Journal of biomedical materials research. Part B, Applied biomaterials最新文献

{"title":"A Compromised Maxillofacial Wound Healing Model for Characterization of Particulate Bone Grafting: An In Vivo Study in Rabbits","authors":"Nourhan Hussein,&nbsp;Vasudev Vivekanand Nayak,&nbsp;Neeraja Dharmaraj,&nbsp;Nicholas A. Mirsky,&nbsp;William Norton,&nbsp;Lori Ramagli,&nbsp;Ramesh Tailor,&nbsp;F. Kurtis Kasper,&nbsp;Paulo G. Coelho,&nbsp;Lukasz Witek,&nbsp;Simon Young","doi":"10.1002/jbm.b.35556","DOIUrl":"https://doi.org/10.1002/jbm.b.35556","url":null,"abstract":"<div>\u0000 \u0000 <p>Preclinical testing of tissue engineering modalities are commonly performed in a healthy wound bed. These conditions do not represent clinically relevant compromised oral wound environments due to radiation treatments seen clinically. This study aimed to characterize the bone regeneration outcomes in critical-sized mandibular defects using particulate grafting in an irradiated preclinical model of compromised wound healing. Sixteen New Zealand white rabbits were divided into two groups (<i>n</i> = 8/group), namely (i) irradiated (experimental) and (ii) non-irradiated (control). The rabbits in the experimental group received a total of 36 Gy radiation, followed by surgical intervention to create critical-sized (10 mm), full-thickness mandibular defects. The control group was subjected to the same surgical intervention. All defects were filled with bovine bone grafting material (Bio-Oss, Geistlich, Princeton, NJ, USA) and allowed to heal for 8 weeks. At the study endpoint, rabbits were euthanized, and their mandibles were harvested for micro-computed tomographic, histological, and histomorphometric processing and analysis. Qualitative histological analysis revealed increased levels of bone formation and bridging in the control group relative to the experimental group. This was accompanied by increased levels of soft tissue presence in the experimental group. Volumetric reconstruction showed a significantly higher degree of bone in the control group (27.59% ± 2.71), relative to the experimental group (22.02% ± 2.71) (<i>p</i> = 0.001). The irradiated rabbit model exhibited decreased bone regeneration capacity relative to the healthy subjects, highlighting its suitability as a robust compromised wound healing environment for further preclinical testing involving growth factors or customized, high-fidelity 3D printed tissue engineering scaffolds.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesoporous Bioactive Glass-Based Composite Cryogel for Noncompressible Hemorrhage","authors":"Jie Zhou,&nbsp;Yang Liu,&nbsp;Changren Mo,&nbsp;Kun Yang,&nbsp;Guangyu Zhang","doi":"10.1002/jbm.b.35552","DOIUrl":"https://doi.org/10.1002/jbm.b.35552","url":null,"abstract":"<p>Uncontrollable bleeding is one of the important causes of death in war, road traffic injuries, surgical accidents, and other accidents. Using hemostatic materials to control bleeding quickly and effectively can improve the survival rate of patients, especially for incompressible visceral bleeding. Traditional inorganic materials and natural polymers alone still have limitations, such as non-degradability and ineffective control of bleeding through wounds. In this work, we designed a cryogel sponge combined Mesoporous bioactive glass (MBG) with Gelatin Methacryloyl (GelMA), which has enhanced mechanical strength and improved in vitro coagulation properties. And MBG@GelMA cryogel could absorb water more than 5 times in 5 min, while it also demonstrates significant improvement in mechanical strength from 4 kap to 12 kpa. Additionally, MBG@GelMA cryogel showed excellent biocompatibility and hemostatic performance. The multi-stage pore structure and hydrophilicity of frozen gel and MBG help to concentrate blood quickly and activate endogenous coagulation pathway through the release of calcium ions to promote coagulation. The findings of this study demonstrate that the MBG@GelMA composite cryogel possesses outstanding properties in terms of hemostasis, portability, and ease of use, suggesting its remarkable potential as a promptly applicable hemostatic material in both civil and military settings.