Journal of biomedical materials research. Part B, Applied biomaterials最新文献

{"title":"Engineering Smart 3D-Printed Antibacterial Bone Scaffolds: Stimuli-Responsive Release and Personalized Therapy for Infected Bone Defects","authors":"Jiamin,&nbsp; Jiaying,&nbsp;Tingting Chen,&nbsp;Lincong Luo,&nbsp; Wenhua","doi":"10.1002/jbm.b.70057","DOIUrl":"10.1002/jbm.b.70057","url":null,"abstract":"<div>\u0000 \u0000 <p>Infectious bone defects present a multifaceted orthopedic challenge, marked by impaired bone repair, antibiotic resistance, and recurrent infections. The integration of 3D printing technology with bone tissue engineering has emerged as a promising approach to address this challenge. This comprehensive review evaluates recent advancements in 3D-printed antibacterial bone scaffolds for the management of infectious bone defects, focusing on achieving a dynamic synergistic control of anti-infection and bone regeneration through innovative scaffold design. The review begins by elucidating the pathological mechanisms underlying infectious bone defects and the limitations of current antibacterial strategies. It highlights advancements in the intelligent structural design and responsive antibacterial properties of 3D-printed scaffolds. Leveraging their precise and customizable structures, these scaffolds provide significant advantages in simultaneously promoting bone regeneration and effectively combating infections, thereby introducing new strategies to address antibiotic resistance. Furthermore, the review discusses the distinct benefits of 3D printing technology in customizing treatments to meet individual patient needs, thereby optimizing therapeutic outcomes. Finally, it examines the potential clinical applications of this technique, aiming to deliver safer and more effective personalized interventions for infectious bone defects.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the Pathological Microenvironment in Diabetic Foot Ulcers: Advances in Drug Delivery Systems for Improved Healing.","authors":"Wanqing Dai, Zhengguang Li, Rucheng Zheng, Xinglong Geng, Ke Wu, Tingting Chang, Xiaoqin Chu","doi":"10.1002/jbm.b.70079","DOIUrl":"https://doi.org/10.1002/jbm.b.70079","url":null,"abstract":"<p><p>Diabetic foot ulcers (DFUs) are among the most severe and disabling complications of diabetes, characterized by delayed healing, frequent recurrence, and a high risk of infection and amputation. Their pathogenesis is sustained by a hostile pathological microenvironment involving persistent inflammation, oxidative stress, protease imbalance, impaired angiogenesis, and immune dysregulation, while systemic factors such as metabolic disturbance and gut-skin axis dysfunction may further aggravate non-healing. Although conventional management remains essential, it often has limited ability to directly correct these underlying drivers. In response, recent advances in formulation technologies have increasingly focused on mechanism-guided intervention in the wound microenvironment. These include nanocarriers and scaffold platforms for local delivery, stimuli-responsive and photoactivatable nanomedicine, functional biomaterials, cell-free regenerative systems, and gut-directed adjunctive strategies. Together, these approaches aim to improve local retention, enable on-demand therapeutic activation, actively remodel the pathological microenvironment, and reduce extra-wound inflammatory and metabolic burdens. This review summarizes recent progress in microenvironment-targeted DFUs therapies and highlights the potential of more precise and mechanism-guided treatment strategies tailored to the biological heterogeneity of wounds.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":"e70079"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Hydrogel Dressings in Management and Prevention of Radiation Dermatitis: A Comparative Review.","authors":"Zintle Mbese, Omobola Oluranti Okoh","doi":"10.1002/jbm.b.70070","DOIUrl":"https://doi.org/10.1002/jbm.b.70070","url":null,"abstract":"<p><p>Radiation dermatitis (RD) is one of the most common adverse effects of radiotherapy and significantly impacts patient comfort, quality of life, and treatment adherence. Effective supportive care strategies are therefore essential to preserve skin integrity and prevent treatment interruption. Among available wound care options, hydrogel dressings have emerged as promising biomaterials due to their ability to maintain a moist environment, reduce transepidermal water loss, provide cooling relief, and enable atraumatic removal. This review aims to critically evaluate the role of hydrogel dressings in the management of RD by integrating current understanding of RD pathophysiology with advances in hydrogel design. The