Journal of biomedical materials research. Part B, Applied biomaterials最新文献

{"title":"Advancements in Cartilage Tissue Engineering: A Focused Review","authors":"Breanne L. Welsh,&nbsp;Prabaha Sikder","doi":"10.1002/jbm.b.35520","DOIUrl":"https://doi.org/10.1002/jbm.b.35520","url":null,"abstract":"<p>Osteoarthritis (OA) is a prevalent joint disorder that is characterized by the degeneration of articular cartilage in synovial joints. Most of the current treatment options for this disorder tend to focus on symptom management rather than addressing the underlying progression of the disease. Cartilage tissue engineering has emerged as a promising approach to address the limitations of current OA treatments, aiming to regenerate cartilage and restore the natural function of affected joints. Like any other tissue engineering field, cartilage tissue engineering uses different fabrication techniques and biomaterials to develop the constructs. Numerous studies over the last few years have demonstrated the preclinical efficacy of tissue-engineered constructs in promoting cartilage regeneration and highlight the potential of tissue-engineered constructs as a viable therapeutic approach for OA. This paper aims to provide a focused review of advancements in tissue-engineered constructs over the past decade. Specifically, we highlight the constructs based on natural, synthetic, and composite biomaterials and the varying conventional and advanced fabrication techniques. We also highlight the challenges in <i>state-of-the-art</i> cartilage tissue engineering that must be overcome in the upcoming years to fully replicate the complex anatomy of the native cartilage. We believe that continued collaborative research efforts among researchers from various facets of engineering and clinicians are required to advance the field of cartilage tissue engineering and become a viable OA therapy.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35520","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Antibacterial Hemostasis Sponge of Gelatin/ε-Poly-L-Lysine Composite","authors":"Yifan Lu,&nbsp;Xiangxin Lou,&nbsp;Wenxin Wang,&nbsp;Ziting Yang,&nbsp;Haochen Yao,&nbsp;Jinglei Wu","doi":"10.1002/jbm.b.35528","DOIUrl":"10.1002/jbm.b.35528","url":null,"abstract":"<div>\u0000 \u0000 <p>Massive bleeding and bacterial infection of wounds may be life-threatening or even lead to death. Nowadays, gelatin-based hemostatic sponges have been widely used, but gelatin is not antibacterial and has poor structural stability. In this study, we mixed an antibacterial polypeptide, ε-poly-L-lysine (EPL), into gelatin. A gelatin/ε-poly-L-lysine (Gel/EPL) sponge with hemostatic and antibacterial functions was prepared by ultraviolet (UV) crosslinking lyophilized Gel/EPL composite. Scanning electron microscopy showed that the sponge had an interconnected porous structure. The incorporation of EPL increased the hydrophilicity and water absorption capacity of the Gel/EPL sponge. The sponge had better structural stability after UV crosslinking. The antibacterial assay showed that bacteria could not grow normally around the Gel/EPL sponge. The contact between blood components and the sponge initiated coagulation via exogenous pathway activation, and no hemolysis occurred. In addition, in vivo experiments confirmed that the sponge has a faster clotting time and lower blood loss. These findings show that the developed Gel/EPL sponge has great potential as a novel hemostatic agent that can quickly stop bleeding and fight bacterial infections.