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Reliability and Stress Distribution of Wide Diameter Extra-Short Implants as Support for Single Crowns and Fixed Partial Dentures","authors":"Vanessa Felipe Vargas-Moreno,&nbsp;Michele Costa de Oliveira Ribeiro,&nbsp;Rafael Soares Gomes,&nbsp;Edmara Tatiely Pedroso Bergamo,&nbsp;Estevam Augusto Bonfante,&nbsp;Altair Antoninha Del Bel Cury,&nbsp;Raissa Micaella Marcello-Machado","doi":"10.1002/jbm.b.35560","DOIUrl":"https://doi.org/10.1002/jbm.b.35560","url":null,"abstract":"<div>\u0000 \u0000 <p>This study evaluated the reliability, failure mode, and stress distribution of wide-diameter extra-short dental implants (ESDI) as support for single crowns (SC) and fixed partial dentures (FPD) (3:1 crown-to-implant ratio [<i>C</i>:<i>I</i>]) for rehabilitation in the posterior atrophic mandible. For that, 126 ESDI (of 5 mm length) were allocated in four groups based on diameter (Ø4 and Ø6 mm) and prostheses (SC and FPD): SC4, SC6, FPD4, and FPD6. The fatigue test was performed by step-stress accelerated life testing (<i>n</i> = 21/group), failure mode by fractographic analysis, and stress distribution by finite element analysis: von Mises stress (<i>σ</i>_vM), maximum shear stress (<i>τ</i>_max), and minimum principal stress (<i>σ</i>_min). Reliability at 200 N was higher than 84% in both SC4 and SC6, with SC6 showing significantly higher reliability at 300 N. Failure mode involved the abutment (SC4 and SC6). The missions were suspended for the FPD groups due to 100% survival at the maximum load. The <i>σ</i>_vM showed a stress reduction of about 40% at the SC6 implant when compared to SC4 and FPD6 compared to FPD4. For the abutment, a minor decrease of at least 6.72% was observed comparing SC6 to SC4 and 2.78% for the FPD6 compared to FPD4. The <i>τ</i>_max and <i>σ</i>_min in the cortical bone demonstrated a stress reduction of at least 38.85% for the SC6 compared to SC4 and at least 3.78% in FPD6 compared to FPD4. The <i>σ</i>_min in the cancellous bone showed an overall reduction of at least 8.46% for SC6 compared to SC4 and for FPD6 compared to FPD4. But, for <i>τ</i>_max, in the cancellous bone, a 19.42% higher stress was found in SC6 compared to SC4 and 27.21% in FPD6 compared to FPD4. Finally, when splinting was used, a general stress reduction was found, about 50% in both diameters in the implant and abutment. According to the limitations of this in vitro study, it is possible to conclude that both groups (SC4 and SC6) showed high reliability in clinically relevant loads for the posterior atrophic mandible, SC6 having the lowest probability of failure at 300 N, with failure restricted to the abutment. Meanwhile, FPD6 has better stress distribution.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Coatings: Advanced Strategies Driving Multifunctionality and Clinical Potential in Dermal Substitutes","authors":"Yixin Wu,&nbsp;Chao Ji,&nbsp;Zhenzhen Yan,&nbsp;Xiaowan Fang,&nbsp;Yuxiang Wang,&nbsp;Yicheng Ma,&nbsp;Jingzhu Li,&nbsp;Shunxin Jin,&nbsp;Hao Chen,&nbsp;Shizhao Ji,&nbsp;Yongjun Zheng,&nbsp;Shichu Xiao","doi":"10.1002/jbm.b.35545","DOIUrl":"https://doi.org/10.1002/jbm.b.35545","url":null,"abstract":"<div>\u0000 \u0000 <p>Skin tissue defects caused by various acute and chronic etiologies frequently occur in clinical medicine. Traditional surgical repair methods have certain limitations, while dermal substitutes combined with skin grafting have become an alternative to conventional surgery. Biological coatings, by loading bioactive substances such as polysaccharides and proteins, or by using bioactive substances as carriers, can promote cell adhesion, proliferation, and differentiation. This optimizes the mechanical properties and biocompatibility of the substitutes, enhances their antibacterial properties, and improves their feasibility for clinical application. This paper explores various common biological coating materials and the construction methods used in the field of dermal substitutes. It highlights the importance and necessity of biological coatings in the development of multifunctional designs for dermal substitutes. By summarizing the current research, this paper aims to offer new insights and references for the multifunctional design and clinical application of dermal substitutes.