Journal of biomedical materials research. Part B, Applied biomaterials最新文献

{"title":"Stage-Adaptive Polymeric Platforms: Design of an Alginate/CMC Hydrogel Co-Loaded With Silver Nanoparticles and α-Pinene-Rich Essential Oil for Wound Regeneration","authors":"Nasrin Kakaei,&nbsp;Abbas Ahmadi,&nbsp;Veria Naseri,&nbsp;Arvin Shajeie,&nbsp;Bahram Nikkhoo,&nbsp;Maryamsadat Mirtalebiesfarjani,&nbsp;Sara Chavoshinezhad,&nbsp;Bijan Nori","doi":"10.1002/jbm.b.70157","DOIUrl":"https://doi.org/10.1002/jbm.b.70157","url":null,"abstract":"<div>\u0000 \u0000 <p>Managing infected wounds requires a delicate balance between rapid antimicrobial activity and continued tissue repair. To meet this challenge, we developed a porous carboxymethyl cellulose (CMC)/alginate hydrogel loaded with Silver nanoparticles and a <i>Pistacia atlantica</i> essential oil rich in <i>α-pinene</i>. The hydrogel displayed remarkable swelling (up to 6362% over 72 h) and changed the essential oil release from a rapid, volatile burst to a sustained, controlled profile (73% steady release over 96 h). In vitro tests revealed potent antibacterial activity against <i>Staphylococcus aureus</i> (MIC = 650 μg/mL), significant antioxidant properties, and excellent cytocompatibility. Importantly, in vivo studies in mice demonstrated a stage-adaptive healing mechanism. Silver nanoparticles allowed rapid early infection control (47.4% wound closure by Day 4). Subsequently, the sustained release of the essential oil promoted robust tissue regeneration during the proliferative phase (82.6% closure by Day 7), driven by an enhanced TAC-mediated antioxidant defense, reduced MDA levels, and accelerated hydroxyproline-associated collagen synthesis. By Day 13, re-epithelialization was near-complete (93.6%), matching commercial controls. Ultimately, this synergistic integration of plant-derived bioactives and metal antimicrobials presents a highly effective, stage-specific platform for accelerated wound healing.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterials Combined With Physical Modulation Strategies for Spinal Cord Injury Repair: Material Design, Mechanism, and Challenges","authors":"Ziqi Wang,&nbsp;Huan Zhou,&nbsp;Hongshui Wang,&nbsp;Xianyang Chen,&nbsp;Lei Yang,&nbsp;Chunyong Liang","doi":"10.1002/jbm.b.70159","DOIUrl":"https://doi.org/10.1002/jbm.b.70159","url":null,"abstract":"<div>\u0000 \u0000 <p>Spinal cord injury (SCI) causes persistent neurological deficits because primary damage initiates dynamic secondary cascades that restrict endogenous repair. Functional biomaterials can bridge lesions, provide structural and biochemical support, guide axonal growth, and remodel the inhibitory microenvironment. However, their cues are generally static or slowly evolving and cannot match the changing pathological and electrophysiological states of injured tissue. Physical modulation complements these functions by delivering electrical, magnetic, ultrasonic, optical/photothermal, or mechanical cues that regulate neural excitability, inflammation, axonal growth, remyelination, and plasticity. Nevertheless, physical modulation alone may suffer from imprecise localization, variable tissue-level dosing, and insufficient structural support. This review examines integrated biomaterial-physical modulation strategies for SCI repair, focusing on material design, mechanisms, and translational challenges. Conductive hydrogels couple lesion support with localized electrical signaling, whereas compliant electrodes improve tissue conformity and charge delivery. Piezoelectric and magnetically responsive materials convert external inputs into localized electrical or mechanical cues. Optical/photothermal systems combine localized energy conversion with on-demand release, whereas engineered matrices link structural support to mechanotransduction. Across these strategies, biomaterials act as regenerative scaffolds and active interfaces that localize, transmit, convert, and sustain physical signals. Physical inputs dynamically regulate cellular and molecular responses within this material-supported environment. This integration couples structural reconstruction and microenvironmental regulation with spatiotemporally controlled biophysical signaling, constituting the central mechanistic basis of these integrated systems. Translation requires standardized tissue-level dosing, evaluation of degradation-dependent signal stability and biocompatibility, cross-species scaling, and validation in relevant large-animal models. Stimuli-responsive materials and closed-loop systems represent important future directions. Overall, benefit depends not on simply adding stimulation to a scaffold, but on engineering coordinated material–stimulus systems. In such systems, material design controls where, when, and how physical cues are delivered during spinal cord regeneration.