Journal of biomedical materials research. Part B, Applied biomaterials最新文献

{"title":"Photocrosslinked Mucoadhesive Hyaluronic Acid Hydrogel for Transmucosal Drug Delivery","authors":"Seth Asamoah,&nbsp;Martin Pravda,&nbsp;Eva Šnejdrová,&nbsp;Martin Čepa,&nbsp;Mrázek Jiří,&nbsp;Carmen Gruber-Traub,&nbsp;Vladimír Velebný","doi":"10.1002/jbm.b.35652","DOIUrl":"https://doi.org/10.1002/jbm.b.35652","url":null,"abstract":"<p>Drug delivery to the central nervous system (CNS) is primarily hindered by the blood–brain barrier (BBB). To address this, mucoadhesive formulations have been designed to prolong residence time at the application site. In this study, we comprehensively characterized the physicochemical and mucoadhesive properties of hyaluronic acid tyramine (HATA) photocrosslinked hydrogels using rheological methods, nanoindentation, contact angle goniometry, and advanced confocal microscopy. A novel parameter, photon count per pixel, was introduced through confocal microscopy to assess hydrogel stability and mucoadhesion on ex vivo porcine olfactory tissues. Crosslinked hydrogels (1% and 2% w/v) exhibited stable mucoadhesive properties, ranging between 16.5 and 18 photon counts per pixel, whereas uncrosslinked counterparts typical of classical nasal formulations showed significant photon count losses (71% and 50% for 1% and 2% HATA, respectively). Nanoindentation analysis revealed a correlation between photoirradiation time, effective Young's modulus, and mucoadhesion, identifying 1 min of irradiation as optimal across all concentrations tested. The optimized hydrogels demonstrated mucoadhesive forces of 0.263, 0.412, and 0.701 mN mm⁻², corresponding to Young's modulus values of 1995, 2465, and 2985 Pa for 1%, 2%, and 3% w/v HATA, respectively. These results highlight the importance of crosslinking for enhancing hydrogel stability and mucoadhesion. Additionally, BSA-labeled rhodamine served as a model protein drug in low-swelling hydrogels for drug release studies, laying the foundation for further optimization in targeted nasal drug delivery systems.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35652","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging and Staining Effects on Optical Properties of Flowable Composites","authors":"M. M. Sly,&nbsp;Y. Korkmaz-Ceyhan,&nbsp;F. Dini,&nbsp;R. L. Ocampo Escobedo,&nbsp;E. Abram,&nbsp;R. D. Paravina","doi":"10.1002/jbm.b.35648","DOIUrl":"https://doi.org/10.1002/jbm.b.35648","url":null,"abstract":"<p>Resin composites have become the preferred restorative material in modern dentistry due to their superior esthetics, improved physical properties, and advancements in curing technologies. To enhance their clinical performance, manufacturers continuously refine the resin matrix and optimize filler particle size and shape, improving both mechanical strength and optical characteristics. Evaluating optical properties is crucial for predicting the performance of resin composites over time, particularly in maintaining color, gloss, translucency, and overall appearance. Translucency refers to a material's ability to transmit and scatter light. This in vitro study evaluated changes in color, translucency, and gloss of nine commercially available flowable resin composites following artificial accelerated aging (AAA) and staining. Specimens were subjected to AAA and staining in black tea, coffee, and red wine. Using a spectrophotometer, color and translucency measurements were performed before and after the AAA and staining. Gloss measurements were performed using a small-area glossmeter before and after the AAA and staining. A two-way ANOVA was used to compare the effects of material and treatment, followed by Tukey's post hoc multiple comparison test to assess differences among levels within each variable (<i>α</i> = 0.05). A statistically significant interaction was observed between materials and procedures (<i>p</i> &lt; 0.05) for color changes. All tested composites displayed translucency parameter changes within clinically acceptable limits. Gloss retention percentage upon treatments remained high across all composites tested. AAA and staining significantly influenced the color stability, translucency, and gloss retention of tested flowable resin composites, and were material- and procedure-dependent.