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Burn Wound Healing and Skin Regeneration in Animal Model Using Alginate/PVA Nanofibrous Wound Dressings Containing Dragon's Blood","authors":"Danial Seyedi,&nbsp;Majid Salehi,&nbsp;Sepehr Zamani,&nbsp;Danial Cheraghali,&nbsp;Farzaneh Dehghani,&nbsp;Mohsen Mehrabi","doi":"10.1002/jbm.b.35553","DOIUrl":"https://doi.org/10.1002/jbm.b.35553","url":null,"abstract":"<div>\u0000 \u0000 <p>The challenge of healing burn wounds is significant importance in global healthcare systems, with a high demand for advanced wound dressings to aid in the treatment of such injuries. Promising options include bioactive electrospun scaffolds made from polymers with antimicrobial properties, which can prevent infections and promote faster healing. This study involved the creation of a nanofibrous scaffold using the electrospinning technique, which consisted of polyvinyl alcohol (PVA), alginate (Alg), and Dragon's blood (DB). The scaffold was then analyzed for both its morphology and chemical composition. Results indicated that the DB was present in the nanofibrous scaffold, which had a uniform and unbranched appearance with fibers measuring approximately 300–400 nm in diameter. Additionally, mechanical property testing revealed promising results that fall within the range of human skin. The scaffold's wound healing potential was evaluated through various measurements, including water contact angle, drug release, water vapor permeability, blood compatibility, blood clotting index, and antibacterial activity. Results from an in vivo study on burn wounds showed that scaffolds containing 20% DB exhibited excellent wound healing ability with 80.3% wound closure after 21 days. This was attributed to the highest collagen synthesis, re-epithelization and remodeling of the burned skin. Therefore, PVA/Alg/DB nanofibrous scaffolds hold promise as a wound dressing to treat burn injuries.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Characterization of Bioactive Glass via CTAB Modified Sol-Gel Method for In Vitro Biological Activities","authors":"Fetene Fufa Bakare,&nbsp;Bethelhem Gashaw Ewente,&nbsp;Tsion Chuni Akililu,&nbsp;Allah Dekama Jara,&nbsp;Getachew Megersa Gonfa","doi":"10.1002/jbm.b.35548","DOIUrl":"https://doi.org/10.1002/jbm.b.35548","url":null,"abstract":"<div>\u0000 \u0000 <p>Bone defect repair methods have significant drawbacks and limitations. The discovery and development of bioactive glasses (BGs) have greatly advanced the treatment of bone diseases. BGs can uniquely bond to living tissues, including bone, due to the formation of a hydroxyapatite (HAp) layer on their surface. These glasses synthesized using various catalysts and structure-directing agents to enhance their biological activities. However, most catalysts generate toxicity, alter pH levels, and work at high concentrations. Similarly, many surfactants have limited surface areas, poor capacity to create well-defined mesoporous structures, and potential toxicity, reducing the bioactivity, biocompatibility, and biodegradability of the BGs. To address these issues, this study evaluates a bioactive glass synthesized via the sol–gel process, using low concentration CTAB as a structure-directing agent and citric acid as a catalyst. The phase composition, surface morphology, specific surface area, inner structure, crystal structure, elemental composition, and functional groups of the samples were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET), transmission electron microscopy (TEM), selected area electron diffraction (SAED), energy-dispersive x-ray spectroscopy (EDS), and Fourier-transform infrared microscopy (FTIR) techniques, respectively. The in vitro bioactivity was tested by soaking samples in simulated body fluid and analyzing the HAp layer formation using XRD, SEM, and FTIR. In addition, the in vitro biocompatibility, and an in vitro biodegradability were measured. 0.3 M of CTAB (BG3) exhibited a larger specific surface area with spherical-shaped particles and pore volume with a mesoporous structure results better in bioactivity and biodegradability. Furthermore, all samples exhibited cell viability above 70%, indicating that the prepared materials are biocompatible. The findings highlight the potential of CTAB-modified BGs for biomedical applications, especially in bone repair and regeneration.