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Assessment of a Load-Bearing Biphasic Osteotendinous Braided Collagen Scaffold for Reconstruction of Massive Irreparable Rotator Cuff Defects","authors":"Joohee Choi,&nbsp;Phillip E. McClellan,&nbsp;Di Fan,&nbsp;Anne D. Straits,&nbsp;Alan Shepardson,&nbsp;Robert J. Gillespie,&nbsp;James M. Anderson,&nbsp;Subba Shankar,&nbsp;Ozan Akkus,&nbsp;Christian T. Denny","doi":"10.1002/jbm.b.70154","DOIUrl":"10.1002/jbm.b.70154","url":null,"abstract":"<div>\u0000 \u0000 <p>Massive, irreparable rotator cuff tears affect a significant patient population and often require invasive procedures such as allograft patch augmentation, superior capsule reconstruction, and muscle transfers due to the limited regenerative capacity and inability to reattach the rotator cuff to the humerus. Current surgical techniques primarily focus on mechanically reinforcing the tendon without promoting biological integration, leading to high re-tear rates and functional limitations. This study aimed to evaluate OsTend, a biphasic osteotendinous scaffold designed to span the MIRC defect by bridging the muscle to the bone footprint. As such, OsTend is designed to be conducive to supporting tendon and bone regeneration while enabling muscle tissue ingrowth. OsTend consists of electrochemically aligned collagen threads braided into a three-region scaffold: a proximal region for muscle integration, a midsection as a tendon regeneration template along with a polycaprolactone membrane as a suture rip-stop, and a hydroxyapatite-infused distal region to facilitate bone ingrowth. A total of 16 New Zealand White rabbits underwent unilateral infraspinatus tendon resection and repair with OsTend, followed by biomechanical testing, micro-computed tomography, and histological analysis at 1 and 3 months postimplantation. Results demonstrated a 65% increase in ultimate tensile strength from 1 month (102.1 ± 21.5 N) to 3 months (167.9 ± 62.3 N). Tendon retraction between 1 month (7.47 ± 2.61 mm) and 3 months (6.77 ± 1.91 mm) was &lt; 2 mm during the study period. Bone volume fraction at 1 month (24.80% ± 8.30%) and 3 months (21.52% ± 4.97%) of the footprint reached approximately 75% of the intact bone (30%). Between 1 and 3 months, the failure mode of repaired shoulders shifted from pullout at the enthesis (80% at 1 month) to rupture at the mid-substance (100% at 3 months), indicating attainment of a functional integration between bone and scaffold over time. Histological analysis revealed collagen fiber alignment in the muscle and tendon regions and bone-like tissue formation surrounding the hydroxyapatite-infused region. These findings suggest that OsTend reestablishes tendon–bone attachment with structural integrity; thus, this multiphasic biotextile platform holds the potential as an off-the-shelf biomaterial for treating massive irreparable rotator cuff tears.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial and Anti-Inflammatory Co-Loaded Chitosan/Polyvinyl Alcohol Hydrogel for Synergistic Treatment of Diabetic Wounds","authors":"Xue Wang,&nbsp;Nana Xiong,&nbsp;Huilin Hu,&nbsp;Haichuan Sun,&nbsp;Fengping Liu,&nbsp;Yutao Zhang,&nbsp;Yaji Xu,&nbsp;Lijia Cheng","doi":"10.1002/jbm.b.70160","DOIUrl":"10.1002/jbm.b.70160","url":null,"abstract":"<div>\u0000 \u0000 <p>To develop a chitosan/polyvinyl alcohol (CS/PVA) hydrogel co-loaded with polyhexamethylene biguanide (PHMB) and celecoxib (CEL) for synergistic treatment of diabetic foot ulcers (DFUs). Blank CS/PVA, CEL/CS/PVA, PHMB/CS/PVA, and CEL/PHMB/CS/PVA hydrogels were prepared by freeze-thaw cycles. Their microstructure, swelling, degradation, antibacterial activity, hemocompatibility, and