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Ceramic Bonding to Cobalt–Chromium, Zirconia and Nickel–Chromium Alloys Fabricated Using of Various Techniques","authors":"Elie E. Daou,&nbsp;Mutlu Özcan","doi":"10.1002/jbm.b.35522","DOIUrl":"10.1002/jbm.b.35522","url":null,"abstract":"<div>\u0000 \u0000 <p>The purpose of this study was to evaluate the characteristics of the ceramic bonding to cobalt–chromium (Co–Cr) alloys fabricated by casting, milling, and additive manufacturing, compared with zirconia and nickel–chromium. One hundred specimens (<i>N</i> = 100), prepared with the dimensions of 25 × 3 × 0.5 mm³, were assigned to five groups (<i>n</i> = 20): presintered milled Co–Cr (Group M), additively manufactured Co–Cr (Group SLM), cast Co–Cr (Group C), presintered zirconia (Group Zi), and cast Ni–Cr (Group Ni). The bar specimens were prepared to receive porcelain on their central area (8 × 3 mm²) of one side of each alloy strip. Only half of the specimens from each group were exposed to thermocycling (5°C–55°C for 5000 times). All specimens were placed in a bending device. Specimen surface morphology was examined by scanning electron microscopy. The bonding values between materials and the aging treatment effect groups were compared with two-way ANOVA. Variances were compared using the Levene test, the Bonferroni adjustment was used for multiple pairwise comparisons. The shape (<i>m</i>) and scale (<i>σ</i>₀) parameters of the two-parameter Weibull distribution values were calculated. Thermocycling did not affect the results of all the groups tested (<i>p</i> = 0.237). Statistical difference was found between the Co–Cr groups, and between groups Ni and Zi when compared to groups C and SLM (<i>p</i> &lt; 0.001). Ni had the lowest adhesion values and cast Co–Cr the highest. A statistical difference was found between the three Co–Cr groups (<i>p</i> &lt; 0.001), with the highest ceramic adhesion found in Group C and the lowest found in Group M. All specimens from Groups M, C, and Ni showed adhesive failures, whereas mixed failures were observed in Groups Zi and SLM. The fit of the maximum-likelihood line was a poor fit in the distribution of the aged SLM group (<i>p</i> &lt; 0.010). Ceramic adhesion and failure types varied with the alloy choice and the manufacturing technique.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Elastic Lipid Nanovesicles for Enhanced Skin Permeation of Whole Plant Extract: A Comprehensive Investigation","authors":"Rahul Maheshwari,&nbsp;Mayank Sharma,&nbsp;Sankha Bhattacharya","doi":"10.1002/jbm.b.35527","DOIUrl":"10.1002/jbm.b.35527","url":null,"abstract":"<div>\u0000 \u0000 <p>A new method is developed using elastic lipid nanovesicles (ELNs) loaded with ethanolic extract of <i>Lantana camara</i> (LC) to enhance skin permeation of plant actives. The ELNs contained cholesterol, 1, 2-distearoyl-sn-glycero-3-phosphocholine, span 80, and tween 80. Firstly, 15 formulations were produced to examine critical factors likely affecting formulation characteristics. In addition, surface characteristics, vesicle size, polydispersity index, zeta potential, degree of deformability, and % entrapment efficiency (% EE) of ELN were examined. As a significant parameter, skin permeation was measured (using Start-M; it highly resembles human skin). The influence of size, hydrophilic–lipophilic balance (HLB), and surface ratio were vital to permeation through Start-M. In particular, the % LC extract permeation decreased at more extensive size ranges, 400, and 350–450 nm. In contrast, the % LC extract permeation increased significantly at smaller size ranges, such as 200 and 100 nm. More than 75% of the LC extract was permeated within 8 h when the surfactant ratio was (span 80:tween 80; 25%:75%). Permeation studies conducted based on HLB values revealed that 78% of LC extract was permeated in 8 h when HLB was 12.2, and that permeation decreased with an increase in HLB. Cell viability assay using SK-MEL-37 cells (skin cancer) revealed that ELN reduced the viability by ~80% in 24 h, further validating the formulation. Future research could investigate the long-term safety and therapeutic potential of these ELNs in clinical settings and their effectiveness in delivering other plant-based extracts for transdermal applications via ELNs.