manuscript adopts a stage-oriented approach, aligning natural, synthetic, and hybrid hydrogel systems with the evolving biological characteristics of irradiated skin. Comparative performance with conventional wound care materials and emerging innovations including bioactive, stimuli-responsive, and multifunctional hydrogel platforms are also discussed. Although hydrogels demonstrate significant short-term benefits in symptom control and wound healing, limitations such as mechanical constraints, cost considerations, and limited long-term clinical evidence remain. Future research should prioritize well-designed randomized trials, standardized outcome measures, and personalized guideline-aligned application strategies to optimize their clinical integration. Hydrogel dressings represent a promising therapeutic platform in RD management, with potential to advance precision supportive oncology care.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":"e70070"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of GelMA Microspheres Loaded With Silver Ions and Curcumin for Antibacterial and Antioxidant Functions in Diabetic Chronic Wounds.","authors":"Zhengnan Zhao, Yingming Li, Yongwei Yin, Guoqing Li, Hong Wang","doi":"10.1002/jbm.b.70058","DOIUrl":"10.1002/jbm.b.70058","url":null,"abstract":"<p><p>Diabetic chronic wounds are difficult to heal due to persistent inflammation, excessive oxidative stress, and high infection risk. Herein, a multifunctional GelMA-based microsphere co-loaded with silver ions and curcumin (GelMA-MS@Ag/Cur) was developed as an advanced wound dressing for diabetic wound repair. The porous GelMA microspheres enabled efficient encapsulation and sustained release of Ag⁺ and curcumin while maintaining good biocompatibility and controlled degradation. GelMA-MS@Ag/Cur exhibited broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria and effectively reduced intracellular reactive oxygen species. The microspheres further promoted macrophage polarization toward the pro-regenerative M2 phenotype. Mechanistically, GelMA-MS@Ag/Cur regulated the KEAP1/Nrf2 signaling pathway and suppressed inflammation-induced ferroptosis by modulating ACSL4, SLC7A11, and GPX4 expression, thereby preserving cellular redox homeostasis. In a diabetic rat full-thickness wound model, GelMA-MS@Ag/Cur significantly accelerated wound closure, enhanced angiogenesis, collagen deposition, and tissue remodeling without observable systemic toxicity. This work provides a promising multifunctional strategy for diabetic chronic wound management.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":"e70058"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.","authors":"Allen Zennifer, Sai Sadhananth Srinivasan, Suranji Wijekoon, Sumit Yadav, Sama Abdulmalik, Sangamesh G Kumbar","doi":"10.1002/jbm.b.70082","DOIUrl":"10.1002/jbm.b.70082","url":null,"abstract":"<p><p>Large-area bone loss from disease, trauma, or congenital defects requires surgical procedures and bone grafting. Alveolar bone loss from severe periodontal disease and non-unions often demands immediate grafting. Treating large alveolar bone defects using grafts and substitutes is challenging due to the complex oral environment, infection risks, and unstable graft properties, which may compromise strength and bioactivity. Successful grafts must promote vasculature development and osteogenesis while maintaining mechanical stability at the graft site. Current bone graft substitutes are inadequate for optimal alveolar bone healing. New biomaterial technologies including additive manufacturing techniques enhance repair processes by developing anatomically equivalent implants that integrates better with host tissues, provide mechanical stability and activate innate healing mechanisms. Smart stimuli-responsive materials (SSMs), combined with exogenous physical stimulation, further advance this by triggering cell regulatory pathways, promoting bone mineralization, blood vessel development, and mechanical integrity. Electrical, magnetic, mechanical, ultrasound, and shockwave stimulations activate Ras, p38 kinase, PI3K/Akt, JNK, NF-κB, MAPK/ERK, Wnt, BMP, and VEGF pathways, enhancing osteogenic genes like Runx2, YAP, osteopontin, and osteocalcin to promote osteoinduction and osteogenesis. This article provides an in-depth literature analysis of smart biomaterials and stimuli-mediated alveolar bone repair and regeneration mechanisms. It also highlights the unmet needs of innovative biomaterials such as SSMs and explores strategies to manage the bone microenvironment, aiming to enhance clinical translation for large-area bone defects regeneration.