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D Screening and Supplementation—A Novel Approach to Higher Success: An Update and Review of the Current Literature","authors":"Thomas G. Wiedemann,&nbsp;Hyun Woo Jin,&nbsp;Brendan Gallagher,&nbsp;Lukasz Witek,&nbsp;Richard J. Miron,&nbsp;Huzefa S. Talib","doi":"10.1002/jbm.b.35558","DOIUrl":"https://doi.org/10.1002/jbm.b.35558","url":null,"abstract":"<div>\u0000 \u0000 <p>In recognizing the critical role of vitamin D in bone metabolism and osseointegration, research aims to identify whether preoperative vitamin D deficiency serves as a risk factor for early implant failure. By analyzing patient outcomes and their serum vitamin D levels, studies seek to establish evidence-based recommendations for vitamin D assessment and management in the preoperative period, with the ultimate goal of enhancing implant success rates and patient outcomes in dental implantology. Given these insights, it is important for clinicians to incorporate the preoperative evaluation of vitamin D serum levels into their standard protocol for patients undergoing dental implant procedures. The objective of this study is to review and investigate the correlation between early dental implant failure (EDIF) and reduced serum levels of vitamin D, and to evaluate the potential benefits of preoperative screening and supplementation of vitamin D in patients undergoing dental implant surgery. A literature review was performed using a selected database—PubMed, Google Scholar, Cochrane, and SCOPUS—to assess the effect of vitamin D3 level on EDIF and biological factors (i.e., peri-implant bone level). Studies were limited to peer-reviewed, indexed journals. Subsequently, a hypothesis was proposed that vitamin D3 supplementation would mitigate the negative effect of vitamin D3 deficiency. The potential benefit of vitamin D3 supplementation—systemic and topical—was assessed in terms of bone-to-implant contact (BIC) and peri-implant bone level. The deleterious effects of low vitamin D serum levels on osseointegration of dental implants and immune system modulation are increasingly accepted. Evidence has displayed that deficiency of this vitamin can result in impaired peri-implant bone formation. Vitamin D deficiency resulted in nearly a fourfold increase in overall EDIF incidence. Presurgical supplementation of vitamin D3 demonstrated increased levels of implant osseointegration, increased bone–implant contact, enhanced bone level maintenance, and decreased EDIF even in at-risk demographics (i.e., diabetic subjects). The findings of this study reinforce the role of vitamin D in dental implant osseointegration. Our study, particularly, emphasizes the necessity of vitamin D supplementation for individuals with sub-physiologic vitamin D serum levels (≤ 30 ng/mL) and those within specific risk categories: smokers, diabetics, obese individuals, and those with compromised immune systems. Adopting a proactive management plan, including screening and supplementation in these patients, may substantially enhance the clinical outcomes in dental implant surgery.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are All Alginate Dressings Equivalent?","authors":"Laura Duciel,&nbsp;Richard Proust,&nbsp;Anne-Charlotte Ponsen,&nbsp;Fabio Ziarelli,&nbsp;Arnaud Coudreuse,&nbsp;Laurence Jeanmichel,&nbsp;Marina Samardzic,&nbsp;Georges Uzan,&nbsp;Céline des Courtils","doi":"10.1002/jbm.b.35557","DOIUrl":"https://doi.org/10.1002/jbm.b.35557","url":null,"abstract":"<p>Alginate dressings are widely used in wound treatment for their healing and hemostatic properties and their capacity to drain exudate. However, a clear understanding of the heterogeneity within this class of dressings is lacking. Numerous sources of variability exist between alginate dressings: their composition (% of calcium alginate relative to other components), the ratio of D-Mannuronic and L-Guluronic acids in the alginate fraction, their purity (presence of toxic contaminants), and the shape of their fibers (surface and thickness). These parameters affect the performance and safety of alginate dressings, which may thus not be interchangeable in clinical practice. Therefore, clinicians must be aware of these differences to ensure optimal treatment and avoid complications or suboptimal healing. The objective of this study was to compare six alginate dressings to conclude or not on their equivalence. The results obtained demonstrate considerable variability between alginate dressings in the assessed characteristics: composition, Ca²⁺ release, level of cytotoxicity, fiber shape, draining capacity, and their resistance to traction. Algostéril, the only pure calcium alginate rich in G, releases a specific dose of Ca²⁺ and is the only non-cytotoxic dressing. With its multilobed fibers that are statistically the thickest, it provides the best draining capacity and greatest resistance to traction. These results demonstrate that alginate dressings are not equivalent. Each dressing is distinct, and consequently the clinical performance of one cannot be transposed to the others. Therefore, each alginate dressing should demonstrate its own efficacy, in a given indication, through a clinical trial.