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Mechanical and Biological Properties of Polycaprolactone Scaffolds Produced by a Material Extrusion 3D Printer or 3D Pen: A Novel Bone Repair Strategy","authors":"HongXin Cai,&nbsp;Min-Yong Lee,&nbsp;Kwang-Mahn Kim,&nbsp;Heng Bo Jiang,&nbsp;Jae-Sung Kwon","doi":"10.1002/jbm.b.35526","DOIUrl":"10.1002/jbm.b.35526","url":null,"abstract":"<div>\u0000 \u0000 <p>Addressing the high cost and long cycle associated with the multistep digital restoration process involving 3D printing technology, we proposed the 3D pen as an innovative strategy for rapid bone repair. Capitalizing on the low melting point characteristic of polycaprolactone (PCL), we introduced, for the first time, the novel concept of directly constructing scaffolds at bone defect sites using 3D pens. In this in vitro study, we meticulously evaluated both the mechanical and biological properties of 3D pen-printed PCL scaffolds with six distinct textures: unidirectional (UNI) (0°, 45°, 90°), bidirectional (BID) (−45°/45°, 0°/90°), and concentric (CON). The bone repair scaffold creation process was simulated using a fused deposition modeling (FDM) 3D printer and a 3D pen by creating a cattle bone defect model to compare the achieved scaffold time efficiency and accuracy. Mechanical test results revealed that 3D pen-printed scaffolds with different textures exhibited varying results in four tests, except the shear bond test. Optimal scaffold strength was consistently achieved when printing parallel to the applied force. Regarding biological properties, these scaffolds exhibited consistent cell viability over time and showcased excellent cell attachment capabilities overall. Furthermore, cells grew regularly along the printed filaments, with additional living cells at high elevations observed. Additionally, the 3D pen method outperformed traditional digital technology with an FDM 3D printer concerning accuracy and speed. These findings underscored the tremendous potential of the 3D pen in the realm of medical science, specifically within the domain of bone tissue engineering, characterized by its low cost, high speed, and convenience.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iloprost-Loaded Electrospun Polycaprolactone/Gelatin Membranes for Enhanced Healing of Colon Anastomosis","authors":"Ender Erguder,&nbsp;Merve Celik,&nbsp;Pinar Eylem Eser,&nbsp;Abdullah Durhan,&nbsp;Sema Hucumenoglu,&nbsp;Mehmet Ali Akkus,&nbsp;Fatih Buyukserin","doi":"10.1002/jbm.b.35518","DOIUrl":"10.1002/jbm.b.35518","url":null,"abstract":"<div>\u0000 \u0000 <p>Despite the variety of proposed solutions, anastomotic leakage is still a critical complication after colorectal surgery, which causes increased clinical mortality and morbidity. By enhancing microcirculation in the colonic mucosa, the use of Iloprost (Ilo) has shown promising results for the healing of anastomosis. The purpose of this study is to examine the performance of Ilo-impregnated Polycaprolactone:Gelatin electrospun membranes (PCL/Gel/Ilo) on anastomosis repair and intra-abdominal adhesion behavior in the Rat colon. Wistar Albino rats were randomly divided into four groups: sham, Control (only resection-anastomosis), PCL/Gel, and PCL/Gel /Ilo (<i>n</i> = 12 for each). On the seventh day after colon anastomosis, a second laparotomy was conducted. During this procedure, intra-abdominal adhesion was examined, and the anastomotic segment was removed for burst pressure and histological evaluation. There was no statistically significant difference in intra-abdominal adhesions and major complications between the electrospun membrane groups and the control group. The membrane-applied groups exhibited significantly higher anastomotic burst pressure than the control group irrespective of their Ilo content. In terms of neovascularization and muscle necrosis, membrane-applied groups demonstrated statistically significant improvements over the control group. Furthermore, the PCL/Gel/Ilo applied group showed enhanced neovascularization and lower muscular necrosis; however, statistically significant differences were not observed compared to the PCL/Gel applied group. Compared to the control group, the application of electrospun PCL/Gel and PCL/Gel/Ilo membranes resulted in safe and effective healing of colon anastomosis. The fact that Ilo application cannot be distinguished from the regular membrane group necessitates additional research into the doped fibrous mat and its application method.