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":"e70082"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung Biopsy Tract Sealant and Fiducial Marker Based on a Hydrogel/Shape Memory Polymer Foam Composite With Multimodal Contrast.","authors":"Matthew A Jungmann, Donald Bowen, Ethan VanDever, Joseph Alge, Mary P McDougall, Duncan J Maitland, Daniel L Alge","doi":"10.1002/jbm.b.70071","DOIUrl":"https://doi.org/10.1002/jbm.b.70071","url":null,"abstract":"<p><p>Lung tissue biopsies can result in a collapsed lung in the patient via leakage of air (pneumothorax) from an open biopsy tract. To reduce the risk of pneumothorax, clinicians will implant a sealant to prevent leakage of air from the tract. However, current technologies used in the clinic have been proven to be ineffective in preventing pneumothorax and do not have any imaging contrast for visualization of the device and tissue of interest in post-op imaging. We have previously developed a biopsy tract plug based on a shape memory polymer foam and poly(ethylene glycol) hydrogel composite. Here, we are building on our previous work by developing a composite with magnetic resonance imaging (MRI) and computed tomography (CT) contrast so that it may function as a lung biopsy tract sealant as well as a fiducial marker. A peptide-based, norbornene-functionalized gadolinium chelate was synthesized via solid-phase peptide synthesis. This norbornene-functionalized gadolinium chelate will covalently bond into our thiol-ene crosslinked PEG hydrogel. Swelling kinetics and rheology showed that the incorporation of this chelate into the hydrogel network reduced swelling and increased equilibrium storage modulus of the hydrogel, respectively. Composites were fabricated with the gadolinium chelate (MR contrast agent) within the hydrogel network and two platinum marker bands (CT contrast agent) adhered at each end. Characterization revealed that the addition of the multimodal contrast did not affect the cytocompatibility of the composites but delayed their shape recovery. However, this delay proved beneficial for the effective deployment of the devices after exposure to water within the device housing for 2 min. Furthermore, this delay did not affect their ability to seal lung biopsy tracts in vitro. Composites were distinguishable from their surrounding tissue under MRI in vitro in a lung phantom and ex vivo in bovine liver. Finally, in vivo implantation showed that the composites maintained their MRI and CT contrast up to 4 weeks after subcutaneous implantation in mice without inducing a severe immune response to the local tissue or renal injury. Collectively, these results show that the composites with multimodal contrast have potential to serve as both lung biopsy sealants as well as fiducial markers.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":"e70071"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Polycaprolactone Composite Nanofiber Dressing Co-Loaded With Propolis and Silver Nanoparticles for Faster Wound Healing: In Vivo Evidence.","authors":"Nada Ragab, Omali Y El-Khawaga, Refaat Manar, Safaa Saleh, Emad Tolba","doi":"10.1002/jbm.b.70075","DOIUrl":"https://doi.org/10.1002/jbm.b.70075","url":null,"abstract":"<p><p>This study developed and evaluated a novel composite electrospun nanofiber wound dressing co-loaded with propolis (PP) and PP-functionalized silver nanoparticles (PP-AgNPs) in a polycaprolactone (PCL) matrix for accelerated wound healing. Three types of mats-neat PCL, PCL/PP (10 wt.%), and PCL/PP-AgNPs (10 wt.%)-were fabricated. Incorporation of PP-AgNPs significantly altered the solution properties, increasing conductivity to 891.0 ± 3.9 μS and reducing the mean fiber diameter to 256 ± 63 nm, compared to 693 ± 245 nm for neat PCL. In vivo assessment using a full-thickness rat wound model over 14 days demonstrated that the PCL/PP-AgNPs composite dressing (Group 6) superiorly promoted healing. It achieved near-complete wound closure (99.8%), significantly enhanced wound contraction rates, and improved histological outcomes, including complete re-epithelialization and dense, organized collagen deposition. Biochemical analyses revealed that the PCL/PP-AgNPs dressing effectively modulated the wound microenvironment by reducing oxidative stress (increased SOD, decreased MDA) and suppressing pro-inflammatory cytokines (IL-6, TNF-α). Furthermore, it exhibited protective effects on liver (ALT, AST) and kidney (Urea, Creatinine) functions. The synergistic combination of PP's antioxidant and anti-inflammatory properties with the antimicrobial and bioactive effects of AgNPs, delivered via a nanostructured PCL fiber matrix, validates this composite as a highly effective and multifunctional dressing for faster, more complete wound repair.