Journal of biomedical materials research. Part B, Applied biomaterials最新文献

{"title":"Synergistic Effects of Hydroxyapatite Nanoparticles and Platelet Rich Fibrin on Femoral Head Avascular Necrosis Repair in a Rat Model","authors":"Aml Awad, Awad Rizk, Mohamed ElAlfy, Mohamed Hamed, Amr M. Abdelghany, Esam Mosbah, Adel Zaghloul, Gamal Karrouf","doi":"10.1002/jbm.b.35672","DOIUrl":"10.1002/jbm.b.35672","url":null,"abstract":"<div>\u0000 \u0000 <p>Nanomaterials and platelets derivatives provide promising substitutes in regenerative medicine for the management of avascular necrosis of the femoral head (AVN). Thus, this study was accomplished to evaluate the effectiveness of Platelets rich fibrin (PRF) and Hydroxyapatite nanoparticles (HANPs) as innovative strategies for providing immediate mechanical support and protecting the femoral head from collapse in a surgical model of AVN and their influence on optimizing core decompression (CD) via clinical, radiographic, histopathological, and immuno-histochemical analyses. Fifty-six Sprague Dawley rats were divided into four groups. Bipolar electrocoagulation was used to surgically induce AVN by depriving blood flow. HANPs were administered to the ischemic femoral head via CD hole and sealed with PRF gel in the CD-PRF-HANPs treated group, while a CD hole was made and sealed with PRF gel in the CD-PRF treated group. The healing was evaluated at 2- and 8-weeks following surgery clinically, radiographically using Cone beam computed tomography (CBCT), and histopathologically using HE, Masson Trichrome, and Alizarin red S staining's and immunohistochemistry where Osteopontin (OPN) and cluster of differentiation 34 (CD34) were detected. The CD-PRF-HANPs group revealed a significant enhancement in mechanical hyperalgesia compared to the AVN group (<i>p</i> < 0.01) at 2 weeks, with the greatest improvement observed at 8 weeks compared to both AVN (<i>p</i> < 0.0001) and the CD-PRF group (<i>p</i> = 0.0001). It also showed enhanced efficacy in regenerating the ischemic femoral head and maintaining head sphericity, as evidenced by macroscopical images and CBCT measurements. It recorded higher BMD relative to CD-PRF (<i>p</i> = 0.003) at 8 weeks, with complete obliteration of the CD tunnel. In contrast, the AVN group displayed subchondral collapse (crescent sign) at 2 weeks and complete noticeable femoral head deformity, with the lowest CBCT values at 8 weeks (<i>p</i> < 0.0001). Histopathological analysis of the CD-PRF-HANPs group confirmed a significant restoration of normal cortical bone, organized bone lacunae, osteoid matrix, and enhanced mineralization. The AVN group displayed a significant (<i>p</i> < 0.0001) increase in the number of empty lacunae over time, compared to the other groups; in contrast, the CD-PRF-HANPs group demonstrated a significant (<i>p</i> = 0.0005) decrease in the number of empty lacunae compared to the CD-PRF group. Additionally, it exhibited the highest levels of OPN and CD34 (<i>p</i> < 0.0001), indicating a beneficial role in promoting bone matrix deposition, osteogenesis, and angiogenesis, thereby offering enhanced protection and regeneration of the femoral head. In a rat model of AVN, intraosseous administration of HANPs and PRF gel positively influenced the repair of the ischemic femoral head architecture, protected it from accelerated bone turnover, restored joint integrity, and","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrical Stimulation Combined With Hydroxyapatite Hydrogel for Bone Regeneration","authors":"Jingjing Gao,&nbsp;Xue Wang,&nbsp;Ziming Ma,&nbsp;Haichuan Sun,&nbsp;Huilin Hu,&nbsp;Lijia Cheng","doi":"10.1002/jbm.b.35687","DOIUrl":"10.1002/jbm.b.35687","url":null,"abstract":"<div>\u0000 \u0000 <p>Bone tissue exhibits inherent bioelectrical properties, and electrical stimulation (ES) has been demonstrated to effectively accelerate bone healing. However, insufficient attention has been devoted to investigating biocomposite materials that synergize with electrostimulation for bone defect repair. In this study, a composite of strontium-doped hydroxyapatite and chitosan (Sr-HA@CS) was synthesized and demonstrated to promote bone regeneration. Under combined ES, the Sr-HA@CS hydrogel not only exhibited excellent injectability, biocompatibility, and osteoinductivity, but also significantly upregulated osteogenesis-related genes and accelerated the osteogenic process, as revealed by RNA sequencing analysis. This synergistic effect further promoted intracellular calcium enrichment and enhanced bone regeneration in vivo. Therefore, the development of the Sr-HA@CS composite combined with ES therapy holds promise for accelerating bone repair and represents an important area of research.