Journal of biomedical materials research. Part B, Applied biomaterials最新文献

{"title":"Cytotoxic Impact of Catalytic Activity and Heating Efficiency of Manganese Ferrite Nanoparticles With Different Particle Sizes for Magnetic Fluid Hyperthermia","authors":"Marco A. Morales Ovalle,&nbsp;Mariana Raineri,&nbsp;Marcelo Vasquez Mansilla,&nbsp;Elin Lilian Winkler,&nbsp;Roberto Daniel Zysler,&nbsp;Enio Lima Jr,&nbsp;Teobaldo Enrique Torres","doi":"10.1002/jbm.b.35638","DOIUrl":"https://doi.org/10.1002/jbm.b.35638","url":null,"abstract":"<div>\u0000 \u0000 <p>Magnetic nanoparticles have garnered significant attention in cancer treatment for their dual ability to generate localized heat under an alternating magnetic field and catalyze heterogeneous Fenton-based reactions on their surface. These reactions produce free radicals in mildly acidic and reducing environments, such as the tumor microenvironment, leading to oxidative stress in cancer cells. The synergistic combination of magnetic hyperthermia and catalytic activity enhances oxidative stress induction, underscoring the importance of understanding the cytotoxic effects of this approach. In this study, we performed in vitro toxicity assays on the HepG2 cell line to evaluate cytotoxicity and lipid peroxidation induced by hyperthermia using manganese ferrite nanoparticles with mean sizes of 12 and 28 nm. Magnetic hyperthermia efficiency, quantified by Specific Loss Power (SLP), and catalytic activity, assessed through free radical generation using electron paramagnetic resonance (EPR) and substrate oxidation rates via UV–visible spectroscopy, were characterized prior to the biological experiments. Our results showed that the 28 nm nanoparticles achieved a temperature increase of approximately 11.5°C, compared to 3.6°C for the 12 nm particles. Correspondingly, higher cell death was observed for the 28 nm nanoparticles following magnetic fluid hyperthermia treatment. However, lipid peroxidation was more pronounced with the 12 nm nanoparticles, attributed to their larger surface-to-volume ratio enhancing catalytic performance. In conclusion, nanoparticle size critically influences both magnetic and catalytic properties, and optimizing these parameters is essential for maximizing therapeutic efficacy in magnetic fluid hyperthermia.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the Addition of Aminosilane-Functionalized Titanate Nanotubes in Carboxymethylcellulose-Based Film for Biomedical Applications","authors":"Letícia Terumi Kito,&nbsp;Angélica Galvão Santos Silva,&nbsp;Caroline Machado Andrade Ramos,&nbsp;Diego Morais da Silva,&nbsp;Evelyn Alves Nunes Simonetti,&nbsp;Dayane Batista Tada,&nbsp;Tiago Moreira Bastos Campos,&nbsp;Gilmar Patrocínio Thim","doi":"10.1002/jbm.b.35644","DOIUrl":"https://doi.org/10.1002/jbm.b.35644","url":null,"abstract":"<p>Skin injuries occur when cellular integrity is compromised due to mechanical, physical, or metabolic factors. This study reported on a carboxymethylcellulose (CMC)-based film incorporating TiNT, aiming at its application as a wound dressing. As a minimally invasive approach, titanate nanotubes (TiNT) have been studied due to their photocatalytic properties, biocompatibility, large pore volume, and high surface area. Functionalization with aminosilane groups, using the biological responses of nitrogen, has been explored to enhance cellular interaction. Upon exposure to UV radiation, the dressing releases nanotubes, protecting the lesion from external pathogens and promoting healing. TiNTs were synthesized via a hydrothermal method and 0.2% (v/v) functionalized using 3-aminopropyltrimethoxysilane (APTMS). The films were prepared with 1 (wt%) TiNT or TiNT_NH2 in a 2 (wt%) CMC solution and dried at 60°C for 24 h. Results showed enhanced thermal stability and the potential for controlled nanoparticle release under UV light, with no cytotoxic effects observed. The films demonstrated excellent biocompatibility, making them promising candidates for medical applications.