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35648","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cells and Shells: Investigating How Breast Implant Shells Negatively Impact Cell Viability In Vitro","authors":"Sophia Salingaros,&nbsp;Jini Jeon,&nbsp;Abby Chopoorian Fuchsman,&nbsp;Xue Dong,&nbsp;Jason A. Spector","doi":"10.1002/jbm.b.35649","DOIUrl":"https://doi.org/10.1002/jbm.b.35649","url":null,"abstract":"<div>\u0000 \u0000 <p>The pathophysiology of breast implant-related adverse outcomes, such as capsular contracture and breast implant-associated anaplastic large cell lymphoma, remains poorly understood. Herein, we explore the direct and indirect effects of smooth and textured implant shells on the viability of cell lines found within the peri-breast implant environment in vitro. The outer silicone shells of Allergan and Mentor breast implants were de-gelled and cut to exactly line the walls of 96-well cell culture plates. Endothelial, fibroblast, and triple negative breast cancer cell lines were cultured in the presence and absence of implant shells over 8 days. To examine indirect effects, fresh media incubated with implant shells were collected and separately cultured with the same cell lines. These media were further diluted with fresh media and given to cells to examine a “dose dependent” response. Additionally, the effect of pre-soaking implant shells in fresh media prior to cell culture was investigated. Serum free media incubated with implant shells were interrogated for presence of nanoparticles. Cell counts at each culture condition were assessed over 8 days. The presence of implant shells consistently demonstrated a negative effect on cell count that persisted across cell lines and experimental conditions, with a greater effect observed from textured surface shells over smooth. Implant fill silicone gel alone did not influence cell count. Implant-conditioned media (CM) similarly exerted a negative effect, even without direct cell exposure to an implant shell. Dilution of the CM attenuated this effect. Pre-soaking implants in high serum media also reduced the negative effect when incubated with cells, suggesting the role of serum protein adsorption. Nanometer-range sized particles were detected in serum-free media incubated with all implants, with a higher concentration released from textured samples. These studies suggest breast implant shells may negatively impact cell viability through several different mechanisms and uncover valuable insights into the cellular interactions and potential effects of these widely used prostheses on their immediate environment.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open Wound Healing in Guided Bone Regeneration Using a Magnesium Membrane: A Paradigm Shift","authors":"Giorgio Tabanella,&nbsp;Patrick Rider,&nbsp;Svenja Rogge,&nbsp;Marija Čandrlić,&nbsp;Željka Perić Kačarević","doi":"10.1002/jbm.b.35642","DOIUrl":"https://doi.org/10.1002/jbm.b.35642","url":null,"abstract":"<p>Guided bone regeneration (GBR) is essential in implant dentistry for managing bone deficiencies. Despite its high success rate, complications like wound dehiscence, membrane exposure, and infection can compromise outcomes. These issues are influenced by patient health, surgical technique, and the implanted biomaterials. Membrane exposure may lead to significant bone loss and jeopardise treatment success. A resorbable magnesium membrane has been recently introduced for GBR, but soft tissue healing complications have not yet been reported. This case series reviews four instances of wound dehiscence to assess its impact on clinical outcomes. Four patients underwent GBR using a magnesium membrane before implant placement. Each followed a similar protocol: defects were filled with bovine and autologous bone, then covered with the magnesium membrane. Membrane exposure occurred in all cases, varying from small to large. However, none experienced pain or signs of infection, and no additional treatment was required. Implant placement proceeded as planned, with no notable bone loss. Despite varying degrees of exposure, the magnesium membrane prevented infection, pain, or significant bone loss. It effectively maintained a barrier between tissues, suggesting its potential to reduce complications from exposure. Larger studies are needed to validate these findings.