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145389175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Multifunctionality of Cu/Mn-Doped ZnS Nanosheets: A Promising Material for Cancer Therapy and Advanced Antimicrobial Applications","authors":"S. Murugan,&nbsp;M. Ashokkumar,&nbsp;K. J. Senthil Kumar,&nbsp;Manivannan Nandhagopal","doi":"10.1002/jbm.b.35684","DOIUrl":"10.1002/jbm.b.35684","url":null,"abstract":"<div>\u0000 \u0000 <p>This study investigates the structural, morphological, hydrodynamic, colloidal stability, anticancer, antibacterial, antioxidant, and hemolytic properties of Cu and Mn doped ZnS nanosheets (NSs). XRD examination indicated that the produced NSs exhibit high purity with a cubic structure. The average crystallite size was determined to be 1.66 nm for ZCMn1, 1.60 nm for ZCMn2, 1.26 nm for ZCMn3, and 1.39 nm for ZCMn4 NSs (ZnS = ZCMn1; Zn_0.98Cu_0.02S = ZCMn2; Zn_0.97Mn_0.01Cu_0.02S = ZCMn3; Zn_0.96Mn_0.02Cu_0.02S = ZCMn4). TEM analysis showed that the synthesized NSs exhibit a crumpled nanosheet morphology with agglomerated particles. The ZCMn4 NSs displayed the smallest hydrodynamic size and the best colloidal stability. The ZCMn4 NSs also demonstrated superior antibacterial efficacy, with zones of inhibition (ZOI) measuring 14mm, 14 mm, 17 mm, 16 mm, and 13 mm for <i>S. aureus</i>, <i>E. faecalis</i>, <i>P. aeruginosa</i>, <i>E. coli</i>, and <i>C. albicans</i>, respectively. Antioxidant and hemolytic activities were also evaluated, further highlighting the multifunctionality of the synthesized nanomaterials. Notably, the ZCMn4 NSs exhibited minimal hemolytic activity, with a lysis rate of only 0.33% at a dosage of 500 μg/mL. The doped and dual-doped ZnS NSs exhibited strong and selective cytotoxic effects against melanoma cells while sparing normal melanocytes. Furthermore, a TUNEL assay was performed to confirm that the reduction in cell viability resulted from apoptotic cell death. These findings underscore the potential of Mn and Cu-doped ZnS nanosheets as promising therapeutic nanomaterials for cancer treatment, drug delivery, MRI, and other biological applications.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Magnesium Metal and Its Alloys for Promoting Angiogenesis","authors":"Junjie Huang,&nbsp;Jialong Wu,&nbsp;Di Liu,&nbsp;Peng Gao","doi":"10.1002/jbm.b.35671","DOIUrl":"https://doi.org/10.1002/jbm.b.35671","url":null,"abstract":"<p>Magnesium-based materials show great promise for bone repair due to their biodegradability, bone-like mechanical properties, and dual pro-angiogenic/osteogenic activities. Pure magnesium implants enhance vascularization in bone defect models through Mg²⁺ release. Advanced alloys and surface coatings further improve degradation kinetics and angiogenic performance. Mg²⁺ promotes vascular remodeling via multiple mechanisms, including activation of the CGRP/VEGF pathway, stabilization of HIF-1α, and scavenging of reactive oxygen species. Current challenges remain: standard small-animal critical-size defect models and static in vitro conditions poorly mimic real physiological environments; mechanistic studies often focus on isolated pathways rather than integrated networks; and vascularization assessment lacks standardized methodology. Future efforts should prioritize developing large-animal models of complex pathological conditions, establishing dynamic ion release simulation systems, applying multi-omics technologies to decipher the Mg²⁺-mediated “vascular–immune–osseous” regulatory network, and establishing unified evaluation protocols to accelerate clinical translation.