IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL
Ramya Ramadoss, Rajashree Padmanabhan
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引用次数: 0

摘要

牙本质过敏症(DH)的发病率从 72.5% 到 98%不等,从人的第三个十年开始就很常见。尽管现有的产品种类繁多,但牙本质过敏仍是一个长期存在的问题。在现有的大量产品中,陶瓷,特别是磷硅酸钙钠(CSPS)玻璃似乎是治疗牙本质过敏症最通用的材料。文献清楚地表明,磷硅酸钙钠(CSPS)具有多种可能性,因为它可以与软组织和硬组织结合。由于能够产生灵活的结构,因此可以进行一系列的改良。与其他生物材料相比,这些特性对牙本质最为重要,而且具有针对性。开发出治疗牙本质龋齿和牙本质过敏症的长效方法将大大改善患者的生活质量。尽管 CSPS 用于牙本质再矿化已有二十多年的历史,但在强度和结晶形态方面仅取得了部分成功。通过深入了解动态基质和矿化过程,可以更有效地利用 CSPS 进行牙本质再矿化。CSPS 可作为一种智能给药方法进行优化,并在龋齿综合预防计划中作为凹坑和裂隙的密封剂加以应用。基于 CSPS 的给药系统可以有效地重组牙本质基质的关键分子,而这些分子通常会在牙本质龋齿或其他病变过程中受到破坏。对混合物进行额外调整可促进牙本质粘合剂的开发。本综述旨在总结有关 CSPS 对牙本质过敏症的研究,并阐述未来可能采用的重建牙本质基质以有效治疗牙本质过敏症的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Calcium Sodium Phosphosilicate in Management of Dentin Hypersensitivity and Strategies for Reconstitution of the Dentin Matrix

Dentin hypersensitivity (DH) prevalence ranges from 72.5%–98% and is common from the third decade of life. Despite the variety of products available, dentine hypersensitivity remains a persistent issue. From the vast array of existing products, ceramics specifically Calcium sodium phosphosilicate (CSPS) based glasses seem to be the most versatile material to manage dentin hypersensitivity. Literature clearly indicates that Calcium sodium phosphosilicate (CSPS) permits a multitude of possibilities as it allows integration with soft and hard tissues. The ability to generate a flexible structure has resulted in an array of modifications. These characteristics are most vital and target specific to dentin than other biomaterials. Developing a long-lasting cure for dentin caries and dentin hypersensitivity will significantly improve the quality of life for patients. Even though it has been used for dentin remineralization for over two decades, CSPS has been able to achieve only partial success in terms of strength and crystalline pattern. CSPS can be put into more effective use in terms of dentin remineralization by in-depth understanding of the dynamic matrisome and the mineralization process. CSPS can be optimized as a smart delivery method and applied as a sealant for pits and fissures in a comprehensive preventive dental caries initiative. CSPS-based drug delivery systems can effectively reconstitute the key molecules of the dentin matrix that are commonly damaged during dentinal caries or other pathologies. Additional adjustments to the mix can facilitate the development of dentin-bonding agents. This review seeks to summarize the studies on CSPS on dentin hypersensitivity, and it also elaborates on possible futuristic approaches to reconstitute the dentin matrix for effective management of DH.

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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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