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Green Synthesis Silver Nanoparticles Extracts by Eucalyptus citratus Aqueous Leaves and Evaluated Against Schistosoma mansoni","authors":"Lila A. Alkhtaby,&nbsp;Mohamed Abou El-Nour,&nbsp;Samah S. Eldera","doi":"10.1002/jbm.b.35629","DOIUrl":"https://doi.org/10.1002/jbm.b.35629","url":null,"abstract":"<div>\u0000 \u0000 <p>Schistosomiasis stands out as a significant neglected tropical disease in Africa, resulting from the blood fluke, <i>Schistosoma</i> sp. The application of nanotechnology in addressing this particular disease is critically essential to mitigate the undesirable side effects associated with chemotherapy. The current investigation aimed to evaluate the efficacy of biosynthesized silver nanoparticles (AgNPs) extracts by <i>Eucalyptus citratus</i> aqueous leaves, as a novel alternative treatment for schistosomiasis, and to compare their effectiveness with Praziquantel (PZQ). Mature worms subjected to AgNPs at concentrations of 3.125, 6.25, 12.5, 25, 50, and 100, and some of the AgNPs concentrations were added to and mixed with PZQ at concentrations of 12.5 + 0.4, 25 + 0.3, 50 + 0.2, and 75 + 0.1 μg/mL. Concentrations of 100 μg/mL of AgNPs showed complete mortality of adult worms after 6 h; 50 and 25 μg/mL after 12 h; and 12.5 μg/mL after 24 h, where the effectiveness of AgNPs was improved by adding PZQ. In vivo, four groups of hamsters infected with <i>Schistosoma mansoni</i> were treated. In the hamsters, the number of eggs present in the tissues as well as the size and number of granulomas significantly decreased when AgNPs and the mixed with PZQ were added. The properties of silver particles synthesized by <i>E. citratus</i> were identical and confirmed by all previous studies. These results demonstrated that green AgNPs with PZQ showed high activity against <i>S. mansoni</i> in laboratory experiments.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a New Spark Plasma Sintering Biphasic Calcium Phosphate With Bioglass Composite Ceramics and Examination of Its Biological Activity and Osteogenic Characteristics","authors":"Jie Xu,&nbsp;Huifeng Zheng,&nbsp;Wen Li,&nbsp;Yonghong Jian,&nbsp;Feng Liu","doi":"10.1002/jbm.b.35641","DOIUrl":"https://doi.org/10.1002/jbm.b.35641","url":null,"abstract":"<div>\u0000 \u0000 <p>Bone tissue engineering offers a promising strategy for repairing massive bone defects, with diverse biomaterials continuously emerging in this field. However, the capabilities of single-material systems increasingly fail to meet the requirements for bone regeneration. There is an urgent need to develop novel composite biomaterials. Herein, we fabricate biphasic calcium phosphate (BCP)/bioglass composite ceramics via digital light processing (DLP)-assisted spark plasma sintering (SPS) and systematically evaluate bioglass-ratio-dependent biological activity, biodegradability, and osteogenic efficacy through in vitro and in vivo models. We determined that 45S5 bioglass at 20 wt.% optimally enhances osteogenic differentiation, demonstrating significant potential for bone defect repair in future clinical applications.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “BMP2-Mimicking Peptide Modified With E7 Coupling to Calcined Bovine Bone Enhanced Bone Regeneration Associating With Activation of the Runx2/SP7 Signaling Axis”","authors":"","doi":"10.1002/jbm.b.35634","DOIUrl":"https://doi.org/10.1002/jbm.b.35634","url":null,"abstract":"<p>Y. Xi, X. Miao, Y. Li, et al., “Bmp2-Mimicking Peptide Modified With E7 Coupling to Calcined Bovine Bone Enhanced Bone Regeneration Associating With Activation of the Runx2/Sp7 Signaling Axis,” <i>Journal of Biomedical Materials Research Part B: Applied Biomaterials</i> 108, no. 1 (2020): 80–93, https://doi.org/10.1002/jbm.b.34368.</p><p>We apologize for this error.