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35671","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145366842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Particle Synthesis Method on Protein Release and Stability","authors":"Daniela Sanchez,&nbsp;Balaji Narasimhan","doi":"10.1002/jbm.b.35685","DOIUrl":"https://doi.org/10.1002/jbm.b.35685","url":null,"abstract":"<div>\u0000 \u0000 <p>Polyanhydride particle-based vaccines overcome several limitations of current vaccines owing to their ability to encapsulate different types of antigenic payloads, provide tunable release kinetics of payloads, and induce protective immunity against multiple respiratory infections. In this work, two particle synthesis methods were compared by analyzing the structure and antigenicity of released proteins from particles made by these methods. Flash nanoprecipitation is a lab-scale method to synthesize protein-loaded particles. Spray drying is a scalable method that allows for the production of protein-loaded particles. The polyanhydride copolymer used for both synthesis methods was composed of a 20:80 M ratio of 1,8-bis(<i>p</i>-carboxyphenoxy)-3,6-dioxaoctane and 1,6-bis(<i>p</i>-carboxyphenoxy)hexane. The three proteins used in this work are bovine serum albumin (a model, globular protein), and SARS-CoV-2 spike and bovine RSV post-F protein (both clinically relevant proteins). The release kinetics of the encapsulated proteins were studied, and the structure of the released proteins was analyzed using gel electrophoresis and fluorescence spectroscopy. The antigenicity of the released spike and post-F was estimated based on the binding of positive mouse sera from previously inoculated mice. Our results indicate that both flash nanoprecipitation and spray drying resulted in particle formulations that provided a burst release of protein followed by a sustained period of release. The primary and tertiary structures and the antigenicity of the released proteins were maintained consistently across both methods. Altogether, these studies indicate that spray drying can be used to generate particles that stabilize encapsulated antigens and for at-scale particle synthesis in the future.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145366840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State of the Art Technology of Electroactive and Conductive Scaffolds for Bone Tissue Engineering","authors":"Mahendra Kumar Soni,&nbsp;Vimlesh Kumar Soni,&nbsp;Emon Barua","doi":"10.1002/jbm.b.35663","DOIUrl":"10.1002/jbm.b.35663","url":null,"abstract":"<div>\u0000 \u0000 <p>The promising outcome of Bone Tissue Engineering (BTE) via scaffolds for treating segmental bone defects (SBDs) has led the interdisciplinary field of Materials Science to take a new turn and explore innovative biomaterials that enhance tissue regeneration. The most recent advancement is the application of electrical stimulation with the use of conductive and piezoelectric biomaterials to develop conductive and electroactive (EA) scaffolds that activate osteoblast formation, leading to a significantly faster and more robust bone healing process. Researchers have explored plenty of biomaterials and scaffold fabrication techniques. This article presents a comprehensive review of the popular biomaterials that include Conductive Polymers (PANI, Poly-pyrrole, PEDOT), Piezoelectric Polymers (PVDF, TrFE, PLLA, PAs), Metallic Nanoparticles (NPs) (Ag, TiO₂), and Carbon-based NPs (CNTs, Graphene, Graphene Oxide) used for the development of conductive and EA biocompatible scaffolds. Various innovative conductive and electroactive scaffold fabricating methods, like 3D printing, bio-printing, electrospinning, etc., that precisely command over the conductive filler distribution, porosity, and pore size interconnectivity are highlighted. Tests explored by researchers for investigating the conductive and piezoelectric properties of the developed scaffolds and their osteogenic potential (in vitro and in vivo) are also presented. Apart from this, standard protocols for the conduction of these tests, regulatory pathways, scope for clinical translations, and their respective challenges have been reviewed. Most importantly, the review not only focuses on the material versatility and fabrication techniques but also critically analyzes the challenges involved in optimizing the biomaterials and fabrication parameters to develop bone scaffolds with the best-optimized physicochemical, mechanical, biological, and conductive properties.