fibroblast migration were evaluated in vitro. A full-thickness wound model in streptozotocin-induced type 1 diabetic mice was used to assess wound healing, inflammation, angiogenesis, macrophage polarization, and biosafety. All hydrogels showed comparable swelling. On Day 7, the degradation rates were 71.04%, 55.80%, 47.49%, and 25.42%, respectively, with CEL/PHMB/CS/PVA showing the lowest degradation rate. PHMB-containing hydrogels inhibited <i>E. coli</i> and <i>S. aureus</i>. All materials had hemolysis rates &lt; 5%, and the composite group showed 1.74%. The 24 h migration rates were 30%, 37%, 48%, and 67%, with the composite group being highest (<i>p</i> &lt; 0.001). In diabetic mice, the composite group achieved 68.89% wound healing on Day 7 and 94.44% on Day 14, versus 69.59% on Day 14 in the untreated diabetic group (<i>p</i> &lt; 0.001). It also increased collagen deposition, reduced IL-1β and IL-6, and promoted CD31⁺ angiogenesis, α-SMA⁺ vascular maturation, and CD206⁺ M2 macrophage polarization, with no obvious systemic toxicity. The CEL/PHMB/CS/PVA composite hydrogel promotes the healing of diabetic wounds through the synergistic effects of PHMB's antibacterial action and CEL's anti-inflammatory action. The hydrogel demonstrates good biosafety and potential for clinical translation.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Histological Evaluation of Porcine Urinary Bladder Matrix and Artificial Dermis in the Treatment of Tendon/Bone Exposed Wounds","authors":"Bo Yuan,&nbsp;Gang Xu,&nbsp;Chengliang Deng,&nbsp;Huizhong Yang,&nbsp;Jie Zhou,&nbsp;Tao Chen,&nbsp;Wei Wu,&nbsp;Yanguang Lu,&nbsp;Yiwen Xu,&nbsp;Jing Dai,&nbsp;Jian Zhang,&nbsp;Yan Liu","doi":"10.1002/jbm.b.70156","DOIUrl":"https://doi.org/10.1002/jbm.b.70156","url":null,"abstract":"<div>\u0000 \u0000 <p>Full-thickness skin defects involving tendon or bone exposure present significant clinical challenges owing to inadequate vascularity, which renders spontaneous wound healing unlikely. Conventional treatments using autologous flap transplantation may incur donor-site morbidity. Dermal substitutes are employed to enhance wound bed construction and improve skin graft survival by promoting vascularization and extracellular matrix (ECM) deposition. However, currently available substitutes are predominantly composed of purified bovine- or porcine-derived type I collagen and lack the bioactive components. Urinary bladder matrix (UBM), a naturally derived scaffold, contains a rich repertoire of ECM constituents that effectively promote the healing process, offering a potential novel approach for dermal regeneration. Nevertheless, human histological evidence on UBM in tendon/bone-exposed wounds remains limited. In this study, we compared the efficacy of UBM wound matrix (ExceFil Biological Wound Matrix, ZhuoRuan Medical Technology) with that of artificial dermal substitute (Pelnac, GUNZE Medical Division) in treating extremity wounds with tendon/bone exposure in a series of six clinical cases. Clinically, both products successfully promoted wound vascularization and graft survival. Histological analysis revealed that the UBM group exhibited superior regenerative features, including enhanced fibroblast migration, collagen deposition, neovascularization, and immunomodulatory properties, with a higher rate of M2 macrophage polarization at 15 ± 2 days post-implantation. Furthermore, RNA sequencing demonstrated that the UBM matrix significantly upregulated pathways related to cytokine-cytokine receptor interaction and chemokine signaling, both of which modulate immune and regenerative processes within the wound microenvironment. These findings suggest that UBM biological matrix represents a promising dermal substitute for promoting regenerative healing in tendon/bone-exposed wounds.