Journal of biomedical materials research. Part B, Applied biomaterials最新文献

{"title":"Biomechanical Assessment of Femur Fracture Fixation Using Modified Locking Compression Plate Made of Biodegradable and Non-Biodegradable Materials Under Physiological Loading During Healing Phases.","authors":"Girish Chandra, Rajdeep Ghosh, Vivek Verma","doi":"10.1002/jbm.b.70085","DOIUrl":"https://doi.org/10.1002/jbm.b.70085","url":null,"abstract":"<p><p>Transverse femoral fractures heal through a complex secondary healing process, often stabilized using locking compression plates (LCPs) that maintain compression across an interfragmentary gap. Conventional LCPs made of non-biodegradable Ti-alloys provide adequate mechanical support but can induce stress-shielding in newly formed callus and bone, necessitating revision surgeries. To address this, Mg-based biodegradable LCPs have been actively investigated. However, their clinical translation and commercial adoption remain limited, primarily due to concerns regarding their lower mechanical strength and fixation stability compared to Ti-alloys. Embossed structure-based LCP (ELCP) was designed previously to enhance its mechanical performance. However, its biomechanical feasibility under physiological loading across different fracture healing phases has not yet been systematically evaluated. In the present study, fractured femur models for two fixation strategies, a conventional LCP (M2) and the ELCP (M3), were developed. These strategies were tested using three candidate biomaterials (one non-biodegradable material, Ti-alloy, and two biodegradable materials, Mg-alloy and PLA/50% Mg composite). Three physiological loading conditions corresponding to the healing and early repair phases were applied. The results showed that although Ti-alloy-based conventional LCPs provided superior fixation strength, Mg-alloy-based ELCPs also performed substantially better than conventional LCPs, as reflected by high safety factors ranging from 1.81 to 3.42, unlike composite-based plates. Moreover, Mg-alloy-based ELCPs exhibited higher interfragmentary strain (within or above the ideal strain range) in the callus compared to Ti-alloy-based LCPs, which might promote faster callus strengthening. Thus, Mg-alloy-based ELCPs could represent a viable alternative to conventional LCPs by offering adequate fixation strength while potentially reducing stress-shielding.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 5","pages":"e70085"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Delivery of Antimicrobial Peptide via Dual-Functionalized Silica Nanoparticles Achieves Efficient Staphylococcus aureus Biofilm Eradication.","authors":"Ayşenur Pamukçu, M Baran Karakaplan, Nursu Erdoğan, E Hilal Altıntop, Didem Sen Karaman","doi":"10.1002/jbm.b.70086","DOIUrl":"https://doi.org/10.1002/jbm.b.70086","url":null,"abstract":"<p><p>Antimicrobial peptides (AMPs) present potential alternatives; nevertheless, their effectiveness is frequently impeded by inadequate biofilm penetration and breakdown inside the extracellular polymeric substance (EPS) matrix. This study involved the design and assessment of surface-functionalized mesoporous silica nanoparticles (MSNs) to improve the penetration and biofilm eradication efficacy of the synthetic antimicrobial and anti-biofilm peptide-276 (SAAP-276) against established Staphylococcus aureus (S. aureus) biofilms. Fluorescently labeled MSN were altered with polyethylene glycol (PEG) and polypropylene imine (PPI) to examine their penetration profiles. Confocal Raman spectroscopy investigations demonstrated that PPI-modified MSNs displayed enhanced biofilm penetration relative to PEG-modified variants, despite possessing reduced entrapment effectiveness as for PEG-PPI dual polymer conjugation. The conjugation of SAAP-276 significantly improved biofilm eradication, with TMSN-PPI-PEG-SAAP exhibiting the most efficiency due to its optimum antimicrobial peptide loading and uniform distribution throughout the biofilm matrix. Time-dependent research demonstrated that extended exposure markedly diminished biofilm viability. Our findings underscore the pivotal importance of nanoparticle surface chemistry in biofilm interactions and indicate that MSN-based AMP delivery systems can enhance biofilm eradication by enabling even and deeper penetration. These findings offer significant insights for the advancement of nanoparticle-assisted antimicrobial peptide treatments targeting persistent biofilm infections.