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Antibiofilm Activity of Copper Nanoparticles Stabilized With Polyvinyl Pyrrolidone and Polyvinyl Alcohol Against Pseudomonas aeruginosa and Staphylococcus aureus","authors":"Imzazul Rahaman,&nbsp;Namita Srivastava,&nbsp;Damini Thakur,&nbsp;Anshul Jamwal,&nbsp;Lokender Kumar","doi":"10.1002/jbm.b.35633","DOIUrl":"https://doi.org/10.1002/jbm.b.35633","url":null,"abstract":"<div>\u0000 \u0000 <p><i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i> are biofilm-forming pathogens that contribute to persistent infections and exhibit high resistance to conventional antibiotics. In the present study, copper nanoparticles (Cu-NPs) were synthesized using polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) as polymeric stabilizing agents to evaluate their potential in biofilm inhibition. The synthesized Cu-NPs were characterized by Ultraviolet–Visible (UV–Vis) spectroscopy, Fourier-Transform Infrared (FT-IR) spectroscopy, Dynamic Light Scattering (DLS), zeta potential, Field Emission Scanning Electron Microscopy (FE-SEM), Energy-Dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD). The average particle sizes of the two formulations were found to be ~114 nm (PVP-Cu-NP) and ~127 nm (PVA-Cu-NP). Both NPs have demonstrated strong biofilm inhibitory activity at sub-minimum inhibitory concentrations (Sub-MICs) up till Day 3. The inhibitory efficacy of PVP-NP and PVA-NP against <i>P. aeruginosa</i> biofilm was 59.4% and 73.10%, respectively. Whereas the inhibitory efficacy of the two formulations against <i>S. aureus</i> biofilm was found to be 78.94% by PVP-NP and 88.94% by PVA-NP. Additionally, the Sub-MIC concentrations of PVP-NP and PVA-NP significantly reduced cell surface hydrophobicity (CSH) and exopolysaccharide (EPS) production, thereby disrupting key components of biofilm architecture. These findings suggest that polymer-stabilized copper nanoparticles may provide promising therapeutic strategies for the prevention and control of biofilm-forming and antibiotic-resistant disease-causing pathogens.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen/Hydroxyapatite Hydrogels Promote Intercellular Interactions and Osteogenic Differentiation","authors":"Yoon Wha Oh,&nbsp;Seung Won Kang,&nbsp;Sangbae Park,&nbsp;Sang-Wook Park,&nbsp;Hee-Gyeong Yi","doi":"10.1002/jbm.b.35632","DOIUrl":"https://doi.org/10.1002/jbm.b.35632","url":null,"abstract":"<p>Bone defects resulting from trauma, disease, or congenital abnormalities present formidable clinical challenges, necessitating advanced regenerative strategies. In this study, a novel bone tissue engineering approach utilizing the osteoinductive properties of collagen/hydroxyapatite (HA) hydrogels and the structural support provided by 3D-printed polylactic acid (PLA) scaffolds was investigated. Specifically, MG63 osteoblast-like cells were encapsulated within collagen/HA hydrogels formulated at an optimized 5:5 ratio and subsequently loaded into PLA lattices. Cell viability, osteogenic differentiation, and mineralization, assessed through live/dead assays, alkaline phosphatase (ALP) activity, osteogenic gene expression analysis, alizarin red S (ARS) staining, field-emission scanning electron microscopy (FE-SEM), and micro-computed tomography (micro-CT) analyses were conducted in vitro. The results demonstrated that the 5:5 collagen/HA hydrogel supported significantly enhanced cell proliferation compared to other tested ratios and the collagen control group. Under bone morphogenetic protein 2 (BMP-2)-induced osteogenic conditions, the composite hydrogel exhibited markedly higher ALP activity and upregulated key osteogenic markers, including ALP and Osterix, indicating robust early differentiation. ARS staining and FE-SEM imaging revealed accelerated and more uniform mineral deposition in the collagen/HA group. These findings were corroborated by 3D micro-CT analysis, which showed near-complete mineralization of the scaffold interior by Day 30. These findings suggest that integrating HA into collagen hydrogels improves the biological environment for osteoblast proliferation and differentiation while promoting nucleation and mineralized extracellular matrix growth. The innovative strategy of encapsulating cells within the hydrogel before scaffold loading maximizes direct cell-material interactions, thereby facilitating more efficient osteogenic signaling compared to traditional composite scaffold fabrication methods. This composite scaffold design demonstrates strong potential for accelerating bone regeneration and improving clinical outcomes in bone defect repair.