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Biological Evaluation of Cell Affinitive Oligo(poly(ethylene glycol) fumarate)-Gelatin Methacrylate (OPF-GELMA) Interpenetrating Network Hydrogels","authors":"Katherine J. Zhu,&nbsp;Xifeng Liu,&nbsp;Kaelyn L. Gasvoda,&nbsp;Orod Gharibi,&nbsp;Abdelrahman M. Hamouda,&nbsp;Benjamin D. Elder","doi":"10.1002/jbm.b.70155","DOIUrl":"10.1002/jbm.b.70155","url":null,"abstract":"<div>\u0000 \u0000 <p>Hybrid hydrogels that integrate mechanical tunability with biological activity are critical for regenerative medicine. Oligo(poly(ethylene glycol) fumarate) (OPF) offers controllable network formation but lacks intrinsic cell affinity. Here, we incorporated gelatin methacrylate (GelMA) into OPF networks to develop an interpenetrating network (IPN) hybrid OPF-GELMA hydrogel that combines the mechanical versatility of OPF with the bioactivity of GelMA. The crosslinked hydrogels with varying GelMA content exhibited GelMA-dependent modulation of swelling, gel fraction, compressive stiffness, and microstructure. Increasing GelMA concentration reduced water uptake while significantly enhancing mechanical strength and proliferation of rat bone marrow-derived mesenchymal stem cells (rBMSCs). Moreover, GelMA incorporation markedly enhanced rBMSC osteogenic differentiation, as demonstrated by elevated alkaline phosphatase activity and increased Runx2 expression. These results demonstrate that OPF-GELMA hydrogels enable synergistic regulation of biochemical and mechanical cues, providing a versatile scaffold platform for bone tissue engineering and regenerative medicine applications.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiscale Characterization of Jute/Flax Biocomposites: Enhancing Stiffness and Durability for Load-Bearing Rehabilitation Devices","authors":"Shaurya Bhatt,&nbsp;Pawan Kumar Rakesh,&nbsp;Deepak Joshi","doi":"10.1002/jbm.b.70153","DOIUrl":"10.1002/jbm.b.70153","url":null,"abstract":"<div>\u0000 \u0000 <p>In recent years, there has been a substantial rise in the utilization of natural fibers as a means of reinforcement in the production of polymer matrix composites. This is mostly owing to the inherent benefits it offers, including its eco-friendly nature, widespread availability, low density, and relatively high strength. Jute and flax fibers are examples of natural fibers that exhibit superior mechanical qualities as compared to other natural fibers. These fibers are widely available across the Indian subcontinent, making them cost-effective and conveniently accessible. The present work details the process of creating and assessing composites made from Jute and Flax fibers as reinforcement with epoxy. Flax and Jute fibers were combined with epoxy to create composite samples with varying compositions. The study subsequently assessed the influence of fiber content on the composite specimens, with emphasis on their structural strength characteristics, rendering them appropriate for use in rehabilitation devices. The findings indicate that the optimal mechanical properties were achieved at a fiber weight fraction of 40%, with the hybrid Jute-Flax-epoxy (JFE) composite attaining a maximum tensile strength of 59.4 MPa, flexural strength of 419.31 MPa, and impact strength of 72.7 kJ/m². Flax-epoxy composites demonstrated superior tensile and flexural performance compared with Jute-epoxy composites, attributed to the higher Young's modulus of Flax fiber (60 GPa vs. 43.8 GPa for Jute). These results demonstrate the suitability of Jute and Flax fiber laminates for the fabrication of lower-limb prosthetic feet and other load-bearing rehabilitation devices.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Corrosion-Driven Degradation of Mg WE43 Plates for Mandibular Fracture Fixation: An In-Silico Study”","authors":"","doi":"10.1002/jbm.b.70152","DOIUrl":"10.1002/jbm.b.70152","url":null,"abstract":"<p>\u0000 <span>R. Izadi</span>, <span>M. Rajaeirad</span>, and <span>S. Roy</span>, “ <span>Corrosion-Driven Degradation of Mg WE43 Plates for Mandibular Fracture Fixation: An In-Silico Study</span>,” <i>Journal of Biomedical Materials Research Part B: Applied Biomaterials</i> <span>114</span>, no. <span>6</span> (<span>2026</span>): e70112, https://doi.org/10.1002/jbm.b.70112.\u0000 </p><p>In the published version of this article, Figures 1-5, and 6 were incorrect. The corrected figures are provided below.</p><p>The scientific results, interpretation, and conclusions of the article are unaffected by these corrections.</p><p>The online version of the article has been updated.</p><p>We apologize for this error.