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 5","pages":"e70086"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Evaluation of Preconditioned Adipose-Derived Stromal Cells Reveals Limited Impact on Vascular and ECM Remodeling in Polymer Scaffolds.","authors":"Erika Pinheiro-Machado, Timara Kuiper, Romy H Huurman, Arjen H Petersen, Theo Borghuis, Alexandra M Smink","doi":"10.1002/jbm.b.70088","DOIUrl":"https://doi.org/10.1002/jbm.b.70088","url":null,"abstract":"<p><p>Polymer scaffolds are a promising platform for the transplantation of insulin-producing cells in Type 1 Diabetes. While vascularization has been a primary focus due to its role in oxygen and nutrient delivery, the interplay between blood vessels and the extracellular matrix (ECM) is increasingly recognized as critical for establishing a stable and functional graft microenvironment. Adipose-derived stromal cells (ASC) have shown potential to support both vascular and ECM remodeling, and their therapeutic profile may be modulated through preconditioning. However, the in vivo effects of ASC preconditioning and their delivery remain poorly defined. This study aims to evaluate whether preconditioned ASC can enhance vascular and ECM outcomes in a polymer scaffold. To this end, rat ASC were preconditioned within porous polycaprolactone (PCL) scaffolds under normoxic, hypoxic, or hypoxic + high-glucose conditions. Subsequently, scaffolds were implanted subcutaneously in immunodeficient rats and explanted at 7, 14, 21, and 28 days for analysis of vascular and ECM markers. This study showed that the addition of ASC did not enhance vascularization or ECM remodeling within the scaffolds, regardless of whether the ASC were preconditioned. This indicates that previously reported in vitro benefits of ASC preconditioning do not necessarily translate in vivo. Moreover, the results highlight the critical importance of the delivery method: the current scaffold-based ASC delivery method may require further optimization or alternative delivery strategies may be needed to maintain ASC function and achieve efficacy in scaffold-based tissue engineering applications.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 5","pages":"e70088"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposomes: An Intelligent Drug Delivery System for Translational Applications in Bone Biomedicine.","authors":"Weike Feng, Yun Xue, Bin Chang, Chunyang Wang, Ruitang Liu, Yigui Zhou, Longwen Zhan, Qiuming Gao, Bo Fan","doi":"10.1002/jbm.b.70089","DOIUrl":"https://doi.org/10.1002/jbm.b.70089","url":null,"abstract":"<p><p>The treatment of complex orthopedic diseases such as osteomyelitis, rheumatoid arthritis, and osteosarcoma is often hindered by the limitations of systemic drug administration, including poor bioavailability, severe side effects, and an inability to address localized pathologies. Liposomes, with their exceptional biocompatibility, structural versatility, and ability to encapsulate diverse therapeutics, have emerged as a cornerstone of nanomedicine. This review provides a function-centric analysis of how liposomes are engineered as intelligent, multi-functional platforms to tackle the specific challenges of the bone microenvironment. We move beyond a simple catalog of applications to critically examine the design strategies that enable liposomes to: (1) penetrate biofilm barriers and eradicate intracellular pathogens in infectious bone diseases; (2) actively target and reprogram inflammatory cells to resolve chronic inflammation in arthritis; (3) provide spatiotemporal control over growth factor and gene delivery for enhanced bone and cartilage regeneration; and (4) enable combinatorial chemo-gene therapies and novel cytotoxic mechanisms for osteosarcoma. By comparing and contrasting these strategies, this review identifies key technological advancements-such as stimuli-responsive release, biomimetic camouflage, and stem-cell fate engineering-that are driving the field forward. We conclude by discussing the persistent challenges for clinical translation and outlining future directions for the next generation of \"smart\" liposomes that promise to transform the paradigm of orthopedic treatment from symptomatic management to pathology-modifying and regenerative intervention.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 5","pages":"e70089"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Influence of Modified Surfaces on Early Dynamics of Osseointegration by Histomorphometric Analysis: An In Vivo Study.","authors":"Hanna Aludden, Ana Flávia P Santos, Christer Dahlin, Marcel F Kunrath","doi":"10.1002/jbm.b.70076","DOIUrl":"https://doi.org/10.1002/jbm.b.70076","url":null,"abstract":"<p><p>Rapid osseointegration remains a topic of interest in implant dentistry; however, the effects of modified surfaces during the early stages of osseointegration are not entirely elucidated. With that purpose, this study aimed to critically investigate early osseointegration parameters in cortical and trabecular bone through histological analysis in a preclinical model, and to assess the impact of a hydrophilic implant surface modification on the early peri-implant bone characteristics changes. Hydrophilic micro-texturized (HMT) and machined Ti (MT) implants were developed and their physical-chemical properties were characterized. A total of 48 implants were placed in the distal femoral epiphysis in rats. The implants were retrieved for histological and histomorphometric analyses after 6, 14, or 28 days. Physicochemical characterization showed significant differences with regard to morphology, roughness, and wettability of the developed HMT and MT implants. Bone to implant contact (BIC) values were significantly higher for HMT implants (test) compared with MT implants (control), both in cortical bone and trabecular bone at 14 and 28 days. BIC was significantly higher from 6 to 14 days in the test group, suggesting a time range when the modified implant surface exerts an influence over osseointegration and bone maturation. In conclusion, HMT implants significantly increased BIC values earlier than MT implants. A significant improvement in osseointegration parameters was present from 6 to 14 days for the modified surface, which reflects to the earlier period of time that hydrophilic rougher surface modification affects osseointegration process. Further studies are needed to correlate these histological findings with molecular and mechanical data.