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145354940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen Hydrogel Loaded With Propolis-Loaded ZIF-8 Nanoparticles and Menstrual Blood Stem Cells for Osteoarthritis Treatment","authors":"Yue Zou,&nbsp;Yanyan Zhang,&nbsp;Xiujiang Sun,&nbsp;Guodong Zhang","doi":"10.1002/jbm.b.35683","DOIUrl":"10.1002/jbm.b.35683","url":null,"abstract":"<div>\u0000 \u0000 <p>Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage breakdown and chronic inflammation. Current therapies mainly relieve symptoms but do not halt disease progression. We developed collagen hydrogels incorporating propolis-loaded zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (PROZIF) and menstrual blood-derived stem cells (MenSCs). In vitro assays evaluated microstructure, cell viability, anti-inflammatory activity, drug release, and cytoprotection. An osteoarthritis model was induced in rats by monosodium iodoacetate (MIA). Animals received intra-articular injections of hydrogels, and outcomes were assessed by histology, enzyme-linked immunosorbent assay (ELISA), knee swelling, and locomotor function. Collagen–PROZIF–MenSCs hydrogels with 2% nanoparticle content (COL-PROZIF-MenSCs-2) preserved MenSC viability, showed strong anti-inflammatory effects, and provided sustained propolis release. In vivo, this group significantly reduced cartilage degeneration, decreased tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β), and increased transforming growth factor-beta (TGF-β) and fibroblast growth factor (FGF) levels compared to controls. Knee swelling was reduced, and locomotor scores improved. Combining ZIF-8 nanoparticles with MenSCs in collagen hydrogels synergistically mitigated OA progression in rats by reducing inflammation and supporting cartilage repair. This approach demonstrates promise as a localized, cell- and drug-based therapy for OA, warranting further long-term and translational studies.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145354965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the Concentration of Different Amino Acids on the Corrosion Behavior of Mg Alloy AZ31—A Respirometric Study","authors":"M. P. Bruns,&nbsp;G. Schulze,&nbsp;M. G. Strebl,&nbsp;S. Virtanen","doi":"10.1002/jbm.b.35676","DOIUrl":"10.1002/jbm.b.35676","url":null,"abstract":"<p>In view of the potential use of Mg-based materials as biodegradable metals in temporary implantation, it is important to study the role of different components of the biological environment on the corrosion behavior. This work focuses on the effect of selected amino acids and their concentrations on time-dependent corrosion of Mg alloy AZ31. The influence of different concentrations of glycine, glutamine, phenylalanine, cysteine, glutamic acid, and aspartic acid in 0.1 M NaCl on the corrosion behavior of Mg alloy AZ31 was investigated with respirometric measurements, mass loss, and electrochemical methods. At low concentrations, all investigated amino acids exhibited cathodic inhibition. At higher concentrations, strong acceleration of corrosion was observed, which can be attributed to the buffering effect of the amphoteric amino acids, hence decelerating alkalization of the electrolyte caused by Mg corrosion. For all here studied amino acids except cysteine, Mg corrosion occurred with hydrogen evolution reaction (HER) as the dominant cathodic reaction with around 10% of the oxygen reduction reaction (ORR) of the total cathodic reactions. However, the presence of cysteine changes the cathodic reactions during Mg corrosion to around 30% ORR. Moreover, Mg ions were shown to act as a catalyst for the oxidation of cysteine to cystine.