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.70152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alignment of Micrometer-Scale Electrospun Fibers Does Not Enhance Performance of Primary Human Renal Proximal Tubular Epithelial Cells","authors":"IJsbrand M. Vermue,&nbsp;Christian G. M. van Dijk,&nbsp;Ihsan Chrifi,&nbsp;Ymke Appels,&nbsp;Jurjen van Meijeren,&nbsp;Bastiaan Terhaard,&nbsp;Nahid Kasaiyan,&nbsp;Marianne C. Verhaar,&nbsp;Caroline Cheng","doi":"10.1002/jbm.b.70151","DOIUrl":"10.1002/jbm.b.70151","url":null,"abstract":"<p>Renal failure remains a leading cause of morbidity and mortality, as current renal replacement therapies restore filtration but fail to replicate the kidney's transport, metabolic, and endocrine functions. Bioengineered systems using primary renal epithelial cells show promise in recapitulating these processes, and integration into synthetic tubular platforms may further enhance biological mimicry, advancing drug discovery, and next-generation bioartificial kidneys. The native proximal tubule basement membrane contains aligned ridges (~200 nm), suggesting that scaffold fiber alignment could improve epithelial cell function. We therefore hypothesized that aligned electrospun fibers would promote proximal tubule epithelial cell organization and enhance functional performance compared to random fibers. Polycaprolactone scaffolds with random or aligned fibers were fabricated in both flat and tubular configurations using solution electrospinning (SES). Human renal proximal tubule epithelial cells (HRPTEpiC) were cultured for up to 11 days and assessed for morphology, barrier function, polarization, and transporter expression. Aligned fibers induced cytoskeletal organization but did not affect tight junction formation, polarization, or monolayer formation. Barrier function was significantly reduced on aligned scaffolds at Day 11, attributed to larger pore sizes (15.3 vs. 7.5 μm²). Transporter expression showed transient differences, with ATP1A1 and AQP1 reduced on aligned scaffolds at Day 7 but equalized by Day 11. Functional transport assays revealed significant ABC transporter inhibition only on random scaffolds (<i>p</i> = 0.048 vs. <i>p</i> = 0.058 for aligned). Overall, these findings show that at the tested diameters (1.2–1.6 μm), fiber alignment influenced cell morphology but offered limited functional benefit compared to random fibers.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.70151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication, In Vitro and In Vivo Evaluation of Bioactive Glass-Doped Biodegradable Bilayer Polymeric Dental Nanofibrous Membranes for Guided Tissue Regeneration Applications","authors":"Ceren Keçeciler-Emir,&nbsp;Nurettin Diker,&nbsp;Yeşim Müge Şahin,&nbsp;Sevil Yücel","doi":"10.1002/jbm.b.70149","DOIUrl":"10.1002/jbm.b.70149","url":null,"abstract":"<div>\u0000 \u0000 <p>Barrier membranes are used in guided bone regeneration (GBR) to prevent the migration of fibroblastic cells into the alveolar bone defects and to ensure the regeneration of bone tissue. The regeneration capabilities of alveolar bone tissue and connective tissue are different, so the niche required by the tissues must also meet this need. In this study, a bilayer synthetic polymeric barrier membrane containing 45S5 bioactive glass (BG) was prepared by the electrospinning method to provide regeneration of both tissues. A fibrous layer was fabricated using polyvinyl alcohol (PVA) containing 3% BG for the soft tissue interface, and a second fibrous layer was fabricated on top of this layer using poly(lactide-co-glycolide) (PLGA) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend polymers containing 10% BG for the hard tissue interface. It has been demonstrated that bilayer nanofiber membranes show suitable mechanical, thermal, and physicochemical properties for using GBR applications, as well as high bioactivity and suitable bioresorbable properties. In vitro and in vivo animal study biological assays have demonstrated that nanofibrous multilayer dental membranes are highly biocompatible with fibroblast and bone cells, accelerate cell proliferation, and increase cell adhesion to the membranes. It has been demonstrated that the designed bioactive bilayer nanofiber membranes can meet the requirements for use as a support material in GBR applications in dentistry.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}