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 5","pages":"e70076"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized Protocol for the Isolation of UHMWPE Wear Debris by Lyophilization and Chemometric Identification (EDS/PCA).","authors":"Luis Antonio da Costa Bento, Vanessa Kapps, Rafael Mello Trommer, Bráulio Soares Archanjo, José Mauro Granjeiro, Marcia Marie Maru de Moraes","doi":"10.1002/jbm.b.70081","DOIUrl":"https://doi.org/10.1002/jbm.b.70081","url":null,"abstract":"<p><p>Aseptic osteolysis induced by ultra-high-molecular-weight polyethylene (UHMWPE) wear debris has historically been a major cause of late failure in total hip arthroplasty, highlighting the need for more robust methods to isolate and identify wear particles in complex biological matrices. To validate an optimized protocol for the isolation and identification of UHMWPE wear debris from hip simulator lubricant serum by combining lyophilization, alkaline digestion, and chemometric analysis based on principal component analysis (PCA) applied to energy-dispersive x-ray spectroscopy (EDS) data. Wear tests were performed in a hip simulator in accordance with ABNT NBR ISO 14242-1, using metal-on-UHMWPE and ceramic-on-UHMWPE bearing couples lubricated with 25% fetal bovine serum. Three isolation procedures were compared: direct liquid digestion and two protocols based on lyophilization followed by alkaline digestion with 6 mol/L KOH. Particles retained on polyethersulfone (PES) membranes were characterized by scanning electron microscopy (SEM; ASTM F1877) and EDS. Weight percentages of C, O, Na, K, Ca, Cl, S, and Au were subjected to PCA after autoscaling. Lyophilization increased filtration efficiency from 17% (0.2 g) to 25% (~4 g) and markedly reduced sample storage volume. SEM micrographs revealed typical fibrillar and globular UHMWPE particles ranging from 0.1 to 20 μm. PCA explained 67.4% of the total variance in the first three components and generated a distinct cluster of carbon-rich regions, clearly separated from areas dominated by salts and membrane background. The combination of lyophilization, alkaline digestion, and PCA-assisted EDS analysis improves recovery efficiency, preserves particle morphology, and supports the discrimination of UHMWPE wear debris in complex serum matrices, providing a practical and transferable approach for preclinical wear testing.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 5","pages":"e70081"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Fabrication, and Molecular Docking Evaluation of Eco-Friendly Polyvinyl Alcohol (PVA)/Aloe Vera Gel (AVG)/gelatin Biocomposite Films as Antimicrobial Coatings for Mobile Devices","authors":"Sameer A. Awad,&nbsp;Ahmed A. Al-Kubaisi,&nbsp;Nuaman F. Alheety,&nbsp;Mahmood Y. Mukhlif,&nbsp;Eman M. Khalaf","doi":"10.1002/jbm.b.70073","DOIUrl":"10.1002/jbm.b.70073","url":null,"abstract":"<div>\u0000 \u0000 <p>The natural polymer-based biocomposites have received more attention recently owing to their biocompatibility, renewability, and tunable physicochemical properties for biomedical as well as environmental applications. Herein, new films based on polyvinyl alcohol (PVA) and aloe vera gel (AVG)/gelatin (GL) were developed and characterized. Fourier transform infrared spectroscopy (FTIR), ultraviolet–visible spectroscopy (UV–vis), and x-ray diffraction analyses confirmed intermolecular hydrogen bonding between the components and a partial crystallinity within the polymer network. Scanning electron microscope (SEM) analysis of the morphological characteristics demonstrated a uniform dispersion of aloe vera and GL within the PVA matrix. Differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) provided information on the thermal behavior, showing that, compared to pure PVA, the co-PPGe/PVA amalgam exhibits higher thermodynamic stability and more suitable viscoelastic properties. Water uptake studies revealed the hydrophilic properties of the composites, making them suitable for applications in drug delivery and wound healing. The antimicrobial activity of the films showed strong effectiveness against <i>Staphylococcus aureus</i>, <i>Bacillus</i> spp., <i>Pseudomonas aeruginosa</i>, and <i>Candida albicans</i> (ZOI: ~18, ~12, and ~28 mm, respectively). Additionally, in silico molecular docking revealed favorable binding interactions of aloe vera bioactives with bacterial and fungal enzymes, aligning with the antimicrobial effects seen in vitro. Overall, these results suggest that PVA/AVG/GL biocomposites are a promising group of multifunctional biomaterials with potential applications in antimicrobial coatings.