含氮双膦酸盐涂层在牙种植体上的骨整合:一项实验性先导研究

IF 3.4 4区 医学 Q2 ENGINEERING, BIOMEDICAL
Reza Ardeshir Mokhtari, Marcel Kunrath, Christelle Darnaud, Hanna Aludden, Lotta Tollstoy, Anders Palmquist, Christer Dahlin
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引用次数: 0

摘要

比较两种不同类型含氮双膦酸盐(N-BP)涂层牙种植体在绵羊体内模型中的骨整合性能。总共8只羊被分为两组,在两个时间点接受植入。每只动物接受四种种植体,唑来膦酸盐包被的AddBIO STL种植体(Zol)和依班膦酸盐和帕米膦酸盐包被的AddBIO STL种植体(IbaPam)作为试验组,未包被的AddBIO STL种植体(UC)和斯特劳曼原SLA种植体(SSLA)作为对照组。植入物放置于双侧跖骨,愈合时间为10天或28天。在基线和安乐死时测量种植体稳定商(ISQ)。解剖后评估去除扭矩(RT),然后进行组织形态学分析以评估骨与种植体接触(BIC)和骨面积(BA)。使用配对t检验评估植入物之间的差异。10 d后,Zol种植体的RT (Ncm mean±SD)值为26.0(±18.0),显著高于IbaPam种植体8.3(±14.9)(p = 0.011)。SSLA种植体的RT值(34.6(±22.2))显著高于Zol和ibapam涂层种植体(p = 0.048), Zol涂层种植体的RT值显著高于UC种植体(12.0(±7.6))(p = 0.015)。28天时,两组间RT无显著差异。在两个时间点上,各组间在ISQ、BIC或BA方面没有观察到差异。与依邦膦酸盐/帕米膦酸盐包被种植体相比,唑来膦酸盐包被种植体表现出更高的早期机械稳定性。然而,这种优势在28天后就消失了,这表明唑来膦酸钠的早期合成代谢作用可能是有时间限制的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Osseointegration of Nitrogen-Containing Bisphosphonate Coatings on Dental Implants: An Experimental Pilot Study

Osseointegration of Nitrogen-Containing Bisphosphonate Coatings on Dental Implants: An Experimental Pilot Study

To compare the osseointegration properties of two different types of nitrogen-containing bisphosphonate (N-BP)-coated dental implants in an experimental in vivo sheep model. In total, eight sheep were divided into two groups receiving implants at two time points. Each animal received four types of implants, AddBIO STL implants coated with Zoledronate (Zol) and AddBIO STL implants coated with Ibandronate and Pamidronate (IbaPam) as test groups and uncoated AddBIO STL implants (UC) and Straumann original SLA implants (SSLA) as controls. Implants were placed in the metatarsus bilaterally, and healing times were either 10 or 28 days. Implant stability quotient (ISQ) was measured at baseline and at euthanasia. Removal torque (RT) was assessed post-mortem, followed by histomorphometric analysis to evaluate bone-to-implant contact (BIC) and bone area (BA). The differences between implants were evaluated using paired t-tests. The significance level was set at p value < 0.05 After 10 days, Zol implants presented significantly higher RT (Ncm mean ± SD) values 26.0 (± 18.0) than IbaPam implants 8.3 (± 14.9) (p = 0.011). SSLA implants demonstrated significantly higher RT values 34.6 (± 22.2) than Zol and IbaPam-coated implants (p = 0.048) and Zol-coated implants showed significantly higher RT values than UC implants 12.0 (± 7.6) than UC implants (p = 0.015). No significant differences in RT were detected at 28 days. No differences were observed among the groups regarding ISQ, BIC, or BA at either time point. Zoledronate-coated implants exhibited enhanced early mechanical stability compared to ibandronate/pamidronate-coated implants. However, this advantage was eradicated after 28 days, suggesting that the early anabolic effect of zoledronate may be time-limited.

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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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