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Template-Assisted Electrospinning and 3D Printing of Multilayered Hierarchical Vascular Grafts","authors":"Moein Zarei,&nbsp;Marek J. Żwir,&nbsp;Beata Michalkiewicz,&nbsp;Jarosław Gorący,&nbsp;Miroslawa El Fray","doi":"10.1002/jbm.b.35525","DOIUrl":"10.1002/jbm.b.35525","url":null,"abstract":"<p>Fabricating complex hierarchical structures mimicking natural vessels and arteries is pivotal for addressing problems of cardiovascular diseases. Various fabrication strategies have been explored to achieve this goal, each contributing unique advantages and challenges to the development of functional vascular grafts. In this study, a three-layered tubular structure resembling vascular grafts was fabricated using biocompatible and biodegradable copolymers of poly(butylene succinate) (PBS) using advanced manufacturing techniques. The outer layer was fabricated by template-assisted electrospinning utilizing a 3D-printed scaffold with a precise hexagonal pore design as the template, and the inner layer was coated with gelatin through perfusion. Cellulose nanocrystals (CNCs) were incorporated into electrospun fibers to enhance mechanical properties. The gelatin coating was applied to the lumen using perfusion coating, resembling the inner layer. Integration of 3D-printed structures with electrospun fibers via template-assisted electrospinning and gelatin coating resulted in a seamless multilayered scaffold. Mechanical testing demonstrated robustness, surpassing natural arteries in some aspects, while the gelatin coating significantly reduced liquid leakage, ensuring leak-free functionality. Cytotoxicity assessment confirmed the biocompatibility of processed materials with fibroblast cells, supporting potential for medical applications.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35525","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial Effects of Tilapia Fish Skin on Excisional Skin Wound Healing in a Type I Diabetic Rat Model","authors":"Omar Hussein Hosny,&nbsp;Khaled Radad,&nbsp;Magda Mahmoud Ali,&nbsp;Ahmed Fathy Ahmed","doi":"10.1002/jbm.b.35524","DOIUrl":"10.1002/jbm.b.35524","url":null,"abstract":"<div>\u0000 \u0000 <p>IntroductionProlonged hyperglycemia in diabetic patients often impairs wound healing, leading to chronic infections and complications. This study aimed to evaluate the potential of fresh Tilapia fish skin as a treatment to enhance wound healing in diabetic rats. MethodsThirty-nine healthy adult albino rats, weighing between 150 and 200 g, were divided into three groups: non-diabetic rats with untreated wounds [C-], diabetic rats with untreated wounds [C+], and diabetic rats treated with fresh Tilapia skin [TT]. The healing process was monitored through clinical observation, gross examination, and histopathological analysis. ResultsThe results demonstrated that the Tilapia skin treatment accelerated wound healing, as evidenced by complete reepithelialization, full epidermal cell differentiation, an intact dermo-epidermal junction, and a reorganized dermis with fewer blood vessels. ConclusionFresh Tilapia skin proved to be a safe and effective dressing for promoting wound healing and managing infection in diabetic wounds.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Tissue Engineering With Chitosan, Carbon Nanotubes, and Hydroxyapatite Biomaterials Enriched With Mesenchymal Stem Cells: A Radiographic and Histological Evaluation in a Sheep Model Undergoing Ostectomy (Bone Tissue Engineering in a Sheep Model)","authors":"Geissiane de Moraes Marcondes,&nbsp;Nicole Fidalgo Paretsis,&nbsp;Danielle Cristinne Baccarelli da Silva,&nbsp;Anderson Fernando de Souza,&nbsp;Mario Antônio Ferraro Rego,&nbsp;Grazieli Cristina Monteiro da Silva,&nbsp;Joice Fülber,&nbsp;Luciana Corrêa,&nbsp;Simone Peixe Friedrichsdorf,&nbsp;Ana Maria de Guzzi Plepis,&nbsp;Virginia da Conceição Amaro Martins,&nbsp;Silvia Renata Gaido Cortopassi,&nbsp;André Luis do Valle De Zoppa","doi":"10.1002/jbm.b.35523","DOIUrl":"10.1002/jbm.b.35523","url":null,"abstract":"<div>\u0000 \u0000 <p>Comminuted fractures associated with tissue loss