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35642","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Evaluation of ZnAg3—A New Bioabsorbable Material in Fracture Treatment Compared to Biodegradable Mg Alloys","authors":"Maria Roesner,&nbsp;Anna Baghnavi,&nbsp;Bianca Riedel,&nbsp;Adalbert Kovacs,&nbsp;Moritz Benner,&nbsp;Roland Barkhoff,&nbsp;Hagen Schmal,&nbsp;Eva Johanna Kubosch,&nbsp;Michael Seidenstuecker","doi":"10.1002/jbm.b.35647","DOIUrl":"https://doi.org/10.1002/jbm.b.35647","url":null,"abstract":"<p>Permanent implants, which are primarily used to treat fractures, are either removed during a subsequent procedure or remain in the body after being surgically inserted. Bioabsorbable implants are designed to be reabsorbed by the body, minimizing the risk of chronic infections or foreign body reactions. The qualification of a novel zinc-silver alloy containing 3.3 wt% silver (ZnAg3) as a bioabsorbable implant was investigated in this in vivo study on New Zealand white rabbits. The osteointegration of ZnAg3 pins and MAGNEZIX pins, which served as controls, was evaluated histomorphometrically and histologically at 4, 8, and 16-week intervals. The implant area and the osteoid area were measured in order to assess the degradation of the material as well as the bone formation. The histological evaluation included a cell count of osteogenic cells and a descriptive evaluation of the histological images. The animal trial was accompanied by frequent blood, urine, and X-ray tests. The results showed adequate degradation of ZnAg3 with an implant area of 93.92% ± 5.85% at week 16 and a sufficient number of osteogenic cells, allowing progressive osteointegration. In comparison, the MAGNEZIX pin degraded significantly faster and, after 16 weeks, diminished to 77.54% ± 13.59% of the original implant area. Furthermore, harmful hydrogen gas pockets were found, which correlated with reduced bone formation, represented by a lower cell count of osteoblasts after 4 weeks. ICP-OES measurements performed on the animals' blood samples did not reveal any increased metal ion concentrations above the tolerable level. Thus, ZnAg3 pins showed excellent results compared to MAGNEZIX pins, which are in clinical use as bioabsorbable implants.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35647","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PB/CeO2 Nanoparticles Regulating Reactive Oxygen Species for the Control of Enterococcus faecalis Infection in Root Canals","authors":"Huiwen Wang,&nbsp;Yuting Wu,&nbsp;Mingrui Dai,&nbsp;Tingting Zhu,&nbsp;Daming Wu,&nbsp;Diya Leng","doi":"10.1002/jbm.b.35646","DOIUrl":"https://doi.org/10.1002/jbm.b.35646","url":null,"abstract":"<div>\u0000 \u0000 <p>To investigate the antibacterial effect, mechanism, and cytotoxicity of Prussian blue/Cerium dioxide (PB/CeO₂) nanoparticles against <i>Enterococcus faecalis (E. faecalis)</i> and biofilm. PB/CeO₂ nanoparticles were synthesized and characterized. The antibacterial mechanism of nanoparticles was explored through peroxidase (POD) activity assay, hydroxyl radicals (·OH) detection, and measurement of bacterial reactive oxygen species (ROS) and glutathione (GSH)/glutathione disulfide (GSSG) levels. The biocompatibility of PB/CeO₂ was evaluated by Cell Counting Kit-8 (CCK-8) assay and histological examination of the major visceral organs of rats. The antibacterial effect of PB/CeO₂ was assessed using the colony-forming unit (CFU) method. The impact of PB/CeO₂ on <i>E. faecalis</i> biofilm on dentin slices was further observed with CLSM and SEM. ANOVA and <i>t</i>-test were applied for statistical analysis (<i>p</i> &lt; 0.05). PB/CeO₂ demonstrated significant antibacterial activity against <i>E. faecalis</i>, mainly when used with H₂O₂, significantly enhancing its antibacterial effect and effectively disrupting <i>E. faecalis</i> biofilms on dentin slices. PB/CeO₂ nanoparticles catalyzed ROS production, disrupting the antioxidant defense system of <i>E. faecalis</i> cells, damaging bacterial cell membranes, and ultimately causing bacterial death. PB/CeO₂ nanoparticles exhibit good biocompatibility at appropriate concentrations in vivo and in vitro. The novel multifunctional nanocomposite shows great antibacterial effects against <i>E. faecalis</i> and its biofilm, with low cytotoxicity and good biocompatibility, offering a novel disinfection strategy for root canal treatment.