700°C, 900°C, and 1050°C are applied to both monetite and Cobalt-doped monetite, facilitating the development of purer, more crystalline phases with varied particle sizes and optimized cellular responses. Comprehensive physicochemical characterization through XRD, FTIR, Raman, SEM/EDS, and ASAP analyses shows significant phase transformations into pyrophosphate, influencing the materials' structural and functional attributes. When utilized to condition a culture medium for MC3T3-E1 cells, these materials demonstrate non-cytotoxic behavior and provoke specific gene responses associated with the osteoblastic phenotype, angiogenesis, adhesion, and extracellular matrix remodeling. Significantly, non-heat-treated Cobalt-doped Monetite retains properties advantageous for clinical applications such as dental and orthopedic implants, where lower processing temperatures are crucial. This attribute, combined with the material's straightforward production, highlights its practicality and potential cost-effectiveness. Further research is essential to assess the long-term safety and efficacy of these materials in clinical settings. Our findings underscore the promising role of Cobalt-doped Monetite in advancing bone repair and regeneration, setting the stage for future innovations in treating bone lesions, enhancing implant integration, and developing advanced prosthetic coatings within the field of tissue engineering.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solution Blow Spinning: An Emerging Nanomaterials-Based Wound-Care Technology","authors":"Md Salauddin Sk,&nbsp;Ruth Mwangomo,&nbsp;Luke Daniel,&nbsp;Jordon Gilmore","doi":"10.1002/jbm.b.35513","DOIUrl":"10.1002/jbm.b.35513","url":null,"abstract":"<p>Application of one-dimensional nanofibers have witnessed exponential growth over the past few decades and are still emerging with their excellent physicochemical and electrical properties. The driving force behind this intriguing transition lies in their unique high surface-to-volume ratio, ubiquitous nanodomains, improved tensile strength, and flexibility to incorporate deliberate functionalities required for specific and advanced applications. Besides numerous benefits, nanomaterials may adversely interact with biological tissues and potentially be cytotoxic and carcinogenic. However, precisely engineered design can outperform the risk with myriad benefits. Wound care technologies are evolving, and products involved in wound care management have a yearly market value of $15–22 billion. Solution blow spinning (SBS) is a facile technique to synthesize biocompatible nanofibers with scalable processing variables for multidirectional biomedical applications. SBS is feasible for a wide range of thermoplastic polymers and nanomaterials to fabricate nanocomposites. This review will focus on the relevance of SBS technology for wound care, including dressings, drug delivery, tissue engineering scaffolds, and sensors.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35513","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photooxidation Cross-Linked, Glutaraldehyde Cross-Linked, or Enzyme and Hydrostatic Pressure Processed Decellularized Biomaterials for Cardiovascular Repair Do Not Affect Host Response in a Rat Right Ventricular Outflow Flow Tract Reconstruction (RVOT) Model","authors":"Parnaz Boodagh,&nbsp;Laura Modica De Mohac,&nbsp;Yasurani Hayashi,&nbsp;Danila Vella,&nbsp;Sang-Ho Ye,&nbsp;Federica Cosentino,&nbsp;Taro Fujii,&nbsp;Emily Gorge,&nbsp;Garrett Coyan,&nbsp;Joan Dario Laubrie Soto,&nbsp;Gaetano Burriesci,&nbsp;William R. Wagner,&nbsp;Antonio D'Amore","doi":"10.1002/jbm.b.35529","DOIUrl":"10.1002/jbm.b.35529","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;p&gt;Cardiovascular diseases (CVDs) were responsible for approximately 19 million deaths in 2020, marking an increase of 18.7% since 2010. Biological decellularized patches are common therapeutic solutions for CVD such as cardiac and valve defects. The preparation of biomaterials for cardiac patches involves two main processing methods: glutaraldehyde or photooxidation cross-linking (fixation) and noncross-linked (nonfixation) processing. Despite the variety of products available in the market, cardiac patches still suffer from significant limitations, failing to adequately mimic the properties of biological tissue and restore its function. This study assesses the impact of different processing methodologies on the biological and biomechanical outcomes of three commercially available cardiac patches (CorPatch, CardioCel, PhotoFix) and one newly developed decellularized cardiac patch (Adeka) when implanted as right ventricular outflow tract (RVOT) repair material on a rat model. Four different patches for cardiovascular repair were selected based on their processing approaches and included: photooxidation crosslinked (PhotoFix), glutaraldehyde crosslinked (CardioCel), noncross-linked small intestine submucosa (CorPatch) or enzyme, and hydrostatic pressure (Adeka) processed decellularized biomaterials. Structure and function were characterized prior to implantation via thickness mapping, cross-section morphology, 2D surface topography, 3D volume microstructure, biaxial testing, uniaxial tensile testing, ball burst, and suture retention. Their host–biomaterials response was assessed in vivo using a relevant model for cardiovascular repair: a rat (RVOT) reconstruction with 8 and 16-week timepoints. Topological analysis showed that the crosslinked cardiac patches had a more homogeneous thickness distribution when compared to the noncrosslinked patches. This agreed with histological evaluation, where cross-linking processed materials better preserved collagen content than noncrosslinked patches who were also more delaminated. Biaxial data demonstrated that all patches, except CorPatch, recapitulated the anisotropic behavior of healthy left ventricle tissue. The Adeka patch in-plane mechanics at 16 weeks was the one who better resembled the mechanics of healthy cardiac tissue. All patches showed appropriate biocompatibility and function at 8- and 16-week timepoints for RVOT patching. This included echocardiographic assessment, biomechanics, macrophage infiltration and polarization, and angiogenesis. Consistently with a more porous laminae structure, explants histology showed higher cell infiltration in non-crosslinked Adeka when compared to the crosslinked PhotoFix. Overall, both in vitro and in vivo tests indicate that the material processing does not impact the function, biomechanical performance, and the host response of the patches that can be considered as equally effective as materials based cardiac repair solutions.&lt;/p&gt;\u0000 ","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Self-Healing Hydrogels in the Treatment of Intervertebral Disc Degeneration","authors":"Cunliang Guo,&nbsp;Xinyi Jiao,&nbsp;Xiaoxun Du,&nbsp;Tongxing Zhang,&nbsp;Bing Peng,&nbsp;Baoshan Xu","doi":"10.1002/jbm.b.35532","DOIUrl":"10.1002/jbm.b.35532","url":null,"abstract":"<div>\u0000 \u0000 <p>Intervertebral disc degeneration (IDD) is one of the leading causes of chronic pain and disability, and traditional treatment methods often struggle to restore its complex biomechanical properties. This article explores the innovative application of self-healing hydrogels in the treatment of IDD, offering new hope for disc repair due to their exceptional self-repair capabilities and adaptability. As a key support structure in the human body, intervertebral discs are often damaged by trauma or degenerative changes. Self-healing hydrogels not only mimic the mechanical properties of natural intervertebral discs but also self-repair when damaged, thereby maintaining stable functionality. This article reviews the self-healing mechanisms and design strategies of self-healing hydrogels and, for the first time, outlines their potential in the treatment of IDD. Furthermore, the article looks forward to future developments in the field, including intelligent material design, multifunctional integration, encapsulation and release of bioactive molecules, and innovative combinations with tissue engineering and stem cell therapy, offering new perspectives and strategies for IDD treatment.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}