can adversely affect bone regeneration. Biomaterials enriched with mesenchymal stem cells (MSCs) employed for supporting osteosynthesis and potentiating osteoconduction are necessary to fill these bone defects. Natural compound biomaterials, similar to bone tissue, have been extensively tested in animal models for clinical use. Bone tissue engineering studies have used critical-size defects in ovine tibia monitored by imaging and histological examinations to evaluate the regenerative process. This study aimed to monitor the regenerative process in ovine tibial defects with or without chitosan, carbon nanotubes, or hydroxyapatite biomaterials, enriched or not enriched with MSCs. A 3-cm ostectomy was performed in 18 female Suffolk sheep. A 10-hole 4.5 mm narrow locking compression plate was used for osteosynthesis. The animals were randomly divided into three groups (<i>n</i> = 6): control (CON); defects filled with chitosan, carbon nanotubes, and hydroxyapatite biomaterial (BIO); and the same biomaterial enriched with bone marrow MSCs (BIO + CELL). The animals were evaluated monthly using radiographic examinations until 90 postoperative days, when they were euthanized. The limbs were subjected to micro-computed tomography (micro-CT), and bone specimens were subjected to histological evaluations. The radiographic examinations revealed construction stability without plate deviation, fracture, or bone lysis. Micro-CT evaluation demonstrated a difference in bone microarchitecture between the CON and biomaterial treatment groups (BIO and BIO + CELL). In the histological evaluations, the CON group did not demonstrate bone formation, and in the treatment groups (BIO and BIO + CELL), biocompatibility with sheep tissue was noted, and bone formation with trabeculae interspersed with remnants of the biomaterial was observed, with no differences between the groups. In conclusion, biomaterials present osteoconduction with beneficial characteristics for filling bone-lost fractures, and MSCs did not interfere with bone formation.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesoporous Lanthanum-Doped Magnesium Phosphate Nanopowders Promote Healing of Critical-Size Bone Defects: An In Vivo Study","authors":"Mona Moaness,&nbsp;Shaimaa ElShebiney,&nbsp;Hanan H. Beherei,&nbsp;Mostafa Mabrouk","doi":"10.1002/jbm.b.35515","DOIUrl":"10.1002/jbm.b.35515","url":null,"abstract":"<div>\u0000 \u0000 <p>Treating severe bone deformities and abnormalities continues to be a major clinical hurdle, necessitating the adoption of suitable materials that can actively stimulate bone regeneration. Magnesium phosphate (MP) is a material that has the ability to stimulate the growth of bones. The current study involved the synthesis of mesoporous MP and lanthanum (La)-doped nanopowders using a chemical precipitation approach. The nanopowders were analyzed using several techniques, including XRD, FTIR, HR-TEM, BET, XPS, and FE-SEM. The results confirmed the nanopowders' size of less than 40 nm and the successful incorporation of La³⁺ ions into the MP structure. The bioactivity of the materials was assessed in vitro using simulated bodily fluid (SBF) at 37°C for a duration of 14 days in a shaker incubator (50 rpm). The SEM showed that a bone-like apatite layer formed quickly on the nanopowders' surface, proving that they have unique bioactive properties. The EDX spectra confirmed the presence of Ca, P, Mg, and La elements after immersion in SBF. The MP nanopowders, both with and without La doping, demonstrated the capacity to stimulate bone formation in a rat femoral bone defect model over a 28-day duration. Radiographic and histological studies showed that the La-doped MP nanopowders greatly improved bone repair and regeneration in comparison to the La-free nanopowders. Finally, the readily producible mesoporous MP nanomaterials, especially those with increased La doping (up to 7 wt%), exhibit significant potential for the restoration of large bone defects. Hence, fabricated nanopowders have immense promise for repairing bone criterion defects.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}