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35632","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Chitosan-sodium percarbonate-based hydrogels with sustained oxygen release potential stimulated angiogenesis and accelerated wound healing","authors":"","doi":"10.1002/jbm.b.35635","DOIUrl":"https://doi.org/10.1002/jbm.b.35635","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;p&gt;\u0000 &lt;b&gt;RETRACTION&lt;/b&gt;: &lt;span&gt;T.S. Waris&lt;/span&gt;, &lt;span&gt;S.T. Abbas Shah&lt;/span&gt;, &lt;span&gt;A. Mehmood&lt;/span&gt;, &lt;span&gt;A. Mushtaq&lt;/span&gt;, &lt;span&gt;M. Zehra&lt;/span&gt;, &lt;span&gt;S. Zulfiqar&lt;/span&gt;, &lt;span&gt;A. Andleeb&lt;/span&gt;, &lt;span&gt;F. Jabbar&lt;/span&gt;, &lt;span&gt;M.A. Anjum&lt;/span&gt;, &lt;span&gt;A.A. Chaudhry&lt;/span&gt;, &lt;span&gt;I. Ur Rehman&lt;/span&gt;, and &lt;span&gt;M. Yar&lt;/span&gt;, “ &lt;span&gt;Chitosan-sodium percarbonate-based hydrogels with sustained oxygen release potential stimulated angiogenesis and accelerated wound healing&lt;/span&gt;,” &lt;i&gt;Journal of Biomedical Materials Research Part B: Applied Biomaterials&lt;/i&gt; &lt;span&gt;112&lt;/span&gt;, no. &lt;span&gt;1&lt;/span&gt; (&lt;span&gt;2024&lt;/span&gt;): e35344. https://doi.org/10.1002/jbm.b.35344.\u0000 &lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;p&gt;The above article, published online on 9 November 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal's Editor-in-Chief Danielle Benoit; and John Wiley &amp; Sons Ltd.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;p&gt;The retraction has been agreed following an investigation of the concerns raised by &lt;i&gt;Mycosphaerella arachidis&lt;/i&gt; on PubPeer [1], which identified unexpected similarities between multiple panels of Figure 7.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;p&gt;More specifically, the images depicting the wounds of animals in the CSPUO&lt;sub&gt;2&lt;/sub&gt; and Control groups after 10 days appear identical to the image of the T4-W group after 15 days. Additional concerns have been identified regarding the similarity of the Day 0 and Day 5 panels of the CSPUO&lt;sub&gt;2&lt;/sub&gt; group to two panels in Figure 6A from another publication by the author group, where they are attributed to a different experimental condition [2].&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;p&gt;As a result of the investigation, the data and conclusions of this article are considered unreliable.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;p&gt;The authors disagree with this retraction.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; References&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;\u0000 [1] &lt;span&gt;Mycosphaerella arachidis&lt;/span&gt;, “ &lt;span&gt;Chitosan-sodium percarbonate-based hydrogels with sustained oxygen release potential stimulated angiogenesis and accelerated wound healing&lt;/span&gt;,” &lt;i&gt;PubPeer&lt;/i&gt;, November &lt;span&gt;2024&lt;/span&gt;, https://pubpeer.com/publications/CDB4F612F15EB0A3EC34A7A73D5747.