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":"e70075"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Hybrid Chitosan Coatings With Cu Nanoparticles on the Shape Memory NiTi Enabling Bactericidal Activity.","authors":"Piotr Jabłoński, Agnieszka Kyzioł, Halina Krawiec, Victor Sebastian, Karol Kyzioł","doi":"10.1002/jbm.b.70077","DOIUrl":"https://doi.org/10.1002/jbm.b.70077","url":null,"abstract":"<p><p>In this study, we introduce a hybrid approach for fabricating multifunctional coatings composed of chitosan and copper nanoparticles (CuNPs) on NiTi substrates. The fabrication process combines the immersion technique for chitosan layer deposition with inert gas condensation (IGC) based on magnetron sputtering for the generation of CuNPs. This method enables precise control over nanoparticle size and concentration, allowing for their uniform incorporation into a biopolymer matrix. The resulting CS/CuNPs/CS multilayers exhibit excellent surface coverage, nanoscale roughness (R_a of 30-65 nm), and moderately hydrophilic character (contact angle of 30°-35°), which collectively support cell adhesion and proliferation. Surface characterization confirmed the stability and durability of the coatings, which can be attributed to prior substrate activation using Piranha solution and plasma treatment. Electrochemical tests demonstrated enhanced corrosion resistance of the CS/CuNPs/CS layers, with a reduced current density (4.10 × 10^-4 mA/cm²) and good temporal stability. In vitro studies using the MG-63 osteoblast-like cell line indicated non-cytotoxicity response of the coatings, confirming their plausible applicability in tissue engineering. Antibacterial assays revealed effective inhibition of Staphylococcus aureus growth and complete elimination of Escherichia coli, highlighting the strong bactericidal potential of the developed system. Moreover, Cu ion release within the surface layer profiles obtained in Ringer's solution over a 7-day period showed a predominantly linear release of copper ions, indicating a controlled and sustained antimicrobial effect. The ability to modulate chitosan layer thickness and nanoparticle loading during sequential deposition steps enables the customization of the coating properties to meet specific therapeutic requirements while minimizing nanoparticle usage. This strategy offers a promising platform for developing safe, effective, and tunable antibacterial coatings for biomedical implants.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":"e70077"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Extracellular Matrix-Based Combination Scaffold for Guided Regeneration of Large-Area Full-Thickness Rabbit Burn Wounds Upon a Single Application\".","authors":"","doi":"10.1002/jbm.b.70078","DOIUrl":"https://doi.org/10.1002/jbm.b.70078","url":null,"abstract":"","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":"e70078"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Cell Migration Through Electrospun PCL Fiber Mats With Controlled Thickness.","authors":"Yosuke Uemura, Hiroyuki Tonami","doi":"10.1002/jbm.b.70080","DOIUrl":"https://doi.org/10.1002/jbm.b.70080","url":null,"abstract":"<p><p>Electrospun fiber mats are widely studied as scaffolds, yet cell migration in the thickness (z) direction remains poorly understood. In this study, poly(ε-caprolactone) (PCL) mats with reproducibly controlled thicknesses were prepared by conventional electrospinning, using optical transmittance monitoring only to determine the collection endpoint based on a previously established calibration. NIH3T3 fibroblasts and human umbilical vein endothelial cells (HUVECs) were seeded to evaluate vertical migration through the mats. Cell penetration from the top to the bottom surface was quantified using confocal microscopy and MTT assays. Scanning electron microscopy (SEM) images were additionally used to confirm fibrous morphology and to measure fiber diameter. Mat thickness had a marked effect on migration: in 40-μm mats, cells localized mainly at the top and bottom surfaces, whereas in 80-μm mats, cells were also distributed within the interior. Although differences in proliferation were observed between cell types and mat structures, both NIH3T3 cells and HUVECs showed lower apparent top-to-bottom transition rates in thicker mats. A mathematical model was applied to describe migration and proliferation dynamics, enabling quantitative comparison across conditions. These findings demonstrate that scaffold thickness strongly influences vertical cell migration and internal cell retention in electrospun fiber mats, providing useful design insights for biomaterial scaffolds in tissue engineering.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"114 4","pages":"e70080"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}