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Enhanced Bone Regeneration: Investigating the Impact of Wollastonite Phases and Buffered Solutions in Calcium Silicate Cements","authors":"Renata Guimarães Ribas,&nbsp;Juliani Caroline Ribeiro de Araújo,&nbsp;Hanna Flávia Santana dos Santos,&nbsp;Vinícius Danilo Nonato Bezzon,&nbsp;Tiago Moreira Bastos Campos,&nbsp;Luana Marotta Reis de Vasconcellos,&nbsp;Gilmar Patrocínio Thim","doi":"10.1002/jbm.b.35666","DOIUrl":"10.1002/jbm.b.35666","url":null,"abstract":"<p>As life expectancy rises, the demand for effective bone regeneration materials becomes imperative, particularly in addressing age-related conditions such as osteoporosis, arthritis, and dental surgeries. This study focuses on the urgent development of materials aimed at filling the implant-bone interface and enhancing bone regeneration. Wollastonite (CaSiO₃), a calcium silicate ceramic, stands out for its superior biocompatibility and hydroxyapatite-forming capability compared to phosphate-based cements. The primary objective of this research is to assess the influence of different wollastonite phases and buffered solutions on the production of calcium silicate cements. Four types of cement were evaluated, varying the studied phase (α and β-wollastonite) and the activating solution ((NH₄)₂HPO₄ and K₂HPO₄). Characterization techniques such as X-ray powder diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), Raman spectroscopy, and scanning electron microscopy (SEM) were employed to elucidate the impact of each phase and ion on material properties. Compressive strength analysis and biological tests were also conducted. The physicochemical analysis revealed that the α-wollastonite phase exhibits more non-bridge oxygen (NBO) bonds and silanol groups than β-wollastonite, suggesting superior bioactivity. XRD, FT-IR, and Raman results demonstrated that cements prepared with ammonium buffer solutions formed hydroxyapatite, enhancing compatibility with bone tissue. Compressive strength tests showed overall equivalent strengths (approximately 6 MPa), except for the sample prepared with β-wollastonite and potassium phosphate, which exhibited lower resistance to compression. Alkaline phosphatase data indicated that cements formed with α-wollastonite phase and (NH₄)2HPO₄ presented superior potential for bone regeneration.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35666","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Suture Type on Implant Wound Healing and Bacterial Adherence","authors":"Ahmed H. Al-Ani,&nbsp;Priyadharshini Sekar,&nbsp;Zaid G. Hamdoon,&nbsp;Waad kheder,&nbsp;Natheer H. Al-Rawi","doi":"10.1002/jbm.b.35679","DOIUrl":"10.1002/jbm.b.35679","url":null,"abstract":"<div>\u0000 \u0000 <p>Suture selection influences wound healing, patient comfort, and infection risk in implant surgery. Although monofilament sutures are commonly recommended for implant surgery, the comparative clinical performance of different types of monofilament sutures remains underexplored. This study compared the clinical and microbiological performance of polyamide and polytetrafluoroethylene (PTFE) sutures. A split-mouth design was used in 19 patients (38 implant sites) to compare wound healing, patient comfort, and bacterial adherence associated with polyamide and PTFE sutures. Wound healing was assessed using the early wound healing score (EHS, 0–10 scale), patient comfort via a visual analog scale (VAS, 1–10), and bacterial colonization using real-time quantitative PCR (qPCR) analysis of seven oral pathogens. Knot retention was recorded on days 0 and 7. Mean early wound healing scores were similar between PTFE (6.47 ± 0.52) and polyamide (6.63 ± 0.63) (<i>p</i> &gt; 0.05). No significant differences were found between the two groups regarding surrounding tissue irritation (<i>p</i> &gt; 0.05). However, knot stability decreased significantly for both materials, with polyamide showing higher knot loss (44.4% vs. 22.2%, <i>p</i> = 0.008). A significant number of <i>Porphyromonas gingivalis</i> were detected in PTFE compared to polyamide, which demonstrated enhanced reepithelialization and minimal tissue reaction. Both suture types achieved satisfactory healing and patient comfort, but their distinct microbial adhesion patterns may influence long-term peri-implant outcomes. Polyamide demonstrated lower <i>P. gingivalis</i> colonization and better re-epithelialization, suggesting potential clinical advantages.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}