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35557","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Microporous Surface Zirconia on Mechanical Properties and Biological Behavior of Human Gingival Fibroblasts","authors":"Luyang Zhang,&nbsp;Lin He,&nbsp;Xiaoyu Wang,&nbsp;Jiangqi Hu,&nbsp;Qingsong Jiang","doi":"10.1002/jbm.b.35547","DOIUrl":"https://doi.org/10.1002/jbm.b.35547","url":null,"abstract":"<div>\u0000 \u0000 <p>As a commonly used material in prosthodontics, zirconia has garnered widespread attention. Addressing the shortcomings of existing zirconia materials, this study aims to investigate the mechanical properties of microporous surface zirconia ceramics and their impact on the biological behavior of human gingival cells. Microporous surface zirconia was developed using a novel ceramic plasticity process, sintered at 1460°C for densification. The surface morphology and composition were determined through scanning electron microscopy and energy dispersive spectrometer. Surface roughness was measured using atomic force microscopy, hydrophilicity angle was determined using a contact angle measurement instrument, and X-ray diffractometer assessed the crystalline phase content before and after aging. Material flexural strength was determined using a universal testing machine. The influence of microporous surface zirconia on the adhesion and proliferation of human gingival fibroblasts (HGFs) was investigated through CCK-8 and immunofluorescence staining for Integrin β1 and F-actin. The pore structure of microporous surface zirconia (MZ) group is uniform, with a flexural strength of 1375.86 ± 76.97 MPa, significantly higher than the control (Cont) group (<i>p</i> &lt; 0.05). The percentage of HGFs adhesion to the MZ group was markedly higher than the Cont group (<i>p</i> &lt; 0.05). Fluorescence of Integrin β1 and F-actin in the MZ group was significantly higher than in the Cont group. In conclusion, Microporous surface zirconia promotes the attachment and proliferation of human gingival fibroblasts, facilitating early closure of soft tissues.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Evaluation of Thermally Drawn Biodegradable Optical Fibers as Brain Implants","authors":"Parinaz Abdollahian,&nbsp;Kunyang Sui,&nbsp;Guanghui Li,&nbsp;Jiachen Wang,&nbsp;Cuiling Zhang,&nbsp;Yazhou Wang,&nbsp;Rune W. Berg,&nbsp;Marcello Meneghetti,&nbsp;Christos Markos","doi":"10.1002/jbm.b.35549","DOIUrl":"https://doi.org/10.1002/jbm.b.35549","url":null,"abstract":"<p>Optical fiber technology plays a critical role in modern neuroscience towards understanding the complex neuronal dynamics within the nervous system. In this study, we manufactured and characterized amorphous thermally drawn poly D, L-lactic acid (PDLLA) biodegradable optical fibers in different diameters. These optical fibers were then implanted into the lateral posterior region of the mouse brain for four months, allowing us to assess their degradation characteristics. The gradual dissolution of the implanted PDLLA optical fibers in the brain was confirmed by optical, photoacoustic, and scanning electron microscopy (SEM), light propagation characteristics, and molecular weight measurements. The results indicate that the degradation rate of the biodegradable optical fiber was mainly pronounced during the first week. After four months, degradation led to the formation of micropores on the surface of the implanted fiber within the gray matter region of the brain. We believe that the PDLLA biodegradable optical fiber developed in this study constitutes a promising candidate for further functionalization and development of next-generation biocompatible, soft, and biodegradable bi-directional neural interfaces.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}