Calcium Sulfate Bone Substitutes in Clinical Use: History, Material Properties, Application, and Outlook for the Future

IF 3.2 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2025-03-29 DOI:10.1002/jbm.b.35555

Josina Straub, Andreas Sewing, Nike Walter, Ronald Man Yeung Wong, Volker Alt, Christian Heiss, Markus Rupp

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Abstract

Calcium sulfate-based materials have been used in medicine since the 19th century. Their application makes a significant part in the field of bone regeneration in biomedical engineering. Calcium sulfate is a versatile product that is used not only in the reconstruction of bone defects but also as an antibiotic carrier. Various types of calcium sulfate-based bone grafts have demonstrated their safety, well-tolerance, biodegradability, and osteoconductive properties, making them a potential substitute for autogenous bone transplant in the treatment of bone defects. Calcium sulfate and different-sized calcium sulfate beads can be produced and loaded with different antimicrobial substances. High concentrations of antimicrobial agents can be obtained by applying these locally to affected tissue. This review aims to (1) highlight the development and milestones already achieved in the use of calcium sulfate products and (2) outline the material properties and application areas with their related advantages and disadvantages of calcium sulfate products. Lastly, (3) an outlook for the future of calcium sulfate-based biomaterials is given.

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临床应用的硫酸钙骨替代物：历史、材料特性、应用和未来展望

自19世纪以来，硫酸钙基材料一直用于医学。它们的应用是生物医学工程中骨再生领域的重要组成部分。硫酸钙是一种用途广泛的产品，不仅用于骨缺损的重建，而且还用作抗生素载体。各种类型的硫酸钙骨移植物已被证明具有安全性、良好的耐受性、生物降解性和骨导电性，使其成为骨缺损治疗中自体骨移植的潜在替代品。硫酸钙和不同大小的硫酸钙珠可以生产和装载不同的抗菌物质。高浓度的抗菌剂可通过局部应用于受影响的组织而获得。本文旨在(1)重点介绍硫酸钙产品的发展和已取得的里程碑；(2)概述硫酸钙产品的材料特性和应用领域及其相关的优缺点。最后，对硫酸钙基生物材料的发展前景进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of biomedical materials research. Part B, Applied biomaterials 工程技术-材料科学：生物材料

CiteScore

7.50

自引率

2.90%

发文量

199

审稿时长

12 months

期刊介绍： Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.