Analysis of Corrosion Behavior of Brushite-Coated Magnesium in Different Environments: Non-Hematoma vs. Hematoma

IF 3.4 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2025-07-25 DOI:10.1002/jbm.b.35622

Yu Yusa, Yoshinaka Shimizu, Yoshimoto Okada, Masanobu Hayashi, Takayuki Aizawa, Mayuko Izumi, Akimitsu Sato, Chieko Miura, Yoshimichi Imai

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Abstract

The corrosion rate of these alloys is observed to be the fastest immediately after implantation. In addition, bleeding can accelerate corrosion and cause treatment failure in vivo, and therefore, it is necessary to optimize the corrosion rate. The brushite (CaHPO₄・2H₂O) coating treatment, a type of calcium phosphate, is used as a method to optimize the corrosion rate of magnesium and is expected to have the same coating effect under hematoma as under non-hematoma conditions. The purpose of this study was to evaluate the effect of brushite coating treatment with and without hematoma up to 14 days of implantation in vivo experiments. Specimens of cylindrical Pure Magnesium (99.9%, 1.2 mm × 6 mm), treated with a brushite coating by precipitation, were implanted in hematoma or non-hematoma rat femurs. The insoluble salts that precipitated on the specimens were analyzed by inductively coupled plasma mass spectrometry, scanning electron microscopy-energy dispersive X-ray analysis, and Raman spectroscopy. Results showed that weight loss at 14 days of implantation in the hematoma group (24.83 ± 2.26 μg mm⁻²) was significantly greater than in the non-hematoma group (18.88 ± 1.95 μg mm⁻²). The hematoma group had increased precipitation of insoluble salt magnesium and phosphorus. However, the amount of magnesium contained in insoluble salt per weight loss was significantly greater in the non-hematoma group at all time points, particularly after 1 days of implantation (non-hematoma group: 19.42% ± 3.56%; hematoma group: 10.73% ± 0.41%, p < 0.01). The brushite coating transformed the insoluble salts in the surface layer to an optimum structure compatible with the implantation environment. This enhanced the coating's protective function and more effectively inhibited magnesium corrosion. Given the clinical challenge of fully controlling intra-and postoperative bleeding, a brushite coating adaptable to hematoma conditions offers significant utility.

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电刷镀镁在不同环境下的腐蚀行为分析：非血肿与血肿

这些合金在注入后的腐蚀速度最快。此外，出血在体内会加速腐蚀，导致治疗失败，因此有必要优化腐蚀速率。电刷石（CaHPO4·2H2O）涂层处理是磷酸钙的一种，被用作优化镁腐蚀速率的方法，并且有望在血肿条件下具有与非血肿条件下相同的涂层效果。本研究的目的是在体内实验中评估有血肿和无血肿的刷石涂层处理对植入14天的影响。将圆柱形纯镁（99.9%,1.2 mm × 6 mm）样品经沉淀刷石涂层处理后，植入血肿或非血肿大鼠股骨。采用电感耦合等离子体质谱、扫描电子显微镜-能量色散x射线分析和拉曼光谱分析了样品上沉淀的不溶性盐。结果显示，血肿组大鼠14 d体重减轻（24.83±2.26 μg mm−2）明显大于非血肿组（18.88±1.95 μg mm−2）。血肿组不溶性盐、镁、磷沉淀增加。然而，在所有时间点，非血肿组的不溶性盐中含镁量在每减重中均显著高于非血肿组，特别是在植入1天后(非血肿组：19.42%±3.56%；血肿组：10.73%±0.41%,p < 0.01)。刷石涂层将表层的不溶性盐转化为与植入环境相适应的最佳结构。这增强了涂层的保护功能，更有效地抑制了镁的腐蚀。考虑到完全控制术中和术后出血的临床挑战，适用于血肿条件的刷石涂层提供了重要的实用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of biomedical materials research. Part B, Applied biomaterials 工程技术-材料科学：生物材料

CiteScore

7.50

自引率

2.90%

发文量

199

审稿时长

12 months

期刊介绍： Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.