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Beyond Pills: The Era of Implantable Microchips in Controlled Drug Delivery","authors":"Aritra Saha,&nbsp;Anoushka Khanna,&nbsp;Ashrit Nair,&nbsp;Bhupendra Singh Butola,&nbsp;Nitin Sharma,&nbsp;Navneet Sharma","doi":"10.1002/jbm.b.35645","DOIUrl":"https://doi.org/10.1002/jbm.b.35645","url":null,"abstract":"<div>\u0000 \u0000 <p>Controlled drug delivery systems are crucial for maintaining therapeutic efficacy while minimizing side effects. However, they have long presented a significant challenge in the field of medicine. It is difficult to precisely control the drug release kinetics with conventional drug delivery methods, leading to reduced effectiveness and potential toxicity. As a result, there is an increased demand for advanced drug delivery platforms, capable of providing precise and sustained drug release, thereby improving performance and patient outcomes. Implantable microchips are advanced microelectromechanical systems-based devices that have the potential to revolutionize drug delivery and are the preferred choice for researchers and industry pioneers. They are a promising and superior alternative to traditional systems, as they are biocompatible, easy to manufacture, and have patient-friendly designs. Microchips are designed to provide precise control over both the rate and timing of drug release. A single microchip can be engineered with multiple reservoirs (loaded with different active moieties) via different microfabrication techniques, enabling multi-drug therapy. Currently, most implantable microchips are designed as single-use devices, intended to be removed or replaced once the drug reservoirs are depleted. Nevertheless, research is ongoing to address this issue, and efforts are being made to design refillable microchips. They have a wide range of applications, including chronic disease management for conditions like diabetes and cardiovascular diseases, cancer therapy, and treatment of neurological disorders like Parkinson's disease. The current review offers a comprehensive exploration of the evolution of implantable microchips for drug delivery, tracing their development from inception to the latest advancements along with their working methods and fabrication technologies.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant Performance in UHMWPE Knee Bearings: A Mid-Term Retrieval Report","authors":"Peder Solberg,&nbsp;Kori Jevsevar,&nbsp;Barbara Currier,&nbsp;Alexander Orem,&nbsp;David Jevsevar,&nbsp;Douglas Van Citters","doi":"10.1002/jbm.b.35627","DOIUrl":"https://doi.org/10.1002/jbm.b.35627","url":null,"abstract":"<div>\u0000 \u0000 <p>Joint arthroplasty bearing materials must maintain a balance between wear resistance, toughness, and oxidation resistance. Antioxidant-doped polyethylene has been introduced to stabilize free radicals resulting from the cross-linking process while avoiding mechanical property losses associated with previous generations of highly cross-linked polyethylene. Furthermore, the antioxidant should prevent or greatly reduce oxidation occurring in vivo. The purpose of this study is to understand the extent to which retrieved, antioxidant-doped UHMWPE devices exhibit chemical and microstructural signs of oxidation. A group of 261 antioxidant knee bearings from an IRB-approved retrieval database were assessed for oxidation and microstructural changes that would be expected with oxidation. Three different antioxidant materials were included in this study, including diffused vitamin E (VE-D), blended vitamin E (VE-B) and pentaerythritol tetrakis[3-(3,5- di-tert-butyl-4-hydroxyphenyl)] propionate (PBHP), with an emphasis on the latter. Ketone oxidation index (KOI) and crystallinity were assessed for all materials, while crosslink density was assessed for the PBHP materials. In vivo durations were 0–107 months, making this the largest and longest known study of antioxidant efficacy in retrieved devices. Increases to KOI with in vivo duration were minimal, with nearly all values remaining below 0.2 out to the maximum duration observed. These increases were largely attributed to the presence of absorbed species near the material surface, where maximum KOI occurred in most devices. Microstructural changes typically associated with oxidation did not yield any meaningful changes, indicating that polymer degradation is not occurring in these materials to any significant extent. Subsurface KOI peaks were noted in five devices, suggesting that small amounts of polymer oxidation may develop in these materials given the right conditions. However, unlike subsurface ketone peaks associated with oxidation in previous generations of UHMWPE, these were very small and pose no threat to the mechanical properties of the materials. In retrievals evaluated to date, all antioxidant formulations appear to be effectively controlling in vivo oxidation. Small amounts of polymer oxidation observed in several devices are not likely to have clinical relevance. Continued monitoring over the long term will be necessary to ensure this remains the case.