\u0000 &lt;/p&gt;\u0000 \u0000 &lt;p&gt;\u0000 [2] &lt;span&gt;T. S. Waris&lt;/span&gt;, &lt;span&gt;S. T. Abbas Shah&lt;/span&gt;, &lt;span&gt;A. Mehmood&lt;/span&gt;, &lt;span&gt;Z. Iqbal&lt;/span&gt;, &lt;span&gt;M. Zehra&lt;/span&gt;, &lt;span&gt;A. A. Chaudhry&lt;/span&gt;, &lt;span&gt;I. Ur Rehman&lt;/span&gt;, and &lt;span&gt;M. Yar&lt;/span&gt;, “ &lt;span&gt;Design and development of thyr","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Biocompatible Polymeric Blend for pH Driven Delivery of Cytarabine: Effect of Feed Contents on Swelling and Release Kinetics","authors":"","doi":"10.1002/jbm.b.35637","DOIUrl":"https://doi.org/10.1002/jbm.b.35637","url":null,"abstract":"<p>\u0000 <b>RETRACTION</b>: <span>N. Batool</span>, <span>R. M. Sarfraz</span>, <span>A. Mahmood</span>, <span>N. Zafar</span>, <span>M. U. Minhas</span>, <span>Z. Hussain</span>, and <span>U. Rehman</span>, “ <span>Biocompatible Polymeric Blend for pH Driven Delivery of Cytarabine: Effect of Feed Contents on Swelling and Release Kinetics</span>,” <i>Journal of Biomedical Materials Research Part B: Applied Biomaterials</i> <span>110</span>, no. <span>7</span> (<span>2022</span>): <span>1545</span>–<span>1562</span>, https://doi.org/10.1002/jbm.b.35016.\u0000 </p><p>The above article, published online on 31 January 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Danielle Benoit; the Society for Biomaterials; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Specifically, the control group panels in Figure 12 were previously published by the same author group without appropriate citation to the previous work or permission for reuse. The authors stated that the same control rabbits were used in both studies and that identical representative images were selected. However, several control group results in Tables 4 and 5 significantly differ from those in the earlier publication, despite referencing the same animals. The authors failed to adequately address these discrepancies. Accordingly, the article has been retracted as the editors have lost trust in the accuracy and integrity of the whole body of data presented in the article. The authors disagree with the decision of retraction.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Response Toward Inflammation of DPSCs Co-Cultured With Streptococcus mutans in the Presence of Alginate/Hydroxyapatite-Based Scaffolds Enriched With Silver Nanoparticles","authors":"Valentina Puca,&nbsp;Noemi Mencarelli,&nbsp;Benedetta Pellegrini,&nbsp;Eleonora Marsich,&nbsp;Amelia Cataldi,&nbsp;Rossella Grande,&nbsp;Marialucia Gallorini","doi":"10.1002/jbm.b.35636","DOIUrl":"https://doi.org/10.1002/jbm.b.35636","url":null,"abstract":"<div>\u0000 \u0000 <p>Managing bone defects is challenging, with autologous grafts being the most effective treatment. Biomaterials like alginate/hydroxyapatite (Alg/Hap) composites are increasingly used due to their biocompatibility and osteoconductive properties. Graft implantation in the oral cavity may trigger inflammatory responses, such as periodontitis, pulpitis, or caries, due to biomaterial recognition as non-self and the presence of pathogens like <i>Streptococcus mutans</i>. Conjugating Alg/Hap composites with antimicrobial silver nanoparticles (nAg) offers a strategy to counteract oral inflammation caused by microbial biofilms. This study explores the anti-inflammatory and antibiofilm activities of these biomaterials during early implantation (24–72 h), as well as DPSC viability and collagen expression. A co-culture model of dental pulp stem cells (DPSCs) and <i>Streptococcus mutans</i> UA 159 strains was established. <i>Streptococcus mutans</i> viability and biofilm formation on scaffolds were evaluated through the live/dead assay and confocal microscopy. Lactate dehydrogenase (LDH), interleukin-6 (IL-6), and collagen type 1 from DPSCs were measured via ELISA assays. Nrf2 and COX-2 protein expression was evaluated by western blotting. Alg/Hap/nAg composites reduce <i>S. mutans</i>-derived biofilm formation, preserving biocompatibility toward DPSCs. Decreased IL-6 levels, restored collagen type 1 secretion (5.98 pg/mL in DPSCs-MOI 0.1-Alg/Hap/Ag vs. 3.04 pg/mL in DPSCs-Alg/Hap/Ag at 72 h), and modulation of antioxidant and inflammatory proteins were observed, including a two-fold increase of Nrf2 expression in cells seeded onto scaffolds in the presence of nAg. These findings highlight the potential of smart biomaterials to promote DPSC osteogenic and odontogenic differentiation, advancing oral tissue regeneration strategies.</p>\u0000 </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}