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Post-Processing in the Form of Ion Etching in Ar and O Applied to Metallic 3D Prints Produced Using the DMP Method on Their Cleaning Efficiency and Biological Response","authors":"Dorota Bociaga,&nbsp;Jacek Grabarczyk,&nbsp;Piotr Niedzielski,&nbsp;Bartłomiej Januszewicz,&nbsp;Michał Bogdański,&nbsp;Ireneusz Kotela,&nbsp;Urszula Borowska- Skarzyńska","doi":"10.1002/jbm.b.70068","DOIUrl":"10.1002/jbm.b.70068","url":null,"abstract":"<p>Direct Metal Printing (DMP) three-dimensional (3D) printing technology, also known as direct laser sintering of metal powders, enables the production of metal components with complex geometries that are not achievable with traditional casting methods or subtractive techniques. The DMP method enables the production of metal objects with high precision. One of the important applications of additive manufacturing is the production of medical implants. A significant challenge in the production of medical devices using DMP technology is the so-called post-processing. An improperly performed postproduction cleaning process may lead to the presence of metal powder particles that were not bound during laser melting. Their presence in the friction pair after implantation, and/or their release into surrounding tissues, may cause accelerated wear and induce inflammatory reactions. The most common drawbacks of widely available and commonly used post-processing methods include their limited effectiveness in removing surface powder residues and a significant loss in volume and mass of the prints. In the second case, the result is a reduction in the mechanical strength of the implant (e.g., with electrochemical methods), and in the first case, there is a risk of inducing an immune response in the body. According to literature reports, regardless of size, at high concentrations in the body (1 × 10⁶ particles/mL), unbound powder particles induce an immune response already at an early stage. Electrochemical methods effectively remove unbound particles, but at the same time cause significant losses in the volume and mass of prints, which affects their strength. This study aimed to improve the quality of 3D-printed implants by cleaning their surfaces of unbound metal particles (post-processing). Comparing the results reported in the literature for various surface treatment methods (chemical, electrochemical, mechanical, plasma), plasma treatment was identified as the most promising solution. Oxygen and argon plasma cleaning was performed at different time periods (1, 2, and 4 h) on sandblasted substrates after production and without this treatment. The study aimed to verify the effectiveness of the plasma cleaning process in removing particles from metallic 3D-printed components and to assess the impact of surface treatments on biological response using an osteoblast cell model.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.70068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Horizontal Flow Bioreactor Using Tissue Engineering Scaffolds for Evaluating Prostate Cancer Metastasis to Bone","authors":"Preetham Ravi,&nbsp;Shrinwanti Ghosh,&nbsp;Sharad V. Jaswandkar,&nbsp;Pooyan Vahidi Pashaki,&nbsp;David Ha,&nbsp;Jiha Kim,&nbsp;Dinesh R. Katti,&nbsp;Kalpana S. Katti","doi":"10.1002/jbm.b.70069","DOIUrl":"10.1002/jbm.b.70069","url":null,"abstract":"<div>\u0000 \u0000 <p>The high mortality rates of prostate cancer correlate with patients who are diagnosed with bone metastasis. We have fabricated an innovative bioreactor with an injection port ideal for recapitulating the EMT (epithelial to mesenchymal transition) to MET (mesenchymal to epithelial transition) cascade of circulating prostate cancer cells. Further, the migration to bone by hypoxic cancer cells was evaluated under fluid flow. First, we demonstrated that hypoxia, an initiator of metastasis, activates αVβ3 integrins, leading to enhanced cell attachment and growth. We assessed the expression of αVβ3 and the MET biomarkers vimentin and E-cadherin to evaluate role of interstitial fluid flow on circulating prostate cancer cells. We observed upregulation of αV, β3, and E-cadherin expression in normoxic and hypoxic PC3 cells. Hypoxic PC3 cells expressed higher angiogenic markers such as VEGF (vascular endothelial growth factor), MMP-9 (matrix metalloproteinase protein-9), and FAK (focal adhesion kinase). We recapitulated the migration of clustered cells using hanging drop spheroids and observed different migratory pattern and that the crosstalk between PC3 cells and cancer-associated-fibroblasts alters the angiogenicity of cancer spheroids. Overall, this study showcases the ability of this bioreactor to mimic prostate cancer migration to bone under interstitial fluid flow. Understanding the migratory patterns of metastatic prostate cancer can help in predicting cancer progression and identifying appropriate therapies for patients with advanced-stage prostate cancer.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technical Commentary on Boron-Derivative PMMA Cements: Critical Requirements for Mechanical and Longitudinal Validation","authors":"Umut Hatay Gölge","doi":"10.1002/jbm.b.70072","DOIUrl":"10.1002/jbm.b.70072","url":null,"abstract":"","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}