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sciatic Nerve Regeneration in Rat Model With PLGA-MWCNT Conduit Loaded by Fibrin Hydrogel Containing Nanolycopene and Schwann Cells","authors":"Jafar Ai,&nbsp;Majid Salehi,&nbsp;Shima Shojaie,&nbsp;Tahmineh Jazdani,&nbsp;Arian Ehterami,&nbsp;Sepehr Zamani,&nbsp;Mozhdeh Salehi Namini,&nbsp;Farzaneh Torabi Mehr,&nbsp;Ali Farzin,&nbsp;Fariborz Sharifianjazi,&nbsp;Kourosh Mansoori,&nbsp;Hossein Kargar Jahromi","doi":"10.1002/jbm.b.35643","DOIUrl":"https://doi.org/10.1002/jbm.b.35643","url":null,"abstract":"<div>\u0000 \u0000 <p>This study developed a biodegradable neural guidance conduit using electrospun poly(lactic-co-glycolic acid) (PLGA) and multiwall carbon nanotubes (MWCNT) to deliver allogeneic Schwann cells (SCs) for enhanced peripheral nerve regeneration. The conduit incorporated fibrin and lycopene-chitosan nanoparticles (Lyco-CNPs) optimized for enhanced stability and drug delivery (diameter: 163 ± 6 nm; zeta potential: −9.3 mV), addressing limitations of prior formulations. Key structural and mechanical properties included a fiber diameter of 251 ± 22 nm, tensile strength of 5.86 ± 0.98 MPa, Young's modulus of 1.68 ± 0.25 MPa, and pore diameter of 21.8 nm, ensuring robustness and nutrient diffusion. In vitro studies confirmed a dose-dependent increase in Schwann cell proliferation via MTT assay with the addition of lycopene nanoparticles (NL). In a 10-mm sciatic nerve defect model in rats, the PLGA-CNT-nanoLyco conduit seeded with SCs demonstrated superior regeneration, evidenced by 35.31% higher myelinated nerve density compared to controls. Histopathological (hematoxylin–eosin/Luxol fast blue) and walking-footprint analysis confirmed enhanced axonal alignment and remyelination. These results highlight the conduit's dual functionality as a structural scaffold and bioactive delivery system for nerve repair.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Different Bone Cement Formulations Containing Boron Derivatives","authors":"Didem Aksu,&nbsp;Nisa İrem Büyük,&nbsp;Burak Çağrı Aksu,&nbsp;Gökhan Meriç,&nbsp;Gamze Torun Köse","doi":"10.1002/jbm.b.35640","DOIUrl":"https://doi.org/10.1002/jbm.b.35640","url":null,"abstract":"<div>\u0000 \u0000 <p>PMMA bone cement is mainly utilized to stabilize prosthetic implants; however, it is impacted by a variety of obstacles, including a lack of biocompatibility, limited thermal stability, a greater tendency to infection, and restricted mechanical strength. This study incorporates three different boron derivatives, boric acid, borax pentahydrate, and borax decahydrate into the polymethylmethacrylate (PMMA) bone cement formulation, leveraging their antibacterial properties to address the identified challenges. All three bone cement formulations were evaluated using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), and mechanical analysis. In addition, three formulations of bone cement were evaluated for cellular viability, antibacterial properties, and biocompatibility via a hemolysis assay. Borax decahydrate significantly influenced the biomechanical properties (214.32 MPa) of bone cement samples by decreasing the development of surface porosity in the materials. Borax pentahydrate demonstrated a greater beneficial effect than borax decahydrate in the majority of analyses; nevertheless, the most optimal results were achieved with boric acid. In the 3% boric acid bone cement samples, the cellular viability was significantly enhanced until 14 days as a consequence of the formation of porous structures. Moreover, these bone cement samples exhibited promising antibacterial characteristics and biocompatibility compared to commercial bone cement, both unmodified and antibiotic-incorporated, demonstrating potential features for further research and development.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}